{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:10:00Z","timestamp":1790122200572,"version":"4.0.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.expneurol.2008.05.017","type":"journal-article","created":{"date-parts":[[2008,5,31]],"date-time":"2008-05-31T04:05:05Z","timestamp":1212206705000},"page":"137-144","source":"Crossref","is-referenced-by-count":101,"title":["Aberrant connectivity of lateral prefrontal networks in presymptomatic Huntington's disease"],"prefix":"10.1016","volume":"213","author":[{"given":"Robert Christian","family":"Wolf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Sambataro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenad","family":"Vasic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Sch\u00f6nfeldt-Lecuona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Landwehrmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2008.05.017_bib1","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1093\/brain\/120.12.2207","article-title":"Cognitive deficits in Huntington's disease are predicted by dopaminergic PET markers and brain volumes","volume":"120","author":"Backman","year":"1997","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2008.05.017_bib2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.neuroimage.2004.01.007","article-title":"The chronoarchitecture of the human brain\u2014natural viewing conditions reveal a time-based anatomy of the brain","volume":"22","author":"Bartels","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.expneurol.2008.05.017_bib3","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"Beck","year":"1961","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.expneurol.2008.05.017_bib4","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1093\/brain\/awf180","article-title":"Impaired glutamate transport and glutamate\u2013glutamine cycling: downstream effects of the Huntington mutation","volume":"125","author":"Behrens","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2008.05.017_bib5","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.1523\/JNEUROSCI.16-17-05523.1996","article-title":"Expression of normal and mutant huntingtin in the developing brain","volume":"16","author":"Bhide","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2008.05.017_bib6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/hbm.1048","article-title":"A method for making group inferences from functional MRI data using independent component analysis","volume":"14","author":"Calhoun","year":"2001","journal-title":"Hum. Brain Mapp"},{"key":"10.1016\/j.expneurol.2008.05.017_bib7","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.mri.2004.09.004","article-title":"A method for comparing group fMRI data using independent component analysis: application to visual, motor and visuomotor tasks","volume":"22","author":"Calhoun","year":"2004","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.expneurol.2008.05.017_bib8","doi-asserted-by":"crossref","first-page":"10222","DOI":"10.1523\/JNEUROSCI.2250-06.2006","article-title":"Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis","volume":"26","author":"Celone","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2008.05.017_bib9","first-page":"215","article-title":"Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington's disease","volume":"47","author":"Ciarmiello","year":"2006","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.expneurol.2008.05.017_bib10","first-page":"401","article-title":"Comparison of blind source separation algorithms for FMRI using a new Matlab toolbox: GIFT","volume":"5","author":"Correa","year":"2005","journal-title":"Proc. IEEE Int Conf Acoustics, Speech, Signal Processing"},{"key":"10.1016\/j.expneurol.2008.05.017_bib54","doi-asserted-by":"crossref","unstructured":"Damoiseaux, J.S., Beckmann, C.F., Sanz Arigita, E.J., Barkhof, F., Scheltens, Ph., Stam, C.J., Smith, S.M., Rombouts S.A.R.B., in press. Reduced resting-state brain activity in the \"default network\" in normal aging. Cereb. Cortex. doi:10.1093\/cercor\/bhm207.","DOI":"10.1093\/cercor\/bhm207"},{"key":"10.1016\/j.expneurol.2008.05.017_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s002210000395","article-title":"Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies","volume":"133","author":"D'Esposito","year":"2000","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.expneurol.2008.05.017_bib12","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s11068-004-0514-8","article-title":"Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements","volume":"33","author":"DiProspero","year":"2004","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.expneurol.2008.05.017_bib13","series-title":"The Human Brain","author":"Duvernoy","year":"1999"},{"key":"10.1016\/j.expneurol.2008.05.017_bib14","first-page":"1591","article-title":"Metabolic network abnormalities in early Huntington's disease: an [(18)F]FDG PET study","volume":"42","author":"Feigin","year":"2001","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.expneurol.2008.05.017_bib15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/ana.20684","article-title":"Preclinical Huntington's disease: compensatory brain responses during learning","volume":"59","author":"Feigin","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2008.05.017_bib16","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1523\/JNEUROSCI.17-09-03052.1997","article-title":"Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum","volume":"17","author":"Ferrante","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2008.05.017_bib17","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/mrm.1910330508","article-title":"Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of cluster-size threshold","volume":"33","author":"Forman","year":"1995","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.expneurol.2008.05.017_bib18","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1006\/nimg.2001.1037","article-title":"Thresholding of statistical maps in functional neuroimaging using the false discovery rate","volume":"15","author":"Genovese","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.expneurol.2008.05.017_bib19","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1212\/01.wnl.0000257090.01107.2f","article-title":"Decreased frontal choline and neuropsychological performance in preclinical Huntington disease","volume":"68","author":"Gomez-Anson","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2008.05.017_bib20","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1523\/JNEUROSCI.19-07-02522.1999","article-title":"Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology","volume":"19","author":"Gutekunst","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2008.05.017_bib21","doi-asserted-by":"crossref","unstructured":"Hassel, B., Tessler, S., Faull, R.M., Emson, P.C., 2007. Glutamate uptake is reduced in prefrontal cortex in Huntington's Disease. Neurochem Res published online. DOI 10.1007\/s11064-11007-19463-11061.","DOI":"10.1007\/s11064-007-9463-1"},{"key":"10.1016\/j.expneurol.2008.05.017_bib22","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1159\/000072863","article-title":"The use of transgenic and knock-out mice to study Huntington's disease","volume":"100","author":"Hickey","year":"2003","journal-title":"Cytogenet. Genome Res."},{"key":"10.1016\/j.expneurol.2008.05.017_bib23","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"Unified Huntington's Disease Rating Scale: reliability and consistency","volume":"11","year":"1996","journal-title":"Movement Disorders"},{"key":"10.1016\/j.expneurol.2008.05.017_bib24","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1136\/jnnp.2004.047993","article-title":"Progression of structural neuropathology in preclinical Huntington's disease: a tensor based morphometry study","volume":"76","author":"Kipps","year":"2007","journal-title":"Journal Neurol Neurosurg and Psychiatry"},{"key":"10.1016\/j.expneurol.2008.05.017_bib25","doi-asserted-by":"crossref","first-page":"9112","DOI":"10.1523\/JNEUROSCI.21-23-09112.2001","article-title":"Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease","volume":"21","author":"Laforet","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2008.05.017_bib26","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/hbm.20345","article-title":"Bias between MNI and Talairach coordinates analyzed using the ICBM-152 brain template","volume":"28","author":"Lancaster","year":"2007","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.expneurol.2008.05.017_bib27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1399-0004.2004.00241.x","article-title":"A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length","volume":"65","author":"Langbehn","year":"2004","journal-title":"Clin. Genet."},{"issue":"Pt 7","key":"10.1016\/j.expneurol.2008.05.017_bib28","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/brain\/121.7.1329","article-title":"Evidence for specific cognitive deficits in preclinical Huntington's disease","volume":"121","author":"Lawrence","year":"1998","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2008.05.017_bib29","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/hbm.20359","article-title":"Estimating the number of independent components for functional magnetic resonance imaging data","volume":"28","author":"Li","year":"2007","journal-title":"Human Brain Mapping"},{"key":"10.1016\/j.expneurol.2008.05.017_bib30","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0165-0173(99)00040-5","article-title":"Basal ganglia and cerebellar loops: motor and cognitive circuits","volume":"31","author":"Middleton","year":"2000","journal-title":"Brain Research Reviews"},{"key":"10.1016\/j.expneurol.2008.05.017_bib31","first-page":"21","article-title":"Brain imaging and cognitive dysfunctions in Huntington's disease","volume":"31","author":"Montoya","year":"2006","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.expneurol.2008.05.017_bib32","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1176\/appi.neuropsych.13.3.342","article-title":"Effects of depression on working memory in presymptomatic Huntington's disease","volume":"13","author":"Nehl","year":"2001","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.expneurol.2008.05.017_bib33","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1176\/appi.ajp.2007.06081266","article-title":"Morphology of the cerebral cortex in preclinical Huntington's disease","volume":"164","author":"Nopoulos","year":"2007","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.expneurol.2008.05.017_bib34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness: the Edinburgh inventory","volume":"9","author":"Oldfield","year":"1971","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.expneurol.2008.05.017_bib35","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/hbm.20131","article-title":"N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies","volume":"25","author":"Owen","year":"2005","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.expneurol.2008.05.017_bib36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biopsych.2005.06.003","article-title":"Brain structure in preclinical Huntington's disease","volume":"59","author":"Paulsen","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.expneurol.2008.05.017_bib37","first-page":"1715","article-title":"fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington's Disease","volume":"25","author":"Paulsen","year":"2004","journal-title":"AJNR"},{"key":"10.1016\/j.expneurol.2008.05.017_bib38","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/ana.20121","article-title":"Functional brain changes in presymptomatic Huntington's disease","volume":"55","author":"Reading","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2008.05.017_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscychresns.2005.05.011","article-title":"Regional white matter change in pre-symptomatic Huntington's disease: a diffusion tensor imaging study","volume":"140","author":"Reading","year":"2005","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"10.1016\/j.expneurol.2008.05.017_bib40","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1212\/01.wnl.0000174432.87383.87","article-title":"Regional cortical thinning in preclinical Huntington disease and its relationship to cognition","volume":"65","author":"Rosas","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2008.05.017_bib41","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/mds.20979","article-title":"Diffusion tensor imaging in presymptomatic and early Huntington's disease: selective white matter pathology and its relationship to clinical measures","volume":"21","author":"Rosas","year":"2006","journal-title":"Mov. Disord."},{"key":"10.1016\/j.expneurol.2008.05.017_bib42","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/ana.410420411","article-title":"Huntingtin localization in brains of normal and Huntington's disease patients","volume":"42","author":"Sapp","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2008.05.017_bib43","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.neuropsychologia.2006.12.015","article-title":"Verbal episodic memory declines prior to diagnosis in Huntington's disease","volume":"45","author":"Solomon","year":"2007","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.expneurol.2008.05.017_bib44","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1126\/science.153.3736.652","article-title":"High-speed scanning in human memory","volume":"153","author":"Sternberg","year":"1966","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2008.05.017_bib45","article-title":"Brain network dynamics during error commission","author":"Stevens","year":"2007","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.expneurol.2008.05.017_bib46","series-title":"Co-Planar Stereotaxic Atlas of the Human Brain","author":"Talairach","year":"1988"},{"key":"10.1016\/j.expneurol.2008.05.017_bib47","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1136\/jnnp.2006.098368","article-title":"Functional connectivity of the prefrontal cortex in Huntington's disease","volume":"78","author":"Thiruvady","year":"2007","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"10.1016\/j.expneurol.2008.05.017_bib48","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington's disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2008.05.017_bib49","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1017\/S1355617706060565","article-title":"A four-year prospective study of cognitive functioning in Huntington's disease","volume":"12","author":"Ward","year":"2006","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.expneurol.2008.05.017_bib50","article-title":"Cortical dysfunction in patients with Huntington's disease during working memory performance","author":"Wolf","year":"2008","journal-title":"Human Brain Mapping"},{"key":"10.1016\/j.expneurol.2008.05.017_bib51","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1093\/brain\/awm210","article-title":"Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington's disease: evidence from event-related fMRI","volume":"130","author":"Wolf","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2008.05.017_bib52","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pscychresns.2005.06.002","article-title":"Evaluation of a novel event-related parametric fMRI paradigm investigating prefrontal function","volume":"140","author":"Wolf","year":"2005","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"10.1016\/j.expneurol.2008.05.017_bib53","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1017\/S1355617707071214","article-title":"fMRI detection of early neural dysfunction in preclinical Huntington's disease","volume":"13","author":"Zimbelman","year":"2007","journal-title":"Journal of the International Neuropsychological Society"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488608002239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488608002239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T16:27:09Z","timestamp":1557592029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488608002239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0014488608002239"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2008.05.017","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}