{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:05:46Z","timestamp":1792785946696,"version":"4.5.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea","award":["A111345"],"award-info":[{"award-number":["A111345"]}],"id":[{"id":"https:\/\/ror.org\/00vxgjw72","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Korea government (MSIP)","award":["2008-0062282"],"award-info":[{"award-number":["2008-0062282"]}]},{"name":"Korea government (MSIP)","award":["2012M3A9B6055414"],"award-info":[{"award-number":["2012M3A9B6055414"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.expneurol.2014.01.009","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T09:47:07Z","timestamp":1389952027000},"page":"41-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["The pivotal role played by lipocalin-2 in chronic inflammatory pain"],"prefix":"10.1016","volume":"254","author":[{"given":"Mithilesh Kumar","family":"Jha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangmin","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myungwon","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyeon","family":"Ock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Heon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Ha","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoungho","family":"Suk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2014.01.009_bb0005","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1128\/IAI.05114-11","article-title":"Klebsiella pneumoniae yersiniabactin promotes respiratory tract infection through evasion of lipocalin 2","volume":"79","author":"Bachman","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0010","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/glia.22342","article-title":"Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis","volume":"60","author":"Berard","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0015","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.ejpain.2006.12.008","article-title":"Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice","volume":"11","author":"Boettger","year":"2007","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0020","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.pain.2004.08.029","article-title":"Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells","volume":"112","author":"Brack","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0025","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0030","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.neubiorev.2008.03.009","article-title":"Spinal glial activation contributes to pathological pain states","volume":"32","author":"Cao","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0035","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/j.1532-2149.2012.00240.x","article-title":"Neutrophils recruited by CXCR1\/2 signalling mediate post-incisional pain","volume":"17","author":"Carreira","year":"2013","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0040","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0045","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.neulet.2013.02.005","article-title":"The contribution of TNF-alpha in the amygdala to anxiety in mice with persistent inflammatory pain","volume":"541","author":"Chen","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0050","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ejpain.2006.02.003","article-title":"Role of spinal microglia in rat models of peripheral nerve injury and inflammation","volume":"11","author":"Clark","year":"2007","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0055","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0165-0270(97)00097-6","article-title":"Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli","volume":"76","author":"Dirig","year":"1997","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0060","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0065","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature03104","article-title":"Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron","volume":"432","author":"Flo","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0167-4838(00)00148-5","article-title":"The lipocalin protein family: structural and sequence overview","volume":"1482","author":"Flower","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0075","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1210\/me.2005-0423","article-title":"Spermatogonial cell-mediated activation of an IkappaBzeta-independent nuclear factor-kappaB pathway in Sertoli cells induces transcription of the lipocalin-2 gene","volume":"20","author":"Fujino","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0080","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0085","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/(SICI)1521-1878(199901)21:1<17::AID-BIES3>3.0.CO;2-4","article-title":"Chemokines: extracellular messengers for all occasions?","volume":"21","author":"Gale","year":"1999","journal-title":"Bioessays"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0090","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.neuroscience.2007.09.060","article-title":"Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia","volume":"150","author":"Gendron","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0095","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1523\/JNEUROSCI.5054-03.2004","article-title":"Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia","volume":"24","author":"Ghilardi","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0100","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nm.2235","article-title":"Nociceptor sensitization in pain pathogenesis","volume":"16","author":"Gold","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0105","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0110","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbrc.2012.08.039","article-title":"Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone attenuates postincisional pain by regulating macrophage polarization","volume":"426","author":"Hasegawa-Moriyama","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0115","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1189\/jlb.0809532","article-title":"The murine IL-8 homologues KC, MIP-2, and LIX are found in endothelial cytoplasmic granules but not in Weibel-Palade bodies","volume":"87","author":"Hol","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0120","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jpain.2013.02.003","article-title":"Repetitive hyperbaric oxygen treatment attenuates complete Freund's adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord","volume":"14","author":"Hui","year":"2013","journal-title":"J. Pain"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0125","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1744-8069-8-43","article-title":"Contribution of microglia and astrocytes to the central sensitization, inflammatory and neuropathic pain in the juvenile rat","volume":"8","author":"Ikeda","year":"2012","journal-title":"Mol. Pain"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0130","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/bit.20535","article-title":"Identification of neutrophil gelatinase-associated lipocalin (NGAL) as a discriminatory marker of the hepatocyte-secreted protein response to IL-1beta: a proteomic analysis","volume":"91","author":"Jayaraman","year":"2005","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0135","doi-asserted-by":"crossref","first-page":"24116","DOI":"10.1074\/jbc.M113.454140","article-title":"Role of lipocalin-2-chemokine axis in the development of neuropathic pain following peripheral nerve injury","volume":"288","author":"Jeon","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4110\/in.2012.12.2.41","article-title":"Glia as a link between neuroinflammation and neuropathic pain","volume":"12","author":"Jha","year":"2012","journal-title":"Immune Netw."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0145","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pain.2013.06.022","article-title":"Glia and pain: is chronic pain a gliopathy?","volume":"154","author":"Ji","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0150","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/35093019","article-title":"Molecular mechanisms of nociception","volume":"413","author":"Julius","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0155","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1155\/2013\/259273","article-title":"Pentraxins as key disease markers for periodontal diagnosis","volume":"34","author":"Kathariya","year":"2013","journal-title":"Dis. Markers"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0160","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1523\/JNEUROSCI.3338-07.2008","article-title":"Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord","volume":"28","author":"Kawasaki","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0165","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1124\/jpet.111.187724","article-title":"Epigenetic augmentation of the macrophage inflammatory protein 2\/C-X-C chemokine receptor type 2 axis through histone H3 acetylation in injured peripheral nerves elicits neuropathic pain","volume":"340","author":"Kiguchi","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0170","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4110\/in.2011.11.6.342","article-title":"Modulation of glial and neuronal migration by lipocalin-2 in zebrafish","volume":"11","author":"Kim","year":"2011","journal-title":"Immune Netw."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0175","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1152\/jn.01075.2004","article-title":"Effect of chronic inflammation on dorsal horn nociceptive neurons in aged rats","volume":"93","author":"Kitagawa","year":"2005","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0180","doi-asserted-by":"crossref","first-page":"7667","DOI":"10.1523\/JNEUROSCI.4968-12.2013","article-title":"Fractalkine signaling in microglia contributes to ectopic orofacial pain following trapezius muscle inflammation","volume":"33","author":"Kiyomoto","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0185","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3389\/fphys.2012.00391","article-title":"Development of inflammation-induced hyperalgesia and allodynia is associated with the upregulation of extrasynaptic AMPA receptors in tonically firing lamina II dorsal horn neurons","volume":"3","author":"Kopach","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0190","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2004.01.092","article-title":"A parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in rats","volume":"1020","author":"Lao","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0195","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0091-3057(86)90043-2","article-title":"Pain threshold changes in adjuvant-induced inflammation: a possible model of chronic pain in the mouse","volume":"24","author":"Larson","year":"1986","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0200","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central sensitization: a generator of pain hypersensitivity by central neural plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J. Pain"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0205","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.pain.2006.08.006","article-title":"Neutrophil infiltration is implicated in the sustained thermal hyperalgesic response evoked by allergen provocation in actively sensitized rats","volume":"125","author":"Lavich","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0210","doi-asserted-by":"crossref","first-page":"43855","DOI":"10.1074\/jbc.M111.299248","article-title":"Lipocalin-2 Is a chemokine inducer in the central nervous system: role of chemokine ligand 10 (CXCL10) in lipocalin-2-induced cell migration","volume":"286","author":"Lee","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0215","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.4049\/jimmunol.179.5.3231","article-title":"A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia","volume":"179","author":"Lee","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0220","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1744-8069-6-79","article-title":"Distinctive response of CNS glial cells in oro-facial pain associated with injury, infection and inflammation","volume":"6","author":"Lee","year":"2010","journal-title":"Mol Pain"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0225","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.pain.2011.10.032","article-title":"The complement component C5a receptor mediates pain and inflammation in a postsurgical pain model","volume":"153","author":"Liang","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0230","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neulet.2012.08.039","article-title":"Expression profiling of Rab GTPases reveals the involvement of Rab20 and Rab32 in acute brain inflammation in mice","volume":"527","author":"Liang","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0235","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ijdevneu.2009.01.005","article-title":"Long-lasting neonatal inflammation enhances pain responses to subsequent inflammation, but not peripheral nerve injury in adult rats","volume":"27","author":"Lim","year":"2009","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0240","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jneuroim.2007.09.003","article-title":"Dissociation of spinal microglia morphological activation and peripheral inflammation in inflammatory pain models","volume":"192","author":"Lin","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0245","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/ALN.0b013e31820b8b1e","article-title":"Inflammation confers dual effects on nociceptive processing in chronic neuropathic pain model","volume":"114","author":"Liou","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0250","doi-asserted-by":"crossref","first-page":"22565","DOI":"10.1074\/jbc.270.38.22565","article-title":"Identification of a new acute phase protein","volume":"270","author":"Liu","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0255","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0260","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuroscience.2013.03.003","article-title":"Spinal injection of docosahexaenoic acid attenuates carrageenan-induced inflammatory pain through inhibition of microglia-mediated neuroinflammation in the spinal cord","volume":"241","author":"Lu","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0265","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0197-4580(01)00289-5","article-title":"Inflammation, autotoxicity and Alzheimer disease","volume":"22","author":"McGeer","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0270","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.expneurol.2004.11.001","article-title":"Immune and glial cell factors as pain mediators and modulators","volume":"192","author":"McMahon","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0275","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejphar.2013.01.061","article-title":"A catalytically-inactive snake venom Lys49 phospholipase A2 homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages","volume":"708","author":"Moreira","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0280","doi-asserted-by":"crossref","first-page":"12533","DOI":"10.1523\/JNEUROSCI.2840-11.2011","article-title":"Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1beta and TNF: implications for neuropathic pain","volume":"31","author":"Nadeau","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0285","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1182\/blood-2009-05-223354","article-title":"Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2","volume":"114","author":"Nairz","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0290","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1096\/fj.11-202457","article-title":"Lipocalin 2: novel component of proinflammatory signaling in Alzheimer's disease","volume":"26","author":"Naude","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0295","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1749-6632.2003.tb03213.x","article-title":"Tissue involution and the acute phase response","volume":"995","author":"Nilsen-Hamilton","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0300","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1523\/JNEUROSCI.4514-08.2009","article-title":"Persistent inflammation induces GluR2 internalization via NMDA receptor-triggered PKC activation in dorsal horn neurons","volume":"29","author":"Park","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0305","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1523\/JNEUROSCI.2389-11.2012","article-title":"Comprehensive gene expression profiling in the prefrontal cortex links immune activation and neutrophil infiltration to antinociception","volume":"32","author":"Poh","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0310","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1460-9568.2004.03514.x","article-title":"Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS","volume":"20","author":"Raghavendra","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0315","doi-asserted-by":"crossref","first-page":"13412","DOI":"10.1523\/JNEUROSCI.0116-11.2011","article-title":"Lipocalin 2 plays an immunomodulatory role and has detrimental effects after spinal cord injury","volume":"31","author":"Rathore","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0320","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2202-12-11","article-title":"Macrophage presence is essential for the regeneration of ascending afferent fibres following a conditioning sciatic nerve lesion in adult rats","volume":"12","author":"Salegio","year":"2011","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0325","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1189\/jlb.1206713","article-title":"Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1","volume":"82","author":"Sasmono","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0330","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0014-2999(95)00581-5","article-title":"Endogenous nitric oxide increases prostaglandin biosynthesis in carrageenin rat paw oedema","volume":"286","author":"Sautebin","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0335","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.expneurol.2011.12.021","article-title":"Immune responses of microglia in the spinal cord: contribution to pain states","volume":"234","author":"Schomberg","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0340","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1002\/eji.201142351","article-title":"Lipocalin-2 ameliorates granulocyte functionality","volume":"42","author":"Schroll","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0345","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.nbd.2007.02.007","article-title":"Is functional state of spinal microglia involved in the anti-allodynic and anti-hyperalgesic effects of electroacupuncture in rat model of monoarthritis?","volume":"26","author":"Shan","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0350","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1002\/art.37840","article-title":"Differential role of lipocalin 2 during immune complex-mediated acute and chronic inflammation in mice","volume":"65","author":"Shashidharamurthy","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0355","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.4049\/jimmunol.173.6.4197","article-title":"IL-8 is a key chemokine regulating neutrophil recruitment in a new mouse model of Shigella-induced colitis","volume":"173","author":"Singer","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0360","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neulet.2003.12.007","article-title":"Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia","volume":"361","author":"Sommer","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0365","doi-asserted-by":"crossref","first-page":"R1488","DOI":"10.1152\/ajpregu.00465.2005","article-title":"Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study","volume":"290","author":"Summan","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0370","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pain.2006.09.035","article-title":"New evidence for the involvement of spinal fractalkine receptor in pain facilitation and spinal glial activation in rat model of monoarthritis","volume":"129","author":"Sun","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0375","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainresbull.2007.07.027","article-title":"Evidence for suppression of electroacupuncture on spinal glial activation and behavioral hypersensitivity in a rat model of monoarthritis","volume":"75","author":"Sun","year":"2008","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0380","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S1286-4579(02)01615-5","article-title":"Genetic approaches to the study of Toll-like receptor function","volume":"4","author":"Takeuchi","year":"2002","journal-title":"Microbes Infect."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0385","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0969-2126(99)80023-9","article-title":"The physiological structure of human C-reactive protein and its complex with phosphocholine","volume":"7","author":"Thompson","year":"1999","journal-title":"Structure"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0390","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/00062752-200001000-00012","article-title":"Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states","volume":"7","author":"Urieli-Shoval","year":"2000","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0395","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-1759(94)90012-4","article-title":"Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications","volume":"174","author":"Van Rooijen","year":"1994","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0400","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pharmthera.2006.04.001","article-title":"Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?","volume":"112","author":"Verri","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0405","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nrd1251","article-title":"Glia: a novel drug discovery target for clinical pain","volume":"2","author":"Watkins","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0410","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.trsl.2011.10.003","article-title":"Chronic inflammation and pain in a tumor necrosis factor receptor (TNFR) (p55\/p75\u2212\/\u2212) dual deficient murine model","volume":"160","author":"Westlund","year":"2012","journal-title":"Transl. Res."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0415","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.bbi.2008.03.005","article-title":"Interleukin-1 signaling is required for induction and maintenance of postoperative incisional pain: genetic and pharmacological studies in mice","volume":"22","author":"Wolf","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.expneurol.2014.01.009_bb0420","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","article-title":"Neuronal plasticity: increasing the gain in pain","volume":"288","author":"Woolf","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0425","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1756-6606-5-18","article-title":"Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats","volume":"5","author":"Yang","year":"2012","journal-title":"Mol. Brain"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0430","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.pain.2003.08.003","article-title":"Effect of knock down of spinal cord PSD-93\/chapsin-110 on persistent pain induced by complete Freund's adjuvant and peripheral nerve injury","volume":"106","author":"Zhang","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2014.01.009_bb0435","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1111\/j.1471-4159.2008.05675.x","article-title":"The antipsychotic spiperone attenuates inflammatory response in cultured microglia via the reduction of proinflammatory cytokine expression and nitric oxide production","volume":"107","author":"Zheng","year":"2008","journal-title":"J. Neurochem."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488614000223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488614000223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T04:50:12Z","timestamp":1538887812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488614000223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":87,"alternative-id":["S0014488614000223"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2014.01.009","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The pivotal role played by lipocalin-2 in chronic inflammatory pain","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2014.01.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}