{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:37:52Z","timestamp":1790519872114,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["23110003"],"award-info":[{"award-number":["23110003"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["25293014"],"award-info":[{"award-number":["25293014"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.expneurol.2015.07.009","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T21:20:56Z","timestamp":1438204856000},"page":"126-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"PB","title":["Involvement of chondroitin 6-sulfation in temporal lobe epilepsy"],"prefix":"10.1016","volume":"274","author":[{"given":"Noriko","family":"Yutsudo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2015.07.009_bb0005","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00401-005-1060-2","article-title":"Loss of perineuronal net N-acetylgalactosamine in Alzheimer's disease","volume":"110","author":"Baig","year":"2005","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.schres.2014.12.040","article-title":"Losing the sugar coating: potential impact of perineuronal net abnormalities on interneurons in schizophrenia","author":"Berretta","year":"2015","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0015","doi-asserted-by":"crossref","first-page":"9429","DOI":"10.1523\/JNEUROSCI.0394-12.2012","article-title":"Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex","volume":"32","author":"Beurdeley","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0020","doi-asserted-by":"crossref","first-page":"9422","DOI":"10.1073\/pnas.94.17.9422","article-title":"A single dose of kainic acid elevates the levels of enkephalins and activator protein-1 transcription factors in the hippocampus for up to 1year","volume":"94","author":"Bing","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0025","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1750-3639.2008.00195.x","article-title":"Brain extracellular matrix in neurodegeneration","volume":"19","author":"Bonneh-Barkay","year":"2009","journal-title":"Brain Pathol."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0030","doi-asserted-by":"crossref","first-page":"9130","DOI":"10.1073\/pnas.1300454110","article-title":"Perineuronal nets protect fast-spiking interneurons agaist oxidative stress","volume":"110","author":"Cabungcal","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0035","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S0166-2236(98)01298-3","article-title":"Perineuronal nets: past and present","volume":"21","author":"Celio","year":"1998","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0040","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/nn.2621","article-title":"Narp regulates homeostatic scaling of excitatory synapses on parvalbumin interneurons","volume":"13","author":"Chang","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0045","doi-asserted-by":"crossref","first-page":"27384","DOI":"10.1074\/jbc.M111.310029","article-title":"Semaphorin 3A binds to the perineuronal nets via chondroitin sulfate type E motifs in rodent brains","volume":"288","author":"Dick","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresrev.2006.09.006","article-title":"The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system","volume":"54","author":"Galtrey","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0055","doi-asserted-by":"crossref","first-page":"24164","DOI":"10.1074\/jbc.M211721200","article-title":"Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan\/receptor protein tyrosine phosphatase-\u03b2, interacts with neuronal receptors and promotes neurite outgrowth","volume":"278","author":"Garwood","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0060","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/00001756-199210000-00012","article-title":"Wisteria floribunda agglutinin-labelled nets surround parvalbumin-containing neurons","volume":"3","author":"H\u00e4rtig","year":"1992","journal-title":"NeuroReport"},{"key":"10.1016\/j.expneurol.2015.07.009_bb0065","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.bbrc.2007.10.040","article-title":"DACS, novel matrix structure composed of chondroitin sulfate proteoglycan in the brain","volume":"364","author":"Hayashi","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0070","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/jnr.20459","article-title":"Decomposition and long-lasting downregulation of extracellular matrix in perineuronal nets induced by focal cerebral ischemia in rats","volume":"80","author":"Hobohm","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0075","doi-asserted-by":"crossref","first-page":"31377","DOI":"10.1074\/jbc.272.50.31377","article-title":"Developmental regulation of the sulfation profile of chondroitin sulfate chains in the chicken embryo brain","volume":"272","author":"Kitagawa","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0080","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0006-8993(01)02128-X","article-title":"Expression of brain specific chondroitin sulfate proteoglycans, neurocan and phosphacan, in the developing and adult hippocampus of Ihara's epileptic rats","volume":"898","author":"Kurazono","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0085","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.yebeh.2014.05.031","article-title":"The consequences of refractory epilepsy and its treatment","volume":"37","author":"Laxer","year":"2014","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0090","doi-asserted-by":"crossref","first-page":"e21499","DOI":"10.1371\/journal.pone.0021499","article-title":"6-Sulphated chondroitins have a positive influence on axonal regeneration","volume":"6","author":"Lin","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.expneurol.2015.07.009_bb0095","doi-asserted-by":"crossref","first-page":"111","DOI":"10.31887\/DCNS.2007.9.2\/clyketsos","article-title":"Phychiatric manifestations of neurologic disease: where are we headed?","volume":"9","author":"Lyketsos","year":"2007","journal-title":"Dialog. Clin. Neurosci."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0100","doi-asserted-by":"crossref","first-page":"35805","DOI":"10.1074\/jbc.M305530200","article-title":"Heterogeneity of the chondroitin sulfate portion of phosphacan\/6B4 proteoglycan regulates its binding affinity for pleiotrophin\/heparin binding growth-associated molecule","volume":"278","author":"Maeda","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0105","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0306-4522(02)00136-7","article-title":"Transient expression of juvenile-type neurocan by reactive astrocytes in adult rat brains injured by kainate-induced seizures as well as surgical incision","volume":"112","author":"Matsui","year":"2002","journal-title":"Neurosci."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0120","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.neuint.2012.08.007","article-title":"The perineuronal net component of the extracellular matrix in plasticity and epilepsy","volume":"61","author":"McRae","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0115","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.nbd.2010.05.015","article-title":"Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure","volume":"39","author":"McRae","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0110","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1111\/j.1460-9568.2012.08268.x","article-title":"Persistent decrease in multiple components of the perineuronal net following status epilepticus","volume":"36","author":"McRae","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0125","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1016\/j.bbagen.2013.06.006","article-title":"Biosynthesis and function of chondroitin sulfate","volume":"1830","author":"Mikami","year":"2013","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/j.expneurol.2015.07.009_bb0130","doi-asserted-by":"crossref","first-page":"36115","DOI":"10.1074\/jbc.M306044200","article-title":"Specificities of three distinct human chondroitin\/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis","volume":"278","author":"Mikami","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0135","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/jb\/mvu067","article-title":"Mechanisms for modulation of neural plasticity and axon regeneration by chondroitin sulphate","volume":"157","author":"Miyata","year":"2015","journal-title":"J. Biochem."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0140","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nn.3023","article-title":"Persistent cortical plasticity by upregulation of chondroitin 6-sulfation","volume":"15","author":"Miyata","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0145","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.neuroscience.2010.05.022","article-title":"Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease","volume":"169","author":"Morawski","year":"2010","journal-title":"Neurosci."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0150","doi-asserted-by":"crossref","first-page":"27333","DOI":"10.1074\/jbc.M802997200","article-title":"Chondroitin 4-O-sulfotransferase-1 modulates Wnt-3a signaling through control of E disaccharide expression of chondroitin sulfate","volume":"283","author":"Nadanaka","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0155","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1042\/BJ20100101","article-title":"Biosynthesis of heparan sulfate in EXT1-deficient cells","volume":"428","author":"Okada","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0160","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0014-4886(03)00251-6","article-title":"Kainic acid-induced convulsions cause prolonged changes in the chondroitin sulfate proteoglycans neurocan and phosphacan in the limbic structures","volume":"184","author":"Okamoto","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0165","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/jnc.12736","article-title":"OASIS regulates chondroitin 6-O-sulfotransferase 1 gene transcription in the injured adult mouse cerebral cortex","volume":"130","author":"Okuda","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0170","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0006-8993(74)90640-4","article-title":"Kainic acid: a powerful neurotoxic analogue of glutamate","volume":"77","author":"Olney","year":"1974","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0175","doi-asserted-by":"crossref","first-page":"e496","DOI":"10.1038\/tp.2014.128","article-title":"Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala","volume":"5","author":"Pantazopoulos","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.expneurol.2015.07.009_bb0180","doi-asserted-by":"crossref","first-page":"172","DOI":"10.5698\/1535-7597-13.4.172","article-title":"Interneuron development and epilepsy: early genetic defects cause long-term consequences in seizures and susceptibility","volume":"13","author":"Powell","year":"2013","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0185","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1460-9568.2005.03876.x","article-title":"Chondroitin 6-sulphate synthesis is up-regulated in injured CNS, induced by injury-related cytokines and enhanced in axon-growth inhibitory glia","volume":"21","author":"Properzi","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0190","first-page":"797","article-title":"Psychiatric disorders and traumatic brain injury","volume":"4","author":"Schwarzbold","year":"2008","journal-title":"Neurobiol. Dis. Treat."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0195","first-page":"223","article-title":"The role of GABAergic system in neurodevelopemental disorders: a focus on autism and epilepsy","volume":"3","author":"Sgad\u00f2","year":"2011","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0200","doi-asserted-by":"crossref","first-page":"e1119","DOI":"10.1038\/cddis.2014.25","article-title":"Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress","volume":"5","author":"Suttkus","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0205","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1515\/bmc-2012-0042","article-title":"Sugar glues for broken neurons","volume":"4","author":"Swarup","year":"2013","journal-title":"Biomol. Concepts"},{"key":"10.1016\/j.expneurol.2015.07.009_bb0210","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0014-5793(98)01532-4","article-title":"Functional expression and genomic structure of human chondroitin 6-sulfotransferase","volume":"441","author":"Tsutsumi","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0215","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/1096-9861(20000828)424:3<532::AID-CNE10>3.0.CO;2-Z","article-title":"Chondroitin sulfate proteoglycan expression pattern in hippocampal development: potential regulation of axon tract formation","volume":"424","author":"Wilson","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2015.07.009_bb0220","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/39899","article-title":"Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene","volume":"389","author":"Yang","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2015.07.009_bb0225","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1002\/cne.23156","article-title":"Alterations in sulfated chondroitin glycosaminoglycans following controlled cortical impact injury in mice","volume":"520","author":"Yi","year":"2012","journal-title":"J. Comp. Neurol."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448861530042X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448861530042X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T02:11:36Z","timestamp":1655345496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448861530042X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":45,"alternative-id":["S001448861530042X"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2015.07.009","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of chondroitin 6-sulfation in temporal lobe epilepsy","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2015.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}