{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:07:39Z","timestamp":1767924459111,"version":"3.49.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.expneurol.2010.08.016","type":"journal-article","created":{"date-parts":[[2010,8,15]],"date-time":"2010-08-15T08:32:17Z","timestamp":1281861137000},"page":"136-147","source":"Crossref","is-referenced-by-count":24,"title":["Antiparkinsonian trophic action of glial cell line-derived neurotrophic factor and transforming growth factor \u03b21 is enhanced after co-infusion in rats"],"prefix":"10.1016","volume":"226","author":[{"given":"Ramiro","family":"Gonzalez-Aparicio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Fernandez-Espejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.expneurol.2010.08.016_bb0005","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1002\/pmic.200300710","article-title":"Convenient and versatile subcellular extraction procedure, that facilitates classical protein expression profiling and functional protein analysis","volume":"4","author":"Abdolzade-Bavil","year":"2004","journal-title":"Proteomics"},{"issue":"3","key":"10.1016\/j.expneurol.2010.08.016_bb0010","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0304-3940(99)00706-5","article-title":"A stereological study on the neuroprotective actions of acute modafinil treatment on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced nigral lesions of the male black mouse","volume":"275","author":"Aguirre","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0015","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1046\/j.1460-9568.2000.00239.x","article-title":"Inhibition of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression reduces dopaminergic sprouting in the injured striatum","volume":"12","author":"Batchelor","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/373339a0","article-title":"Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain","volume":"373","author":"Beck","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2010.08.016_bb0025","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"issue":"12","key":"10.1016\/j.expneurol.2010.08.016_bb0030","doi-asserted-by":"crossref","first-page":"645","DOI":"10.33588\/rn.4912.2009564","article-title":"Reorganizaci\u00f3n de la vascularizaci\u00f3n cerebral tras isquemia","volume":"49","author":"Brea","year":"2009","journal-title":"Rev. Neurol."},{"issue":"2","key":"10.1016\/j.expneurol.2010.08.016_bb0035","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.nbd.2004.03.002","article-title":"Effects on turning of microinjections into basal ganglia of D(1) and D(2) dopamine receptors agonists and the cannabinoid CB(1) antagonist SR141716A in a rat Parkinson's model","volume":"16","author":"El-Banoua","year":"2004","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.expneurol.2010.08.016_bb0040","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1523\/JNEUROSCI.4421-04.2005","article-title":"Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease","volume":"25","author":"Eslamboli","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0045","doi-asserted-by":"crossref","first-page":"9888","DOI":"10.1523\/JNEUROSCI.21-24-09888.2001","article-title":"Functional regeneration in a rat Parkinson's model after intrastriatal grafts of GDNF and TGF-\u00df1-expressing extra-adrenal chromaffin cells of the Zuckerkandl's organ","volume":"21","author":"Espejo","year":"2001","journal-title":"J. Neurosci."},{"issue":"39","key":"10.1016\/j.expneurol.2010.08.016_bb0050","doi-asserted-by":"crossref","first-page":"9599","DOI":"10.1523\/JNEUROSCI.2589-08.2008","article-title":"Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1","volume":"28","author":"Feng","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0055","doi-asserted-by":"crossref","first-page":"540","DOI":"10.33588\/rn.3606.2002588","article-title":"Transplante de c\u00e9lulas naturales dopaminotr\u00f3ficas: nuevo concepto terap\u00e9utico antiparkinsoniano","volume":"3","author":"Fernandez-Espejo","year":"2003","journal-title":"Rev. Neurol. (Barc)"},{"key":"10.1016\/j.expneurol.2010.08.016_bb0060","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.brainresrev.2005.01.004","article-title":"Cells of the sympathoadrenal lineage: biological properties as donor tissue for cell-replacement therapies for Parkinson's disease","volume":"49","author":"Fernandez-Espejo","year":"2005","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0065","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.nbd.2007.11.009","article-title":"Grafts of extra-adrenal chromaffin cells as aggregates show better survival rate and regenerative effects on parkinsonian rats than dispersed cells","volume":"29","author":"Galan-Rodriguez","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0070","doi-asserted-by":"crossref","first-page":"G121","DOI":"10.1002\/ana.410440718","article-title":"Neuroprotective and neurorestorative properties of GDNF","volume":"44","author":"Gash","year":"1998","journal-title":"Ann. Neurol. (suppl.)"},{"issue":"4","key":"10.1016\/j.expneurol.2010.08.016_bb0075","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/(SICI)1097-4547(20000515)60:4<458::AID-JNR4>3.0.CO;2-Z","article-title":"Recruitment of the Arp2\/3 complex and mena for the stimulation of actin polymerization in growth cones by nerve growth factor","volume":"60","author":"Goldberg","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0080","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrm2026","article-title":"The ARP2\/3 complex: an actin nucleator comes of age","volume":"13","author":"Goley","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0085","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1699-0463.1988.tb00954.x","article-title":"The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis","volume":"96","author":"Gundersen","year":"1988","journal-title":"APMIS"},{"issue":"20","key":"10.1016\/j.expneurol.2010.08.016_bb0090","doi-asserted-by":"crossref","first-page":"11682","DOI":"10.1016\/S0021-9258(19)38451-0","article-title":"Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40","volume":"265","author":"Haycock","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.expneurol.2010.08.016_bb0095","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1073\/pnas.89.6.2365","article-title":"ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ","volume":"89","author":"Haycock","year":"1992","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"13","key":"10.1016\/j.expneurol.2010.08.016_bb0100","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1523\/JNEUROSCI.18-13-04929.1998","article-title":"Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons","volume":"18","author":"Horger","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0105","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1523\/JNEUROSCI.20-12-04686.2000","article-title":"Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system","volume":"20","author":"Kirik","year":"2000","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.expneurol.2010.08.016_bb0110","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.nbd.2010.02.011","article-title":"TGF-beta 1 enhances neurite outgrowth via regulation of proteasome function and EFABP","volume":"38","author":"Kn\u00f6ferle","year":"2010","journal-title":"Neurobiol. Dis."},{"issue":"suppl 3","key":"10.1016\/j.expneurol.2010.08.016_bb0115","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1002\/ana.10485","article-title":"In vivo gene delivery of glial cell line-derived neurotrophic factor for Parkinson's disease","volume":"53","author":"Kordower","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0120","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/1531-8249(199909)46:3<419::AID-ANA21>3.0.CO;2-Q","article-title":"Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease","volume":"46","author":"Kordower","year":"1999","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.expneurol.2010.08.016_bb0125","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/j.1460-2075.1995.tb07052.x","article-title":"TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity","volume":"14","author":"Krieglstein","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0130","doi-asserted-by":"crossref","first-page":"9822","DOI":"10.1523\/JNEUROSCI.18-23-09822.1998","article-title":"Glia cell line-derived neurotrophic factor requires transforming growth factor-beta for exerting its full neurotrophic potential on peripheral an CNS neurons","volume":"18","author":"Krieglstein","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0135","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1046\/j.1460-9568.1998.00324.x","article-title":"Transforming growth factor-beta mediates the neurotrophic effect of fibroblast growth factor-2 on midbrain dopaminergic neurons","volume":"10","author":"Krieglstein","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0140","first-page":"185","article-title":"An efficient method to estimate cell number and volume in multiple dorsal root ganglia","volume":"18","author":"Lagares","year":"1999","journal-title":"Acta Stereol"},{"key":"10.1016\/j.expneurol.2010.08.016_bb0145","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/gerona\/62.9.943","article-title":"Glial cell-derived neurotrophic factor protects against proteasome inhibition-induced dopamine neuron degeneration by suppression of endoplasmic reticulum stress and caspase-3 activation","volume":"62","author":"Li","year":"2007","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0150","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1126\/science.8493557","article-title":"GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons","volume":"260","author":"Lin","year":"1993","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.expneurol.2010.08.016_bb0155","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nm0705-703","article-title":"Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain","volume":"11","author":"Love","year":"2005","journal-title":"Nat. Med."},{"issue":"11","key":"10.1016\/j.expneurol.2010.08.016_bb0160","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1523\/JNEUROSCI.11-11-03388.1991","article-title":"Differential expression of synaptophysin and synaptoporin mRNAs in the postnatal rat central nervous system","volume":"11","author":"Marqu\u00e8ze-Pouey","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0165","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1471-4159.2002.00821.x","article-title":"Impairment of the ubiquitin\u2013proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures","volume":"81","author":"McNaught","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0170","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2005"},{"key":"10.1016\/j.expneurol.2010.08.016_bb0175","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1083\/jcb.200203115","article-title":"TGFbeta induces GDNF responsiveness in neurons by recruitment of GFRalpha1 to the plasma membrane","volume":"159","author":"Peterziel","year":"2002","journal-title":"J. Cell Biol."},{"issue":"15","key":"10.1016\/j.expneurol.2010.08.016_bb0180","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1002\/elps.1150181520","article-title":"Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis","volume":"18","author":"Reymond","year":"1997","journal-title":"Electrophoresis"},{"key":"10.1016\/j.expneurol.2010.08.016_bb0185","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1046\/j.1460-9568.1999.00566.x","article-title":"Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle","volume":"11","author":"Rosenblad","year":"1999","journal-title":"Eur. J. Neurosci."},{"issue":"2","key":"10.1016\/j.expneurol.2010.08.016_bb0190","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1046\/j.1471-4159.2001.00593.x","article-title":"Depolarization-stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situ","volume":"79","author":"Salvatore","year":"2001","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.expneurol.2010.08.016_bb0195","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1471-4159.2004.02496.x","article-title":"Striatal GDNF administration increases tyrosine hydroxylase phosphorylation in the rat striatum and substantia nigra","volume":"90","author":"Salvatore","year":"2004","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.expneurol.2010.08.016_bb0200","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.expneurol.2006.07.015","article-title":"Point source concentration of GDNF may explain failure of phase II clinical trial","volume":"202","author":"Salvatore","year":"2006","journal-title":"Exp. Neurol."},{"issue":"12","key":"10.1016\/j.expneurol.2010.08.016_bb0205","doi-asserted-by":"crossref","first-page":"e8466","DOI":"10.1371\/journal.pone.0008466","article-title":"Aging reveals a role for nigral tyrosine hydroxylase ser31 phosphorylation in locomotor activity generation","volume":"4","author":"Salvatore","year":"2009","journal-title":"PLoSOne"},{"issue":"2","key":"10.1016\/j.expneurol.2010.08.016_bb0210","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0306-4522(94)90605-X","article-title":"Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat","volume":"59","author":"Sauer","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2010.08.016_bb0215","doi-asserted-by":"crossref","first-page":"8935","DOI":"10.1073\/pnas.92.19.8935","article-title":"Glial cell line-derived neurotrophic factor but not transforming growth factor \u00df3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion","volume":"92","author":"Sauer","year":"1995","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.expneurol.2010.08.016_bb0220","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1523\/JNEUROSCI.19-06-02008.1999","article-title":"Glial cell line-derived neurotrophic factor rescues target-deprived sympathetic spinal cord neurons but requires transforming growth factor-beta as cofactor in vivo","volume":"19","author":"Schober","year":"1999","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.expneurol.2010.08.016_bb0225","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.nbd.2006.10.005","article-title":"GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-beta for its neuroprotective action","volume":"25","author":"Schober","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0230","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0301-0082(96)00040-8","article-title":"The unilateral 6-hydroxydopamine lesion model in behavioral brain research: analysis of functional deficits, recovery and treatments","volume":"50","author":"Schwarting","year":"1996","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0235","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0968-0004(91)90123-D","article-title":"Stathmin: a relay phosphoprotein for multiple signal transduction?","volume":"16","author":"Sobel","year":"1991","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0240","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-2818.1984.tb02501.x","article-title":"The unbiased estimation of number and sizes of arbitrary particles using the disector","volume":"134","author":"Sterio","year":"1984","journal-title":"J. Microsc."},{"issue":"4","key":"10.1016\/j.expneurol.2010.08.016_bb0245","doi-asserted-by":"crossref","first-page":"S571","DOI":"10.1042\/bst025s571","article-title":"A stress-activated kinase cascade can mediate the activation of tyrosine hydroxylase in chromaffin cells","volume":"25","author":"Thomas","year":"1997","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0250","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/373335a0","article-title":"Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo","volume":"373","author":"Tomac","year":"1995","journal-title":"Nature"},{"issue":"24(3)","key":"10.1016\/j.expneurol.2010.08.016_bb0255","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0006-8993(70)90187-3","article-title":"Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system","volume":"18","author":"Ungerstedt","year":"1970","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0260","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/exnr.1993.1149","article-title":"The trophic cocktail made by adrenal chromaffin cells","volume":"123","author":"Unsicker","year":"1993","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0265","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0301-0082(95)00045-3","article-title":"Growth factors in chromaffin cells","volume":"48","author":"Unsicker","year":"1996","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.expneurol.2010.08.016_bb0270","first-page":"70","article-title":"Growth factors function in the development and maintenance of midbrain dopaminergic neurons: concepts, facts and prospects for TGF-\u03b2","volume":"196","author":"Unsicker","year":"1996","journal-title":"Ciba Found. Symp."},{"issue":"4","key":"10.1016\/j.expneurol.2010.08.016_bb0275","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/j.1471-4159.1991.tb08296.x","article-title":"Vasoactive intestinal peptide stimulates catecholamine biosynthesis in isolated adrenal chromaffin cells: evidence for a cyclic AMP-dependent phosphorylation and activation of tyrosine hydroxylase","volume":"57","author":"Waymire","year":"1991","journal-title":"J. Neurochem."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488610002980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488610002980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T14:40:58Z","timestamp":1740408058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488610002980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0014488610002980"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2010.08.016","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}