{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:23:04Z","timestamp":1761744184911,"version":"3.37.3"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["12-03"],"award-info":[{"award-number":["12-03"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013151","name":"Scientific Research Foundation for Returned Scholars of Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81171232","81371348","81371427"],"award-info":[{"award-number":["81171232","81371348","81371427"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.expneurol.2015.09.007","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T09:33:31Z","timestamp":1442396011000},"page":"273-287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Newly generated neurons at 2 months post-status epilepticus are functionally integrated into neuronal circuitry in mouse hippocampus"],"prefix":"10.1016","volume":"273","author":[{"given":"Ming","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Shui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Li","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2015.09.007_bb0005","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuroscience.2010.08.004","article-title":"Basal dendrites are present in newly born dentate granule cells of young but not aged pilocarpine-treated chronic epileptic rats","volume":"170","author":"Avanzi","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2015.09.007_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/ejn.12387","article-title":"Different subsets of newborn granule cells: a possible role in epileptogenesis?","volume":"39","author":"Bielefeld","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0015","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/j.1460-9568.2006.04635.x","article-title":"Long-term neuronal replacement in adult rat hippocampus after status epilepticus despite chronic inflammation","volume":"23","author":"Bonde","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0020","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.braindev.2003.12.006","article-title":"Spontaneous recurrent seizure following status epilepticus enhances dentate gyrus neurogenesis","volume":"26","author":"Cha","year":"2004","journal-title":"Brain Dev."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0025","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.neurobiolaging.2012.10.017","article-title":"Spatial behavior and seizure-induced changes in c-fos mRNA expression in young and old rats","volume":"34","author":"Chawla","year":"2013","journal-title":"Neurobiol. Aging."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0030","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/cne.903020203","article-title":"Quantitative, three-dimensional analysis of granule cell dendrites in the rat dentate gyrus","volume":"302","author":"Claiborne","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0035","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.nbd.2005.01.020","article-title":"Increased number of neural progenitors in human temporal lobe epilepsy","volume":"19","author":"Crespel","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0040","article-title":"Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction","author":"Cruz","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0045","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.neuroscience.2004.03.025","article-title":"Altered regulation of brain-derived neurotrophic factor protein in hippocampus following slice preparation","volume":"126","author":"Danzer","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2015.09.007_bb0050","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0920-1211(03)00082-2","article-title":"Temporal profile of hilar basal dendrite formation on dentate granule cells after status epilepticus","volume":"54","author":"Dashtipour","year":"2003","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0055","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.conb.2005.08.018","article-title":"Mapping behaviorally relevant neural circuits with immediate-early gene expression","volume":"15","author":"Guzowski","year":"2005","journal-title":"Curr. Opin. Neurobiol."},{"issue":"Suppl. 5","key":"10.1016\/j.expneurol.2015.09.007_bb0065","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1528-1167.2008.01635.x","article-title":"Implications of decreased hippocampal neurogenesis in chronic temporal lobe epilepsy","author":"Hattiangady","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2015.09.007_bb0070","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/hipo.20594","article-title":"Decreased neuronal differentiation of newly generated cells underlies reduced hippocampal neurogenesis in chronic temporal lobe epilepsy","volume":"20","author":"Hattiangady","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.expneurol.2015.09.007_bb0060","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.nbd.2004.08.008","article-title":"Chronic temporal lobe epilepsy is associated with severely declined dentate neurogenesis in the adult hippocampus","volume":"17","author":"Hattiangady","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0075","doi-asserted-by":"crossref","first-page":"8926","DOI":"10.1523\/JNEUROSCI.5161-12.2013","article-title":"Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity","volume":"33","author":"Hester","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0080","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nn1847","article-title":"Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus","volume":"10","author":"Kee","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.expneurol.2015.09.007_bb9000","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/hipo.450050302","article-title":"Spontaneous and synaptic input from granule cells and the perforant path to dentate basket cells in the rat hippocampus","volume":"5","author":"Kneisler","year":"1995","journal-title":"Hippocampus"},{"key":"10.1016\/j.expneurol.2015.09.007_bb0085","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1111\/j.1460-9568.2005.04386.x","article-title":"Disruption of the neurogenic potential of the dentate gyrus in a mouse model of temporal lobe epilepsy with focal seizures","volume":"22","author":"Kralic","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0095","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1111\/j.1471-4159.2006.04272.x","article-title":"CCR7, CCR8, CCR9 and CCR10 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus","volume":"100","author":"Liu","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0100","first-page":"e17562","article-title":"Novel control by the CA3 region of the hippocampus on neurogenesis in the dentate gyrus of the adult rat","volume":"63","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2015.09.007_bb0090","article-title":"Gadd45b mediates axonal plasticity and subsequent functional recovery after experimental stroke in rats","author":"Liu","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0110","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/jnr.20731","article-title":"Reorganization of CA3 area of the mouse hippocampus after pilocarpine induced temporal lobe epilepsy with special reference to the CA3-septum pathway","volume":"83","author":"Ma","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0105","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1166859","article-title":"Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis","volume":"323","author":"Ma","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2015.09.007_bb0115","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/876712","article-title":"Modulation of c-Fos and BDNF protein expression in pentylenetetrazole-kindled mice following the treatment with novel antiepileptic compound HHL-6","author":"Malhi","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0125","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00702-009-0207-z","article-title":"The FGF-2\/FGFRs neurotrophic system promotes neurogenesis in the adult brain","volume":"116","author":"Mud\u00f2","year":"2009","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0130","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1523\/JNEUROSCI.2728-10.2011","article-title":"Heterogeneous integration of adult-generated granule cells into the epileptic brain","volume":"31","author":"Murphy","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0135","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1535-7511.2009.01332.x","article-title":"Waiting for Gadd45b","volume":"9","author":"Parent","year":"2009","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0140","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1523\/JNEUROSCI.17-10-03727.1997","article-title":"Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus","volume":"17","author":"Parent","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0145","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1471-4159.2003.01979.x","article-title":"Hippocampal neurotrophin levels in a kainate model of temporal lobe epilepsy: a lack of correlation between brain-derived neurotrophic factor content and progression of aberrant dentate mossy fiber sprouting","volume":"87","author":"Shetty","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0150","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/4151030a","article-title":"Functional neurogenesis in the adult hippocampus","volume":"415","author":"van Praag","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2015.09.007_bb0155","doi-asserted-by":"crossref","first-page":"15567","DOI":"10.1523\/JNEUROSCI.1845-13.2013","article-title":"The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365\/367 in the GABA(A)-receptor \u03b32 subunit","volume":"33","author":"Vithlani","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0160","doi-asserted-by":"crossref","first-page":"7541","DOI":"10.1523\/JNEUROSCI.0431-07.2007","article-title":"Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells","volume":"27","author":"Walter","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0170","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nrn3028","article-title":"Adult neurogenesis: uncoupling the roles of VEGF","volume":"12","author":"Welberg","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0175","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1600-079X.2011.00912.x","article-title":"Melatonin improves D-galactose-induced aging effects on behavior, neurogenesis, and lipid peroxidation in the mouse dentate gyrus via increasing pCREB expression","volume":"52","author":"Yoo","year":"2012","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0180","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s10571-010-9536-6","article-title":"Wnt3a promotes hippocampal neurogenesis by shortening cell cycle duration of neural progenitor cells","volume":"30","author":"Yoshinaga","year":"2010","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.expneurol.2015.09.007_bb0185","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/jnr.21941","article-title":"Patterns of hippocampal neuronal loss and axon reorganization of the dentate gyrus in the mouse pilocarpine model of temporal lobe epilepsy","volume":"87","author":"Zhang","year":"2009","journal-title":"J. Neurosci. Res."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488615300893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488615300893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T04:59:37Z","timestamp":1718081977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488615300893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":36,"alternative-id":["S0014488615300893"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2015.09.007","relation":{},"ISSN":["0014-4886"],"issn-type":[{"type":"print","value":"0014-4886"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Newly generated neurons at 2 months post-status epilepticus are functionally integrated into neuronal circuitry in mouse hippocampus","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2015.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}