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Neurochem."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0265","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1089\/neu.1997.14.715","article-title":"Progressive atrophy and neuron death for one year following brain trauma in the rat","volume":"14","author":"Smith","year":"1997","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2012.08.015_bb0270","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/1073858405278321","article-title":"Reactive astrocytes in neural repair and protection","volume":"11","author":"Sofroniew","year":"2005","journal-title":"Neuroscientist"},{"key":"10.1016\/j.expneurol.2012.08.015_bb0275","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.tins.2009.08.002","article-title":"Molecular dissection of reactive astrogliosis and glial scar formation","volume":"32","author":"Sofroniew","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0280","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/1097-4547(20010101)63:1<90::AID-JNR11>3.0.CO;2-9","article-title":"Morphology of reactive microglia in the injured cerebral cortex. Fractal analysis and complementary quantitative methods","volume":"63","author":"Soltys","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0290","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0140-6736(03)14412-1","article-title":"Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states","volume":"362","author":"Stenzel-Poore","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.expneurol.2012.08.015_bb0285","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1161\/01.STR.0000143735.89281.bb","article-title":"Genomics of preconditioning","volume":"35","author":"Stenzel-Poore","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2012.08.015_bb0295","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1046\/j.1460-9568.2002.02030.x","article-title":"Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia","volume":"15","author":"Tang","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0300","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1101\/gr.772403","article-title":"PANTHER: a library of protein families and subfamilies indexed by function","volume":"13","author":"Thomas","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0305","doi-asserted-by":"crossref","first-page":"W645","DOI":"10.1093\/nar\/gkl229","article-title":"Applications for protein sequence-function evolution data: mRNA\/protein expression analysis and coding SNP scoring tools","volume":"34","author":"Thomas","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0310","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2012.08.015_bb9075","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.nbd.2005.11.015","article-title":"Differential regulation of the CXCR2 chemokine network in rat brain trauma: implications for neuroimmune interactions and neuronal survival","volume":"22","author":"Valles","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0315","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.expneurol.2005.05.002","article-title":"Neuroprotective effects of HSP70 overexpression after cerebral ischaemia\u2013an MRI study","volume":"195","author":"van der Weerd","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2012.08.015_bb9065","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.1523\/JNEUROSCI.19-13-05236.1999","article-title":"Interleukin-6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor","volume":"19","author":"Van Wagoner","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2012.08.015_bb9070","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/00004647-200005000-00001","article-title":"Serine protease inhibitors: novel therapeutic targets for stroke?","volume":"20","author":"Vivien","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0320","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/1471-2164-9-146","article-title":"Brain gene expression profiles of Cln1 and Cln5 deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases","volume":"9","author":"von Schantz","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.expneurol.2012.08.015_bb9060","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1046\/j.1471-4159.1998.71031194.x","article-title":"Prolonged expression of interferon-inducible protein-10 in ischemic cortex after permanent occlusion of the middle cerebral artery in rat","volume":"71","author":"Wang","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0325","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1046\/j.1471-4159.2002.01225.x","article-title":"CD44 deficiency in mice protects brain from cerebral ischemia injury","volume":"83","author":"Wang","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0330","first-page":"197","article-title":"Don't fence me in: harnessing the beneficial roles of astrocytes for spinal cord repair","volume":"26","author":"White","year":"2008","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0335","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/cne.22282","article-title":"Regional heterogeneity in astrocyte responses following contusive spinal cord injury in mice","volume":"518","author":"White","year":"2010","journal-title":"J. Comp. Neurol."},{"issue":"5","key":"10.1016\/j.expneurol.2012.08.015_bb9190","doi-asserted-by":"crossref","first-page":"e00096","DOI":"10.1042\/AN20110020","article-title":"Mice lacking the beta2 adrenergic receptor have a unique genetic profile before and after focal brain ischemia","volume":"4","author":"White","year":"2012","journal-title":"ASN Neuro."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0340","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.schres.2005.03.011","article-title":"Cortical gene expression in the neonatal ventral\u2013hippocampal lesion rat model","volume":"77","author":"Wong","year":"2005","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0345","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1471-4159.2008.05777.x","article-title":"Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death","volume":"108","author":"Xing","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0350","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1161\/STROKEAHA.110.593772","article-title":"Increased brain injury and worsened neurological outcome in interleukin-4 knockout mice after transient focal cerebral ischemia","volume":"42","author":"Xiong","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2012.08.015_bb0360","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0304-3940(99)00882-4","article-title":"Overexpression of bcl-2, bcl-xL or hsp70 in murine cortical astrocytes reduces injury of co-cultured neurons","volume":"277","author":"Xu","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0365","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/jcbfm.2008.125","article-title":"Overexpression of mitochondrial Hsp70\/Hsp75 in rat brain protects mitochondria, reduces oxidative stress, and protects from focal ischemia","volume":"29","author":"Xu","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0355","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/glia.20985","article-title":"Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia","volume":"58","author":"Xu","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.expneurol.2012.08.015_bb0370","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neulet.2010.11.047","article-title":"Heat shock protein 72 (Hsp72) improves long term recovery after focal cerebral ischemia in mice","volume":"488","author":"Xu","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0375","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1128\/MCB.23.11.3813-3824.2003","article-title":"Inactivation of dual-specificity phosphatases is involved in the regulation of extracellular signal-regulated kinases by heat shock and hsp72","volume":"23","author":"Yaglom","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0380","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/ana.410440403","article-title":"Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy","volume":"44","author":"Yenari","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2012.08.015_bb9000","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1160\/TH03-12-0766","article-title":"Neuroserpin: a selective inhibitor of tissue-type plasminogen activator in the central nervous system","volume":"91","author":"Yepes","year":"2004","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.expneurol.2012.08.015_bb9005","first-page":"173","article-title":"Tissue-type plasminogen activator and neuroserpin: a well-balanced act in the nervous system? Trends Cardiovasc","volume":"14","author":"Yepes","year":"2004","journal-title":"Med."},{"key":"10.1016\/j.expneurol.2012.08.015_bb9010","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neulet.2004.07.083","article-title":"Delayed expressed TNFR1 co-localize with ICAM-1 in astrocyte in mice brain after transient focal ischemia","volume":"370","author":"Yin","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2012.08.015_bb9015","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neures.2006.02.009","article-title":"Differential effects and changes of ceruloplasmin in the hippocampal CA1 region between adult and aged gerbils after transient cerebral ischemia","volume":"55","author":"Yoo","year":"2006","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0385","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1523\/JNEUROSCI.6221-11.2012","article-title":"Genomic analysis of reactive astrogliosis","volume":"32","author":"Zamanian","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2012.08.015_bb0390","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/sj.jcbfm.9600502","article-title":"Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke","volume":"28","author":"Zheng","year":"2008","journal-title":"J. Cereb. 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