{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:23:08Z","timestamp":1791314588825,"version":"4.3.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.expneurol.2009.09.007","type":"journal-article","created":{"date-parts":[[2009,9,18]],"date-time":"2009-09-18T09:17:15Z","timestamp":1253265435000},"page":"320-327","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["A role for galectin-1 in the immune response to peripheral nerve injury"],"prefix":"10.1016","volume":"220","author":[{"given":"Andrew D.","family":"Gaudet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Poirier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Kadoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Horie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt S.","family":"Ramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2009.09.007_bib1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.expneurol.2004.02.004","article-title":"Blocking of up-regulated ICAM-1 does not prevent macrophage infiltration during Wallerian degeneration of peripheral nerve","volume":"187","author":"Avellino","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.4049\/jimmunol.178.1.436","article-title":"A novel function for galectin-1 at the crossroad of innate and adaptive immunity: galectin-1 regulates monocyte\/macrophage physiology through a nonapoptotic ERK-dependent pathway","volume":"178","author":"Barrionuevo","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib3","doi-asserted-by":"crossref","first-page":"10892","DOI":"10.1523\/JNEUROSCI.23-34-10892.2003","article-title":"Caught in the act: in vivo mapping of macrophage infiltration in nerve injury by magnetic resonance imaging","volume":"23","author":"Bendszus","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2009.09.007_bib4","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1002\/(SICI)1521-4141(199808)28:08<2311::AID-IMMU2311>3.0.CO;2-G","article-title":"Beta-galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells","volume":"28","author":"Blaser","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib5","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1460-9568.1994.tb00285.x","article-title":"Further studies on motor and sensory nerve regeneration in mice with delayed Wallerian degeneration","volume":"6","author":"Brown","year":"1994","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2009.09.007_bib6","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1046\/j.1469-7580.2003.00248.x","article-title":"Wallerian degeneration in C57BL\/6J and A\/J mice: differences in time course of neurofilament and myelin breakdown, macrophage recruitment and iNOS expression","volume":"203","author":"de la Hoz","year":"2003","journal-title":"J. Anat."},{"key":"10.1016\/j.expneurol.2009.09.007_bib7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1242\/jeb.124.1.225","article-title":"Cell surface glycoconjugates and carbohydrate-binding proteins: possible recognition signals in sensory neurone development","volume":"124","author":"Dodd","year":"1986","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/jnen\/62.2.162","article-title":"Oxidized galectin-1 stimulates the migration of Schwann cells from both proximal and distal stumps of transected nerves and promotes axonal regeneration after peripheral nerve injury","volume":"62","author":"Fukaya","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib9","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2174\/1389450054021864","article-title":"Expression and functions of galectin-1 in sensory and motoneurons","volume":"6","author":"Gaudet","year":"2005","journal-title":"Curr. Drug Targets."},{"key":"10.1016\/j.expneurol.2009.09.007_bib46","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/jemt.10108","article-title":"Myelin phagocytosis by macrophages and nonmacrophages during Wallerian degeneration","volume":"57","author":"Hirata","year":"2002","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.expneurol.2009.09.007_bib10","doi-asserted-by":"crossref","first-page":"9964","DOI":"10.1523\/JNEUROSCI.19-22-09964.1999","article-title":"Galectin-1 regulates initial axonal growth in peripheral nerves after axotomy","volume":"19","author":"Horie","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2009.09.007_bib11","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1523\/JNEUROSCI.4483-03.2004","article-title":"Oxidized galectin-1 stimulates macrophages to promote axonal regeneration in peripheral nerves after axotomy","volume":"24","author":"Horie","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2009.09.007_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0306-4522(02)00065-9","article-title":"Macrophage and lymphocyte invasion of dorsal root ganglia after peripheral nerve lesions in the rat","volume":"112","author":"Hu","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2009.09.007_bib13","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0014-4886(03)00307-8","article-title":"Distinct functional types of macrophage in dorsal root ganglia and spinal nerves proximal to sciatic and spinal nerve transections in the rat","volume":"184","author":"Hu","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib14","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1523\/JNEUROSCI.10-03-01004.1990","article-title":"Selective expression of an endogenous lactose-binding lectin gene in subsets of central and peripheral neurons","volume":"10","author":"Hynes","year":"1990","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2009.09.007_bib15","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.brainres.2003.08.064","article-title":"Galectin-1 is involved in the potentiation of neuropathic pain in the dorsal horn","volume":"993","author":"Imbe","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2009.09.007_bib16","first-page":"2955","article-title":"Oxidized galectin-1 promotes axonal regeneration in peripheral nerves but does not possess lectin properties","volume":"267","author":"Inagaki","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.expneurol.2009.09.007_bib17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.exphem.2006.09.015","article-title":"A novel anti-inflammatory function of human galectin-1: inhibition of hematopoietic progenitor cell mobilization","volume":"35","author":"Kiss","year":"2007","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib18","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S0002-9440(10)63507-9","article-title":"A novel biological activity for galectin-1: inhibition of leukocyte\u2013endothelial cell interactions in experimental inflammation","volume":"163","author":"La","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib19","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1111\/j.1460-9568.2007.05971.x","article-title":"Complement activation contributes to leukocyte recruitment and neuropathic pain following peripheral nerve injury in rats","volume":"26","author":"Li","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2009.09.007_bib20","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/BF01195557","article-title":"Responses of macrophages in rat dorsal root ganglia following peripheral nerve injury","volume":"22","author":"Lu","year":"1993","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib21","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.tcb.2005.09.002","article-title":"Inflammatory cells during wound repair: the good, the bad and the ugly","volume":"15","author":"Martin","year":"2005","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib22","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/glia.20766","article-title":"Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease","volume":"56","author":"Martini","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.expneurol.2009.09.007_bib23","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1111\/j.1460-9568.2004.03802.x","article-title":"Galectin-1 in regenerating motoneurons","volume":"20","author":"McGraw","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2009.09.007_bib24","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neuroscience.2004.06.075","article-title":"Galectin-1 expression correlates with the regenerative potential of rubrospinal and spinal motoneurons","volume":"128","author":"McGraw","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2009.09.007_bib25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.expneurol.2005.04.004","article-title":"Regulation of neuronal and glial galectin-1 expression by peripheral and central axotomy of rat primary afferent neurons","volume":"195","author":"McGraw","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.pain.2004.10.009","article-title":"Altered primary afferent anatomy and reduced thermal sensitivity in mice lacking galectin-1","volume":"114","author":"McGraw","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2009.09.007_bib27","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/sj.cdd.4401462","article-title":"Galectin-1beta, a natural monomeric form of galectin-1 lacking its six amino-terminal residues promotes axonal regeneration but not cell death","volume":"11","author":"Miura","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.expneurol.2009.09.007_bib28","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/01.LAB.0000056993.28149.BF","article-title":"Macrophage response to peripheral nerve injury: the quantitative contribution of resident and hematogenous macrophages","volume":"83","author":"Mueller","year":"2003","journal-title":"Lab. Invest."},{"key":"10.1016\/j.expneurol.2009.09.007_bib29","doi-asserted-by":"crossref","first-page":"7460","DOI":"10.1523\/JNEUROSCI.0023-06.2006","article-title":"Pancreatitis-associated protein-III is a novel macrophage chemoattractant implicated in nerve regeneration","volume":"26","author":"Namikawa","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2009.09.007_bib30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.expneurol.2005.07.015","article-title":"Intravitreal macrophage activation enables cat retinal ganglion cells to regenerate injured axons into the mature optic nerve","volume":"196","author":"Okada","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib31","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/378736a0","article-title":"Apoptosis of T cells mediated by galectin-1","volume":"378","author":"Perillo","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2009.09.007_bib32","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1093\/brain\/awh407","article-title":"Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration","volume":"128","author":"Perrin","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2009.09.007_bib33","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1084\/jem.165.4.1218","article-title":"The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration","volume":"165","author":"Perry","year":"1987","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.expneurol.2009.09.007_bib34","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nn1897","article-title":"Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells","volume":"10","author":"Plachta","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.expneurol.2009.09.007_bib35","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1242\/dev.119.4.1229","article-title":"Normal development of mice carrying a null mutation in the gene encoding the L14 S-type lectin","volume":"119","author":"Poirier","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.expneurol.2009.09.007_bib36","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1006\/dbio.1996.0257","article-title":"Role of galectin-1 in the developing mouse olfactory system","volume":"179","author":"Puche","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib37","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.4049\/jimmunol.160.10.4831","article-title":"Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: biochemical and functional characterization","volume":"160","author":"Rabinovich","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib38","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/(SICI)1521-4141(200005)30:5<1331::AID-IMMU1331>3.0.CO;2-H","article-title":"Evidence of a role for galectin-1 in acute inflammation","volume":"30","author":"Rabinovich","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib39","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-3083.2007.01986.x","article-title":"An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer","volume":"66","author":"Rabinovich","year":"2007","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.expneurol.2009.09.007_bib40","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1523\/JNEUROSCI.21-08-02651.2001","article-title":"Two-tiered inhibition of axon regeneration at the dorsal root entry zone","volume":"21","author":"Ramer","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2009.09.007_bib41","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1073\/pnas.83.7.2248","article-title":"Selective expression of endogenous lactose-binding lectins and lactoseries glycoconjugates in subsets of rat sensory neurons","volume":"83","author":"Regan","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.expneurol.2009.09.007_bib42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1460-9568.2003.03102.x","article-title":"Synthesis, localization and externalization of galectin-1 in mature dorsal root ganglion neurons and Schwann cells","volume":"19","author":"Sango","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2009.09.007_bib43","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/(SICI)1097-4547(19980715)53:2<260::AID-JNR15>3.0.CO;2-A","article-title":"Monocyte chemoattractant protein 1 is responsible for macrophage recruitment following injury to sciatic nerve","volume":"53","author":"Toews","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2009.09.007_bib44","doi-asserted-by":"crossref","first-page":"6696","DOI":"10.1523\/JNEUROSCI.22-15-06696.2002","article-title":"Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF","volume":"22","author":"Tofaris","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2009.09.007_bib45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1189\/jlb.70.1.73","article-title":"Regulated expression of galectin-1 during B-cell activation and implications for T-cell apoptosis","volume":"70","author":"Zuniga","year":"2001","journal-title":"J. Leukoc. Biol."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448860900380X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448860900380X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:39:36Z","timestamp":1758001176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448860900380X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S001448860900380X"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2009.09.007","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A role for galectin-1 in the immune response to peripheral nerve injury","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2009.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}