{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T00:07:27Z","timestamp":1794355647833,"version":"4.9.0"},"reference-count":165,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["41NS064708"],"award-info":[{"award-number":["41NS064708"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1 NS083078"],"award-info":[{"award-number":["RO1 NS083078"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.expneurol.2015.05.006","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T16:44:14Z","timestamp":1432226654000},"page":"97-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":311,"special_numbering":"C","title":["Models and mechanisms of vascular dementia"],"prefix":"10.1016","volume":"272","author":[{"given":"Poornima","family":"Venkat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Chopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.expneurol.2015.05.006_bb0005","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000109998","article-title":"Prevalence of dementia in the United States: the aging, demographics, and memory study","volume":"29","author":"Plassman","year":"2007","journal-title":"Neuroepidemiology"},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0010","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2337\/db08-0586","article-title":"Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study","volume":"58","author":"Xu","year":"2009","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0015","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.2337\/diabetes.51.4.1256","article-title":"Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: the Honolulu-Asia Aging Study","volume":"51","author":"Peila","year":"2002","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0020","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/oxfordjournals.aje.a009106","article-title":"Risk of dementia among persons with diabetes mellitus: a population-based cohort study","volume":"145","author":"Leibson","year":"1997","journal-title":"Am. J. Epidemiol."},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0025","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.archger.2010.09.004","article-title":"Mid-life and late-life vascular risk factors and dementia in Korean men and women","volume":"52","author":"Kimm","year":"2011","journal-title":"Arch. Gerontol. Geriatr."},{"issue":"9","key":"10.1016\/j.expneurol.2015.05.006_bb0030","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1212\/WNL.53.9.1937","article-title":"Diabetes mellitus and the risk of dementia: the Rotterdam Study","volume":"53","author":"Ott","year":"1999","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.expneurol.2015.05.006_bb0035","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.2337\/db10-0539","article-title":"Accelerated progression from mild cognitive impairment to dementia in people with diabetes","volume":"59","author":"Xu","year":"2010","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.expneurol.2015.05.006_bb0040","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00125-007-0894-7","article-title":"Predictors of cognitive impairment and dementia in older people with diabetes","volume":"51","author":"Bruce","year":"2008","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0045","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1001\/archneurol.2008.579","article-title":"Different patterns of cerebral injury in dementia with or without diabetes","volume":"66","author":"Sonnen","year":"2009","journal-title":"Arch. Neurol."},{"issue":"11","key":"10.1016\/j.expneurol.2015.05.006_bb0050","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.2337\/dc06-1637","article-title":"Brain imaging in patients with diabetes: a systematic review","volume":"29","author":"van Harten","year":"2006","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0055","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1368-5031.2006.00682.x","article-title":"Diabetes mellitus and stroke","volume":"60","author":"Idris","year":"2006","journal-title":"Int. J. Clin. Pract."},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0060","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/oxfordjournals.aje.a114934","article-title":"Diabetes mellitus: an independent risk factor for stroke?","volume":"128","author":"Barrett-Connor","year":"1988","journal-title":"Am. J. Epidemiol."},{"issue":"8","key":"10.1016\/j.expneurol.2015.05.006_bb0065","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1212\/WNL.45.8.1483","article-title":"Risk factors for lacunar infarction syndromes","volume":"45","author":"You","year":"1995","journal-title":"Neurology"},{"issue":"7090","key":"10.1016\/j.expneurol.2015.05.006_bb0070","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1136\/bmj.314.7090.1303","article-title":"Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long term follow up study","volume":"314","author":"Weir","year":"1997","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0075","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1161\/01.STR.0000057975.15221.40","article-title":"Association between diabetes and stroke subtype on survival and functional outcome 3months after stroke: data from the European BIOMED Stroke Project","volume":"34","author":"Megherbi","year":"2003","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0080","first-page":"286","article-title":"Effect of age on hypertension: analysis of over 4,800 referred hypertensive patients","volume":"10","author":"Anderson","year":"1999","journal-title":"Saudi J. Kidney Dis. Transpl."},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0085","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/1756285609103483","article-title":"Blood pressure and dementia \u2014 a comprehensive review","volume":"2","author":"Kennelly","year":"2009","journal-title":"Ther. Adv. Neurol. Disord."},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0090","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1046\/j.1532-5415.2003.51117.x","article-title":"Association between dementia and midlife risk factors: the Radiation Effects Research Foundation Adult Health Study","volume":"51","author":"Yamada","year":"2003","journal-title":"J. Am. Geriatr. Soc."},{"issue":"6","key":"10.1016\/j.expneurol.2015.05.006_bb0095","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1159\/000330020","article-title":"Vascular risk factors and dementia: 40-year follow-up of a population-based cohort","volume":"31","author":"Ronnemaa","year":"2011","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0100","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0197-4580(00)00096-8","article-title":"Midlife blood pressure and dementia: the Honolulu-Asia Aging Study","volume":"21","author":"Launer","year":"2000","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0105","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1161\/01.HYP.0000132475.32317.bb","article-title":"Midlife blood pressure and the risk of hippocampal atrophy: the Honolulu Asia Aging Study","volume":"44","author":"Korf","year":"2004","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.expneurol.2015.05.006_bb0110","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/HYPERTENSIONAHA.111.00430","article-title":"High blood pressure and cerebral white matter lesion progression in the general population","volume":"61","author":"Verhaaren","year":"2013","journal-title":"Hypertension"},{"issue":"9","key":"10.1016\/j.expneurol.2015.05.006_bb0115","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1001\/archinte.163.9.1069","article-title":"Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease","volume":"163","author":"Tzourio","year":"2003","journal-title":"Arch. Intern. Med."},{"issue":"18","key":"10.1016\/j.expneurol.2015.05.006_bb0120","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1001\/archinte.162.18.2046","article-title":"The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study","volume":"162","author":"Forette","year":"2002","journal-title":"Arch. Intern. Med."},{"issue":"6","key":"10.1016\/j.expneurol.2015.05.006_bb0125","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1093\/oxfordjournals.aje.a114749","article-title":"Blood pressure and cognitive performance. The Framingham Study","volume":"126","author":"Farmer","year":"1987","journal-title":"Am. J. Epidemiol."},{"issue":"7034","key":"10.1016\/j.expneurol.2015.05.006_bb0130","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1136\/bmj.312.7034.805","article-title":"Low blood pressure and dementia in elderly people: the Kungsholmen project","volume":"312","author":"Guo","year":"1996","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.expneurol.2015.05.006_bb0135","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0895-4356(98)00003-1","article-title":"Blood pressure reduction, cardiovascular diseases, and cognitive decline in the mini-mental state examination in a community population of normal very old people: a three-year follow-up","volume":"51","author":"Zhu","year":"1998","journal-title":"J. Clin. Epidemiol."},{"issue":"8","key":"10.1016\/j.expneurol.2015.05.006_bb0140","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1161\/01.STR.0000133128.42462.ef","article-title":"Decline in blood pressure over time and risk of dementia: a longitudinal study from the Kungsholmen project","volume":"35","author":"Qiu","year":"2004","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0145","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/01.CIR.0000112379.88385.67","article-title":"Clinical management of metabolic syndrome: report of the American Heart Association\/National Heart. Lung, and Blood Institute\/American Diabetes Association conference on scientific issues related to management","volume":"109","author":"Grundy","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.expneurol.2015.05.006_bb0150","first-page":"4","article-title":"Impact of metabolic syndrome on cognitive decline in older age: protective or harmful, where is the pitfall?","volume":"4","author":"Frisardi","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0155","first-page":"27","article-title":"Metabolic syndrome and longitudinal changes in cognitive function: a systematic review and meta-analysis","volume":"27","author":"Siervo","year":"2014","journal-title":"J. Alzheimers Dis."},{"issue":"14","key":"10.1016\/j.expneurol.2015.05.006_bb0160","first-page":"00032","article-title":"Metabolic syndrome is associated with poor memory and executive performance in elderly community residents: the PROOF study","volume":"25","author":"Rouch","year":"2014","journal-title":"Am. J. Geriatr. Psychiatry"},{"issue":"6","key":"10.1016\/j.expneurol.2015.05.006_bb0165","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s12603-013-0010-2","article-title":"Late-life metabolic syndrome prevents cognitive decline among older men aged 75years and over: one-year prospective cohort study","volume":"17","author":"Liu","year":"2013","journal-title":"J. Nutr. Health Aging"},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0170","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2337\/dc08-0272","article-title":"Metabolic syndrome and risk for incident Alzheimer's disease or vascular dementia: the Three-City Study","volume":"32","author":"Raffaitin","year":"2009","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1016\/j.expneurol.2015.05.006_bb0175","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/oby.20170","article-title":"Low cerebral blood flow is associated with lower memory function in metabolic syndrome","volume":"21","author":"Birdsill","year":"2013","journal-title":"Obesity"},{"issue":"11","key":"10.1016\/j.expneurol.2015.05.006_bb0180","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.neurobiolaging.2009.12.012","article-title":"Metabolic syndrome, mild cognitive impairment, and progression to dementia. The Italian Longitudinal Study on Aging","volume":"32","author":"Solfrizzi","year":"2011","journal-title":"Neurobiol. Aging"},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0185","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/jnnp.2009.181743","article-title":"Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing","volume":"81","author":"Solfrizzi","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"18","key":"10.1016\/j.expneurol.2015.05.006_bb0190","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1001\/jama.292.18.2237","article-title":"The metabolic syndrome, inflammation, and risk of cognitive decline","volume":"292","author":"Yaffe","year":"2004","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.expneurol.2015.05.006_bb0195","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4068\/cmj.2011.47.2.66","article-title":"Vascular dementia","volume":"47","author":"Lee","year":"2011","journal-title":"Chonnam. Med. J."},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0200","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1161\/01.STR.27.1.30","article-title":"Comparison of different diagnostic criteria for vascular dementia (ADDTC, DSM-IV, ICD-10, NINDS-AIREN)","volume":"27","author":"Wetterling","year":"1996","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0205","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00213-008-1294-5","article-title":"Alcohol-induced retrograde memory impairment in rats: prevention by caffeine","volume":"201","author":"Spinetta","year":"2008","journal-title":"Psychopharmacology"},{"issue":"9","key":"10.1016\/j.expneurol.2015.05.006_bb0210","doi-asserted-by":"crossref","first-page":"e75467","DOI":"10.1371\/journal.pone.0075467","article-title":"Chronic pravastatin but not atorvastatin treatment impairs cognitive function in two rodent models of learning and memory","volume":"8","author":"Stuart","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0215","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1023\/A:1021694307672","article-title":"Differences in measures of exploration and fear in MHC-congenic C57BL\/6J and B6-H-2K mice","volume":"29","author":"Brown","year":"1999","journal-title":"Behav. Genet."},{"issue":"8","key":"10.1016\/j.expneurol.2015.05.006_bb0220","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1111\/j.1460-9568.2006.04746.x","article-title":"Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability","volume":"23","author":"Ohno","year":"2006","journal-title":"Eur. J. Neurosci."},{"issue":"2\u20133","key":"10.1016\/j.expneurol.2015.05.006_bb0225","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejphar.2007.06.058","article-title":"Lurasidone (SM-13496), a novel atypical antipsychotic drug, reverses MK-801-induced impairment of learning and memory in the rat passive-avoidance test","volume":"572","author":"Ishiyama","year":"2007","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.expneurol.2015.05.006_bb0230","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/(SICI)1520-6769(199809\/10)23:2<77::AID-NRC2>3.0.CO;2-Y","article-title":"Spatial learning and memory in aging C57BL\/6 mice","volume":"23","author":"Weiss","year":"1998","journal-title":"Neurosci. Res. Commun."},{"issue":"2","key":"10.1016\/j.expneurol.2015.05.006_bb0235","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1254\/fpj.113.85","article-title":"Availability of 2VO rats as a model for chronic cerebrovascular disease","volume":"113","author":"Nanri","year":"1999","journal-title":"Nihon Yakurigaku Zasshi"},{"issue":"9","key":"10.1016\/j.expneurol.2015.05.006_bb0240","doi-asserted-by":"crossref","first-page":"e74631","DOI":"10.1371\/journal.pone.0074631","article-title":"The ins and outs of the BCCAo model for chronic hypoperfusion: a multimodal and longitudinal MRI approach","volume":"8","author":"Soria","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.expneurol.2015.05.006_bb0245","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/BF00294175","article-title":"Glial activation and white matter changes in the rat brain induced by chronic cerebral hypoperfusion: an immunohistochemical study","volume":"87","author":"Wakita","year":"1994","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0250","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00004647-200201000-00012","article-title":"Blood\u2013brain barrier disruption in white matter lesions in a rat model of chronic cerebral hypoperfusion","volume":"22","author":"Ueno","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0255","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0166-4328(02)00090-6","article-title":"Persistent impairment of gait performances and working memory after bilateral common carotid artery occlusion in the adult Wistar rat","volume":"136","author":"Sarti","year":"2002","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0260","first-page":"1","article-title":"Depressive-like behaviors in a rat model of chronic cerebral hypoperfusion","author":"Lee","year":"2014","journal-title":"Transl. Stroke Res."},{"issue":"11","key":"10.1016\/j.expneurol.2015.05.006_bb0265","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3109\/00207454.2014.880435","article-title":"Comparison of cognitive performance between two rat models of vascular dementia","volume":"124","author":"Zhang","year":"2014","journal-title":"Int. J. Neurosci."},{"issue":"18","key":"10.1016\/j.expneurol.2015.05.006_bb0270","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/j.lfs.2004.10.035","article-title":"Inhibitory avoidance memory retention in the elevated T-maze is impaired after perivascular manipulation of the common carotid arteries","volume":"76","author":"de Bortoli","year":"2005","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0275","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainresrev.2007.01.003","article-title":"Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases","volume":"54","author":"Farkas","year":"2007","journal-title":"Brain Res. Rev."},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0280","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/jnr.22257","article-title":"Divergent role for MMP-2 in myelin breakdown and oligodendrocyte death following transient global ischemia","volume":"88","author":"Walker","year":"2010","journal-title":"J. Neurosci. Res."},{"issue":"6","key":"10.1016\/j.expneurol.2015.05.006_bb0285","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1111\/j.1460-9568.2007.05427.x","article-title":"Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia","volume":"25","author":"Lai","year":"2007","journal-title":"Eur. J. Neurosci."},{"issue":"5","key":"10.1016\/j.expneurol.2015.05.006_bb0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2011.10.033","article-title":"Selective white matter abnormalities in a novel rat model of vascular dementia","volume":"33","author":"Kitamura","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0295","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1161\/01.STR.0000014204.05597.0C","article-title":"Retinal and optic nerve degeneration after chronic carotid ligation: time course and role of light exposure","volume":"33","author":"Stevens","year":"2002","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.expneurol.2015.05.006_bb0300","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.exer.2005.09.019","article-title":"Complex neurodegeneration in retina following moderate ischemia induced by bilateral common carotid artery occlusion in Wistar rats","volume":"82","author":"Yamamoto","year":"2006","journal-title":"Exp. Eye Res."},{"issue":"1\u20132","key":"10.1016\/j.expneurol.2015.05.006_bb0305","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jneumeth.2006.03.010","article-title":"Hippocampal (CA1) activities in Wistar rats from different vendors. Fundamental differences in acute ischemia","volume":"156","author":"Marosi","year":"2006","journal-title":"J. Neurosci. Methods"},{"issue":"5","key":"10.1016\/j.expneurol.2015.05.006_bb0310","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1007\/s12975-014-0350-1","article-title":"Strain differences in fatigue and depression after experimental stroke","volume":"5","author":"Kunze","year":"2014","journal-title":"Transl. Stroke Res."},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0315","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/01.STR.10.3.267","article-title":"A new model of bilateral hemispheric ischemia in the unanesthetized rat","volume":"10","author":"Pulsinelli","year":"1979","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.expneurol.2015.05.006_bb0320","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.bbr.2004.12.016","article-title":"Permanent, 3-stage, 4-vessel occlusion as a model of chronic and progressive brain hypoperfusion in rats: a neurohistological and behavioral analysis","volume":"160","author":"Neto","year":"2005","journal-title":"Behav. Brain Res."},{"issue":"7","key":"10.1016\/j.expneurol.2015.05.006_bb0325","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/01.STR.19.7.913","article-title":"The four-vessel occlusion rat model: method for complete occlusion of vertebral arteries and control of collateral circulation","volume":"19","author":"Pulsinelli","year":"1988","journal-title":"Stroke"},{"issue":"7","key":"10.1016\/j.expneurol.2015.05.006_bb0330","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/j.1460-9568.2011.07824.x","article-title":"Middle-aged, but not young, rats develop cognitive impairment and cortical neurodegeneration following the four-vessel occlusion\/internal carotid artery model of chronic cerebral hypoperfusion","volume":"34","author":"Ferreira","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0335","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainresbull.2012.08.010","article-title":"Sildenafil provides sustained neuroprotection in the absence of learning recovery following the 4-vessel occlusion\/internal carotid artery model of chronic cerebral hypoperfusion in middle-aged rats","volume":"90","author":"Dias Fiuza Ferreira","year":"2013","journal-title":"Brain Res. Bull."},{"issue":"2","key":"10.1016\/j.expneurol.2015.05.006_bb0340","doi-asserted-by":"crossref","first-page":"86","DOI":"10.9758\/cpn.2011.9.2.86","article-title":"Effects of sinapic acid of 4 vessel occlusion model-induced ischemia and cognitive impairments in the rat","volume":"9","author":"Kim","year":"2011","journal-title":"Clin. Psychopharmacol. Neurosci."},{"issue":"2","key":"10.1016\/j.expneurol.2015.05.006_bb0345","first-page":"292","article-title":"Injury markers in two models of cerebral ischemia","volume":"33","author":"Cespedes","year":"2013","journal-title":"Biomedica"},{"issue":"2","key":"10.1016\/j.expneurol.2015.05.006_bb0350","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.expneurol.2007.12.005","article-title":"Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice","volume":"210","author":"Yoshizaki","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0355","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fnagi.2014.00010","article-title":"Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice","volume":"6","author":"Zhao","year":"2014","journal-title":"Front. Aging Neurosci."},{"issue":"11","key":"10.1016\/j.expneurol.2015.05.006_bb0360","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1161\/01.STR.0000143725.19053.60","article-title":"White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion","volume":"35","author":"Shibata","year":"2004","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.expneurol.2015.05.006_bb0365","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1161\/STROKEAHA.110.581686","article-title":"A mouse model characterizing features of vascular dementia with hippocampal atrophy","volume":"41","author":"Nishio","year":"2010","journal-title":"Stroke"},{"issue":"11","key":"10.1016\/j.expneurol.2015.05.006_bb0370","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1161\/01.STR.0000244808.17972.55","article-title":"Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents","volume":"37","author":"Nakaji","year":"2006","journal-title":"Stroke"},{"issue":"10","key":"10.1016\/j.expneurol.2015.05.006_bb0375","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1161\/STROKEAHA.107.490151","article-title":"Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion","volume":"38","author":"Shibata","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2015.05.006_bb0380","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/978761","article-title":"Lessons from a mouse model characterizing features of vascular cognitive impairment with white matter changes","volume":"2011","author":"Ihara","year":"2011","journal-title":"J. Aging Res."},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0385","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s12975-014-0374-6","article-title":"Remote ischemic postconditioning: harnessing endogenous protection in a murine model of vascular cognitive impairment","volume":"6","author":"Khan","year":"2015","journal-title":"Transl. Stroke Res."},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0390","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1161\/STROKEAHA.110.595082","article-title":"Microinfarct pathology, dementia, and cognitive systems","volume":"42","author":"Arvanitakis","year":"2011","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0395","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1176\/appi.ajp.2011.11010009","article-title":"Association of cerebral emboli with accelerated cognitive deterioration in Alzheimer's disease and vascular dementia","volume":"169","author":"Purandare","year":"2012","journal-title":"Am. J. Psychiatry"},{"issue":"8","key":"10.1016\/j.expneurol.2015.05.006_bb0400","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/ar.22715","article-title":"Evaluation of hippocampal injury and cognitive function induced by embolization in the rat brain","volume":"296","author":"Zhang","year":"2013","journal-title":"Anat. Rec."},{"issue":"6","key":"10.1016\/j.expneurol.2015.05.006_bb0405","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1254\/fpj.121.440","article-title":"The model of stroke induced by microsphere embolism in rats","volume":"121","author":"Takagi","year":"2003","journal-title":"Nihon Yakurigaku Zasshi"},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0410","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/01.STR.24.3.415","article-title":"Sustained decrease in brain regional blood flow after microsphere embolism in rats","volume":"24","author":"Miyake","year":"1993","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0415","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0014-2999(02)02360-9","article-title":"Effects of nefiracetam on spatial memory function and acetylcholine and GABA metabolism in microsphere-embolized rats","volume":"453","author":"Fukatsu","year":"2002","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.expneurol.2015.05.006_bb0420","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/PL00005636","article-title":"Failure in learning task and loss of cortical cholingergic fibers in microsphere-embolized rats","volume":"114","author":"Takagi","year":"1997","journal-title":"Exp. Brain Res."},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0425","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0091-3057(86)90575-7","article-title":"Cerebral embolization leads to memory impairment of several learning tasks in rats","volume":"24","author":"Kiyota","year":"1986","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"8","key":"10.1016\/j.expneurol.2015.05.006_bb0430","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1161\/STROKEAHA.107.496737","article-title":"Microemboli composed of cholesterol crystals disrupt the blood\u2013brain barrier and reduce cognition","volume":"39","author":"Rapp","year":"2008","journal-title":"Stroke"},{"issue":"50","key":"10.1016\/j.expneurol.2015.05.006_bb0435","doi-asserted-by":"crossref","first-page":"17948","DOI":"10.1523\/JNEUROSCI.1860-12.2012","article-title":"Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts","volume":"32","author":"Wang","year":"2012","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0440","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jvs.2008.01.038","article-title":"An experimental model of lacunar infarction: embolization of microthrombi","volume":"48","author":"Rapp","year":"2008","journal-title":"J. Vasc. Surg."},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0445","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nn.3278","article-title":"The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit","volume":"16","author":"Shih","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0450","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neurobiolaging.2005.09.003","article-title":"Studies of the effects of high fat diets on cognitive function in a rat model","volume":"1","author":"Winocur","year":"2005","journal-title":"Neurobiol. Aging"},{"issue":"5","key":"10.1016\/j.expneurol.2015.05.006_bb0455","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/ana.410420514","article-title":"Dietary fat intake and the risk of incident dementia in the Rotterdam Study","volume":"42","author":"Kalmijn","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0460","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuroscience.2013.08.044","article-title":"Inter-relationships among diet, obesity and hippocampal-dependent cognitive function","volume":"253","author":"Davidson","year":"2013","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.expneurol.2015.05.006_bb0465","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1212\/01.WNL.0000038345.77753.46","article-title":"Diet and risk of dementia: does fat matter?: the Rotterdam Study","volume":"59","author":"Engelhart","year":"2002","journal-title":"Neurology"},{"issue":"1\u20132","key":"10.1016\/j.expneurol.2015.05.006_bb0470","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jneuroim.2009.11.010","article-title":"Cognitive impairment following high fat diet consumption is associated with brain inflammation","volume":"219","author":"Pistell","year":"2010","journal-title":"J. Neuroimmunol."},{"issue":"6","key":"10.1016\/j.expneurol.2015.05.006_bb0475","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1111\/j.1471-4159.2010.06865.x","article-title":"High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling","volume":"114","author":"Morrison","year":"2010","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0480","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1161\/01.STR.7.1.46","article-title":"Pathogenetic similarity of strokes in stroke-prone spontaneously hypertensive rats and humans","volume":"7","author":"Yamori","year":"1976","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2015.05.006_bb0485","first-page":"200","article-title":"Memory deficit accompanying cerebral neurodegeneration after stroke in stroke-prone spontaneously hypertensive rats (SHRSP)","volume":"60","author":"Yamaguchi","year":"1994","journal-title":"Acta Neurochir. Suppl."},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0490","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1161\/STROKEAHA.111.643080","article-title":"Myelin loss associated with neuroinflammation in hypertensive rats","volume":"43","author":"Jalal","year":"2012","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0495","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/BF00690831","article-title":"Cerebrovascular lesions in stroke-prone spontaneously hypertensive rats","volume":"68","author":"Fredriksson","year":"1985","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0500","doi-asserted-by":"crossref","first-page":"701976","DOI":"10.1155\/2012\/701976","article-title":"Interleukin-1beta accelerates the onset of stroke in stroke-prone spontaneously hypertensive rats","volume":"2012","author":"Chiba","year":"2012","journal-title":"Mediat. Inflamm."},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0505","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/jcbfm.2009.246","article-title":"Hypertension-induced vascular remodeling contributes to reduced cerebral perfusion and the development of spontaneous stroke in aged SHRSP rats","volume":"30","author":"Henning","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0510","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2040-7378-5-4","article-title":"Blood brain barrier breakdown as the starting point of cerebral small vessel disease? \u2014 new insights from a rat model","volume":"5","author":"Schreiber","year":"2013","journal-title":"Exp. Transl. Stroke Med."},{"issue":"5","key":"10.1016\/j.expneurol.2015.05.006_bb0515","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1007\/s12975-014-0354-x","article-title":"Evaluation of the protective potential of brain microvascular endothelial cell autophagy on blood\u2013brain barrier integrity during experimental cerebral ischemia-reperfusion injury","volume":"5","author":"Li","year":"2014","journal-title":"Transl. Stroke Res."},{"issue":"5","key":"10.1016\/j.expneurol.2015.05.006_bb0520","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0047-6374(01)00362-1","article-title":"The hippocampus in spontaneously hypertensive rats: an animal model of vascular dementia?","volume":"123","author":"Sabbatini","year":"2002","journal-title":"Mech. Ageing Dev."},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0525","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s40478-014-0169-8","article-title":"Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease","volume":"2","author":"Kaiser","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0530","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1476-5381.2012.01911.x","article-title":"The use of animal models in diabetes research","volume":"166","author":"King","year":"2012","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.expneurol.2015.05.006_bb0535","doi-asserted-by":"crossref","first-page":"H2660","DOI":"10.1152\/ajpheart.00489.2006","article-title":"Streptozotocin-induced diabetes progressively increases blood\u2013brain barrier permeability in specific brain regions in rats","volume":"291","author":"Huber","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0540","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jnutbio.2013.11.005","article-title":"Dietary resveratrol supplementation normalizes gene expression in the hippocampus of streptozotocin-induced diabetic C57Bl\/6 mice","volume":"25","author":"Thomas","year":"2014","journal-title":"J. Nutr. Biochem."},{"issue":"2","key":"10.1016\/j.expneurol.2015.05.006_bb0545","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.bbrc.2013.12.039","article-title":"TLR4-dependent metabolic changes are associated with cognitive impairment in an animal model of type 1 diabetes","volume":"443","author":"Kawamoto","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0550","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbr.2008.11.001","article-title":"Cognitive dysfunction and hippocampal changes in experimental type 1 diabetes","volume":"198","author":"Alvarez","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0555","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/1742-2094-9-182","article-title":"Recurrent\/moderate hypoglycemia induces hippocampal dendritic injury, microglial activation, and cognitive impairment in diabetic rats","volume":"9","author":"Won","year":"2012","journal-title":"J. Neuroinflammation"},{"issue":"6","key":"10.1016\/j.expneurol.2015.05.006_bb0560","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1161\/HYPERTENSIONAHA.107.099374","article-title":"Amelioration of cognitive impairment in the type-2 diabetic mouse by the angiotensin II type-1 receptor blocker candesartan","volume":"50","author":"Tsukuda","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.expneurol.2015.05.006_bb0565","doi-asserted-by":"crossref","first-page":"609202","DOI":"10.1155\/2011\/609202","article-title":"Vascular pathology and blood\u2013brain barrier disruption in cognitive and psychiatric complications of type 2 diabetes mellitus","volume":"2011","author":"Serlin","year":"2011","journal-title":"Cardiovasc. Psychiatry Neurol."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0570","doi-asserted-by":"crossref","first-page":"796840","DOI":"10.1155\/2014\/796840","article-title":"Brain aging and AD-like pathology in streptozotocin-induced diabetic rats","volume":"2014","author":"Wang","year":"2014","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0575","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2147\/CIA.S74042","article-title":"Link between type 2 diabetes and Alzheimer's disease: from epidemiology to mechanism and treatment","volume":"10","author":"Li","year":"2015","journal-title":"Clin. Interv. Aging"},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0580","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0197-4580(92)90009-M","article-title":"Cerebrovascular permeability and cognition in the aging rat","volume":"13","author":"Goldman","year":"1992","journal-title":"Neurobiol. Aging"},{"issue":"12","key":"10.1016\/j.expneurol.2015.05.006_bb0585","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/sj.jcbfm.9600491","article-title":"Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain","volume":"27","author":"Park","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"2","key":"10.1016\/j.expneurol.2015.05.006_bb0590","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1161\/STROKEAHA.113.002944","article-title":"Perfusion of ischemic brain in young and aged animals: a laser speckle flowmetry study","volume":"45","author":"Manwani","year":"2014","journal-title":"Stroke"},{"issue":"34","key":"10.1016\/j.expneurol.2015.05.006_bb0595","doi-asserted-by":"crossref","first-page":"10913","DOI":"10.1523\/JNEUROSCI.23-34-10913.2003","article-title":"Long-lasting functional disabilities in middle-aged rats with small cerebral infarcts","volume":"23","author":"Lindner","year":"2003","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.expneurol.2015.05.006_bb0600","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1093\/jnci\/66.6.1113","article-title":"Prevention of spontaneous tumors of aged mice by immunopharmacologic manipulation: study of immune antitumor mechanisms","volume":"66","author":"Bruley-Rosset","year":"1981","journal-title":"J. Natl. Cancer Inst."},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0605","doi-asserted-by":"crossref","first-page":"935","DOI":"10.3892\/mmr.2013.1573","article-title":"Protective effect of bilobalide on learning and memory impairment in rats with vascular dementia","volume":"8","author":"Li","year":"2013","journal-title":"Mol. Med. Rep."},{"issue":"22","key":"10.1016\/j.expneurol.2015.05.006_bb0610","first-page":"2050","article-title":"Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia","volume":"8","author":"Ma","year":"2013","journal-title":"Neural. Regen. Res."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0615","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuint.2013.12.004","article-title":"Effects of acupuncture on declined cerebral blood flow, impaired mitochondrial respiratory function and oxidative stress in multi-infarct dementia rats","volume":"65","author":"Zhang","year":"2014","journal-title":"Neurochem. Int."},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0620","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.pbb.2007.03.003","article-title":"Protective effects of Nicotiflorin on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats","volume":"86","author":"Huang","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0625","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2174\/156720212799297074","article-title":"Gene expression suggests spontaneously hypertensive rats may have altered metabolism and reduced hypoxic tolerance","volume":"9","author":"Ritz","year":"2012","journal-title":"Curr. Neurovasc. Res."},{"issue":"9","key":"10.1016\/j.expneurol.2015.05.006_bb0630","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3109\/00207454.2012.686543","article-title":"Cerebral hypoperfusion and cognitive impairment: the pathogenic role of vascular oxidative stress","volume":"122","author":"Liu","year":"2012","journal-title":"Int. J. Neurosci."},{"issue":"9","key":"10.1016\/j.expneurol.2015.05.006_bb0635","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.freeradbiomed.2010.01.006","article-title":"Linking oxidative stress to inflammation: toll-like receptors","volume":"48","author":"Gill","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.expneurol.2015.05.006_bb0640","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1161\/STROKEAHA.110.600825","article-title":"Matrix metalloproteinases are associated with increased blood\u2013brain barrier opening in vascular cognitive impairment","volume":"42","author":"Candelario-Jalil","year":"2011","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.expneurol.2015.05.006_bb0645","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s12975-014-0381-7","article-title":"Effect of simvastatin on MMPs and TIMPs in human brain endothelial cells and experimental stroke","volume":"6","author":"Reuter","year":"2015","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0650","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1742-4933-6-13","article-title":"Pathophysiology of vascular dementia","volume":"6","author":"Iemolo","year":"2009","journal-title":"Immun. Ageing"},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0655","first-page":"34","article-title":"Changes of interleukin-1beta and TNF-alpha contents in the hippocampus and the interventional effect of electroacupuncture in vascular dementia rats","volume":"32","author":"Li","year":"2007","journal-title":"Zhen Ci Yan Jiu"},{"issue":"2","key":"10.1016\/j.expneurol.2015.05.006_bb0660","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1161\/STROKEAHA.110.596486","article-title":"White matter damage and the effect of matrix metalloproteinases in type 2 diabetic mice after stroke","volume":"42","author":"Chen","year":"2011","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0665","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/jnr.22237","article-title":"Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion","volume":"88","author":"Wang","year":"2010","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.expneurol.2015.05.006_bb0670","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1523\/JNEUROSCI.22-02-00455.2002","article-title":"Selective vulnerability of late oligodendrocyte progenitors to hypoxia\u2013ischemia","volume":"22","author":"Back","year":"2002","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.expneurol.2015.05.006_bb0675","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00401-009-0635-8","article-title":"Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodies","volume":"119","author":"Ihara","year":"2010","journal-title":"Acta Neuropathol."},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0680","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neulet.2010.07.046","article-title":"A high-fat diet impairs neurogenesis: involvement of lipid peroxidation and brain-derived neurotrophic factor","volume":"482","author":"Park","year":"2010","journal-title":"Neurosci. Lett."},{"issue":"11","key":"10.1016\/j.expneurol.2015.05.006_bb0685","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/hipo.20470","article-title":"Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats","volume":"18","author":"Stranahan","year":"2008","journal-title":"Hippocampus"},{"key":"10.1016\/j.expneurol.2015.05.006_bb0690","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3389\/fnhum.2014.00382","article-title":"Neurorestorative therapy for stroke","volume":"8","author":"Chen","year":"2014","journal-title":"Front. Hum. Neurosci."},{"issue":"7","key":"10.1016\/j.expneurol.2015.05.006_bb0695","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/jcbfm.2012.25","article-title":"Pathophysiology of the neurovascular unit: disease cause or consequence?","volume":"32","author":"Stanimirovic","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"Pt 5","key":"10.1016\/j.expneurol.2015.05.006_bb0700","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1093\/brain\/awu040","article-title":"Pathophysiology of white matter perfusion in Alzheimer's disease and vascular dementia","volume":"137","author":"Barker","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2015.05.006_bb0705","doi-asserted-by":"crossref","first-page":"261672","DOI":"10.1155\/2014\/261672","article-title":"Association between risk factors for vascular dementia and adiponectin","volume":"2014","author":"Song","year":"2014","journal-title":"Biomed. Res. Int."},{"issue":"3\u20134","key":"10.1016\/j.expneurol.2015.05.006_bb0710","first-page":"145","article-title":"Pathology and pathophysiology of cerebrovascular dementia: pure subgroups of obstructive and hypoperfusive etiology","volume":"5","author":"Brun","year":"1994","journal-title":"Dementia"},{"issue":"7","key":"10.1016\/j.expneurol.2015.05.006_bb0715","first-page":"3504","article-title":"Is apolipoprotein E4 an important risk factor for vascular dementia?","volume":"7","author":"Rohn","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0720","first-page":"938","article-title":"Apolipoprotein E pathology in vascular dementia","volume":"7","author":"Rohn","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"5\u20136","key":"10.1016\/j.expneurol.2015.05.006_bb0725","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/FBP.0b013e328356c3f2","article-title":"The effect of simvastatin treatment on behavioral parameters, cognitive performance, and hippocampal morphology in rats fed a standard or a high-fat diet","volume":"23","author":"Can","year":"2012","journal-title":"Behav. Pharmacol."},{"issue":"5","key":"10.1016\/j.expneurol.2015.05.006_bb0730","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s00415-009-5008-7","article-title":"Effects of statins on the progression of cerebral white matter lesion: post hoc analysis of the ROCAS (Regression of Cerebral Artery Stenosis) study","volume":"256","author":"Mok","year":"2009","journal-title":"J. Neurol."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0735","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pneurobio.2013.11.006","article-title":"Excitotoxicity and stroke: identifying novel targets for neuroprotection","volume":"115","author":"Lai","year":"2014","journal-title":"Prog. Neurobiol."},{"issue":"7","key":"10.1016\/j.expneurol.2015.05.006_bb0740","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1161\/01.STR.0000020094.08790.49","article-title":"Efficacy and safety of memantine in patients with mild to moderate vascular dementia: a randomized, placebo-controlled trial (MMM 300)","volume":"33","author":"Orgogozo","year":"2002","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.expneurol.2015.05.006_bb0745","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1602\/neurorx.1.1.101","article-title":"Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults","volume":"1","author":"Lipton","year":"2004","journal-title":"NeuroRx"},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0750","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/01.WNL.0000078943.50032.FC","article-title":"Donepezil in vascular dementia: a randomized, placebo-controlled study","volume":"61","author":"Wilkinson","year":"2003","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0755","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/gps.2340","article-title":"The long-term efficacy and tolerability of donepezil in patients with vascular dementia","volume":"25","author":"Wilkinson","year":"2010","journal-title":"Int. J. Geriatr. Psychiatry"},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0760","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1177\/026988110001400410","article-title":"Adverse effects associated with the use of donepezil in general practice in England","volume":"14","author":"Dunn","year":"2000","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0765","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.pneurobio.2013.11.004","article-title":"Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials","volume":"115","author":"Liu","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0770","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pneurobio.2013.11.007","article-title":"Cell based therapies for ischemic stroke: from basic science to bedside","volume":"115","author":"Liu","year":"2014","journal-title":"Prog. Neurobiol."},{"issue":"10","key":"10.1016\/j.expneurol.2015.05.006_bb0775","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/cns.12307","article-title":"HUCBCs increase angiopoietin 1 and induce neurorestorative effects after stroke in T1DM rats","volume":"20","author":"Yan","year":"2014","journal-title":"CNS Neurosci. Ther."},{"issue":"382","key":"10.1016\/j.expneurol.2015.05.006_bb0780","article-title":"Neurorestorative therapy for stroke","volume":"8","author":"Chen","year":"2014","journal-title":"Front. Hum. Neurosci."},{"issue":"5","key":"10.1016\/j.expneurol.2015.05.006_bb0785","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3727\/096368911X627417","article-title":"Therapeutic benefit of treatment of stroke with simvastatin and human umbilical cord blood cells: neurogenesis, synaptic plasticity, and axon growth","volume":"21","author":"Cui","year":"2012","journal-title":"Cell Transplant."},{"issue":"3","key":"10.1016\/j.expneurol.2015.05.006_bb0790","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1089\/scd.2012.0345","article-title":"Multiple low-dose infusions of human umbilical cord blood cells improve cognitive impairments and reduce amyloid-beta-associated neuropathology in Alzheimer mice","volume":"22","author":"Darlington","year":"2013","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0795","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.neuroscience.2012.03.009","article-title":"The dose\u2013response effect of acute intravenous transplantation of human umbilical cord blood cells on brain damage and spatial memory deficits in neonatal hypoxia\u2013ischemia","volume":"210","author":"de Paula","year":"2012","journal-title":"Neuroscience"},{"issue":"118","key":"10.1016\/j.expneurol.2015.05.006_bb0800","article-title":"Mesenchymal stem cells can modulate longitudinal changes in cortical thickness and its related cognitive decline in patients with multiple system atrophy","volume":"6","author":"Sunwoo","year":"2014","journal-title":"Front. Aging Neurosci."},{"issue":"2","key":"10.1016\/j.expneurol.2015.05.006_bb0805","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s12031-013-0141-2","article-title":"Resveratrol pretreatment attenuates the isoflurane-induced cognitive impairment through its anti-inflammation and -apoptosis actions in aged mice","volume":"52","author":"Li","year":"2014","journal-title":"J. Mol. Neurosci."},{"issue":"23","key":"10.1016\/j.expneurol.2015.05.006_bb0810","first-page":"1742","article-title":"TNF-alpha protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation","volume":"9","author":"Belarbi","year":"2012","journal-title":"J. Neuroinflammation"},{"issue":"4","key":"10.1016\/j.expneurol.2015.05.006_bb0815","doi-asserted-by":"crossref","first-page":"378","DOI":"10.2174\/156720507781788873","article-title":"TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets","volume":"4","author":"Tweedie","year":"2007","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0820","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pneurobio.2013.12.006","article-title":"Neurogenesis in neurological and psychiatric diseases and brain injury: from bench to bedside","volume":"115","author":"Ruan","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.expneurol.2015.05.006_bb0825","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.pneurobio.2013.12.002","article-title":"Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair","volume":"115","author":"An","year":"2014","journal-title":"Prog. Neurobiol."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488615001533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488615001533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T17:43:45Z","timestamp":1772732625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488615001533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":165,"alternative-id":["S0014488615001533"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2015.05.006","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Models and mechanisms of vascular dementia","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2015.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}