{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:45:44Z","timestamp":1791017144929,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022108","name":"Universit\u00e9 de Poitiers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014653","name":"Manchester Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.expneurol.2010.07.022","type":"journal-article","created":{"date-parts":[[2010,7,30]],"date-time":"2010-07-30T04:19:41Z","timestamp":1280463581000},"page":"24-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Neuropeptide Y modifies the disease course in the R6\/2 transgenic model of Huntington's disease"],"prefix":"10.1016","volume":"226","author":[{"given":"M.","family":"Decressac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Tyers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gaillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2010.07.022_bb0005","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/306584a0","article-title":"Neuropeptide Y distribution in human brain","volume":"306","author":"Adrian","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0010","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1634\/stemcells.2008-0056","article-title":"Neuropeptide Y promotes neurogenesis in murine subventricular zone","volume":"26","author":"Agasse","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0015","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1126\/science.6136091","article-title":"Neuropeptide Y distribution in the rat brain","volume":"221","author":"Allen","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neuroscience.2007.12.027","article-title":"Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy","volume":"152","author":"Alvaro","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0025","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/321168a0","article-title":"Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid","volume":"321","author":"Beal","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0030","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/ana.410230606","article-title":"Somatostatin and neuropeptide Y concentrations in pathologically graded cases of Huntington's disease","volume":"23","author":"Beal","year":"1988","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0035","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1007\/s00018-006-6242-0","article-title":"Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies","volume":"63","author":"Borrell-Pages","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0040","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999","article-title":"Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation","volume":"19","author":"Carter","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0045","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1172\/JCI31778","article-title":"Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease","volume":"117","author":"Cho","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0050","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1210\/endo-115-1-427","article-title":"Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats","volume":"115","author":"Clark","year":"1984","journal-title":"Endocrinology"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0055","doi-asserted-by":"crossref","first-page":"9023","DOI":"10.1073\/pnas.1532244100","article-title":"Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain","volume":"100","author":"Curtis","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0060","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.neuroscience.2004.12.051","article-title":"The distribution of progenitor cells in the subependymal layer of the lateral ventricle in the normal and Huntington's disease human brain","volume":"132","author":"Curtis","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0065","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jchemneu.2005.05.001","article-title":"A histochemical and immunohistochemical analysis of the subependymal layer in the normal and Huntington's disease brain","volume":"30","author":"Curtis","year":"2005","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0070","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","article-title":"Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation","volume":"90","author":"Davies","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0075","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0006-8993(85)90921-7","article-title":"Survival of basal ganglia neuropeptide Y-somatostatin neurones in Huntington's disease","volume":"340","author":"Dawbarn","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0080","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.nbd.2009.02.017","article-title":"Neuropeptide Y stimulates proliferation, migration and differentiation of neural precursors from the subventricular zone in adult mice","volume":"34","author":"Decressac","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0085","doi-asserted-by":"crossref","unstructured":"Decressac, M., et al., 2010. Exogenous neuropeptide Y promotes in vivo hippocampal neurogenesis. Hippocampus doi:10.1002\/hipo.20765.","DOI":"10.1002\/hipo.20765"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0090","doi-asserted-by":"crossref","first-page":"13411","DOI":"10.1523\/JNEUROSCI.4832-06.2006","article-title":"Proliferating neural precursor cells as first step toward neuroregeneration in Huntington's disease?","volume":"26","author":"Fan","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0095","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.nbd.2005.05.006","article-title":"Reduced hippocampal neurogenesis in R6\/2 transgenic Huntington's disease mice","volume":"20","author":"Gil","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0100","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.pbb.2008.04.005","article-title":"Neuropeptide Y administration into the amygdala suppresses ethanol drinking in alcohol-preferring (P) rats following multiple deprivations","volume":"90","author":"Gilpin","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0105","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.expneurol.2007.12.026","article-title":"The metabolic profile of early Huntington's disease\u2014a combined human and transgenic mouse study","volume":"210","author":"Goodman","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0265","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2818.1987.tb02837.x","article-title":"The efficiency of systematic sampling in stereology and its prediction","volume":"147","author":"Gundersen","year":"1987","journal-title":"J. Microsc."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0255","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1699-0463.1988.tb00954.x","article-title":"The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis","volume":"96","author":"Gundersen","year":"1988","journal-title":"APMIS"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0110","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/35073601","article-title":"Neuropeptide Y functions as a neuoproliferative factor","volume":"410","author":"Hansel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0115","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1602\/neurorx.1.3.298","article-title":"Translating therapies for Huntington's disease from genetic animal models to clinical trials","volume":"1","author":"Hersch","year":"2004","journal-title":"NeuroRx"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0120","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1046\/j.1471-4159.2003.01895.x","article-title":"Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells","volume":"86","author":"Howell","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0125","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/j.1471-4159.2005.03057.x","article-title":"Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus","volume":"93","author":"Howell","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0130","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.nbd.2006.12.014","article-title":"Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus","volume":"26","author":"Howell","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0135","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/BJ20071619","article-title":"Huntington's disease: from pathology and genetics to potential therapies","volume":"412","author":"Imarisio","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0140","doi-asserted-by":"crossref","first-page":"18189","DOI":"10.1073\/pnas.0506375102","article-title":"FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease","volume":"102","author":"Jin","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0145","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.npep.2004.06.003","article-title":"NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy","volume":"38","author":"Kalra","year":"2004","journal-title":"Neuropeptides"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0150","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/00001756-200404090-00014","article-title":"Decreased hippocampal cell proliferation in R6\/1 Huntington's mice","volume":"15","author":"Lazic","year":"2004","journal-title":"NeuroReport"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0155","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.brainres.2007.03.018","article-title":"Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6\/1 transgenic mice and reduced olfactory discrimination in patients","volume":"1151","author":"Lazic","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0160","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/0196-9781(84)90165-7","article-title":"Neuropeptide Y: a potent inducer of consummatory behavior in rats","volume":"5","author":"Levine","year":"1984","journal-title":"Peptides"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0165","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0170","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1440-1789.2008.00959.x","article-title":"Lack of association between PSA-NCAM expression and migration in the rostral migratory stream of a Huntington's disease transgenic mice model","volume":"29","author":"Moraes","year":"2009","journal-title":"Neuropathology"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0175","first-page":"R516","article-title":"Neuropeptide Y increases food intake in mice","volume":"253","author":"Morley","year":"1987","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0180","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.brainresbull.2008.10.007","article-title":"The detection and measurement of locomotor deficits in a transgenic mouse model of Huntington's disease are task- and protocol-dependent: influence of non-motor factors on locomotor function","volume":"78","author":"Pallier","year":"2009","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0260","series-title":"The rat brain in Stereotaxic coordinates","author":"Paxinos","year":"2007"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0185","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/hmg\/ddn428","article-title":"Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models","volume":"18","author":"Phan","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0190","doi-asserted-by":"crossref","first-page":"11564","DOI":"10.1523\/JNEUROSCI.3796-05.2005","article-title":"Abnormalities of neurogenesis in the R6\/2 mouse model of Huntington's disease are attributable to the in vivo microenvironment","volume":"25","author":"Phillips","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0195","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1523\/JNEUROSCI.4220-08.2009","article-title":"Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease","volume":"29","author":"Rose","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0200","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2174\/1568007054546153","article-title":"The putative neuroprotective role of neuropeptide Y in the central nervous system","volume":"4","author":"Silva","year":"2005","journal-title":"Curr. Drug Targets CNS Neurol. Disord."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0205","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/cne.20680","article-title":"Chronology of behavioral symptoms and neuropathological sequela in R6\/2 Huntington's disease transgenic mice","volume":"490","author":"Stack","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0210","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1073\/pnas.0712303105","article-title":"Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain","volume":"105","author":"Stanic","year":"2008","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0215","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1073\/pnas.82.11.3940","article-title":"Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior","volume":"82","author":"Stanley","year":"1985","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0220","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.neuroscience.2004.04.061","article-title":"Neurogenesis in the striatum of the quinolinic acid lesion model of Huntington's disease","volume":"127","author":"Tattersfield","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0225","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pain.2006.12.018","article-title":"Neuropeptide Y acts at Y1 receptors in the rostral ventral medulla to inhibit neuropathic pain","volume":"131","author":"Taylor","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2010.07.022_bb0230","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.1523\/JNEUROSCI.4893-04.2005","article-title":"Neuropeptide Y protects against methamphetamine-induced neuronal apoptosis in the mouse striatum","volume":"25","author":"Thiriet","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0235","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.brainresbull.2007.01.006","article-title":"Effect of basal forebrain neuropeptide Y administration on sleep and spontaneous behavior in freely moving rats","volume":"72","author":"Toth","year":"2007","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0240","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nbd.2007.07.029","article-title":"Increased metabolism in the R6\/2 mouse model of Huntington's disease","volume":"29","author":"van der Burg","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0245","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1111\/j.1460-9568.2008.06172.x","article-title":"Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia","volume":"27","author":"Xapelli","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.07.022_bb0250","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nrneurol.2009.54","article-title":"Brain-derived neurotrophic factor in neurodegenerative disease","volume":"5","author":"Zuccato","year":"2009","journal-title":"Nat. Rev. Neurol."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488610002608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488610002608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:44:14Z","timestamp":1762148654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488610002608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0014488610002608"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2010.07.022","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuropeptide Y modifies the disease course in the R6\/2 transgenic model of Huntington's disease","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2010.07.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}