{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:17:03Z","timestamp":1789607823727,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002879","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-97727)"],"award-info":[{"award-number":["MOP-97727)"]}],"id":[{"id":"10.13039\/501100002879","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.expneurol.2015.06.010","type":"journal-article","created":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T23:18:45Z","timestamp":1434237525000},"page":"228-240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Myenteric expression of nerve growth factor and the p75 neurotrophin receptor regulate axonal remodeling as a consequence of colonic inflammation in mice"],"prefix":"10.1016","volume":"271","author":[{"given":"Casey N.","family":"Petrie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Armitage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Kawaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2015.06.010_bb0005","doi-asserted-by":"crossref","first-page":"5765","DOI":"10.1523\/JNEUROSCI.15-08-05765.1995","article-title":"BDNF enhances the differentiation but not the survival of CNS stem cell-derived neuronal precursors","volume":"15","author":"Ahmed","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0010","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1523\/JNEUROSCI.14-03-01422.1994","article-title":"Overexpression of nerve growth factor in epidermis of transgenic mice causes hypertrophy of the peripheral nervous system","volume":"14","author":"Albers","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0015","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1002\/art.1780350315","article-title":"Nerve growth factor in the synovial fluid of patients with chronic arthritis","volume":"35","author":"Aloe","year":"1992","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0020","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/BF00302155","article-title":"Studies on carrageenan-induced arthritis in adult rats: presence of nerve growth factor and role of sympathetic innervation","volume":"12","author":"Aloe","year":"1992","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0025","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/jnr.490360106","article-title":"Protein growth factor requirements of rat neural crest cells","volume":"36","author":"Bannerman","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0030","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.cyto.2007.04.005","article-title":"Up-regulation of nerve growth factor and interleukin-10 in inflamed and non-inflamed intestinal segments in rats with experimental colitis","volume":"37","author":"Barada","year":"2007","journal-title":"Cytokine"},{"key":"10.1016\/j.expneurol.2015.06.010_bb0035","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1002\/neu.480251107","article-title":"The Trk family of neurotrophin receptors","volume":"25","author":"Barbacid","year":"1994","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0040","doi-asserted-by":"crossref","first-page":"30645","DOI":"10.1016\/S0021-9258(18)43862-8","article-title":"The low affinity neurotrophin receptor, p75LNTR, is palmitoylated by thioester formation through cysteine 279","volume":"269","author":"Barker","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0045","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02199-9","article-title":"Retrograde signaling by the neurotrophins follows a well-worn trk","volume":"25","author":"Barker","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0050","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/cne.23423","article-title":"Birthdating of myenteric neuron subtypes in the small intestine of the mouse","volume":"522","author":"Bergner","year":"2014","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0060","doi-asserted-by":"publisher","first-page":"3240","DOI":"10.1002\/(SICI)1521-4141(199810)28:10<3240::AID-IMMU3240>3.0.CO;2-U","article-title":"Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma","volume":"28","author":"Braun","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0065","doi-asserted-by":"publisher","first-page":"7029","DOI":"10.1371\/journal.pone.0007029","article-title":"Inhibitors of MyD88-dependent proinflammatory cytokine production identified utilizing a novel RNA interference screening approach","volume":"4","author":"Cho","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2015.06.010_bb0070","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/0092-8674(94)90378-6","article-title":"Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons","volume":"76","author":"Crowley","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2015.06.010_bb0075","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/0301-0082(94)90075-2","article-title":"Neurotrophin receptors","volume":"42","author":"Dechant","year":"1994","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0090","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.expneurol.2005.12.022","article-title":"Null mutations for exon III and exon IV of the p75 neurotrophin receptor gene enhance sympathetic sprouting in response to elevated levels of nerve growth factor in transgenic mice","volume":"198","author":"Dhanoa","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0080","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1136\/gut.46.5.670","article-title":"Nerve growth factor and trk high affinity receptor (TrkA) gene expression in inflammatory bowel disease","volume":"46","author":"di Mola","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.expneurol.2015.06.010_bb0095","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00403-006-0657-1","article-title":"Increased nerve growth factor and its receptors in atopic dermatitis: an immunohistochemical study","volume":"298","author":"Dou","year":"2006","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0100","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0092-8674(89)90412-1","article-title":"Directed expression of NGF to pancreatic beta cells in transgenic mice leads to selective hyperinnervation of the islets","volume":"58","author":"Edwards","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2015.06.010_bb0105","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1097\/WNR.0b013e32831add70","article-title":"Transgenic mice expressing nerve growth factor in smooth muscle cells","volume":"20","author":"Elliott","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/j.expneurol.2015.06.010_bb0110","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1183\/09031936.02.00269202","article-title":"Upregulation of nerve growth factor expression by human airway smooth muscle cells in inflammatory conditions","volume":"20","author":"Freund","year":"2002","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0115","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00441-004-0895-5","article-title":"Projections and chemistry of Dogiel type II neurons in the mouse colon","volume":"317","author":"Furness","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0120","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/0169-328X(92)90231-Y","article-title":"Thyroid hormone regulation of NGF, NT-3 and BDNF RNA in the adult rat brain","volume":"16","author":"Giordano","year":"1992","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0125","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1111\/j.0953-816X.2004.03381.x","article-title":"TrkA and mitogen-activated protein kinase phosphorylation are enhanced in sympathetic neurons lacking functional p75 neurotrophin receptor expression","volume":"19","author":"Hannila","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0135","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1002\/ibd.20072","article-title":"Study of expression patterns and levels of neurotrophins and neurotrophin receptors in ulcerative colitis","volume":"13","author":"Johansson","year":"2007","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0130","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20487","article-title":"New aspects concerning ulcerative colitis and colonic carcinoma: analysis of levels of neuropeptides, neurotrophins, and TNFalpha\/TNF receptor in plasma and mucosa in parallel with histological evaluation of the intestine","volume":"14","author":"Johansson","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0140","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1002\/neu.480251108","article-title":"Neurotrophin signal transduction by the Trk receptor","volume":"25","author":"Kaplan","year":"1994","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0145","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.1002\/cne.22629","article-title":"Nerve growth factor promoter activity revealed in mice expressing enhanced green fluorescent protein","volume":"519","author":"Kawaja","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0150","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1538\/expanim.48.137","article-title":"Changes in colonic mucosal permeability in mouse colitis induced with dextran sulfate sodium","volume":"48","author":"Kitajima","year":"1999","journal-title":"Exp. Anim."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0155","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.1523\/JNEUROSCI.19-13-05393.1999","article-title":"Functionally antagonistic interactions between the TrkA and p75 neurotrophin receptors regulate sympathetic neuron growth and target innervation","volume":"19","author":"Kohn","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0160","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1523\/JNEUROSCI.13-07-02739.1993","article-title":"The neurotrophic factor concept: a reexamination","volume":"13","author":"Korsching","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0165","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/0092-8674(92)90286-L","article-title":"Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system","volume":"69","author":"Lee","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2015.06.010_bb0170","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1749-6632.1960.tb49963.x","article-title":"Effects of the extract of the mouse submaxillary salivary glands on the sympathetic system of mammals","volume":"85","author":"Levi-Montalcini","year":"1960","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.expneurol.2015.06.010_bb0175","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1523\/JNEUROSCI.3982-03.2004","article-title":"Enteric dopaminergic neurons: definition, developmental lineage, and effects of extrinsic denervation","volume":"24","author":"Li","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0185","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1097\/00001756-199703030-00001","article-title":"The progressive tactile hyperalgesia induced by peripheral inflammation is nerve growth factor dependent","volume":"8","author":"Ma","year":"1997","journal-title":"NeuroReport"},{"key":"10.1016\/j.expneurol.2015.06.010_bb0180","doi-asserted-by":"publisher","first-page":"5308","DOI":"10.1128\/IAI.72.9.5308-5314.2004","article-title":"Live Lactobacillus rhamnosus is essential for the inhibitory effect on tumor necrosis factor alpha-induced interleukin-8 expression","volume":"72","author":"Ma","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0190","first-page":"G544","article-title":"Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis","volume":"274","author":"M\u00e4hler","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0200","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/0166-2236(92)90047-C","article-title":"The nerve growth factor family of receptors","volume":"15","author":"Meakin","year":"1992","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0205","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1111\/j.1572-0241.2004.40065.x","article-title":"Activity of inducible and neuronal nitric oxide synthases in colonic mucosa predicts progression of ulcerative colitis","volume":"99","author":"Mench\u00e9n","year":"2004","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0210","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/cne.10948","article-title":"Correlation of electrophysiological and morphological characteristics of enteric neurons in the mouse colon","volume":"468","author":"Nurgali","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0215","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1097\/00001756-199805110-00038","article-title":"Rapid increase in NGF, BDNF and NT-3 mRNAs in inflamed bladder","volume":"11","author":"Oddiah","year":"1998","journal-title":"NeuroReport"},{"key":"10.1016\/j.expneurol.2015.06.010_bb0220","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1002\/cne.23302","article-title":"Overexpression of nerve growth factor by murine muscle cells: role of the p75 neurotrophin receptor on sympathetic and sensory sprouting","volume":"521","author":"Petrie","year":"2013","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0225","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.pain.2010.06.029","article-title":"Colitis elicits differential changes in the expression levels of receptor tyrosine kinase TrkA and TrkB in colonic afferent neurons: a possible involvement of axonal transport","volume":"151","author":"Qiao","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2015.06.010_bb0230","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1053\/gast.2000.9307","article-title":"Protective role of neurotrophins in experimental inflammation of the rat gut","volume":"119","author":"Reinshagen","year":"2000","journal-title":"Gastroent"},{"key":"10.1016\/j.expneurol.2015.06.010_bb0235","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s004410050565","article-title":"Chemical coding of neurons in the myenteric plexus and external muscle of the small and large intestine of the mouse","volume":"284","author":"Sang","year":"1996","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0240","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/368246a0","article-title":"Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk\/NGF receptor gene","volume":"368","author":"Smeyne","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2015.06.010_bb0245","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.expneurol.2008.01.028","article-title":"Inflammation causes expression of NGF in epithelial cells of the rat colon","volume":"211","author":"Stanzel","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2015.06.010_bb0250","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1097\/00001756-199604260-00008","article-title":"Increase of p75 immunoreactivity in rat urinary bladder following inflammation","volume":"7","author":"Wakabayashi","year":"1996","journal-title":"NeuroReport"},{"key":"10.1016\/j.expneurol.2015.06.010_bb0255","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1034\/j.1600-0854.2001.020103.x","article-title":"Regulation of receptor tyrosine kinase signaling by endocytic trafficking","volume":"2","author":"Wiley","year":"2001","journal-title":"Traffic"},{"key":"10.1016\/j.expneurol.2015.06.010_bb0260","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1523\/JNEUROSCI.18-09-03273.1998","article-title":"Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival","volume":"18","author":"Yoon","year":"1998","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.expneurol.2015.06.010_bb0265","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/(SICI)1097-0177(199910)216:2<137::AID-DVDY5>3.0.CO;2-6","article-title":"Expression of Ret-, p75(NTR)-, Phox2a-, Phox2b-, and tyrosine hydroxylase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut","volume":"216","author":"Young","year":"1999","journal-title":"Dev. Dyn."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488615300200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488615300200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T14:01:20Z","timestamp":1717941680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488615300200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":50,"alternative-id":["S0014488615300200"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2015.06.010","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myenteric expression of nerve growth factor and the p75 neurotrophin receptor regulate axonal remodeling as a consequence of colonic inflammation in mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2015.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}