{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:18:48Z","timestamp":1792653528674,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.expneurol.2015.02.009","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T03:15:17Z","timestamp":1424056517000},"page":"11-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Guidelines for standard preclinical experiments in the mouse model of myasthenia gravis induced by acetylcholine receptor immunization"],"prefix":"10.1016","volume":"270","author":[{"given":"Erdem","family":"Tuzun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Berrih-Aknin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talma","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda L.","family":"Kusner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozen","family":"Le Panse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Socrates","family":"Tzartos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premkumar","family":"Christadoss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2015.02.009_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2006.12.015","article-title":"Lost in translation: treatment trials in the SOD1 mouse and in human ALS","volume":"26","author":"Benatar","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0010","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.ejphar.2011.07.006","article-title":"The gut as communicator between environment and host: immunological consequences","volume":"668","author":"Brandtzaeg","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0015","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.autrev.2013.03.010","article-title":"Etiology of myasthenia gravis: innate immunity signature in pathological thymus","volume":"12","author":"Cavalcante","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0020","doi-asserted-by":"crossref","first-page":"e52119","DOI":"10.1371\/journal.pone.0052119","article-title":"Prophylactic effect of probiotics on the development of experimental autoimmune myasthenia gravis","volume":"7","author":"Chae","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2015.02.009_bb0025","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/clim.1999.4807","article-title":"Animal models of myasthenia gravis","volume":"94","author":"Christadoss","year":"2000","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0030","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.immuni.2014.02.002","article-title":"Circadian clock proteins and immunity","volume":"40","author":"Curtis","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.expneurol.2015.02.009_bb0035","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000258727","article-title":"Models of aging of neuroimmunomodulation: strategies for its improvement","volume":"17","author":"De la Fuente","year":"2010","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.expneurol.2015.02.009_bb0040","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/ilar.43.4.207","article-title":"Sample size determination","volume":"43","author":"Dell","year":"2002","journal-title":"ILAR J."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0045","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.4049\/jimmunol.175.8.5050","article-title":"Estrogen enhances susceptibility to experimental autoimmune myasthenia gravis by promoting type 1-polarized immune responses","volume":"175","author":"Delpy","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0050","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.4049\/jimmunol.169.2.1077","article-title":"Resistance to experimental autoimmune myasthenia gravis in IL-6-deficient mice is associated with reduced germinal center formation and C3 production","volume":"169","author":"Deng","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0055","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1749-6632.1976.tb47676.x","article-title":"The motor end plate in myasthenia gravis and in experimental autoimmune myasthenia gravis. A quantitative ultrastructural study","volume":"274","author":"Engel","year":"1976","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0060","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.autrev.2013.03.009","article-title":"Impairment of regulatory T cells in myasthenia gravis: studies in an experimental model","volume":"12","author":"Gertel-Lapter","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0065","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2119\/molmed.2013.00158","article-title":"Environmental enrichment alters splenic immune cell composition and enhances secondary influenza vaccine responses in mice","volume":"20","author":"Gurfein","year":"2014","journal-title":"Mol. Med."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0070","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1203\/00006450-199609000-00013","article-title":"Wheat kernel ingestion protects from progression of muscle weakness in mdx mice, an animal model of Duchenne muscular dystrophy","volume":"40","author":"H\u00fcbner","year":"1996","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0075","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jaut.2013.01.003","article-title":"Complement C2 siRNA mediated therapy of myasthenia gravis in mice","volume":"42","author":"Huda","year":"2013","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0080","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/B978-0-444-59565-2.00015-0","article-title":"Autoimmune myasthenia gravis","volume":"113","author":"Jayawant","year":"2013","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0085","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.4049\/jimmunol.164.10.5236","article-title":"Absence of IFN-gamma or IL-12 has different effects on experimental myasthenia gravis in C57BL\/6 mice","volume":"164","author":"Karachunski","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0090","doi-asserted-by":"crossref","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0095","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1749-6632.2012.06783.x","article-title":"The role of complement in experimental autoimmune myasthenia gravis","volume":"1274","author":"Kusner","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0100","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1084\/jem.144.3.726","volume":"144","author":"Lindstrom","year":"1976","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0105","doi-asserted-by":"crossref","first-page":"2","DOI":"10.6030\/1939-067X-2.2.2","article-title":"Rodent stroke model guidelines for preclinical stroke trials","volume":"2","author":"Liu","year":"2009","journal-title":"J. Exp. Stroke Transl. Med."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/imm.12076","article-title":"SMAD regulatory networks construct a balanced immune system","volume":"139","author":"Malhotra","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/j.expneurol.2015.02.009_bb0115","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1258\/0023677041958927","article-title":"The use of sodium lamps to brightly illuminate mouse houses during their dark phases","volume":"38","author":"McLennan","year":"2004","journal-title":"Lab. Anim."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0120","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.1016\/j.vaccine.2013.09.040","article-title":"Highly immunostimulatory RNA derived from a Sendai virus defective viral genome","volume":"31","author":"Mercado-L\u00f3pez","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.expneurol.2015.02.009_bb0125","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jneuroim.2011.03.002","article-title":"Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis","volume":"234","author":"Qi","year":"2011","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0130","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.4049\/jimmunol.1303245","article-title":"Modulation of T cell and innate immune responses by retinoic acid","volume":"192","author":"Raverdeau","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0140","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejphar.2007.03.048","article-title":"Clinical efficacy of buprenorphine to minimize distress in MRL\/lpr mice","volume":"567","author":"Swenson","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0135","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1038\/nprot.2010.114","article-title":"An environmental enrichment model for mice","volume":"5","author":"Sztainberg","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0145","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1348-0421.1978.tb00433.x","article-title":"Difference in antibody production to hererologus erythrocytes in conventional, specific-pathogen-free (SPF), germfree and antigen-free mice","volume":"22","author":"Taniguchi","year":"1978","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0150","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.autrev.2013.03.003","article-title":"Complement associated pathogenic mechanisms in myasthenia gravis","volume":"12","author":"T\u00fcz\u00fcn","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0160","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.4049\/jimmunol.172.9.5743","article-title":"Circulating immune complexes augment severity of antibody-mediated myasthenia gravis in hypogammaglobulinemic RIIIS\/J mice","volume":"172","author":"T\u00fcz\u00fcn","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0165","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jneuroim.2006.10.014","article-title":"Pros and cons of treating murine myasthenia gravis with anti-C1q antibody","volume":"182","author":"T\u00fcz\u00fcn","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0155","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jaut.2011.05.006","article-title":"Complement and cytokine based therapeutic strategies in myasthenia gravis","volume":"37","author":"T\u00fcz\u00fcn","year":"2011","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0170","doi-asserted-by":"crossref","first-page":"14863","DOI":"10.1073\/pnas.1002220107","article-title":"Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise","volume":"107","author":"Valdez","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0175","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.nmd.2011.04.012","article-title":"Enhancing translation: guidelines for standard pre-clinical experiments in mdx mice","volume":"22","author":"Willmann","year":"2012","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0180","first-page":"1","article-title":"Experimental autoimmune myasthenia gravis in the mouse","author":"Wu","year":"2013","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0185","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.4049\/jimmunol.175.3.2018","article-title":"IL-1 receptor antagonist-mediated therapeutic effect in murine myasthenia gravis is associated with suppressed serum proinflammatory cytokines, C3, and anti-acetylcholine receptor IgG1","volume":"175","author":"Yang","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2015.02.009_bb0190","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1167\/iovs.07-0271","article-title":"A new mouse model of autoimmune ocular myasthenia gravis","volume":"48","author":"Yang","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488615000321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488615000321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T02:22:48Z","timestamp":1537842168000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488615000321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":38,"alternative-id":["S0014488615000321"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2015.02.009","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Guidelines for standard preclinical experiments in the mouse model of myasthenia gravis induced by acetylcholine receptor immunization","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2015.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}