{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T01:11:15Z","timestamp":1773105075762,"version":"3.50.1"},"reference-count":93,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":568,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.expneurol.2011.11.005","type":"journal-article","created":{"date-parts":[[2011,11,15]],"date-time":"2011-11-15T20:49:51Z","timestamp":1321390191000},"page":"391-399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Signaling mechanisms downstream of quinolinic acid targeting the cytoskeleton of rat striatal neurons and astrocytes"],"prefix":"10.1016","volume":"233","author":[{"given":"Paula","family":"Pierozan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariane","family":"Zamoner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c2ngela Krombauer","family":"Soska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara Ortiz","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina Pires","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Zamboni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moacir","family":"Wajner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Pessoa-Pureur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.expneurol.2011.11.005_bb0005","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1083\/jcb.200303138","article-title":"Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments","volume":"161","author":"Ackerley","year":"2003","journal-title":"J. Cell Biol."},{"issue":"6","key":"10.1016\/j.expneurol.2011.11.005_bb0010","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.neuint.2011.02.009","article-title":"Ethanol-induced modulation of synaptic output from the dorsolateral striatum in rat is regulated by cholinergic interneurons","volume":"58","author":"Adermark","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.expneurol.2011.11.005_bb0015","series-title":"Molecular Biology of the Cell Published by Garland Science","author":"Albert","year":"2008"},{"issue":"6066","key":"10.1016\/j.expneurol.2011.11.005_bb0020","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/321168a0","article-title":"Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid","volume":"321","author":"Beal","year":"1986","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.expneurol.2011.11.005_bb0025","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/sj.bjp.0702940","article-title":"Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl","volume":"128","author":"Behan","year":"1999","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.expneurol.2011.11.005_bb0030","doi-asserted-by":"crossref","first-page":"6356","DOI":"10.1074\/jbc.271.11.6356","article-title":"Expression and function of ryanodine receptors in nonexcitable cells","volume":"271","author":"Bennett","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.expneurol.2011.11.005_bb0035","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.neuropharm.2008.05.020","article-title":"Distinct roles of group I mGlu receptors in striatal function","volume":"55","author":"Bonsi","year":"2008","journal-title":"Neuropharmacology"},{"issue":"15","key":"10.1016\/j.expneurol.2011.11.005_bb0040","doi-asserted-by":"crossref","first-page":"6515","DOI":"10.1523\/JNEUROSCI.22-15-06515.2002","article-title":"Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann\u2013Pick type C murine model","volume":"22","author":"Bu","year":"2002","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.expneurol.2011.11.005_bb0045","first-page":"1","article-title":"Kynurenine Pathway Metabolites in Humans: Disease and Healthy States","volume":"2","author":"Chen","year":"2009","journal-title":"Int J of Trypt Res"},{"issue":"Pt 13","key":"10.1016\/j.expneurol.2011.11.005_bb0050","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1242\/jcs.112.13.2233","article-title":"Analysis of the roles of the head domains of type IV rat neuronal intermediate filament proteins in filament assembly using domain-swapped chimeric proteins","volume":"112","author":"Ching","year":"1999","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.expneurol.2011.11.005_bb0055","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/j.1476-5381.1988.tb11474.x","article-title":"Quinolinic acid effects on amino acid release from the rat cerebral cortex in vitro and in vivo","volume":"93","author":"Connick","year":"1988","journal-title":"Br. J. Pharmacol."},{"issue":"1\u20133","key":"10.1016\/j.expneurol.2011.11.005_bb0060","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ejphar.2010.09.024","article-title":"GABA(B) receptors modulate depolarization-stimulated [(3)H]glutamate release in slices of the pars reticulata of the rat substantia nigra","volume":"649","author":"Cortes","year":"2010","journal-title":"Eur. J. Pharmacol."},{"issue":"5525","key":"10.1016\/j.expneurol.2011.11.005_bb0065","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/257416a0","article-title":"Synthetic substrate for cyclic AMP-dependent protein kinase","volume":"257","author":"Daile","year":"1975","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.expneurol.2011.11.005_bb0070","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1046\/j.1471-4159.2002.00927.x","article-title":"Myelin-associated glycoprotein modulates expression and phosphorylation of neuronal cytoskeletal elements and their associated kinases","volume":"81","author":"Dashiell","year":"2002","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.expneurol.2011.11.005_bb0075","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0197-0186(95)00091-7","article-title":"The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits","volume":"28","author":"de Carvalho","year":"1996","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.expneurol.2011.11.005_bb0080","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.brainres.2007.04.019","article-title":"Arsenic inhibits neurofilament transport and induces perikaryal accumulation of phosphorylated neurofilaments: roles of JNK and GSK-3beta","volume":"1181","author":"DeFuria","year":"2007","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.expneurol.2011.11.005_bb0085","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1111\/j.1471-4159.2004.02607.x","article-title":"Permissive role of adenosine A2A receptors on metabotropic glutamate receptor 5 (mGluR5)-mediated effects in the striatum","volume":"90","author":"Domenici","year":"2004","journal-title":"J. Neurochem."},{"issue":"9\u201310","key":"10.1016\/j.expneurol.2011.11.005_bb0090","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1023\/A:1007677003387","article-title":"Glial fibrillary acidic protein: GFAP-thirty-one years (1969\u20132000)","volume":"25","author":"Eng","year":"2000","journal-title":"Neurochem. Res."},{"issue":"3","key":"10.1016\/j.expneurol.2011.11.005_bb0095","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.arcmed.2007.11.011","article-title":"Excitotoxic neuronal death and the pathogenesis of Huntington's disease","volume":"39","author":"Estrada Sanchez","year":"2008","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.expneurol.2011.11.005_bb0100","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.bi.63.070194.002021","article-title":"Intermediate filaments: structure, dynamics, function, and disease","volume":"63","author":"Fuchs","year":"1994","journal-title":"Annu. Rev. Biochem."},{"issue":"12","key":"10.1016\/j.expneurol.2011.11.005_bb0485","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1046\/j.1460-9568.2002.02017.x","article-title":"Synaptic localization of GABA(A) receptor subunits in the substantia nigra of the rat: effects of quinolinic acid lesions of the striatum","volume":"15","author":"Fujiyama","year":"2002","journal-title":"Eur J Neurosci"},{"issue":"1","key":"10.1016\/j.expneurol.2011.11.005_bb0105","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jns.2003.08.003","article-title":"Alpha-keto-beta-methylvaleric acid increases the in vitro phosphorylation of intermediate filaments in cerebral cortex of young rats through the gabaergic system","volume":"217","author":"Funchal","year":"2004","journal-title":"J. Neurol. Sci."},{"issue":"2","key":"10.1016\/j.expneurol.2011.11.005_bb0110","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1385-299X(03)00022-9","article-title":"In vitro phosphorylation of cytoskeletal proteins from cerebral cortex of rats","volume":"11","author":"Funchal","year":"2003","journal-title":"Brain Res. Brain Res. Protoc."},{"issue":"9","key":"10.1016\/j.expneurol.2011.11.005_bb0115","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s11064-005-7709-3","article-title":"Alpha-ketoisocaproic acid increases phosphorylation of intermediate filament proteins from rat cerebral cortex by mechanisms involving Ca2+ and cAMP","volume":"30","author":"Funchal","year":"2005","journal-title":"Neurochem. Res."},{"issue":"1\u20132","key":"10.1016\/j.expneurol.2011.11.005_bb0120","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jns.2005.06.013","article-title":"Evidence that intracellular Ca2+ mediates the effect of alpha-ketoisocaproic acid on the phosphorylating system of cytoskeletal proteins from cerebral cortex of immature rats","volume":"238","author":"Funchal","year":"2005","journal-title":"J. Neurol. Sci."},{"issue":"2","key":"10.1016\/j.expneurol.2011.11.005_bb0125","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0014-5793(87)80964-X","article-title":"Location and sequence characterization of the major phosphorylation sites of the high molecular mass neurofilament proteins M and H","volume":"221","author":"Geisler","year":"1987","journal-title":"FEBS Lett."},{"issue":"5 Pt 1","key":"10.1016\/j.expneurol.2011.11.005_bb0130","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1083\/jcb.111.5.2005","article-title":"Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit","volume":"111","author":"Gill","year":"1990","journal-title":"J. Cell Biol."},{"issue":"11\u201312","key":"10.1016\/j.expneurol.2011.11.005_bb0135","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1023\/A:1010999509251","article-title":"Neurofilament protein synthesis and phosphorylation","volume":"29","author":"Grant","year":"2000","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.expneurol.2011.11.005_bb0465","article-title":"Diphenyl ditelluride induces hypophosphorylation of intermediate filaments through modulation of DARPP-32-dependent pathways in cerebral cortex of young rats","author":"Heimfarth","year":"2010","journal-title":"Arch. Toxicol."},{"issue":"6 Pt 1","key":"10.1016\/j.expneurol.2011.11.005_bb0145","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1083\/jcb.123.6.1517","article-title":"The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation","volume":"123","author":"Heins","year":"1993","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.expneurol.2011.11.005_bb0150","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1091\/mbc.1.2.237","article-title":"Effects of phosphorylation of the neurofilament L protein on filamentous structures","volume":"1","author":"Hisanaga","year":"1990","journal-title":"Cell Regul."},{"issue":"4\u20135","key":"10.1016\/j.expneurol.2011.11.005_bb0155","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000074624","article-title":"The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator","volume":"12","author":"Hisanaga","year":"2003","journal-title":"Neurosignals"},{"issue":"11","key":"10.1016\/j.expneurol.2011.11.005_bb0160","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1021\/bi972518u","article-title":"Characterization of the phosphorylation sites of human high molecular weight neurofilament protein by electrospray ionization tandem mass spectrometry and database searching","volume":"37","author":"Jaffe","year":"1998","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.expneurol.2011.11.005_bb0165","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbr.2010.07.040","article-title":"Comparative neuroprotective profile of statins in quinolinic acid induced neurotoxicity in rats","volume":"216","author":"Kalonia","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.expneurol.2011.11.005_bb0170","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pbb.2010.04.018","article-title":"Pioglitazone ameliorates behavioral, biochemical and cellular alterations in quinolinic acid induced neurotoxicity: possible role of peroxisome proliferator activated receptor-Upsilon (PPARUpsilon) in Huntington's disease","volume":"96","author":"Kalonia","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"5","key":"10.1016\/j.expneurol.2011.11.005_bb0175","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1111\/j.1471-4159.2008.05551.x","article-title":"The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins","volume":"106","author":"Kanungo","year":"2008","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.expneurol.2011.11.005_bb0180","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1254\/jphs.08298FP","article-title":"Neuronal injury induces cytokine-induced neutrophil chemoattractant-1 (CINC-1) production in astrocytes","volume":"109","author":"Katayama","year":"2009","journal-title":"J. Pharmacol. Sci."},{"issue":"9","key":"10.1016\/j.expneurol.2011.11.005_bb0185","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1073\/pnas.72.9.3448","article-title":"Substrate specificity of the cyclic AMP-dependent protein kinase","volume":"72","author":"Kemp","year":"1975","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"13","key":"10.1016\/j.expneurol.2011.11.005_bb0190","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1101\/gad.1552107","article-title":"Intermediate filament scaffolds fulfill mechanical, organizational, and signaling functions in the cytoplasm","volume":"21","author":"Kim","year":"2007","journal-title":"Genes Dev."},{"issue":"5259","key":"10.1016\/j.expneurol.2011.11.005_bb0195","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.expneurol.2011.11.005_bb0200","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/neu.10270","article-title":"Functions of intermediate filaments in neuronal development and disease","volume":"58","author":"Lariviere","year":"2004","journal-title":"J. Neurobiol."},{"issue":"1\u20132","key":"10.1016\/j.expneurol.2011.11.005_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-3806(97)00113-2","article-title":"Calcium-dependent phosphorylation of glial fibrillary acidic protein (GFAP) in the rat hippocampus: a comparison of the kinase\/phosphatase balance in immature and mature slices using tryptic phosphopeptide mapping","volume":"104","author":"Leal","year":"1997","journal-title":"Brain Res. Dev. Brain Res."},{"issue":"6","key":"10.1016\/j.expneurol.2011.11.005_bb0210","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1073\/pnas.85.6.1998","article-title":"Identification of the major multiphosphorylation site in mammalian neurofilaments","volume":"85","author":"Lee","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.expneurol.2011.11.005_bb0215","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0169-328X(99)00142-4","article-title":"Calcium influx and membrane depolarization induce phosphorylation of neurofilament (NF-M) KSP repeats in PC12 cells","volume":"70","author":"Li","year":"1999","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.expneurol.2011.11.005_bb0470","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1046\/j.1432-1327.1999.00372.x","article-title":"Activation of mitogen-activated protein kinases (Erk1 and Erk2) cascade results in phosphorylation of NF-M tail domains in transfected NIH 3T3 cells","volume":"262","author":"Li","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.expneurol.2011.11.005_bb0230","doi-asserted-by":"crossref","first-page":"6055","DOI":"10.1523\/JNEUROSCI.20-16-06055.2000","article-title":"Integrin alpha(1) beta(1)-mediated activation of cyclin-dependent kinase 5 activity is involved in neurite outgrowth and human neurofilament protein H Lys-Ser-Pro tail domain phosphorylation","volume":"20","author":"Li","year":"2000","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.expneurol.2011.11.005_bb0235","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/emboj\/21.3.324","article-title":"Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3","volume":"21","author":"Li","year":"2002","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.expneurol.2011.11.005_bb0240","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1471-4159.1997.69020581.x","article-title":"Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction","volume":"69","author":"Liu","year":"1997","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.expneurol.2011.11.005_bb0245","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.bbadis.2004.12.007","article-title":"Propionic and methylmalonic acids increase cAMP levels in slices of cerebral cortex of young rats via adrenergic and glutamatergic mechanisms","volume":"1740","author":"Loureiro","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.expneurol.2011.11.005_bb0250","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijdevneu.2009.10.002","article-title":"Hyperhomocysteinemia selectively alters expression and stoichiometry of intermediate filament and induces glutamate- and calcium-mediated mechanisms in rat brain during development","volume":"28","author":"Loureiro","year":"2010","journal-title":"Int. J. Dev. Neurosci."},{"issue":"5","key":"10.1016\/j.expneurol.2011.11.005_bb0255","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ijdevneu.2008.03.001","article-title":"Homocysteine activates calcium-mediated cell signaling mechanisms targeting the cytoskeleton in rat hippocampus","volume":"26","author":"Loureiro","year":"2008","journal-title":"Int. J. Dev. Neurosci."},{"issue":"1","key":"10.1016\/j.expneurol.2011.11.005_bb0260","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2011.11.005_bb0265","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/cm.20122","article-title":"Dynein mediates retrograde neurofilament transport within axons and anterograde delivery of NFs from perikarya into axons: regulation by multiple phosphorylation events","volume":"63","author":"Motil","year":"2006","journal-title":"Cell Motil. Cytoskeleton"},{"issue":"1","key":"10.1016\/j.expneurol.2011.11.005_bb0270","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1750-3639.1993.tb00723.x","article-title":"The regulation of neurofilament protein dynamics by phosphorylation: clues to neurofibrillary pathobiology","volume":"3","author":"Nixon","year":"1993","journal-title":"Brain Pathol."},{"issue":"11","key":"10.1016\/j.expneurol.2011.11.005_bb0275","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0166-2236(91)90062-Y","article-title":"Neurofilament phosphorylation: a new look at regulation and function","volume":"14","author":"Nixon","year":"1991","journal-title":"Trends Neurosci."},{"issue":"7","key":"10.1016\/j.expneurol.2011.11.005_bb0280","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.tibs.2006.05.008","article-title":"\u201cHeads and tails\u201d of intermediate filament phosphorylation: multiple sites and functional insights","volume":"31","author":"Omary","year":"2006","journal-title":"Trends Biochem. Sci."},{"issue":"1","key":"10.1016\/j.expneurol.2011.11.005_bb0285","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1006\/exnr.2000.7542","article-title":"The role of group I and group II metabotropic glutamate receptors in modulation of striatal NMDA and quinolinic acid toxicity","volume":"167","author":"Orlando","year":"2001","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.expneurol.2011.11.005_bb0290","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0006-8993(97)00561-1","article-title":"Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5)","volume":"765","author":"Pant","year":"1997","journal-title":"Brain Res."},{"issue":"9","key":"10.1016\/j.expneurol.2011.11.005_bb0295","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/bies.10140","article-title":"Beyond structure: do intermediate filaments modulate cell signalling?","volume":"24","author":"Paramio","year":"2002","journal-title":"Bioessays"},{"issue":"6\u20137","key":"10.1016\/j.expneurol.2011.11.005_bb0300","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.neuint.2010.03.008","article-title":"Time-course correlation of early toxic events in three models of striatal damage: modulation by proteases inhibition","volume":"56","author":"Perez-De La Cruz","year":"2010","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.expneurol.2011.11.005_bb0475","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.expneurol.2010.03.009","article-title":"Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats","volume":"224","author":"Pierozan","year":"2010","journal-title":"Exp. Neurol."},{"issue":"4","key":"10.1016\/j.expneurol.2011.11.005_bb0490","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/jnr.22574","article-title":"gamma-Aminobutyric acid type B receptor changes in the rat striatum and substantia nigra following intrastriatal quinolinic acid lesions","volume":"89","author":"Rekik","year":"2011","journal-title":"J Neurosci Res"},{"issue":"5","key":"10.1016\/j.expneurol.2011.11.005_bb0310","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2174\/187152710793361612","article-title":"Group I metabotropic glutamate receptor signalling and its implication in neurological disease","volume":"9","author":"Ribeiro","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"4","key":"10.1016\/j.expneurol.2011.11.005_bb0315","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.neuro.2008.04.017","article-title":"Neurotoxicity of cadmium on immature hippocampus and a neuroprotective role for p38 MAPK","volume":"29","author":"Rigon","year":"2008","journal-title":"Neurotoxicology"},{"issue":"10","key":"10.1016\/j.expneurol.2011.11.005_bb0320","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/BF00966592","article-title":"Quinolinic acid is a potent lipid peroxidant in rat brain homogenates","volume":"16","author":"Rios","year":"1991","journal-title":"Neurochem. Res."},{"issue":"6","key":"10.1016\/j.expneurol.2011.11.005_bb0325","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/hmg\/ddl011","article-title":"Aggregate formation and phosphorylation of neurofilament-L Pro22 Charcot\u2013Marie\u2013Tooth disease mutants","volume":"15","author":"Sasaki","year":"2006","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.expneurol.2011.11.005_bb0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.102.034439","article-title":"Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities","volume":"303","author":"Schwarcz","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.expneurol.2011.11.005_bb0480","series-title":"Structure and Function of Ryanodine Receptors","first-page":"95","article-title":"Ryanodine binding sites on the sarcoplasmic reticulum Ca2C release channel","author":"Serysheva","year":"1998"},{"issue":"2","key":"10.1016\/j.expneurol.2011.11.005_bb0340","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0306-4522(02)00450-5","article-title":"Insulin-like growth factor-I inhibits endogenous acetylcholine release from the rat hippocampal formation: possible involvement of GABA in mediating the effects","volume":"115","author":"Seto","year":"2002","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.expneurol.2011.11.005_bb0345","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1074\/jbc.M109324200","article-title":"Phosphorylation of MEK1 by cdk5\/p35 down-regulates the mitogen-activated protein kinase pathway","volume":"277","author":"Sharma","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.expneurol.2011.11.005_bb0350","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1111\/j.1460-9568.2008.06165.x","article-title":"Regulation of neurofilament dynamics by phosphorylation","volume":"27","author":"Shea","year":"2008","journal-title":"Eur. J. Neurosci."},{"issue":"6","key":"10.1016\/j.expneurol.2011.11.005_bb0355","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/jnr.20099","article-title":"Cyclin-dependent kinase 5 increases perikaryal neurofilament phosphorylation and inhibits neurofilament axonal transport in response to oxidative stress","volume":"76","author":"Shea","year":"2004","journal-title":"J. Neurosci. Res."},{"issue":"10","key":"10.1016\/j.expneurol.2011.11.005_bb0360","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.yexcr.2007.04.010","article-title":"Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments","volume":"313","author":"Sihag","year":"2007","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.expneurol.2011.11.005_bb0365","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0021-9258(17)31280-2","article-title":"In vivo phosphorylation of distinct domains of the 70-kilodalton neurofilament subunit involves different protein kinases","volume":"264","author":"Sihag","year":"1989","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.expneurol.2011.11.005_bb0370","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0960-9822(00)00221-9","article-title":"Use of an oriented peptide library to determine the optimal substrates of protein kinases","volume":"4","author":"Songyang","year":"1994","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.expneurol.2011.11.005_bb0375","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cellsig.2005.03.014","article-title":"Adenylyl cyclase type-VIII activity is regulated by G(betagamma) subunits","volume":"18","author":"Steiner","year":"2006","journal-title":"Cell. Signal."},{"issue":"3","key":"10.1016\/j.expneurol.2011.11.005_bb0380","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0031-6997(25)00441-7","article-title":"Neuropharmacology of quinolinic and kynurenic acids","volume":"45","author":"Stone","year":"1993","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.expneurol.2011.11.005_bb0385","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0014-2999(81)90587-2","article-title":"Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS","volume":"72","author":"Stone","year":"1981","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.expneurol.2011.11.005_bb0390","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1074\/jbc.R000030200","article-title":"Ca2+-dependent cell signaling through calmodulin-activated protein phosphatase and protein kinases minireview series","volume":"276","author":"Stull","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.expneurol.2011.11.005_bb0395","doi-asserted-by":"crossref","first-page":"14245","DOI":"10.1074\/jbc.271.24.14245","article-title":"Phosphorylation of the high molecular weight neurofilament protein (NF-H) by Cdk5 and p35","volume":"271","author":"Sun","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.expneurol.2011.11.005_bb0400","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ceca.2010.01.003","article-title":"Calcium, ischemia and excitotoxicity","volume":"47","author":"Szydlowska","year":"2010","journal-title":"Cell Calcium"},{"issue":"7","key":"10.1016\/j.expneurol.2011.11.005_bb0405","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0197-0186(01)00133-4","article-title":"Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes","volume":"40","author":"Tavares","year":"2002","journal-title":"Neurochem. Int."},{"issue":"7","key":"10.1016\/j.expneurol.2011.11.005_bb0410","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1523\/JNEUROSCI.22-07-02590.2002","article-title":"Cdk5\/p35 regulates neurotransmitter release through phosphorylation and downregulation of P\/Q-type voltage-dependent calcium channel activity","volume":"22","author":"Tomizawa","year":"2002","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.expneurol.2011.11.005_bb0415","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/jcbfm.1994.122","article-title":"Mechanism of action and persistence of neuroprotection by cell-permeant Ca2+ chelators","volume":"14","author":"Tymianski","year":"1994","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"7","key":"10.1016\/j.expneurol.2011.11.005_bb0420","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nrm2203","article-title":"Mechanisms of specificity in protein phosphorylation","volume":"8","author":"Ubersax","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.expneurol.2011.11.005_bb0425","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1523\/JNEUROSCI.18-11-04008.1998","article-title":"Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M","volume":"18","author":"Veeranna","year":"1998","journal-title":"J. Neurosci."},{"issue":"13","key":"10.1016\/j.expneurol.2011.11.005_bb0430","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1523\/JNEUROSCI.1633-03.2004","volume":"24","author":"Wang","year":"2004","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.expneurol.2011.11.005_bb0435","first-page":"153","article-title":"Studies of catecholamine shock","volume":"56","author":"Whitaker","year":"1969","journal-title":"I. Disseminated intravascular coagulation. Am J Pathol"},{"issue":"7","key":"10.1016\/j.expneurol.2011.11.005_bb0440","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1016\/S0021-9258(18)42856-6","article-title":"Identification of six phosphorylation sites in the COOH-terminal tail region of the rat neurofilament protein M","volume":"267","author":"Xu","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.expneurol.2011.11.005_bb0445","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/(SICI)1097-0169(200004)45:4<249::AID-CM1>3.0.CO;2-M","article-title":"Phospho-dependent association of neurofilament proteins with kinesin in situ","volume":"45","author":"Yabe","year":"2000","journal-title":"Cell Motil. Cytoskeleton"},{"issue":"3","key":"10.1016\/j.expneurol.2011.11.005_bb0450","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.neuroscience.2008.07.059","article-title":"Nongenomic actions of thyroxine modulate intermediate filament phosphorylation in cerebral cortex of rats","volume":"156","author":"Zamoner","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2011.11.005_bb0455","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.neuro.2008.09.004","article-title":"Congenital hypothyroidism is associated with intermediate filament misregulation, glutamate transporters down-regulation and MAPK activation in developing rat brain","volume":"29","author":"Zamoner","year":"2008","journal-title":"Neurotoxicology"},{"issue":"13\u201314","key":"10.1016\/j.expneurol.2011.11.005_bb0460","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.lfs.2010.02.009","article-title":"Increased expression of cdk5\/p25 in N2a cells leads to hyperphosphorylation and impaired axonal transport of neurofilament proteins","volume":"86","author":"Zhou","year":"2010","journal-title":"Life Sci."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488611004092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488611004092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:46:50Z","timestamp":1762148810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488611004092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":93,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0014488611004092"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2011.11.005","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Signaling mechanisms downstream of quinolinic acid targeting the cytoskeleton of rat striatal neurons and astrocytes","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2011.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}