{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:53:14Z","timestamp":1775893994401,"version":"3.50.1"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["NS048423"],"award-info":[{"award-number":["NS048423"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004381","name":"Western University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004381","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Daljit and Elaine Sarkaria Chair"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.expneurol.2015.04.004","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T11:29:53Z","timestamp":1428751793000},"page":"67-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Enhanced expression of matrix metalloproteinase-12 contributes to Npc1 deficiency-induced axonal degeneration"],"prefix":"10.1016","volume":"269","author":[{"given":"Guanghong","family":"Liao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuangjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Abuelnasr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Baudry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoning","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2015.04.004_bb0010","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bbadis.2010.07.018","article-title":"The many faces of EMMPRIN \u2014 roles in neuroinflammation","volume":"1812","author":"Agrawal","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.expneurol.2015.04.004_bb0005","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1523\/JNEUROSCI.3659-10.2011","article-title":"EMMPRIN: a novel regulator of leukocyte transmigration into the CNS in multiple sclerosis and experimental autoimmune encephalomyelitis","volume":"31","author":"Agrawal","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0015","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1750-3639.2006.00043.x","article-title":"Extensive cortical remyelination in patients with chronic multiple sclerosis","volume":"17","author":"Albert","year":"2007","journal-title":"Brain Pathol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0020","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1042\/bj1930589","article-title":"Mouse macrophage elastase. Purification and characterization as a metalloproteinase","volume":"193","author":"Banda","year":"1981","journal-title":"Biochem. J."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0025","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0014-4886(03)00345-5","article-title":"Postnatal development of inflammation in a murine model of Niemann\u2013Pick type C disease: immunohistochemical observations of microglia and astroglia","volume":"184","author":"Baudry","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0030","first-page":"434","article-title":"The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily","volume":"55","author":"Biswas","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0035","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1152\/jn.00202.2007","article-title":"In vivo roles for matrix metalloproteinase-9 in mature hippocampal synaptic physiology and plasticity","volume":"98","author":"Bozdagi","year":"2007","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0040","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.277.5323.228","article-title":"Niemann\u2013Pick C1 disease gene: homology to mediators of cholesterol homeostasis","volume":"277","author":"Carstea","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2015.04.004_bb0045","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbr.2006.06.020","article-title":"Involvement of tissue inhibition of metalloproteinases-1 in learning and memory in mice","volume":"173","author":"Chaillan","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0050","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1006\/bbrc.1996.1677","article-title":"Macrophage metalloelastase degrades matrix and myelin proteins and processes a tumour necrosis factor-alpha fusion protein","volume":"228","author":"Chandler","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0055","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ntt.2004.02.006","article-title":"Assessment of PC12 cell differentiation and neurite growth: a comparison of morphological and neurochemical measures","volume":"26","author":"Das","year":"2004","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0060","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1365-2990.2010.01157.x","article-title":"Role of matrix metalloproteinase-9 (MMP-9) in striatal blood\u2013brain barrier disruption in a 3-nitropropionic acid model of Huntington's disease","volume":"37","author":"Duran-Vilaregut","year":"2010","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0065","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1002\/jnr.21273","article-title":"Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets","volume":"85","author":"Ethell","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0070","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0168-0102(97)00119-3","article-title":"Expression of basigin, a member of the immunoglobulin superfamily, in the mouse central nervous system","volume":"30","author":"Fan","year":"1998","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0075","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/WNR.0b013e328335b518","article-title":"MMP-2 is involved in synaptic remodeling after cochlear lesion","volume":"21","author":"Fredrich","year":"2010","journal-title":"Neuroreport"},{"key":"10.1016\/j.expneurol.2015.04.004_bb0080","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0306-4522(01)00517-6","article-title":"Neurodegeneration in the Niemann\u2013Pick C mouse: glial involvement","volume":"109","author":"German","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2015.04.004_bb0085","doi-asserted-by":"crossref","first-page":"12189","DOI":"10.1074\/jbc.272.18.12189","article-title":"Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase","volume":"272","author":"Gronski","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0090","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1074\/jbc.272.1.24","article-title":"Stimulation of matrix metalloproteinase production by recombinant extracellular matrix metalloproteinase inducer from transfected Chinese hamster ovary cells","volume":"272","author":"Guo","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0095","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00401-012-0942-3","article-title":"Matrix metalloproteinase-12 deficiency ameliorates the clinical course and demyelination in Theiler's murine encephalomyelitis","volume":"124","author":"Hansmann","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0100","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0301-0082(91)90004-K","article-title":"The modular cerebellum","volume":"36","author":"Hawkes","year":"1991","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0105","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00227765","article-title":"Cerebellar degeneration in the Niemann\u2013Pick type C mouse","volume":"85","author":"Higashi","year":"1993","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0110","doi-asserted-by":"crossref","first-page":"33008","DOI":"10.1074\/jbc.M001836200","article-title":"Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII","volume":"275","author":"Hiller","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0115","doi-asserted-by":"crossref","first-page":"9841","DOI":"10.1523\/JNEUROSCI.1993-06.2006","article-title":"Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury","volume":"26","author":"Hsu","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0120","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.exger.2006.11.012","article-title":"Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K\/Akt pathway","volume":"42","author":"Ito","year":"2007","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0125","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S8756-3282(01)00595-6","article-title":"Human macrophage metalloelastase (MMP-12) expression is induced in chondrocytes during fetal development and malignant transformation","volume":"29","author":"Kerkela","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.expneurol.2015.04.004_bb0130","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.cell.2009.03.049","article-title":"Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol","volume":"137","author":"Kwon","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2015.04.004_bb0140","doi-asserted-by":"crossref","first-page":"7597","DOI":"10.1523\/JNEUROSCI.2092-04.2004","article-title":"The expression of matrix metalloproteinase-12 by oligodendrocytes regulates their maturation and morphological differentiation","volume":"24","author":"Larsen","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0135","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1523\/JNEUROSCI.1880-05.2006","article-title":"Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice","volume":"26","author":"Larsen","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0145","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1212\/01.wnl.0000298724.89870.d1","article-title":"Cortical demyelination in CNS inflammatory demyelinating diseases","volume":"70","author":"Lassmann","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2015.04.004_bb0155","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1021\/jm900809r","article-title":"Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma","volume":"52","author":"Li","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0160","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1021\/jm900093d","article-title":"A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8-(methoxycarbonylamino)dibenzo[b, d]furan-3-sulfonamido)-3-methylbu tanoic acid (MMP408)","volume":"52","author":"Li","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0150","doi-asserted-by":"crossref","first-page":"e52699","DOI":"10.1371\/journal.pone.0052699","article-title":"Macrophage metalloelastase (MMP-12) deficiency mitigates retinal inflammation and pathological angiogenesis in ischemic retinopathy","volume":"7","author":"Li","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.expneurol.2015.04.004_bb0165","article-title":"Abnormal gene expression in cerebellum of Npc1\u2212\/\u2212 mice during postnatal development","volume":"128\u2013140","author":"Liao","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0170","doi-asserted-by":"crossref","first-page":"21653","DOI":"10.1074\/jbc.M500374200","article-title":"Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing","volume":"280","author":"Lyu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0175","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s004010050689","article-title":"GABAergic neuroaxonal dystrophy and other cytopathological alterations in feline Niemann\u2013Pick disease type C","volume":"94","author":"March","year":"1997","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0180","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneuroim.2007.04.010","article-title":"The matrix metalloproteinases and CNS plasticity: an overview","volume":"187","author":"Milward","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0185","first-page":"981","article-title":"Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion","volume":"18","author":"Muramatsu","year":"2003","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0190","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1126\/science.290.5500.2298","article-title":"Identification of HE1 as the second gene of Niemann\u2013Pick C disease","volume":"290","author":"Naureckiene","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2015.04.004_bb0195","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1093\/brain\/124.11.2203","article-title":"T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: involvement of metalloproteinases","volume":"124","author":"Newman","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2015.04.004_bb0200","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s002210100870","article-title":"Neurodegeneration in Niemann\u2013Pick type C disease mice","volume":"141","author":"Ong","year":"2001","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0205","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nri1418","article-title":"Matrix metalloproteinases as modulators of inflammation and innate immunity","volume":"4","author":"Parks","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0210","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/ana.1123","article-title":"Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions","volume":"50","author":"Peterson","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0215","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/ana.10553","article-title":"Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases","volume":"53","author":"Power","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0220","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1523\/JNEUROSCI.0420-09.2009","article-title":"A novel function for p53: regulation of growth cone motility through interaction with Rho kinase","volume":"29","author":"Qin","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0225","doi-asserted-by":"crossref","first-page":"e9999","DOI":"10.1371\/journal.pone.0009999","article-title":"Cholesterol perturbation in mice results in p53 degradation and axonal pathology through p38 MAPK and Mdm2 activation","volume":"5","author":"Qin","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.expneurol.2015.04.004_bb0230","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1471-4159.2010.06976.x","article-title":"Niemann\u2013Pick type C disease: molecular mechanisms and potential therapeutic approaches","volume":"116","author":"Rosenbaum","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0235","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/cne.10522","article-title":"Patterned Purkinje cell degeneration in mouse models of Niemann\u2013Pick type C disease","volume":"456","author":"Sarna","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0240","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.mcn.2008.08.004","article-title":"Vesicular trafficking and secretion of matrix metalloproteinases-2, -9 and tissue inhibitor of metalloproteinases-1 in neuronal cells","volume":"39","author":"Sbai","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0245","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1097\/NEN.0b013e3182294fad","article-title":"Matrix metalloproteinases and their tissue inhibitors in cuprizone-induced demyelination and remyelination of brain white and gray matter","volume":"70","author":"Skuljec","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0250","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/01.wco.0000318863.65635.9a","article-title":"Cortical pathology in multiple sclerosis","volume":"21","author":"Stadelmann","year":"2008","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0255","doi-asserted-by":"crossref","first-page":"26279","DOI":"10.1074\/jbc.M110.134775","article-title":"Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann\u2013Pick type C disease","volume":"285","author":"Strauss","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0260","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1159\/000232561","article-title":"Expression of MMP-12 after neonatal hypoxic\u2013ischemic brain injury in mice","volume":"31","author":"Svedin","year":"2009","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0270","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1159\/000088455","article-title":"Matrix metalloproteinases and their inhibitors in the developing mouse brain and spinal cord: a reverse transcription quantitative polymerase chain reaction study","volume":"27","author":"Ulrich","year":"2005","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0265","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/01.jnen.0000229990.32795.0d","article-title":"MMP-12, MMP-3, and TIMP-1 are markedly upregulated in chronic demyelinating Theiler murine encephalomyelitis","volume":"65","author":"Ulrich","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0275","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1044-7431(03)00196-9","article-title":"MMP-9 deficiency affects axonal outgrowth, migration, and apoptosis in the developing cerebellum","volume":"24","author":"Vaillant","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0280","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/MOL.0b013e3283453e69","article-title":"Function of the Niemann\u2013Pick type C proteins and their bypass by cyclodextrin","volume":"22","author":"Vance","year":"2011","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0285","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0165-5728(03)00036-5","article-title":"Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions","volume":"138","author":"Vos","year":"2003","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0290","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbalip.2004.08.011","article-title":"Consequences of NPC1 and NPC2 loss of function in mammalian neurons","volume":"1685","author":"Walkley","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.expneurol.2015.04.004_bb0295","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/1465-9921-6-148","article-title":"Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells","volume":"6","author":"Xie","year":"2005","journal-title":"Respir. Res."},{"key":"10.1016\/j.expneurol.2015.04.004_bb0300","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/jnen\/60.1.49","article-title":"Neurons in Niemann\u2013Pick disease type C accumulate gangliosides as well as unesterified cholesterol and undergo dendritic and axonal alterations","volume":"60","author":"Zervas","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488615001107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488615001107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T15:56:01Z","timestamp":1537718161000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488615001107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":60,"alternative-id":["S0014488615001107"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2015.04.004","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced expression of matrix metalloproteinase-12 contributes to Npc1 deficiency-induced axonal degeneration","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2015.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}