{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:08:50Z","timestamp":1792267730538,"version":"4.4.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.expneurol.2012.09.018","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T15:00:59Z","timestamp":1349708459000},"page":"158-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"special_numbering":"C","title":["Intra-arterial infusion of human bone marrow-derived mesenchymal stem cells results in transient localization in the brain after cerebral ischemia in rats"],"prefix":"10.1016","volume":"239","author":[{"given":"Bhimashankar","family":"Mitkari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erja","family":"Kerkel\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Nystedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Korhonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Mikkonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuulia","family":"Huhtala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka","family":"Jolkkonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2012.09.018_bb0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/ageing\/afq133","article-title":"Human stem cell therapy in ischaemic stroke: a review","volume":"40","author":"Banerjee","year":"2011","journal-title":"Age Ageing"},{"key":"10.1016\/j.expneurol.2012.09.018_bb0005","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.expneurol.2009.10.010","article-title":"Migration and homing of bone-marrow mononuclear cells in chronic ischemic stroke after intra-arterial injection","volume":"221","author":"Barbosa da Fonseca","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2012.09.018_bb0015","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1002\/stem.139","article-title":"Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow","volume":"27","author":"Bieback","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.expneurol.2012.09.018_bb0020","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.nbd.2009.10.003","article-title":"Optimizing the success of cell transplantation therapy for stroke","volume":"37","author":"Bliss","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2012.09.018_bb0025","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.pneurobio.2011.08.005","article-title":"The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders","volume":"95","author":"Borlongan","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.expneurol.2012.09.018_bb0030","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/jcbfm.2009.198","article-title":"Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats","volume":"30","author":"Brenneman","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2012.09.018_bb0035","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/jcbfm.2010.213","article-title":"Intra-arterial injection of neural stem cells using a microneedle technique does not cause microembolic strokes","volume":"31","author":"Chua","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2012.09.018_bb0040","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.expneurol.2012.09.018_bb0045","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1089\/scd.2008.0253","article-title":"Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect","volume":"18","author":"Fischer","year":"2009","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.expneurol.2012.09.018_bb0050","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00007890-197404000-00001","article-title":"Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo","volume":"17","author":"Friedenstein","year":"1974","journal-title":"Transplantation"},{"key":"10.1016\/j.expneurol.2012.09.018_bb0055","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/MNM.0b013e328318b328","article-title":"Cytotoxicity of 111In-oxine on mesenchymal stem cells: a time-dependent adverse effect","volume":"30","author":"Gholamrezanezhad","year":"2009","journal-title":"Nucl. Med. Commun."},{"key":"10.1016\/j.expneurol.2012.09.018_bb0060","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/ten.tec.2010.0406","article-title":"Optimization of culture conditions for the expansion of umbilical cord-derived mesenchymal stem or stromal cell-like cells using xeno-free culture conditions","volume":"17","author":"Hatlapatka","year":"2011","journal-title":"Tissue Eng. Part C, Methods"},{"key":"10.1016\/j.expneurol.2012.09.018_bb0065","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1460-9568.2008.06599.x","article-title":"Transplantation of human embryonic stem cell (hESC)-derived neural precursor cells and enriched environment after cortical stroke in rats: cell survival and functional recovery","volume":"29","author":"Hicks","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2012.09.018_bb0070","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.stem.2009.02.001","article-title":"Mesenchymal stem cell homing: the devil is in the details","volume":"4","author":"Karp","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.expneurol.2012.09.018_bb0075","doi-asserted-by":"crossref","first-page":"796025","DOI":"10.1155\/2011\/796025","article-title":"Molecular SPECT imaging: an overview","volume":"2011","author":"Khalil","year":"2011","journal-title":"Int. J. Mol. Imaging"},{"key":"10.1016\/j.expneurol.2012.09.018_bb0080","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.neulet.2008.05.090","article-title":"SPECT imaging shows accumulation of stem cells into internal organs after systemic administration in middle cerebral artery occlusion rats","volume":"440","author":"Lappalainen","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2012.09.018_bb0085","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/jcbfm.2009.238","article-title":"Effects of administration route on migration and distribution of neural progenitor cells transplanted into rats with focal cerebral ischemia, an MRI study","volume":"30","author":"Li","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2012.09.018_bb0090","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1161\/STROKEAHA.110.599654","article-title":"Stem cell research in stroke: how far from the clinic?","volume":"42","author":"Lindvall","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2012.09.018_bb0095","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2012.09.018_bb0100","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3727\/096368911X576036","article-title":"Targeted intra-arterial transplantation of stem cells to the injured CNS is more effective than intravenous administration \u2014 engraftment is dependent on cell type and adhesion molecule expression","volume":"21","author":"Lundberg","year":"2012","journal-title":"Cell Transplant."},{"key":"10.1016\/j.expneurol.2012.09.018_bb0110","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.brainres.2006.09.056","article-title":"Human umbilical cord blood cells do not improve sensorimotor or cognitive outcome following transient middle cerebral artery occlusion in rats","volume":"1123","author":"M\u00e4kinen","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2012.09.018_bb0105","series-title":"Advances in the Treatment of Ischemic Stroke","first-page":"141","article-title":"Toward a more effective intravascular cell therapy in stroke","author":"Mitkari","year":"2012"},{"key":"10.1016\/j.expneurol.2012.09.018_bb0115","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1161\/STROKEAHA.109.575993","article-title":"Biodistribution of neural stem cells after intravascular therapy for hypoxic-ischemia","volume":"41","author":"Pendharkar","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2012.09.018_bb0120","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0028-3908(00)00182-9","article-title":"An \u03b12-antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats","volume":"40","author":"Puurunen","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.expneurol.2012.09.018_bb0125","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/978-1-60761-999-4_35","article-title":"Cell surface engineering of mesenchymal stem cells","volume":"698","author":"Sarkar","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.expneurol.2012.09.018_bb0130","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1111\/j.1537-2995.2007.01220.x","article-title":"Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells","volume":"47","author":"Schallmoser","year":"2007","journal-title":"Transfusion"},{"key":"10.1016\/j.expneurol.2012.09.018_bb0135","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1161\/STROKEAHA.107.502047","article-title":"Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia","volume":"39","author":"Walczak","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2012.09.018_bb0140","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.nucmedbio.2009.12.001","article-title":"In vivo tracking of 111In-labeled bone marrow mesenchymal stem cells in acute brain trauma model","volume":"37","author":"Yoon","year":"2010","journal-title":"Nucl. Med. Biol."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488612003809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488612003809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:45:04Z","timestamp":1758001504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488612003809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":28,"alternative-id":["S0014488612003809"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2012.09.018","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intra-arterial infusion of human bone marrow-derived mesenchymal stem cells results in transient localization in the brain after cerebral ischemia in rats","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2012.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}