{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:45:42Z","timestamp":1791067542052,"version":"4.1.0"},"reference-count":122,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD43120"],"award-info":[{"award-number":["HD43120"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS54685"],"award-info":[{"award-number":["NS54685"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.expneurol.2008.10.016","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T04:35:01Z","timestamp":1226464501000},"page":"7-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Prodeath or prosurvival: Two facets of hypoxia inducible factor-1 in perinatal brain injury"],"prefix":"10.1016","volume":"216","author":[{"given":"Wanqiu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Ostrowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Obenaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2008.10.016_bib1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuint.2005.12.008","article-title":"Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats","volume":"48","author":"Althaus","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.expneurol.2008.10.016_bib2","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1074\/jbc.M409223200","article-title":"Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line","volume":"280","author":"Aminova","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2008.10.016_bib3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neulet.2006.09.039","article-title":"Induced angiogenesis under cerebral ischemia by cyclooxygenase 2 and hypoxia-inducible factor naked DNA in a rat indirect-bypass model","volume":"409","author":"Anan","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2008.10.016_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1203\/01.pdr.0000251612.16069.4b","article-title":"Comparison of two neonatal ischemic injury models using magnetic resonance imaging","volume":"61","author":"Ashwal","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1203\/PDR.0b013e3180db291b","article-title":"Temporal and regional evolution of aquaporin-4 expression and magnetic resonance imaging in a rat pup model of neonatal stroke","volume":"62","author":"Badaut","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib6","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1523\/JNEUROSCI.21-17-06480.2001","article-title":"Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity","volume":"21","author":"Bal-Price","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2008.10.016_bib7","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1523\/JNEUROSCI.0449-07.2007","article-title":"Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia","volume":"27","author":"Baranova","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2008.10.016_bib8","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1097\/00004647-199706000-00006","article-title":"Hypoxia\u2013ischemia, but not hypoxia alone, induces the expression of heme oxygenase-1 (HSP32) in newborn rat brain","volume":"17","author":"Bergeron","year":"1997","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2008.10.016_bib9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/1531-8249(200009)48:3<285::AID-ANA2>3.0.CO;2-8","article-title":"Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain","volume":"48","author":"Bergeron","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib10","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1046\/j.1460-9568.1999.00845.x","article-title":"Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain","volume":"11","author":"Bergeron","year":"1999","journal-title":"Eur. J. Neurosci."},{"issue":"2","key":"10.1016\/j.expneurol.2008.10.016_bib11","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1203\/00006450-199908000-00016","article-title":"Increased nitric oxide synthesis is not involved in delayed cerebral energy failure following focal hypoxic\u2013ischemic injury to the developing brain","volume":"46","author":"Blumberg","year":"1999","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib12","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1161\/01.ATV.0000258979.92828.bc","article-title":"Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site","volume":"27","author":"Bonello","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"16","key":"10.1016\/j.expneurol.2008.10.016_bib13","doi-asserted-by":"crossref","first-page":"9082","DOI":"10.1073\/pnas.97.16.9082","article-title":"Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia","volume":"97","author":"Bruick","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2008.10.016_bib14","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/japplphysiol.00268.2006","article-title":"Oxygen treatment after experimental hypoxia\u2013ischemia in neonatal rats alters the expression of HIF-1alpha and its downstream target genes","volume":"101","author":"Calvert","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib15","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1152\/japplphysiol.00630.2003","article-title":"Effect of hyperbaric oxygen on apoptosis in neonatal hypoxia\u2013ischemia rat model","volume":"95","author":"Calvert","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/28867","article-title":"Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis","volume":"394","author":"Carmeliet","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2008.10.016_bib17","doi-asserted-by":"crossref","first-page":"8922","DOI":"10.1523\/JNEUROSCI.22-20-08922.2002","article-title":"Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: potential role of insulin-like growth factor-1","volume":"22","author":"Chavez","year":"2002","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.expneurol.2008.10.016_bib18","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.nbd.2008.05.020","article-title":"HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic\u2013ischemic model","volume":"31","author":"Chen","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2008.10.016_bib19","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.neuro.2005.03.009","article-title":"Neuroprotective effect of simvastatin in stroke: a comparison between adult and neonatal rat models of cerebral ischemia","volume":"26","author":"Cimino","year":"2005","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.expneurol.2008.10.016_bib20","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.bbalip.2006.09.003","article-title":"Endothelial cell COX-2 expression and activity in hypoxia","volume":"1761","author":"Cook-Johnson","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"issue":"24","key":"10.1016\/j.expneurol.2008.10.016_bib21","doi-asserted-by":"crossref","first-page":"15729","DOI":"10.1073\/pnas.232568799","article-title":"Disrupted synaptic development in the hypoxic newborn brain","volume":"99","author":"Curristin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2008.10.016_bib22","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/35088074","article-title":"Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades","volume":"412","author":"Digicaylioglu","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2008.10.016_bib23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1113\/jphysiol.1979.sp012847","article-title":"Studies of the development of brain barrier systems to lipid insoluble molecules in fetal sheep","volume":"292","author":"Dziegielewska","year":"1979","journal-title":"J. Physiol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1203\/01.pdr.0000228323.32445.7d","article-title":"Effect of lipopolysaccharide on global gene expression in the immature rat brain","volume":"60","author":"Eklind","year":"2006","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib25","unstructured":"Fathali N., Lekic T., Jadhav J., Tang J., and Zhang J.H., 2007. Cyclooxygenase-2 inhibition attenuates hypoxic\u2013ischemic brain injury in neonates. Neuroscience Meeting Planner San Diego, CA: Society for Neuroscience, Abstract#380 12\/Z24 Online."},{"issue":"Suppl 7","key":"10.1016\/j.expneurol.2008.10.016_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1528-1167.2005.00302.x","article-title":"Protecting neurons","volume":"46","author":"Ferriero","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2008.10.016_bib27","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1111\/j.1460-9568.2006.04699.x","article-title":"Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat","volume":"23","author":"Freret","year":"2006","journal-title":"Eur. J. Neurosci."},{"issue":"9","key":"10.1016\/j.expneurol.2008.10.016_bib28","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/glia.20515","article-title":"The roles of aquaporin-4 in brain edema following neonatal hypoxia ischemia and reoxygenation in a cultured rat astrocyte model","volume":"55","author":"Fu","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.expneurol.2008.10.016_bib29","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1128\/MCB.23.1.359-369.2003","article-title":"Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia","volume":"23","author":"Goda","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000080708","article-title":"Maternal hypoxia during pregnancy delays the development of motor reflexes in newborn mice","volume":"26","author":"Golan","year":"2004","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.expneurol.2008.10.016_bib31","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/jnr.20269","article-title":"Maternal hypoxia during pregnancy induces fetal neurodevelopmental brain damage: partial protection by magnesium sulfate","volume":"78","author":"Golan","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/hh1301.092678","article-title":"Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: role of the p22(phox)-containing NADPH oxidase","volume":"89","author":"Gorlach","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib33","doi-asserted-by":"crossref","first-page":"H962","DOI":"10.1152\/ajpheart.01218.2003","article-title":"Interaction between endothelial heme oxygenase-2 and endothelin-1 in altered aortic reactivity after hypoxia in rats","volume":"288","author":"Govindaraju","year":"2005","journal-title":"Am. J. Physiol, Heart Circ. Physiol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib34","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/sj.cdd.4400810","article-title":"Hypoxia induces the expression of the pro-apoptotic gene BNIP3","volume":"8","author":"Guo","year":"2001","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.expneurol.2008.10.016_bib35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/exnr.1999.7160","article-title":"HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia","volume":"159","author":"Halterman","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib36","doi-asserted-by":"crossref","first-page":"6818","DOI":"10.1523\/JNEUROSCI.19-16-06818.1999","article-title":"Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53","volume":"19","author":"Halterman","year":"1999","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.expneurol.2008.10.016_bib37","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.neulet.2004.12.080","article-title":"A role for hypoxia-inducible factor-1alpha in desferoxamine neuroprotection","volume":"379","author":"Hamrick","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2008.10.016_bib38","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1523\/JNEUROSCI.4555-04.2005","article-title":"Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic\u2013ischemic damage","volume":"25","author":"Helton","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2008.10.016_bib39","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1097\/01.WCB.0000090621.86921.D5","article-title":"Thrombin preconditioning attenuates brain edema induced by erythrocytes and iron","volume":"23","author":"Hua","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2008.10.016_bib40","doi-asserted-by":"crossref","first-page":"32253","DOI":"10.1074\/jbc.271.50.32253","article-title":"Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit","volume":"271","author":"Huang","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2008.10.016_bib41","first-page":"210","article-title":"Angiogenesis and its regulatory factors in brain tissue of neonatal rat hypoxic\u2013ischemic encephalopathy","volume":"42","author":"Huang","year":"2004","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"10.1016\/j.expneurol.2008.10.016_bib42","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1447-0756.2000.tb01316.x","article-title":"Immature brain injury via peroxynitrite production induced by inducible nitric oxide synthase after hypoxia\u2013ischemia in rats","volume":"26","author":"Ikeno","year":"2000","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib43","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2008.10.016_bib44","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1101\/gad.12.2.149","article-title":"Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha","volume":"12","author":"Iyer","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.expneurol.2008.10.016_bib45","doi-asserted-by":"crossref","first-page":"H298","DOI":"10.1152\/ajpheart.2001.281.1.H298","article-title":"Correlation of HO-1 expression with onset and reversal of hypoxia-induced vasoconstrictor hyporeactivity","volume":"281","author":"Jernigan","year":"2001","journal-title":"Am. J. Physiol, Heart Circ. Physiol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib46","doi-asserted-by":"crossref","first-page":"C1172","DOI":"10.1152\/ajpcell.1996.271.4.C1172","article-title":"Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension","volume":"271","author":"Jiang","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib47","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/00004647-200204000-00004","article-title":"Thrombin-receptor activation and thrombin-induced brain tolerance","volume":"22","author":"Jiang","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2008.10.016_bib48","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0306-4522(00)00207-4","article-title":"Induction of vascular endothelial growth factor and hypoxia-inducible factor-1alpha by global ischemia in rat brain","volume":"99","author":"Jin","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2008.10.016_bib49","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000105478","article-title":"Mast cell stabilization limits hypoxic\u2013ischemic brain damage in the immature rat","volume":"29","author":"Jin","year":"2007","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.expneurol.2008.10.016_bib50","doi-asserted-by":"crossref","first-page":"5384","DOI":"10.1158\/1078-0432.CCR-05-2380","article-title":"Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation","volume":"12","author":"Jones","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib51","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1097\/00004647-200109000-00008","article-title":"Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain","volume":"21","author":"Jones","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2008.10.016_bib52","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1593\/neo.04628","article-title":"Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478","volume":"7","author":"Jordan","year":"2005","journal-title":"Neoplasia"},{"key":"10.1016\/j.expneurol.2008.10.016_bib53","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2261-7-4","article-title":"A long-term \u201cmemory\u201d of HIF induction in response to chronic mild decreased oxygen after oxygen normalization","volume":"7","author":"Kamat","year":"2007","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.expneurol.2008.10.016_bib54","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1074\/jbc.M308197200","article-title":"Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling","volume":"279","author":"Kasuno","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2008.10.016_bib55","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/j.1471-4159.2006.03964.x","article-title":"Hypoxic damage to the periventricular white matter in neonatal brain: role of vascular endothelial growth factor, nitric oxide and excitotoxicity","volume":"98","author":"Kaur","year":"2006","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.expneurol.2008.10.016_bib56","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1750-3639.2008.00156.x","article-title":"Melatonin attenuates hypoxia-induced ultrastructural changes and increased vascular permeability in the developing hippocampus","volume":"18","author":"Kaur","year":"2008","journal-title":"Brain Pathol."},{"issue":"11","key":"10.1016\/j.expneurol.2008.10.016_bib57","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1002\/jnr.21687","article-title":"Increase in dopaminergic neurons from mouse embryonic stem cell-derived neural progenitor\/stem cells is mediated by hypoxia inducible factor-1alpha","volume":"86","author":"Kim","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib58","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s11481-006-9032-4","article-title":"Nanotechnology: a focus on nanoparticles as a drug delivery system","volume":"1","author":"Kingsley","year":"2006","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib59","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/sj.jcbfm.9600369","article-title":"Cyclooxygenase-2 does not contribute to postischemic production of reactive oxygen species","volume":"27","author":"Kunz","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2008.10.016_bib60","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1203\/01.pdr.0000214891.35363.6a","article-title":"Acute hypoxia\u2013ischemia results in hydrogen peroxide accumulation in neonatal but not adult mouse brain","volume":"59","author":"Lafemina","year":"2006","journal-title":"Pediatr. Res."},{"issue":"6","key":"10.1016\/j.expneurol.2008.10.016_bib61","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1023\/A:1023235712524","article-title":"Chronic hypoxia in development selectively alters the activities of key enzymes of glucose oxidative metabolism in brain regions","volume":"28","author":"Lai","year":"2003","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib62","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.brainres.2007.12.059","article-title":"The involvement of phosphoinositid 3-kinase\/Akt pathway in the activation of hypoxia-inducible factor-1alpha in the developing rat brain after hypoxia\u2013ischemia","volume":"1197","author":"Li","year":"2008","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.expneurol.2008.10.016_bib63","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00401-008-0339-5","article-title":"The requirement of extracellular signal-related protein kinase pathway in the activation of hypoxia inducible factor 1alpha in the developing rat brain after hypoxia\u2013ischemia","volume":"115","author":"Li","year":"2008","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib64","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.expneurol.2004.08.036","article-title":"Multiple effects of hyperbaric oxygen on the expression of HIF-1 alpha and apoptotic genes in a global ischemia\u2013hypotension rat model","volume":"191","author":"Li","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib65","doi-asserted-by":"crossref","first-page":"8273","DOI":"10.1074\/jbc.M110768200","article-title":"Identification and functional analysis of the rat caspase-3 gene promoter","volume":"277","author":"Liu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2008.10.016_bib66","doi-asserted-by":"crossref","first-page":"37064","DOI":"10.1074\/jbc.M705015200","article-title":"Calcineurin promotes hypoxia-inducible factor 1{alpha} expression by dephosphorylating RACK1 and blocking RACK1 dimerization","volume":"282","author":"Liu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2008.10.016_bib67","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1042\/BST0321068","article-title":"Nitric oxide, hypoxia and brain inflammation","volume":"32","author":"Mander","year":"2004","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.expneurol.2008.10.016_bib68","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1460-9568.2006.04910.x","article-title":"Intrahippocampal injection of endothelin-1 in immature rats results in neuronal death, development of epilepsy and behavioral abnormalities later in life","volume":"24","author":"Mateffyova","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2008.10.016_bib69","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1471-4159.2004.02483.x","article-title":"HIF-1alpha reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion","volume":"90","author":"Matrone","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2008.10.016_bib70","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0165-3806(96)00043-0","article-title":"Microglia\u2013astrocyte interactions after cortisone treatment in a neonatal hypoxia\u2013ischemia model","volume":"94","author":"McRae","year":"1996","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib71","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4161\/cc.7.2.5193","article-title":"Synergystic induction of HIF-1alpha transcriptional activity by hypoxia and lipopolysaccharide in macrophages","volume":"15","author":"Mi","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.expneurol.2008.10.016_bib72","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.expneurol.2006.09.026","article-title":"Comparison of neuroprotective effects of erythropoietin (EPO) and carbamylerythropoietin (CEPO) against ischemia-like oxygen\u2013glucose deprivation (OGD) and NMDA excitotoxicity in mouse hippocampal slice cultures","volume":"204","author":"Montero","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib73","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.nbd.2003.08.020","article-title":"Regulation of hypoxia-inducible factor 1alpha and induction of vascular endothelial growth factor in a rat neonatal stroke model","volume":"14","author":"Mu","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2008.10.016_bib74","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.expneurol.2005.06.001","article-title":"Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke","volume":"195","author":"Mu","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib75","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1161\/01.STR.28.11.2281","article-title":"Vulnerability to cerebral hypoxic\u2013ischemic insult in neonatal but not in adult rats is in parallel with disruption of the blood\u2013brain barrier","volume":"28","author":"Muramatsu","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2008.10.016_bib76","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1750-3639.2007.00090.x","article-title":"HIF activation and VEGF overexpression are coupled with ZO-1 up-phosphorylation in the brain of dystrophic mdx mouse","volume":"17","author":"Nico","year":"2007","journal-title":"Brain Pathol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib77","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1517\/14728214.10.1.137","article-title":"Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics \u2014 an update","volume":"10","author":"Neckers","year":"2005","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.expneurol.2008.10.016_bib78","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1042\/bj3600049","article-title":"cDNA cloning and promoter analysis of rat caspase-9","volume":"360","author":"Nishiyama","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.expneurol.2008.10.016_bib79","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.clinthera.2006.09.005","article-title":"Intervention strategies for neonatal hypoxic\u2013ischemic cerebral injury","volume":"28","author":"Perlman","year":"2006","journal-title":"Clin. Ther."},{"key":"10.1016\/j.expneurol.2008.10.016_bib80","first-page":"4316","article-title":"Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway","volume":"62","author":"Rapisarda","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib81","first-page":"4","article-title":"Networking neonatal units","volume":"6","author":"Renton","year":"2003","journal-title":"Pract. Midwife"},{"issue":"47","key":"10.1016\/j.expneurol.2008.10.016_bib82","doi-asserted-by":"crossref","first-page":"18789","DOI":"10.1073\/pnas.0706019104","article-title":"Developmental regulation of hypoxia-inducible factor 1 and prolyl-hydroxylases in pulmonary vascular smooth muscle cells","volume":"104","author":"Resnik","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2008.10.016_bib83","doi-asserted-by":"crossref","first-page":"32631","DOI":"10.1074\/jbc.274.46.32631","article-title":"p42\/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1","volume":"274","author":"Richard","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2008.10.016_bib84","doi-asserted-by":"crossref","first-page":"8665","DOI":"10.1158\/1078-0432.CCR-04-1393","article-title":"2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma","volume":"10","author":"Ricker","year":"2004","journal-title":"Clin. Cancer Res."},{"issue":"7196","key":"10.1016\/j.expneurol.2008.10.016_bib85","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nature06905","article-title":"NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha","volume":"453","author":"Rius","year":"2008","journal-title":"Nature"},{"issue":"1\u20132","key":"10.1016\/j.expneurol.2008.10.016_bib86","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0006-8993(99)02365-3","article-title":"Effects of gestational hypoxia on mRNA levels of Glut3 and Glut4 transporters, hypoxia inducible factor-1 and thyroid hormone receptors in developing rat brain","volume":"856","author":"Royer","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib87","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.neuroscience.2006.10.003","article-title":"Glucocorticoids exacerbate hypoxia-induced expression of the pro-apoptotic gene Bnip3 in the developing cortex","volume":"144","author":"Sandau","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2008.10.016_bib88","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.brainres.2003.11.065","article-title":"Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus","volume":"1001","author":"Schmidt-Kastner","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib89","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/978-1-4757-3401-0_18","article-title":"Hypoxia-inducible factor in brain","volume":"502","author":"Sharp","year":"2001","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib90","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1602\/neurorx.1.1.26","article-title":"Hypoxic preconditioning protects against ischemic brain injury","volume":"1","author":"Sharp","year":"2004","journal-title":"NeuroRx"},{"issue":"1","key":"10.1016\/j.expneurol.2008.10.016_bib91","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ijdevneu.2007.08.010","article-title":"Genetic and pharmacologic manipulation of oxidative stress after neonatal hypoxia\u2013ischemia","volume":"26","author":"Sheldon","year":"2008","journal-title":"Int. J. Dev. Neurosci."},{"issue":"1","key":"10.1016\/j.expneurol.2008.10.016_bib92","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/ham.2008.1046","article-title":"Cobalt supplementation promotes hypoxic tolerance and facilitates acclimatization to hypobaric hypoxia in rat brain","volume":"9","author":"Shrivastava","year":"2008","journal-title":"High Alt. Med. Biol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib93","doi-asserted-by":"crossref","first-page":"41732","DOI":"10.1074\/jbc.M504963200","article-title":"Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system","volume":"280","author":"Siddiq","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2008.10.016_bib94","unstructured":"Sowter H.M., Ratcliffe P.J., Watson P., Greenberg A.H., Harris A.L. 2001. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. 15;61(18):6669\u201373."},{"key":"10.1016\/j.expneurol.2008.10.016_bib95","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0140-6736(03)14412-1","article-title":"Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states","volume":"362","author":"Stenzel-Poore","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.expneurol.2008.10.016_bib96","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0165-3806(94)90005-1","article-title":"Early ultrastructural changes in blood\u2013brain barrier vessels of the rat embryo","volume":"78","author":"Stewart","year":"1994","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib97","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0006-8993(02)03145-1","article-title":"Concurrent formation of peroxynitrite with the expression of inducible nitric oxide synthase in the brain during middle cerebral artery occlusion and reperfusion in rats","volume":"951","author":"Suzuki","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib98","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.brainres.2007.12.069","article-title":"HIF-1-regulated vasoactive systems are differentially involved in acute hypoxic stress responses of the developing brain of newborn mice and are not affected by levetiracetam","volume":"1199","author":"Trollmann","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib99","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1097\/00001756-200107200-00044","article-title":"Perinatal hypoxia\/ischemia-induced endothelin-1 mRNA in astrocyte-like and endothelial cells","volume":"12","author":"Tsang","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.expneurol.2008.10.016_bib100","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1203\/00006450-200001000-00015","article-title":"Protective effect of aminoguanidine on hypoxic\u2013ischemic brain damage and temporal profile of brain nitric oxide in neonatal rat","volume":"47","author":"Tsuji","year":"2000","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib101","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1203\/01.pdr.0000200799.64038.19","article-title":"Bilateral molecular changes in a neonatal rat model of unilateral hypoxic\u2013ischemic brain damage","volume":"59","author":"van den Tweel","year":"2006","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib102","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jneuroim.2005.06.031","article-title":"Expression of nitric oxide synthase isoforms and nitrotyrosine formation after hypoxia\u2013ischemia in the neonatal rat brain","volume":"167","author":"van den Tweel","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib103","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.mcn.2006.09.009","article-title":"Evidence of HIF-1 functional binding activity to caspase-3 promoter after photothrombotic cerebral ischemia","volume":"34","author":"Van Hoecke","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"issue":"8","key":"10.1016\/j.expneurol.2008.10.016_bib104","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1523\/JNEUROSCI.5323-07.2008","article-title":"The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes","volume":"28","author":"Vangeison","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2008.10.016_bib105","series-title":"Neurology of the Newborn WB Saunders Company","article-title":"Hypoxic\u2013ischemic encephalopathy","author":"Volpe,","year":"2001"},{"key":"10.1016\/j.expneurol.2008.10.016_bib106","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","article-title":"Hypoxia-inducible factor 1 is a basic-helix\u2013loop\u2013helix-PAS heterodimer regulated by cellular O2 tension","volume":"92","author":"Wang","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2008.10.016_bib107","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1006\/bbrc.1995.2674","article-title":"Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1","volume":"216","author":"Wang","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.expneurol.2008.10.016_bib108","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1203\/PDR.0b013e318123f757","article-title":"Albumin reduces blood\u2013brain barrier permeability but does not alter infarct size in a rat model of neonatal stroke","volume":"62","author":"Wang","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib109","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1196\/annals.1422.035","article-title":"Regulation of cytokine-induced HIF-1alpha expression in rheumatoid synovial fibroblasts","volume":"1108","author":"Westra","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.expneurol.2008.10.016_bib110","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1006\/bbrc.1996.1199","article-title":"In vivo expression of mRNAs encoding hypoxia-inducible factor 1","volume":"225","author":"Wiener","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.expneurol.2008.10.016_bib111","doi-asserted-by":"crossref","first-page":"6297","DOI":"10.1038\/sj.onc.1204012","article-title":"Identification of novel hypoxia dependent and independent target genes of the von Hippel\u2013Lindau (VHL) tumour suppressor by mRNA differential expression profiling","volume":"19","author":"Wykoff","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.expneurol.2008.10.016_bib112","first-page":"591","article-title":"Study on the relationship between perinatal hypoxia and concentration of endothelin-1 in amniotic fluid","volume":"34","author":"Xu","year":"1999","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"10.1016\/j.expneurol.2008.10.016_bib113","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1341-8076.2005.00266.x","article-title":"Expression of inducible nitric oxide synthase and cyclooxygenase-2 mRNA in brain damage induced by lipopolysaccharide and intermittent hypoxia\u2013ischemia in neonatal rats","volume":"31","author":"Yang","year":"2005","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.expneurol.2008.10.016_bib115","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/jnci\/95.7.516","article-title":"YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1","volume":"95","author":"Yeo","year":"2003","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.expneurol.2008.10.016_bib116","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.nbd.2005.07.015","article-title":"TAT-mediated delivery of Bcl-xL protein is neuroprotective against neonatal hypoxic\u2013ischemic brain injury via inhibition of caspases and AIF","volume":"21","author":"Yin","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2008.10.016_bib117","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1161\/01.STR.0000258102.18836.ca","article-title":"Preconditioning suppresses inflammation in neonatal hypoxic ischemia via Akt activation","volume":"38","author":"Yin","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2008.10.016_bib118","first-page":"L818","article-title":"Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung","volume":"275","author":"Yu","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib119","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.neuroscience.2004.03.057","article-title":"Protective effect of vitamin E against focal brain ischemia and neuronal death through induction of target genes of hypoxia-inducible factor-1","volume":"126","author":"Zhang","year":"2004","journal-title":"Neuroscience"},{"issue":"8","key":"10.1016\/j.expneurol.2008.10.016_bib120","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1111\/j.1742-4658.2008.06340.x","article-title":"Hypoxia-driven proliferation of embryonic neural stem\/progenitor cells\u2014role of hypoxia-inducible transcription factor-1alpha","volume":"275","author":"Zhao","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.expneurol.2008.10.016_bib121","doi-asserted-by":"crossref","first-page":"C1280","DOI":"10.1152\/ajpcell.00070.2006","article-title":"Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha","volume":"292","author":"Zhou","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.expneurol.2008.10.016_bib122","first-page":"373","article-title":"Experimental study on the expression of HIF-1alpha and its relationship to apoptosis in tissues around cerebral bleeding loci","volume":"24","author":"Zhu","year":"2004","journal-title":"J. Huazhong Univ. Sci. Technolog. Med. Sci."},{"key":"10.1016\/j.expneurol.2008.10.016_bib123","first-page":"51","article-title":"Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia","volume":"80","author":"Ziello","year":"2007","journal-title":"Yale J. Biol. Med."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488608004093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488608004093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:12:09Z","timestamp":1772100729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488608004093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":122,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0014488608004093"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2008.10.016","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prodeath or prosurvival: Two facets of hypoxia inducible factor-1 in perinatal brain injury","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2008.10.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}