{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:00:54Z","timestamp":1792670454664,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.expneurol.2010.08.024","type":"journal-article","created":{"date-parts":[[2010,9,13]],"date-time":"2010-09-13T10:11:16Z","timestamp":1284372676000},"page":"265-273","source":"Crossref","is-referenced-by-count":43,"title":["18F-FECNT: Validation as PET dopamine transporter ligand in parkinsonism"],"prefix":"10.1016","volume":"226","author":[{"given":"Gunasingh","family":"Masilamoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Votaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Howell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M.","family":"Villalba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"Voll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Stehouwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wichmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoland","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2010.08.024_bb0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neuroimage.2007.05.056","article-title":"Quantitative [(123)I]FP-CIT pinhole SPECT imaging predicts striatal dopamine levels, but not number of nigral neurons in different mouse models of Parkinson's disease","volume":"38","author":"Alvarez-Fischer","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.expneurol.2010.08.024_bb0010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0376-8716(98)00068-4","article-title":"Neurotransmitter transporters as molecular targets for addictive drugs","volume":"51","author":"Amara","year":"1998","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0015","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.parkreldis.2006.10.009","article-title":"SPECT imaging, immunohistochemical and behavioural correlations in the primate models of Parkinson's disease","volume":"13","author":"Ashkan","year":"2007","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0020","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/j.neuroimage.2009.06.008","article-title":"Dopamine release during human emotional processing","volume":"47","author":"Badgaiyan","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.expneurol.2010.08.024_bb0025","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0022-510X(73)90175-5","article-title":"Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations","volume":"20","author":"Bernheimer","year":"1973","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0030","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1523\/JNEUROSCI.15-03-01714.1995","article-title":"The dopamine transporter: immunochemical characterization and localization in brain","volume":"15","author":"Ciliax","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0035","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.neuropsychologia.2009.01.039","article-title":"Dopamine and cognitive functioning in de novo subjects with Parkinson's disease: effects of pramipexole and pergolide on working memory","volume":"47","author":"Costa","year":"2009","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.expneurol.2010.08.024_bb0040","first-page":"855","article-title":"Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNT","volume":"44","author":"Davis","year":"2003","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0045","series-title":"Parkinson's Disease \u2014 Diagnosis and Clinical Management","first-page":"277","article-title":"Status of biological markers","author":"Dorsey","year":"2008"},{"key":"10.1016\/j.expneurol.2010.08.024_bb0050","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0165-6147(93)90029-J","article-title":"Molecular characterization of the dopamine transporter","volume":"14","author":"Giros","year":"1993","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0055","first-page":"119","article-title":"Fluorine-18-FPCT: a PET radiotracer for imaging dopamine transporters","volume":"38","author":"Goodman","year":"1997","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0969-8051(99)00080-3","article-title":"18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters","volume":"27","author":"Goodman","year":"2000","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0065","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0306-4522(91)90180-V","article-title":"Selective retention of MPP+within the monoaminergic systems of the primate brain following MPTP administration: an in vivo autoradiographic study","volume":"40","author":"Herkenham","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2010.08.024_bb0070","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/sj.jcbfm.9600607","article-title":"Measurement of striatal and extrastriatal dopamine transporter binding with high-resolution PET and [11C]PE2I: quantitative modeling and test\u2013retest reproducibility","volume":"28","author":"Hirvonen","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0075","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/frne.1998.0168","article-title":"Localization and dynamic regulation of biogenic amine transporters in the mammalian central nervous system","volume":"19","author":"Hoffman","year":"1998","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0080","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.nucmedbio.2006.04.005","article-title":"Comparison of [18F]FDOPA, [18F]FMT and [18F]FECNT for imaging dopaminergic neurotransmission in mice","volume":"33","author":"Honer","year":"2006","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0085","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/(SICI)1098-2396(19990301)31:3<178::AID-SYN2>3.0.CO;2-M","article-title":"Comparison between the decrease of dopamine transporter and that of L-DOPA uptake for detection of early to advanced stage of Parkinson's disease in animal models","volume":"31","author":"Ito","year":"1999","journal-title":"Synapse"},{"issue":"61","key":"10.1016\/j.expneurol.2010.08.024_bb0090","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1212\/WNL.61.6_suppl_3.S4","article-title":"The MPTP-treated primate as a model of motor complications in PD: primate model of motor complications","volume":"23","author":"Jenner","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2010.08.024_bb0095","first-page":"1521","article-title":"Dopamine transporter imaging with fluorine-18-FPCIT and PET","volume":"39","author":"Kazumata","year":"1998","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0105","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000117169","article-title":"Dopamine transporter: biochemistry, pharmacology and imaging","volume":"30","author":"Kuhar","year":"1990","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0110","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/1531-8249(200004)47:4<493::AID-ANA13>3.0.CO;2-4","article-title":"In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopamine nerve terminals in Parkinson's disease","volume":"474","author":"Lee","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0115","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/1098-2396(200008)37:2<109::AID-SYN5>3.0.CO;2-3","article-title":"Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter","volume":"37","author":"Mach","year":"2000","journal-title":"Synapse"},{"key":"10.1016\/j.expneurol.2010.08.024_bb0120","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/syn.20431","article-title":"Progressive changes of pre- and post-synaptic dopaminergic biomarkers in conscious MPTP-treated cynomolgus monkeys measured by positron emission tomography","volume":"61","author":"Nagai","year":"2007","journal-title":"Synapse"},{"key":"10.1016\/j.expneurol.2010.08.024_bb0125","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/syn.1063","article-title":"Effect of endogenous dopamine on endogenous dopamine on extrastriated [11C]FLB 457 binding measured by PET","volume":"41","author":"Okauchi","year":"2001","journal-title":"Synapse"},{"key":"10.1016\/j.expneurol.2010.08.024_bb0130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0165-0173(94)00007-C","article-title":"Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop","volume":"20","author":"Parent","year":"1995","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0135","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/ana.410340306","article-title":"Correlation of striatal fluorodopa uptake in the MPTP monkey with dopaminergic indices","volume":"34","author":"Pate","year":"1993","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0140","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.bbadis.2008.10.003","article-title":"Imaging neurodegeneration in Parkinson's disease","volume":"1792","author":"Pavese","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.expneurol.2010.08.024_bb0145","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1097\/00004647-200107000-00003","article-title":"Anatomic and biochemical correlates of the dopamine transporter ligand 11C-PE2I in normal and parkinsonian primates: comparison with 6-[18F]fluoro-L-dopa","volume":"21","author":"Poyot","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0150","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1001\/archneur.59.4.580","article-title":"Dopaminergic function and dopamine transporter binding assessed with positron emission tomography in Parkinson disease","volume":"59","author":"Ribeiro","year":"2002","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0155","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.expneurol.2006.08.026","article-title":"Rotigotine treatment partially protects from MPTP toxicity in a progressive macaque model of Parkinson's disease","volume":"203","author":"Scheller","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0160","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0169-328X(92)90220-6","article-title":"Dopamine transporter mRNA: dense expression in ventral midbrain neurons","volume":"13","author":"Shimada","year":"1992","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0165","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0306-4522(91)90250-R","article-title":"Convergence of synaptic inputs from the striatum and the globus pallidus onto identified nigrocollicular cells in the rat: a double anterograde labelling study","volume":"44","author":"Smith","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2010.08.024_bb0170","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/ana.410340304","article-title":"Human positron emission tomographic [18F]fluorodopa studies correlate with dopamine cell counts and levels","volume":"34","author":"Snow","year":"1993","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0175","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0969-8051(99)00073-6","article-title":"2Beta-carbomethoxy-3beta-(4- and 2-[18F]fluoromethylphenyl) tropanes: specific probes for in vivo quantification of central dopamine transporter sites","volume":"26","author":"Stout","year":"1999","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0180","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrn1008","article-title":"Plasma membrane monoamine transporters: structure, regulation and function","volume":"4","author":"Torres","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0185","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/syn.10068","article-title":"Measurement of dopamine transporter occupancy for multiple injections of cocaine using a single injection of [F-18]FECNT","volume":"44","author":"Votaw","year":"2002","journal-title":"Synapse"},{"key":"10.1016\/j.expneurol.2010.08.024_bb0190","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1749-6632.2003.tb07477.x","article-title":"Pathophysiology of Parkinson's disease: the MPTP primate model of the human disorder","volume":"991","author":"Wichmann","year":"2003","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0195","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/mds.1168","article-title":"Novel observations with FDOPA-PET imaging after early nigrostriatal damage","volume":"16","author":"Yee","year":"2001","journal-title":"Mov. Disord."},{"key":"10.1016\/j.expneurol.2010.08.024_bb0200","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1021\/jm9902234","article-title":"Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2beta-carbo-1\u2032-fluoro-2-propoxy-3beta-(4-chlorophenyl)tr opanes. Ligands for the imaging of dopamine transporters by positron emission tomography","volume":"43","author":"Xing","year":"2000","journal-title":"J. Med. Chem."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488610003237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488610003237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T17:02:02Z","timestamp":1559667722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488610003237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0014488610003237"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2010.08.024","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}