{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:46:54Z","timestamp":1793126814157,"version":"4.5.0"},"reference-count":84,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["7-08-RA-102"],"award-info":[{"award-number":["7-08-RA-102"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 DK074517"],"award-info":[{"award-number":["RO1 DK074517"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1DK077141"],"award-info":[{"award-number":["RO1DK077141"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20 RR021945"],"award-info":[{"award-number":["P20 RR021945"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.expneurol.2011.04.002","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T06:38:27Z","timestamp":1303195107000},"page":"106-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative\u2013nitrosative stress and p38 MAPK activation"],"prefix":"10.1016","volume":"230","author":[{"given":"Roman","family":"Stavniichuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor R.","family":"Drel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Shevalye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yury","family":"Maksimchyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara M.","family":"Kuchmerovska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry L.","family":"Nadler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina G.","family":"Obrosova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2011.04.002_bb0005","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.tox.2009.07.023","article-title":"CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells","volume":"264","author":"Androutsopoulos","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0010","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1172\/JCI18058","article-title":"Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily","volume":"114","author":"Bierhaus","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0015","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.2337\/dc08-2110","article-title":"Ranirestat for the management of diabetic sensorimotor polyneuropathy","volume":"32","author":"Bril","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0020","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and molecular cell biology of diabetic complications","volume":"414","author":"Brownlee","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0025","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.2337\/db07-1737","article-title":"Distal degenerative sensory neuropathy in a long-term type 2 diabetes rat model","volume":"57","author":"Brussee","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0030","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2174\/138945008783431718","article-title":"Pro-inflammatory mechanisms in diabetic neuropathy: focus on the nuclear factor kappa B pathway","volume":"9","author":"Cameron","year":"2008","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0035","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1007\/s001250051280","article-title":"Protein kinase C effects on nerve function, perfusion, Na(+), K(+)-ATPase activity and glutathione content in diabetic rats","volume":"42","author":"Cameron","year":"1999","journal-title":"Diabetologia"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0040","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s001250100626","article-title":"Effect of the hydroxyl radical scavenger, dimethylthiourea, on peripheral nerve tissue perfusion, conduction velocity and nociception in experimental diabetes","volume":"44","author":"Cameron","year":"2001","journal-title":"Diabetologia"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0045","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1196\/annals.1333.091","article-title":"Inhibitors of advanced glycation end product formation and neurovascular dysfunction in experimental diabetes","volume":"1043","author":"Cameron","year":"2005","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0050","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/sj.gt.3302533","article-title":"HSV-mediated gene transfer of vascular endothelial growth factor to dorsal root ganglia prevents diabetic neuropathy","volume":"12","author":"Chattopadhyay","year":"2005","journal-title":"Gene Ther."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0055","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s00125-005-1673-y","article-title":"Activation of 12-lipoxygenase in proinflammatory cytokine-mediated beta cell toxicity","volume":"48","author":"Chen","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0060","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neuroscience.2006.11.064","article-title":"Neurotrophic modulation of myelinated cutaneous innervation and mechanical sensory loss in diabetic mice","volume":"145","author":"Christianson","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0065","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1165\/ajrcmb.22.2.3786","article-title":"Regulation of human 12\/15-lipoxygenase by Stat6-dependent transcription","volume":"22","author":"Conrad","year":"2000","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/sj.bjp.0704216","article-title":"Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve","volume":"134","author":"Coppey","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0075","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.2337\/diabetes.50.8.1927","article-title":"Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve","volume":"50","author":"Coppey","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0080","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.neuropharm.2010.09.008","article-title":"Vasopeptidase inhibitor ilepatril (AVE7688) prevents obesity- and diabetes-induced neuropathy in C57Bl\/6J mice","volume":"60","author":"Cotter","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0085","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0014-2999(01)00909-8","article-title":"Neurovascular interactions between aldose reductase and angiotensin-converting enzyme inhibition in diabetic rats","volume":"417","author":"Cotter","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0090","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.pbb.2010.07.007","article-title":"Baicalein is neuroprotective in rat MCAO model: role of 12\/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2","volume":"96","author":"Cui","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0095","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1210\/jc.2008-2385","article-title":"Microvascular reactivity and inflammatory cytokines in painful and painless peripheral diabetic neuropathy","volume":"94","author":"Doupis","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0100","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.2337\/db06-0885","article-title":"The leptin-deficient (ob\/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity","volume":"55","author":"Drel","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0105","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.freeradbiomed.2005.12.034","article-title":"Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells","volume":"40","author":"Drel","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0110","first-page":"783","article-title":"Evaluation of the peroxynitrite decomposition catalyst Fe(III) tetra-mesitylporphyrin octasulfonate on peripheral neuropathy in a mouse model of type 1 diabetes","volume":"20","author":"Drel","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0115","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejphar.2007.05.055","article-title":"A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice","volume":"569","author":"Drel","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0120","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1210\/en.2009-1342","article-title":"New therapeutic and biomarker discovery for peripheral diabetic neuropathy: PARP inhibitor, nitrotyrosine, and tumor necrosis factor-{alpha}","volume":"151","author":"Drel","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0125","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1167\/iovs.09-3674","article-title":"Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function","volume":"51","author":"Du","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0130","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1167\/iovs.02-1022","article-title":"High glucose-induced tyrosine nitration in endothelial cells: role of eNOS uncoupling and aldose reductase activation","volume":"44","author":"El-Remessy","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0135","doi-asserted-by":"crossref","first-page":"934","DOI":"10.2337\/db08-1287","article-title":"Intranasal insulin ameliorates experimental diabetic neuropathy","volume":"58","author":"Francis","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0140","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.2337\/db08-1008","article-title":"The transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy","volume":"58","author":"Gerhardinger","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0145","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1749-6632.2002.tb02906.x","article-title":"Bioflavonoid-rich botanical extracts show antioxidant and gene regulatory activity","volume":"957","author":"Gohil","year":"2002","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0150","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.2337\/diabetes.51.7.2227","article-title":"Herpes simplex-mediated gene transfer of nerve growth factor protects against peripheral neuropathy in streptozotocin-induced diabetes in the mouse","volume":"51","author":"Goss","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0155","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1212\/WNL.53.3.580","article-title":"Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Zenarestat Study Group","volume":"53","author":"Greene","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0160","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.2337\/db05-1497","article-title":"Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage","volume":"55","author":"Ho","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0165","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jmb.2008.08.039","article-title":"Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicalein","volume":"383","author":"Hong","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0170","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.2337\/diacare.24.10.1776","article-title":"Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study","volume":"24","author":"Hotta","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0175","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2174\/1568006043586206","article-title":"Biological properties of baicalein in cardiovascular system","volume":"5","author":"Huang","year":"2005","journal-title":"Curr. Drug Targets Cardiovasc. Haematol. Disord."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0180","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1097\/01.ASN.0000099702.16315.DE","article-title":"Role of 12-lipoxygenase in the stimulation of p38 mitogen-activated protein kinase and collagen alpha5(IV) in experimental diabetic nephropathy and in glucose-stimulated podocytes","volume":"14","author":"Kang","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0185","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.2337\/db07-0740","article-title":"Protective effects of cyclooxygenase-2 gene inactivation against peripheral nerve dysfunction and intraepidermal nerve fiber loss in experimental diabetes","volume":"56","author":"Kellogg","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0190","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.bbrc.2010.03.014","article-title":"NF-kappaB inhibitory action of resveratrol: a probable mechanism of neuroprotection in experimental diabetic neuropathy","volume":"394","author":"Kumar","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0195","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.2337\/diabetes.54.5.1514","article-title":"Low-dose poly(ADP-ribose) polymerase inhibitor-containing combination therapies reverse early peripheral diabetic neuropathy","volume":"54","author":"Li","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0200","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.2337\/db09-0594","article-title":"Caveolin-1 and altered neuregulin signaling contribute to the pathophysiological progression of diabetic peripheral neuropathy","volume":"58","author":"McGuire","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0205","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.2337\/diacare.18.8.1160","article-title":"Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy","volume":"18","author":"Nagamatsu","year":"1995","journal-title":"Diabetes Care"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0210","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/db05-1160","article-title":"Effects of basic fibroblast growth factor on experimental diabetic neuropathy in rats","volume":"55","author":"Nakae","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0215","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.2337\/diabetes.48.10.2090","article-title":"A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats","volume":"48","author":"Nakamura","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0220","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/(SICI)1097-4652(199611)169:2<391::AID-JCP19>3.0.CO;2-C","article-title":"Platelet-derived growth factor BB mediated regulation of 12-lipoxygenase in porcine aortic smooth muscle cells","volume":"169","author":"Natarajan","year":"1996","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0225","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.bbadis.2008.11.005","article-title":"Diabetes and the peripheral nerve","volume":"1792","author":"Obrosova","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0230","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s001250051290","article-title":"Evaluation of a sorbitol dehydrogenase inhibitor on diabetic peripheral nerve metabolism: a prevention study","volume":"42","author":"Obrosova","year":"1999","journal-title":"Diabetologia"},{"issue":"16","key":"10.1016\/j.expneurol.2011.04.002_bb0235","first-page":"123","article-title":"An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense","volume":"2002","author":"Obrosova","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0240","doi-asserted-by":"crossref","first-page":"864","DOI":"10.2337\/diabetes.52.3.864","article-title":"Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats","volume":"52","author":"Obrosova","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0245","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2337\/diabetes.53.3.711","article-title":"Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy","volume":"53","author":"Obrosova","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0250","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1096\/fj.04-1913fje","article-title":"Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst","volume":"19","author":"Obrosova","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0255","doi-asserted-by":"crossref","first-page":"E1645","DOI":"10.1152\/ajpendo.00479.2007","article-title":"Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats","volume":"293","author":"Obrosova","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0260","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.2337\/db06-1176","article-title":"High-fat diet induced neuropathy of pre-diabetes and obesity: effects of \u201chealthy\u201d diet and aldose reductase inhibition","volume":"56","author":"Obrosova","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0265","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.freeradbiomed.2007.09.013","article-title":"PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy","volume":"44","author":"Obrosova","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0270","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.2353\/ajpath.2010.100178","article-title":"Different roles of 12\/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies","volume":"177","author":"Obrosova","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0275","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/jcbfm.2009.281","article-title":"Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12\/15-lipoxygenase-dependent organelle damage pathway","volume":"30","author":"Pallast","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0280","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.brainres.2006.07.109","article-title":"Thioredoxin interacting protein is increased in sensory neurons in experimental diabetes","volume":"1116","author":"Price","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0285","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1096\/fj.01-0253hyp","article-title":"A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy","volume":"15","author":"Purves","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0290","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.2337\/db07-0285","article-title":"Surrogate markers of small fiber damage in human diabetic neuropathy","volume":"56","author":"Quattrini","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0295","doi-asserted-by":"crossref","first-page":"9920","DOI":"10.1074\/jbc.M111305200","volume":"277","author":"Reddy","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0300","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF00418340","article-title":"Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with N-acetylcysteine","volume":"39","author":"Sagara","year":"1996","journal-title":"Diabetologia"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0305","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2337\/diabetes.52.1.165","article-title":"Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy","volume":"52","author":"Schmeichel","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0310","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0197-4580(02)00075-1","article-title":"MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide","volume":"23","author":"Schroeter","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0315","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.abb.2010.04.006","article-title":"Polyphenols and health: update and perspectives","volume":"501","author":"Sies","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"issue":"9","key":"10.1016\/j.expneurol.2011.04.002_bb0320","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2174\/138945008783431745","article-title":"Is C-peptide replacement the missing link for successful treatment of neurological complications in type 1 diabetes?","volume":"2008","author":"Sima","year":"2008","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0325","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.freeradbiomed.2010.06.016","article-title":"Role of 12\/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies","volume":"49","author":"Stavniichuk","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0330","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/BF00404069","article-title":"Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat","volume":"36","author":"Stevens","year":"1993","journal-title":"Diabetologia"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0335","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.2337\/diabetes.49.6.1006","article-title":"Effects of dl-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy","volume":"49","author":"Stevens","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0340","doi-asserted-by":"crossref","first-page":"E497","DOI":"10.1152\/ajpendo.00048.2004","article-title":"C-peptide corrects endoneurial blood flow but not oxidative stress in type 1 BB\/Wor rats","volume":"287","author":"Stevens","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0345","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1212\/WNL.60.1.108","article-title":"The spectrum of neuropathy in diabetes and impaired glucose tolerance","volume":"60","author":"Sumner","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0350","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejphar.2010.01.002","article-title":"Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats","volume":"631","author":"Sun","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0355","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1161\/01.CIR.0000038365.78031.9C","article-title":"Poly(ADP-ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity","volume":"106","author":"Szab\u00f3","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0360","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.2337\/dc10-1303","article-title":"Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments","volume":"33","author":"Tesfaye","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0365","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00125-006-0169-8","article-title":"Remote neurotrophic support of epidermal nerve fibres in experimental diabetes","volume":"49","author":"Toth","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0370","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.2337\/db07-0339","article-title":"Receptor for advanced glycation end products (RAGEs) and experimental diabetic neuropathy","volume":"57","author":"Toth","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0375","article-title":"Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice","volume":"11","author":"Urban","year":"2010","journal-title":"ASN Neuro"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0380","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1046\/j.1365-2362.2001.00826.x","article-title":"Effects of OPB-9195, anti-glycation agent, on experimental diabetic neuropathy","volume":"31","author":"Wada","year":"2001","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0385","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jns.2006.03.011","article-title":"Enhanced inflammatory response via activation of NF-kappaB in acute experimental diabetic neuropathy subjected to ischemia\u2013reperfusion injury","volume":"247","author":"Wang","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0390","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jns.2007.10.004","article-title":"Decreased peripheral nerve damage after ischemia\u2013reperfusion injury in mice lacking TNF-alpha","volume":"267","author":"Wang","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0395","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/mt.2010.215","article-title":"Prevention of diabetic neuropathy by regulatable expression of HSV-mediated erythropoietin","volume":"19","author":"Wu","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0400","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1093\/brain\/124.12.2448","article-title":"Neuropathy in diabetic mice overexpressing human aldose reductase and effects of aldose reductase inhibitor","volume":"124","author":"Yagihashi","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0405","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1167\/iovs.08-2642","article-title":"Baicalein reduces inflammatory process in a rodent model of diabetic retinopathy","volume":"50","author":"Yang","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0410","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10059-009-0059-2","article-title":"Lipoxygenase inhibitors suppressed carrageenan-induced Fos-expression and inflammatory pain responses in the rat","volume":"27","author":"Yoo","year":"2009","journal-title":"Mol. Cells"},{"key":"10.1016\/j.expneurol.2011.04.002_bb0415","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.intimp.2010.06.020","article-title":"Therapeutic effects of Baicalein on atopic dermatitis-like skin lesions of NC\/Nga mice induced by Dermatophagoides pteronyssinus","volume":"10","author":"Yun","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.expneurol.2011.04.002_bb0420","first-page":"203","article-title":"Oral baicalin and liquid extract of licorice reduce sorbitol levels in red blood cell of diabetic rats","volume":"102","author":"Zhou","year":"1989","journal-title":"Chin. Med. J. (Engl.)"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488611001166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488611001166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:11:08Z","timestamp":1778641868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488611001166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":84,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0014488611001166"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2011.04.002","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative\u2013nitrosative stress and p38 MAPK activation","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2011.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}