{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:41:11Z","timestamp":1792737671751,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100014420","name":"Dental Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014420","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE 11964"],"award-info":[{"award-number":["DE 11964"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007683","name":"Nihon University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007683","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007854","name":"School of Dentistry, Nihon University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007854","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.expneurol.2008.08.005","type":"journal-article","created":{"date-parts":[[2008,8,23]],"date-time":"2008-08-23T04:56:25Z","timestamp":1219467385000},"page":"209-218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Modulation of paratrigeminal nociceptive neurons following temporomandibular joint inflammation in rats"],"prefix":"10.1016","volume":"214","author":[{"given":"Yoko","family":"Yamazaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2008.08.005_bib1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1139\/y04-054","article-title":"Barosensitive neurons in the rat tractus solitarius and paratrigeminal nucleus: a new model for medullary, cardiovascular reflex regulation","volume":"82","author":"Balan","year":"2004","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.expneurol.2008.08.005_bib2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0304-3959(01)00450-X","article-title":"Vagotomy prevents morphine-induced reduction in Fos-like immunoreactivity in trigeminal spinal nucleus produced after TMJ injury in a sex-dependent manner","volume":"96","author":"Bereiter","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2008.08.005_bib3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pain.2005.05.013","article-title":"Effect of persistent monoarthritis of the temporomandibular joint region on acute mustard oil-induced excitation of trigeminal subnucleus caudalis neurons in male and female rats","volume":"117","author":"Bereiter","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2008.08.005_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pain.2006.04.029","article-title":"Local blockade of integrins in the temporomandibular joint region reduces Fos-positive neurons in trigeminal subnucleus caudalis of female rats produced by jaw movement","volume":"125","author":"Bereiter","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2008.08.005_bib5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/08869634.1989.11678277","article-title":"Pain assessment in temporomandibular disorders","volume":"7","author":"Bush","year":"1989","journal-title":"Cranio"},{"key":"10.1016\/j.expneurol.2008.08.005_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0304-3959(95)00166-2","article-title":"Effect of cardiac vagus afferent electrostimulation on the responses of trigeminal and trigeminothalamic neurons to noxious orofacial stimulation","volume":"65","author":"Bossut","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2008.08.005_bib7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00221-002-1308-1","article-title":"Activation of brain stem neurons by irritant chemical stimulation of the throat assessed by c-fos immunohistochemistry","volume":"148","author":"Boucher","year":"2003","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.expneurol.2008.08.005_bib8","doi-asserted-by":"crossref","first-page":"8056","DOI":"10.1523\/JNEUROSCI.18-19-08056.1998","article-title":"Evidence that excitatory amino acid receptors within the temporomandibular joint region are involved in the reflex activation of the jaw muscles","volume":"18","author":"Cairns","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2008.08.005_bib9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S1566-0702(01)00338-1","article-title":"Neuronal connections of the paratrigeminal nucleus: a topographic analysis of neurons projecting to bulber, pontine and thalamic nuclei related to cardiovascular, respiratory and sensory functions","volume":"94","author":"Caous","year":"2001","journal-title":"Auton. Neurosci. Basic Clin."},{"key":"10.1016\/j.expneurol.2008.08.005_bib10","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0306-4522(95)00297-V","article-title":"Brainstem neurons expressing c-Fos immunoreactivity following irritant chemical stimulation of the rat's tongue","volume":"69","author":"Carstens","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2008.08.005_bib11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0304-3959(91)90152-N","article-title":"Effect of vagus afferent stimulation on cervical spinothalamic tract neurons in monkeys","volume":"44","author":"Chandler","year":"1991","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2008.08.005_bib12","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1523\/JNEUROSCI.0003-06.2006","article-title":"Activated microglia contribute to the maintenance of chronic pain after spinal cord injury","volume":"26","author":"Hains","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2008.08.005_bib13","first-page":"108","article-title":"Joint tenderness, jaw opening, chewing velocity, and bite force in patients with temporomandibular joint pain and matched healthy control subjects","volume":"18","author":"Hansdottir","year":"2004","journal-title":"J. Orofacial Pain"},{"key":"10.1016\/j.expneurol.2008.08.005_bib14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2008.08.005_bib16","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/cne.903560311","article-title":"Distribution of Fos-like immunoreactivity in the caudal brainstem of the rat following noxious chemical stimulation of the temporomandibular joint","volume":"356","author":"Hathaway","year":"1995","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2008.08.005_bib18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3959(92)90131-T","article-title":"Stimulation of craniofacial muscle afferents induces prolonged facilitatory effects in trigeminal nociceptive brain-stem neurones","volume":"48","author":"Hu","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2008.08.005_bib19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0169-328X(99)00040-6","article-title":"Orofacial deep and cutaneous tissue inflammation differentially upregulates preprodynorphin mRNA in the trigeminal and paratrigeminal nuclei of the rat","volume":"67","author":"Imbe","year":"1999","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.expneurol.2008.08.005_bib20","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000047887","article-title":"Orofacial deep and cutaneous tissue inflammation and trigeminal neuronal activation. Implications for persistent temporomandibular pain.","volume":"169","author":"Imbe","year":"2001","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.expneurol.2008.08.005_bib21","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0006-8993(95)00176-Q","article-title":"Fos induction in the medullary dorsal horn and C1 segment of the spinal cord by acute inflammation in aged rats","volume":"678","author":"Iwata","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2008.08.005_bib22","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1152\/jn.1999.82.3.1244","article-title":"Medullary dorsal horn neuronal activity in rats with persistent temporomandibular joint and perioral inflammation","volume":"82","author":"Iwata","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.expneurol.2008.08.005_bib23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/08990229009144705","article-title":"Trigeminal projections to contralateral dorsal horn: central extent, peripheral origins, and plasticity","volume":"7","author":"Jacquin","year":"1990","journal-title":"Somatosens. Mot. Res."},{"key":"10.1016\/j.expneurol.2008.08.005_bib24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pain.2006.01.038","article-title":"Role of the paratrigeminal nucleus in nocifensive responses of rats to chemical, thermal and mechanical stimuli applied to the hind paw","volume":"122","author":"Koepp","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2008.08.005_bib25","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S1079-2104(96)80192-2","article-title":"Comorbidity of depression with chronic facial pain and temporomandibular disorders","volume":"82","author":"Korszun","year":"1996","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"issue":"4","key":"10.1016\/j.expneurol.2008.08.005_bib26","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/154405910208100411","article-title":"Basal circadian cortisol secretion in women with temporomandibular disorders","volume":"81","author":"Korszun","year":"2002","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.expneurol.2008.08.005_bib27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1155\/2005\/860354","article-title":"Neural mechanisms of temporomandibular joint and masticatory muscle pain: a possible role for peripheral glutamate receptor mechanisms","volume":"10","author":"Lam","year":"2005","journal-title":"Pain Res. Manag."},{"key":"10.1016\/j.expneurol.2008.08.005_bib28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.archoralbio.2004.05.013","article-title":"Synaptic contacts established by inferior alveolar nerve fibres in the paratrigeminal nucleus: an electron microscopic study in the rat","volume":"50","author":"Lapa","year":"2005","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.expneurol.2008.08.005_bib30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0304-3959(00)00237-2","article-title":"Low intensity vagal nerve stimulation lowers human thermal pain thresholds","volume":"86","author":"Ness","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2008.08.005_bib31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00221-003-1538-x","article-title":"A new model of experimental parotitis in rats and its implication for trigeminal nociception","volume":"152","author":"Ogawa","year":"2003","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.expneurol.2008.08.005_bib32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejpain.2004.04.006","article-title":"Evidence for the involvement of endogenous ATP and P2X receptors in TMJ pain","volume":"9","author":"Oliveira","year":"2005","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.expneurol.2008.08.005_bib33","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1986"},{"key":"10.1016\/j.expneurol.2008.08.005_bib34","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/0278-2391(90)90011-P","article-title":"Identification of prostaglandin E2 and leukotriene B4 in the synovial fluid of painful, dysfunctional temporomandibular joints","volume":"48","author":"Quinn","year":"1990","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.expneurol.2008.08.005_bib35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0165-0173(92)90009-B","article-title":"Vagal afferent modulation of nociception","volume":"17","author":"Randich","year":"1992","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.expneurol.2008.08.005_bib36","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1152\/jn.1993.69.5.1530","article-title":"Vagal afferent stimulation-produced effects on nociception in capsaicin-treated rats","volume":"69","author":"Ren","year":"1993","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.expneurol.2008.08.005_bib37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0304-3959(01)00357-8","article-title":"Development of a behavioral model of TMJ pain in rats: the TMJ formalin test","volume":"94","author":"Roveroni","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2008.08.005_bib38","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0169-328X(92)90213-U","article-title":"Expression of c-fos and NGFI-A messenger RNA in the medulla oblongata of the anaesthetized rat following stimulation of vagal and cardiovascular afferents","volume":"13","author":"Rutherfurd","year":"1992","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.expneurol.2008.08.005_bib39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2334\/josnusd.47.65","article-title":"Activation of trigeminal intranuclear pathway in rats with temporomandibular joint inflammation","volume":"47","author":"Sato","year":"2005","journal-title":"J. Oral Sci."},{"key":"10.1016\/j.expneurol.2008.08.005_bib51","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1152\/jn.1988.60.6.2180","article-title":"Time course of mechanosensitivity changes in articular afferents during a developing experimental arthritis","volume":"60","author":"Schaible","year":"1988","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.expneurol.2008.08.005_bib40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1526-4610.1989.hed22904229.x","article-title":"Facial pain, headache, and temporomandibular joint inflammation","volume":"29","author":"Schellhas","year":"1989","journal-title":"Headache"},{"key":"10.1016\/j.expneurol.2008.08.005_bib41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.brainres.2005.12.040","article-title":"Phosphorylation of extracellular signal-regulated kinase in medullary and upper cervical cord neurons following noxious tooth pulp stimulation","volume":"1072","author":"Shimizu","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2008.08.005_bib42","doi-asserted-by":"crossref","first-page":"31S","DOI":"10.1016\/S0002-9343(03)00190-6","article-title":"c-Fos immunoreactivity in the brain after esophageal acid stimulation","volume":"115","author":"Suwanprathes","year":"2003","journal-title":"Am. J. Med."},{"key":"10.1016\/j.expneurol.2008.08.005_bib43","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1152\/jn.00677.2007","article-title":"Differential effects of estradiol on encoding properties of TMJ units in laminae I and V at the spinomedullary junction in female rats","volume":"98","author":"Tashiro","year":"2007","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.expneurol.2008.08.005_bib52","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0304-3959(94)00223-2","article-title":"Responses of on and off cells in the rostral ventral medulla to stimulation of vagal afferents and changes in mean arterial blood pressure in intact and cardiopulmonary deafferented rats","volume":"62","author":"Thurston","year":"1995","journal-title":"Pain."},{"key":"10.1016\/j.expneurol.2008.08.005_bib45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/10641960701813908","article-title":"Heart rate variability for evaluating surgical stress and development of postoperative complications","volume":"30","author":"Ushiyama","year":"2008","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.expneurol.2008.08.005_bib46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1566-0702(03)00022-5","article-title":"Baroreceptor-sensitive neurons in the rat paratrigeminal nucleus","volume":"105","author":"Yu","year":"2003","journal-title":"Auton. Neurosci. Basic Clin."},{"key":"10.1016\/j.expneurol.2008.08.005_bib47","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S1566-0702(02)00035-8","article-title":"Cardiovascular responses to sciatic nerve stimulation are blocked by paratrigeminal nucleus lesion","volume":"98","author":"Yu","year":"2002","journal-title":"Auton. Neurosci. Basic Clin."},{"key":"10.1016\/j.expneurol.2008.08.005_bib48","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.bbi.2006.07.008","article-title":"Involvement of glia in central sensitization in trigeminal subnucleus caudalis (medullary dorsal horn)","volume":"21","author":"Xie","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.expneurol.2008.08.005_bib49","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/(SICI)1096-9861(19990920)412:2<276::AID-CNE7>3.0.CO;2-9","article-title":"Persistent Fos protein expression after orofacial deep or cutaneous tissue inflammation in rats: implications for persistent orofacial pain","volume":"412","author":"Zhou","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2008.08.005_bib50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488608003233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488608003233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:42:34Z","timestamp":1762148554000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488608003233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0014488608003233"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2008.08.005","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of paratrigeminal nociceptive neurons following temporomandibular joint inflammation in rats","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2008.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}