{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:28:02Z","timestamp":1790396882956,"version":"4.1.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"crossref","award":["PIP 112-200801-01767"],"award-info":[{"award-number":["PIP 112-200801-01767"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003074","name":"ANPCyT","doi-asserted-by":"crossref","award":["PICT 0791"],"award-info":[{"award-number":["PICT 0791"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010253","name":"UBACYT","doi-asserted-by":"crossref","award":["20020090200481"],"award-info":[{"award-number":["20020090200481"]}],"id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.expneurol.2012.02.018","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T04:48:53Z","timestamp":1331182133000},"page":"357-367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Cuprizone-induced demyelination in the rat cerebral cortex and thyroid hormone effects on cortical remyelination"],"prefix":"10.1016","volume":"235","author":[{"given":"Lucas","family":"Silvestroff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Bartucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana","family":"Pasquini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2012.02.018_bb0005","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.expneurol.2005.12.027","article-title":"Remyelination after cuprizone-induced demyelination in the rat is stimulated by apotransferrin","volume":"198","author":"Adamo","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0010","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1750-3639.2006.00043.x","article-title":"Extensive cortical remyelination in patients with chronic multiple sclerosis","volume":"17","author":"Albert","year":"2007","journal-title":"Brain Pathol"},{"key":"10.1016\/j.expneurol.2012.02.018_bb0015","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/10611860903318134","article-title":"Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO and NT-4 to the CNS","volume":"18","author":"Alcal\u00e1-Barraza","year":"2010","journal-title":"J. Drug Target."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0020","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/(SICI)1098-1136(199704)19:4<324::AID-GLIA5>3.0.CO;2-X","article-title":"Oligodendrocyte maturation and progenitor cell proliferation are independently regulated by thyroid hormone","volume":"19","author":"Baas","year":"1997","journal-title":"Glia"},{"key":"10.1016\/j.expneurol.2012.02.018_bb0025","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1242\/dev.120.5.1097","article-title":"A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development","volume":"120","author":"Barres","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.expneurol.2012.02.018_bb0030","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1152\/physrev.2001.81.2.871","article-title":"Biology of oligodendrocyte and myelin in the mammalian central nervous system","volume":"81","author":"Baumann","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0035","doi-asserted-by":"crossref","first-page":"9342","DOI":"10.1016\/S0021-9258(19)83519-6","article-title":"Investigations on myelination in vitro: regulation by thyroid hormone in cultures of dissociated brain cells from embryonic mice","volume":"254","author":"Bhat","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0040","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1006\/dbio.2001.0293","article-title":"Role of thyroid hormone receptors in timing oligodendrocyte differentiation","volume":"235","author":"Billon","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0045","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0022-510X(73)90119-6","article-title":"Remyelination of the superior cerebellar peduncle in the mouse following demyelination induced by feeding cuprizone","volume":"20","author":"Blakemore","year":"1973","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0050","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/249577a0","article-title":"Pattern of remyelination in the CNS","volume":"249","author":"Blakemore","year":"1974","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2012.02.018_bb0055","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1191\/1352458503ms917oa","article-title":"Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration","volume":"9","author":"Bo","year":"2003","journal-title":"Mult. Scler."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0060","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/jnen\/62.7.723","article-title":"Subpial demyelination in the cerebral cortex of multiple sclerosis patients","volume":"62","author":"Bo","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0065","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuroscience.2011.08.003","article-title":"Intranasal administration of insulin like growth factor-1 protects against lipopolysaccharide-induced injury in the developing rat brain","volume":"194","author":"Cai","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2012.02.018_bb0070","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1001\/archneurol.2009.174","article-title":"Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis","volume":"66","author":"Calabrese","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0075","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1073\/pnas.052704499","article-title":"Thyroid hormone activates oligodendrocyte precursor and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis","volume":"99","author":"Calz\u00e0","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0080","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.brainresrev.2004.12.022","article-title":"Thyroid hormone and remyelination in adult central nervous system: a lesson from an inflammatory-demyelinating disease","volume":"48","author":"Calz\u00e0","year":"2005","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0085","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1677\/JME-09-0067","article-title":"Cellular approaches to central nervous system remyelination stimulation: thyroid hormone to promote myelin repair via endogenous stem and precursor cells","volume":"44","author":"Calz\u00e0","year":"2010","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0090","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/glia.440020403","article-title":"Gliosis in the spinal cords of rats with experimental allergic encephalomyelitis: immunostaining of carbonic anhydrase and vimentin in reactive astrocytes","volume":"2","author":"Cammer","year":"1989","journal-title":"Glia"},{"key":"10.1016\/j.expneurol.2012.02.018_bb0095","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0165-3806(92)90226-M","article-title":"Carbonic anhydrase in distinct precursors of astrocytes and oligodendrocytes in the forebrains of neonatal and young rats","volume":"67","author":"Cammer","year":"1992","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0100","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/jnr.490360208","article-title":"Atypical location of the oligodendrocytic isoform (PI) of glutathione-S-transferase in astrocytes during cuprizone intoxication","volume":"36","author":"Cammer","year":"1993","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0105","doi-asserted-by":"crossref","first-page":"11376","DOI":"10.1523\/JNEUROSCI.2418-07.2007","article-title":"The marginal zone\/layer I as a novel niche for neurogenesis and gliogenesis in developing cerebral cortex","volume":"27","author":"Costa","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0110","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1212\/01.wnl.0000275229.13012.32","article-title":"Pathogenesis of axonal and neuronal damage in multiple sclerosis","volume":"68","author":"Dutta","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2012.02.018_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2010.09.005","article-title":"Mechanisms of neuronal dysfunction and degeneration in Multiple sclerosis","volume":"93","author":"Dutta","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0120","doi-asserted-by":"crossref","first-page":"16363","DOI":"10.1073\/pnas.0407262101","article-title":"Thyroid hormone administration enhances remyelination in chronic demyelinating inflammatory disease","volume":"101","author":"Fernandez","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0125","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.ijdevneu.2009.08.011","article-title":"Thyroid hormone induces glial lineage of primary neurospheres derived from non-pathological and pathological rat brain: implications for remyelination-enhancing therapies","volume":"27","author":"Fernandez","year":"2004","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0130","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.expneurol.2008.04.039","article-title":"Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination","volume":"212","author":"Franco","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0135","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nrn917","article-title":"Why does remyelination fail in multiple sclerosis?","volume":"3","author":"Franklin","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0140","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nrn2480","article-title":"Remyelination in the CNS: from biology to therapy","volume":"9","author":"Franklin","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0145","doi-asserted-by":"crossref","first-page":"40128","DOI":"10.1074\/jbc.M300909200","article-title":"Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter","volume":"278","author":"Friesema","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0150","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.nbd.2011.05.021","article-title":"Cerebral cortex demyelination and oligodendrocyte precursor response to experimental autoimmune encephalomyelitis","volume":"43","author":"Girolamo","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0155","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.brainres.2009.06.005","article-title":"Regional differences between grey and white matter in cuprizone induced demyelination","volume":"1283","author":"Gudi","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0160","doi-asserted-by":"crossref","first-page":"14189","DOI":"10.1523\/JNEUROSCI.4453-08.2008","article-title":"Recovery from chronic demyelination by thyroid hormone therapy: myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging","volume":"28","author":"Harsan","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0165","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0165-5728(98)00168-4","article-title":"Microglia\/macrophage accumulation during cuprizone-induced demyelination in C57BL\/6 mice","volume":"92","author":"Hiremath","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0928-0987(00)00087-7","article-title":"Transport of drugs from the nasal cavity to the central nervous system","volume":"11","author":"Illum","year":"2000","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0175","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2174\/187221108783331429","article-title":"Recent patents on intranasal administration for CNS drug delivery","volume":"2","author":"Jogani","year":"2008","journal-title":"Recent Pat. Drug Deliv. Formul."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0180","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1600-0404.1980.tb03033.x","article-title":"Thyroid function in multiple sclerosis","volume":"62","author":"Kiessling","year":"1980","journal-title":"Acta Neurol. Scand."},{"issue":"Suppl. 1","key":"10.1016\/j.expneurol.2012.02.018_bb0185","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/1756-6614-4-S1-S7","article-title":"Primary and secondary thyroid hormone transporters","volume":"4","author":"Kinne","year":"2011","journal-title":"Thyroid. Res."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0190","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.bbi.2011.05.003","article-title":"BLBP expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions","volume":"25","author":"Kipp","year":"2011","journal-title":"Brain, Behav. Immun."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0195","first-page":"40","article-title":"Experimental demyelination caused by primary oligodendrocyte dystrophy. Regional distribution of the lesions in the nervous system of mice","volume":"58","author":"Komoly","year":"2005","journal-title":"Ideggyogy. Sz."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0200","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jns.2005.03.027","article-title":"Cortical lesions and brain atrophy in MS","volume":"233","author":"Kutzelnigg","year":"2005","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0205","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1093\/brain\/awh641","article-title":"Cortical demyelination and diffuse white matter injury in multiple sclerosis","volume":"128","author":"Kutzelnigg","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2012.02.018_bb0210","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1750-3639.2006.00041.x","article-title":"Widespread demyelination in the cerebellar cortex in multiple sclerosis","volume":"17","author":"Kutzelnigg","year":"2007","journal-title":"Brain Pathol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0215","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0022-510X(88)90127-X","article-title":"Cuprizone neurotoxicity in the rat: morphologic observations","volume":"84","author":"Love","year":"1988","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0220","first-page":"597","article-title":"Central nervous system demyelination and remyelination in the mouse","volume":"39","author":"Ludwin","year":"1978","journal-title":"Lab. Investig."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0225","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1750-3639.2010.00444.x","article-title":"An animal model of cortical and callosal pathology in multiple sclerosis","volume":"21","author":"Mangiardi","year":"2011","journal-title":"Brain Pathol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0230","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/(SICI)1097-4547(19980715)53:2<251::AID-JNR14>3.0.CO;2-9","article-title":"Sustained neonatal hyperthyroidism in the rat affects myelination in the central nervous system","volume":"53","author":"Marta","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0235","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0002-9440(10)63726-1","article-title":"Oligodendrocytes and progenitors become progressively depleted within chronically demyelinated lesions","volume":"164","author":"Mason","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0240","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1750-3639.2001.tb00385.x","article-title":"The neurotoxicant Cuprizone as a model to study demyelination and remyelination in the central nervous system","volume":"11","author":"Matsushima","year":"2001","journal-title":"Brain Pathol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0245","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2165\/00126839-200708030-00001","article-title":"Can nasal drug delivery bypass the blood\u2013brain-barrier? Questioning the direct transport theory","volume":"8","author":"Merkus","year":"2007","journal-title":"Drugs R&D"},{"key":"10.1016\/j.expneurol.2012.02.018_bb0250","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1111\/j.1468-1331.2007.01882.x","article-title":"Prevalence of autoimmune thyroid disorders in a Spanish multiple sclerosis cohort","volume":"14","author":"Munteis","year":"2007","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0255","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1007\/s00415-003-1053-9","article-title":"Prevalence of autoimmune thyroiditis and non-immune thyroid disease in multiple sclerosis","volume":"250","author":"Niderwiesser","year":"2003","journal-title":"J. Neurol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0260","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/BF00993263","article-title":"Quantitative aspects of reactive gliosis: a review","volume":"17","author":"Norton","year":"1992","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000112080","article-title":"Thyroid hormones and the central nervous system","volume":"16","author":"Pasquini","year":"1994","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0270","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/187221109787158355","article-title":"CNS drug delivery systems: novel approaches","volume":"3","author":"Pathan","year":"2009","journal-title":"Recent Pat. Drug Deliv. Formul."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0275","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1986"},{"key":"10.1016\/j.expneurol.2012.02.018_bb0280","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/ana.1123","article-title":"Transected neurites, apoptotic neurons and reduced inflammation in cortical MS lesions","volume":"50","author":"Peterson","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0285","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/ana.20703","article-title":"Diagnostic criteria for multiple scerosis: 2005 revisions to the \u201cMcDonald Criteria\u201d","volume":"58","author":"Polman","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0290","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisons to the \u201cMcDonald Criteria\u201d","volume":"69","author":"Polman","year":"2011","journal-title":"Ann. Neurol."},{"issue":"Suppl. 2","key":"10.1016\/j.expneurol.2012.02.018_bb0295","doi-asserted-by":"crossref","first-page":"S235","DOI":"10.1007\/s10072-010-0368-4","article-title":"Cortical lesions ans cognitive impairment in multiple sclerosis","volume":"31","author":"Rinaldi","year":"2010","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0300","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.1210\/en.2008-0378","article-title":"Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood\u2013brain-barrier","volume":"149","author":"Roberts","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.expneurol.2012.02.018_bb0305","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/(SICI)1097-4695(19990915)40:4<497::AID-NEU7>3.0.CO;2-#","article-title":"Oligodendrocyte development and thyroid hormone","volume":"40","author":"Rodr\u00edguez-Pe\u00f1a","year":"1999","journal-title":"J. Neurobiol."},{"issue":"4","key":"10.1016\/j.expneurol.2012.02.018_bb0310","doi-asserted-by":"crossref","first-page":"e18711","DOI":"10.1371\/journal.pone.0018711","article-title":"The rostral migratory stream plays a key role in intranasal delivery of drugs into the CNS","volume":"6","author":"Scranton","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2012.02.018_bb0315","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1002\/cne.22330","article-title":"Cuprizone-induced demyelination in CNP::GFP transgenic mice","volume":"518","author":"Silvestroff","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0320","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2353\/ajpath.2008.070850","article-title":"Cortical demyelination is prominent in the murine cuprizone model and is strain\u2013dependent","volume":"172","author":"Skripuletz","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0325","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1750-3639.2003.tb00032.x","article-title":"Quantifying the early stages of remyelination following cuprizone-induced demyelination","volume":"13","author":"Stidworthy","year":"2003","journal-title":"Brain Pathol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0330","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1097\/01.jnen.0000248547.13176.9d","article-title":"Cortical demyelination can be modeled in specific rat models of autoimmune encephalomyelitis and is major histocompatibility complex (MHC) haplotype-related","volume":"65","author":"Storch","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0335","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.expneurol.2004.05.038","article-title":"Endogenous Nkx2.2+\/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes","volume":"192","author":"Talbott","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0340","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s11060-006-9181-6","article-title":"Nestin expression in reactive astrocytes of human pathology","volume":"80","author":"Tamagno","year":"2006","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0345","first-page":"889","article-title":"In situ hybridization analysis of glial fibrillary acidic protein mRNA reveals evidence of biphasic astrocyte activation during acute experimental autoimmune encephalomyelitis","volume":"148","author":"Tani","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0350","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.neuroscience.2004.05.029","article-title":"Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration","volume":"127","author":"Thorne","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2012.02.018_bb0355","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.neuro.30.051606.094313","article-title":"Multiple sclerosis: an immune or neurodegenerative disorder ?","volume":"31","author":"Trapp","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0360","article-title":"Cortical dysfunction underlies disability in multiple sclerosis","author":"Vucic","year":"2011","journal-title":"Mult. Scler."},{"key":"10.1016\/j.expneurol.2012.02.018_bb0365","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/jmri.21111","article-title":"MRI identification of the rostral-caudal pattern of pathology within the corpus callosum in the cuprizone mouse model","volume":"27","author":"Wu","year":"2008","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.expneurol.2012.02.018_bb0370","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1097\/NEN.0b013e3181e3de90","article-title":"Rostrocaudal analysis of corpus callosum demyelination and axon damage across disease stages refines diffusion tensor imaging correlations with pathological features","volume":"69","author":"Xie","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488612000945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488612000945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:44:19Z","timestamp":1758001459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488612000945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0014488612000945"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2012.02.018","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cuprizone-induced demyelination in the rat cerebral cortex and thyroid hormone effects on cortical remyelination","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2012.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}