{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:44:55Z","timestamp":1781844295262,"version":"3.54.5"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.expneurol.2014.11.007","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T16:39:05Z","timestamp":1417019945000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":138,"special_numbering":"C","title":["Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia"],"prefix":"10.1016","volume":"264","author":[{"given":"Li-Jun","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Bing","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxing","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Creed M.","family":"Stary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rona G.","family":"Giffard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2014.11.007_bb0005","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jns.2007.04.031","article-title":"Thrombolytic therapy for acute ischemic stroke","volume":"261","author":"Blakeley","year":"2007","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.expneurol.2014.11.007_bb0010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.1091903","article-title":"MicroRNAs modulate hematopoietic lineage differentiation","volume":"303","author":"Chen","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2014.11.007_bb0015","first-page":"997","article-title":"MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2","volume":"23","author":"Chen","year":"2010","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.expneurol.2014.11.007_bb0020","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/jcbfm.1993.71","article-title":"Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats","volume":"13","author":"Dietrich","year":"1993","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2014.11.007_bb0025","doi-asserted-by":"crossref","first-page":"e32834","DOI":"10.1371\/journal.pone.0032834","article-title":"miR-181a post-transcriptionally downregulates oncogenic RalA and contributes to growth inhibition and apoptosis in chronic myelogenous leukemia (CML)","volume":"7","author":"Fei","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.expneurol.2014.11.007_bb0030","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1213\/ane.0b013e318187ba6b","article-title":"Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor","volume":"108","author":"Han","year":"2009","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.expneurol.2014.11.007_bb0035","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1749-6632.2010.05735.x","article-title":"NF-kappaB and innate immunity in ischemic stroke","volume":"1207","author":"Harari","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.expneurol.2014.11.007_bb0040","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.0105-2896.2006.00375.x","article-title":"Circuitry of nuclear factor kappaB signaling","volume":"210","author":"Hoffmann","year":"2006","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.expneurol.2014.11.007_bb0045","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/glia.22483","article-title":"Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes","volume":"61","author":"Hutchison","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.expneurol.2014.11.007_bb0050","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nm.2399","article-title":"The immunology of stroke: from mechanisms to translation","volume":"17","author":"Iadecola","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.expneurol.2014.11.007_bb0055","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/00000542-200005000-00023","article-title":"Isoflurane delays but does not prevent cerebral infarction in rats subjected to focal ischemia","volume":"92","author":"Kawaguchi","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.expneurol.2014.11.007_bb0060","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cell.2007.03.008","article-title":"miR-181a is an intrinsic modulator of T cell sensitivity and selection","volume":"129","author":"Li","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2014.11.007_bb0065","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/jcbfm.2009.186","article-title":"Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures","volume":"30","author":"Liu","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2014.11.007_bb0070","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.expneurol.2014.11.007_bb0075","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.mito.2013.01.003","article-title":"Mitochondrial dysfunction and the inflammatory response","volume":"13","author":"L\u00f3pez-Armada","year":"2013","journal-title":"Mitochondrion"},{"issue":"12","key":"10.1016\/j.expneurol.2014.11.007_bb0080","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1038\/jcbfm.2013.157","article-title":"Inhibition of microRNA-181 reduces forebrain ischemia-induced neuronal loss","volume":"33","author":"Moon","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2014.11.007_bb0085","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.mito.2011.09.001","article-title":"miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes","volume":"12","author":"Ouyang","year":"2012","journal-title":"Mitochondrion"},{"key":"10.1016\/j.expneurol.2014.11.007_bb0090","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.nbd.2011.09.012","article-title":"miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo","volume":"45","author":"Ouyang","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2014.11.007_bb0095","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2174\/138945013804806424","article-title":"microRNAs: innovative targets for cerebral ischemia and stroke","volume":"14","author":"Ouyang","year":"2013","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.expneurol.2014.11.007_bb0100","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.brainres.2008.07.085","article-title":"hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells","volume":"1236","author":"Shi","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2014.11.007_bb0105","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.bbrc.2010.12.055","article-title":"miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras","volume":"404","author":"Shin","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.expneurol.2014.11.007_bb0110","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.febslet.2013.01.067","article-title":"Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75\/mortalin","volume":"587","author":"Voloboueva","year":"2013","journal-title":"FEBS Lett."},{"key":"10.1016\/j.expneurol.2014.11.007_bb0115","doi-asserted-by":"crossref","first-page":"e58639","DOI":"10.1371\/journal.pone.0058639","article-title":"miR-181a regulates inflammation responses in monocytes and macrophages","volume":"8","author":"Xie","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.expneurol.2014.11.007_bb0120","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1161\/STROKEAHA.110.593772","article-title":"Increased brain injury and worsened neurological outcome in interleukin-4 knockout mice after transient focal cerebral ischemia","volume":"42","author":"Xiong","year":"2011","journal-title":"Stroke"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488614003677?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488614003677?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T07:54:15Z","timestamp":1538034855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488614003677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":24,"alternative-id":["S0014488614003677"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2014.11.007","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2014.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}