{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:42:19Z","timestamp":1790854939639,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.expneurol.2010.03.005","type":"journal-article","created":{"date-parts":[[2010,3,15]],"date-time":"2010-03-15T09:35:11Z","timestamp":1268645711000},"page":"155-162","source":"Crossref","is-referenced-by-count":63,"title":["Ex vivo delivery of GDNF maintains motor function and prevents neuronal loss in a transgenic mouse model of Huntington's disease"],"prefix":"10.1016","volume":"224","author":[{"given":"Allison D.","family":"Ebert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia E.","family":"Barber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany M.","family":"Heins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive N.","family":"Svendsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2010.03.005_bib1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/096368970000900108","article-title":"Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease","volume":"9","author":"Armstrong","year":"2000","journal-title":"Cell Transplant."},{"key":"10.1016\/j.expneurol.2010.03.005_bib2","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0140-6736(00)03310-9","article-title":"Motor and cognitive improvements in patients with Huntington's disease after neural transplantation","volume":"356","author":"Bachoud-Levi","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.expneurol.2010.03.005_bib3","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1111\/j.1460-9568.2006.04743.x","article-title":"Neural progenitor cells engineered to secrete GDNF show enhanced survival, neuronal differentiation and improve cognitive function following traumatic brain injury","volume":"23","author":"Bakshi","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.03.005_bib4","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/sj.gt.3302679","article-title":"Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates","volume":"13","author":"Behrstock","year":"2006","journal-title":"Gene Ther."},{"key":"10.1016\/j.expneurol.2010.03.005_bib5","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/sj.mp.4002084","article-title":"Transplantation of neural progenitors enhances production of endogenous cells in the impaired brain","volume":"13","author":"Ben-Shaanan","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.expneurol.2010.03.005_bib6","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1093\/hmg\/ddn033","article-title":"Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II","volume":"17","author":"Benchoua","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.expneurol.2010.03.005_bib7","doi-asserted-by":"crossref","first-page":"6809","DOI":"10.1073\/pnas.120166397","article-title":"Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice","volume":"97","author":"Bibb","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2010.03.005_bib8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3727\/000000005783983098","article-title":"Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measures","volume":"14","author":"Bjugstad","year":"2005","journal-title":"Cell Transplant."},{"key":"10.1016\/j.expneurol.2010.03.005_bib9","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jneumeth.2007.02.022","article-title":"Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy","volume":"163","author":"Capowski","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.expneurol.2010.03.005_bib10","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1073\/pnas.95.11.6480","article-title":"Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene","volume":"95","author":"Cha","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2010.03.005_bib11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.nbd.2007.07.028","article-title":"Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo","volume":"29","author":"Charvin","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2010.03.005_bib12","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1126\/science.275.5301.838","article-title":"Dopaminergic neurons protected from degeneration by GDNF gene therapy","volume":"275","author":"Choi-Lundberg","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2010.03.005_bib13","doi-asserted-by":"crossref","first-page":"12483","DOI":"10.1073\/pnas.0904239106","article-title":"Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration","volume":"106","author":"Cicchetti","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2010.03.005_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1089\/10430340050016256","article-title":"Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease","volume":"11","author":"Deglon","year":"2000","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.expneurol.2010.03.005_bib15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.expneurol.2007.09.022","article-title":"Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease","volume":"209","author":"Ebert","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2010.03.005_bib16","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.expneurol.2003.08.014","article-title":"Neuronal and glial differentiation within expanded glial cultures derived from the lateral and medial ganglionic eminences","volume":"184","author":"Eriksson","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2010.03.005_bib17","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0014-4886(03)00271-1","article-title":"Neuronal differentiation following transplantation of expanded mouse neurosphere cultures derived from different embryonic forebrain regions","volume":"184","author":"Eriksson","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2010.03.005_bib18","doi-asserted-by":"crossref","first-page":"13877","DOI":"10.1073\/pnas.97.25.13877","article-title":"Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology","volume":"97","author":"Freeman","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2010.03.005_bib19","doi-asserted-by":"crossref","first-page":"6437","DOI":"10.1523\/JNEUROSCI.1122-04.2004","article-title":"Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time-and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system","volume":"24","author":"Georgievska","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.03.005_bib20","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nm850","article-title":"Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease","volume":"9","author":"Gill","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.expneurol.2010.03.005_bib21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1046\/j.1471-4159.2002.00804.x","article-title":"The role of dopamine in motor symptoms in the R6\/2 transgenic mouse model of Huntington's disease","volume":"81","author":"Hickey","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2010.03.005_bib22","doi-asserted-by":"crossref","first-page":"18117","DOI":"10.1073\/pnas.0408258102","article-title":"Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha\/CXC chemokine receptor 4 pathway","volume":"101","author":"Imitola","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2010.03.005_bib23","first-page":"239","article-title":"Neuronal cell death in Huntington's disease: a potential role for dopamine","volume":"23","author":"Jakel","year":"2000","journal-title":"TINS"},{"key":"10.1016\/j.expneurol.2010.03.005_bib24","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1212\/01.wnl.0000264504.14301.f5","article-title":"Neural transplantation in Huntington disease: long-term grafts in two patients","volume":"68","author":"Keene","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2010.03.005_bib25","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nm0698-727","article-title":"Functional integration of striatal allografts in a primate model of Huntington's disease","volume":"4","author":"Kendall","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.expneurol.2010.03.005_bib26","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1006\/exnr.1998.6952","article-title":"Dopamine D-1 and D-2 receptor-mediated acute and long-lasting behavioral effects of glial cell line-derived neurotrophic factor administered into the striatum","volume":"154","author":"Kobayashi","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2010.03.005_bib27","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/ana.20737","article-title":"Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease","volume":"59","author":"Lang","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2010.03.005_bib28","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0014-4886(03)00044-X","article-title":"Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF","volume":"181","author":"McBride","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2010.03.005_bib29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/cne.20176","article-title":"Human neural stem cell transplants improve motor function in a rat model of Huntington's disease","volume":"475","author":"McBride","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2010.03.005_bib30","doi-asserted-by":"crossref","first-page":"9345","DOI":"10.1073\/pnas.0508875103","article-title":"Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease","volume":"103","author":"McBride","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2010.03.005_bib31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1212\/WNL.60.1.69","article-title":"Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD","volume":"60","author":"Nutt","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2010.03.005_bib32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/exnr.2000.7427","article-title":"Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation","volume":"164","author":"Ostenfeld","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2010.03.005_bib33","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/nbt750","article-title":"Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons","volume":"20","author":"Ourednik","year":"2002","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.expneurol.2010.03.005_bib34","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nm0898-963","article-title":"Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease","volume":"4","author":"Palfi","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.expneurol.2010.03.005_bib35","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1006\/nbdi.2002.0534","article-title":"Evidence for dysfunction of the nigrostriatal pathway in the R6\/1 line of transgenic Huntington's disease mice","volume":"11","author":"Petersen","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2010.03.005_bib36","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.nbd.2007.01.003","article-title":"Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease","volume":"26","author":"Ramaswamy","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2010.03.005_bib37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.nbd.2008.12.005","article-title":"Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease","volume":"34","author":"Ramaswamy","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2010.03.005_bib38","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1046\/j.1460-9568.2003.02456.x","article-title":"Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system","volume":"17","author":"Rosenblad","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.03.005_bib39","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/hmg\/8.3.397","article-title":"Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin","volume":"8","author":"Schilling","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.expneurol.2010.03.005_bib40","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.20861","article-title":"Crossroads in GDNF therapy for Parkinson's disease","volume":"21","author":"Sherer","year":"2006","journal-title":"Mov. Disord."},{"key":"10.1016\/j.expneurol.2010.03.005_bib41","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3171\/jns.2005.102.2.0216","article-title":"Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor","volume":"102","author":"Slevin","year":"2005","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.expneurol.2010.03.005_bib42","doi-asserted-by":"crossref","first-page":"6920","DOI":"10.1523\/JNEUROSCI.22-16-06920.2002","article-title":"Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis","volume":"22","author":"Wang","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.03.005_bib43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/mcne.1998.0674","article-title":"Incorporation and glial differentiation of mouse EGF-responsive neural progenitor cells after transplantation into the embryonic rat brain","volume":"11","author":"Winkler","year":"1998","journal-title":"Mol. Cell. Neurosci."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488610000749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488610000749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:29:46Z","timestamp":1558916986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488610000749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0014488610000749"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2010.03.005","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}