{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:19:07Z","timestamp":1790835547879,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T00:00:00Z","timestamp":1486166400000},"content-version":"am","delay-in-days":340,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100013899","name":"M.S.I. Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS091540"],"award-info":[{"award-number":["R01NS091540"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000971","name":"Amyotrophic Lateral Sclerosis Association","doi-asserted-by":"publisher","award":["J10IZ9"],"award-info":[{"award-number":["J10IZ9"]}],"id":[{"id":"10.13039\/100000971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000971","name":"Amyotrophic Lateral Sclerosis Association","doi-asserted-by":"publisher","award":["15-IIP-201"],"award-info":[{"award-number":["15-IIP-201"]}],"id":[{"id":"10.13039\/100000971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011089","name":"University of Wisconsin Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.expneurol.2016.01.008","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T10:17:18Z","timestamp":1452766638000},"page":"275-282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"special_numbering":"C","title":["Macrophage-mediated inflammation and glial response in the skeletal muscle of a rat model of familial amyotrophic lateral sclerosis (ALS)"],"prefix":"10.1016","volume":"277","author":[{"given":"Jonathan M.","family":"Van Dyke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy M.","family":"Smit-Oistad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Macrander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Krakora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2016.01.008_bb0005","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.bbadis.2014.08.010","article-title":"Sporadic and hereditary amyotrophic lateral sclerosis (ALS)","volume":"1852","author":"Ajroud-Driss","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0010","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/neu.480250804","article-title":"Differential neural regulation of a neuromuscular junction-associated antigen in muscle fibers and Schwann cells","volume":"25","author":"Astrow","year":"1994","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0015","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nature02544","article-title":"VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model","volume":"429","author":"Azzouz","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0020","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.freeradbiomed.2009.11.018","article-title":"Oxidative stress in ALS: key role in motor neuron injury and therapeutic target","volume":"48","author":"Barber","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0025","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.bbi.2010.12.008","article-title":"Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice","volume":"25","author":"Beers","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0030","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00401-013-1125-6","article-title":"Protein aggregation in amyotrophic lateral sclerosis","volume":"125","author":"Blokhuis","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0035","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2174\/187152710791292576","article-title":"Amyotrophic lateral sclerosis and excitotoxicity: from pathological mechanism to therapeutic target","volume":"9","author":"Bogaert","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0040","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1123511","article-title":"Onset and progression in inherited ALS determined by motor neurons and microglia","volume":"312","author":"Boillee","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0045","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF01986686","article-title":"Biological effects of cyclosporin A: a new antilymphocytic agent. 1976","volume":"43","author":"Borel","year":"1994","journal-title":"Agents Actions"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0050","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0306-4522(02)00291-9","article-title":"In vivo proliferation, migration and phenotypic changes of Schwann cells in the presence of myelinated fibers","volume":"115","author":"Cheng","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0055","doi-asserted-by":"crossref","first-page":"20960","DOI":"10.1073\/pnas.0911405106","article-title":"Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice","volume":"106","author":"Chiu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0060","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2174\/156652412800619950","article-title":"Immunosuppressive properties of mesenchymal stem cells: advances and applications","volume":"12","author":"De Miguel","year":"2012","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017910","article-title":"In vivo imaging reveals distinct inflammatory activity of CNS microglia versus PNS macrophages in a mouse model for ALS","volume":"6","author":"Dibaj","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0070","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1365-2990.2011.01166.x","article-title":"Review: the role of mitochondria in the pathogenesis of amyotrophic lateral sclerosis","volume":"37","author":"Duffy","year":"2011","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0075","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.coph.2009.03.007","article-title":"Neuromuscular junction destruction during amyotrophic lateral sclerosis: insights from transgenic models","volume":"9","author":"Dupuis","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0080","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mcn.2012.10.008","article-title":"Inflammation and neurovascular changes in amyotrophic lateral sclerosis","volume":"53","author":"Evans","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0085","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1196\/annals.1405.016","article-title":"The role of glial cells in the formation and maintenance of the neuromuscular junction","volume":"1132","author":"Feng","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0090","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","article-title":"Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man","volume":"185","author":"Fischer","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0095","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1742-2094-7-8","article-title":"Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis","volume":"7","author":"Graber","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0100","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","article-title":"Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation","volume":"264","author":"Gurney","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0105","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/(SICI)1098-1136(199807)23:3<249::AID-GLIA7>3.0.CO;2-#","article-title":"Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS","volume":"23","author":"Hall","year":"1998","journal-title":"Glia"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0110","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3109\/17482968.2012.654393","article-title":"Gonadectomy and dehydroepiandrosterone (DHEA) do not modulate disease progression in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis","volume":"13","author":"Hayes-Punzo","year":"2012","journal-title":"Amyotroph. Lateral Scler."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0115","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1113\/jphysiol.2007.149286","article-title":"Preferential motor unit loss in the SOD1 G93A transgenic mouse model of amyotrophic lateral sclerosis","volume":"586","author":"Hegedus","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0120","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.7973664","article-title":"GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle","volume":"266","author":"Henderson","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0125","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1182\/blood.V81.6.1607.1607","article-title":"Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins","volume":"81","author":"Holness","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0130","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1073\/pnas.032539299","article-title":"Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)","volume":"99","author":"Howland","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0135","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.1523\/JNEUROSCI.0621-07.2007","article-title":"Regulation of the intermediate filament protein nestin at rodent neuromuscular junctions by innervation and activity","volume":"27","author":"Kang","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0140","doi-asserted-by":"crossref","first-page":"6323","DOI":"10.1523\/JNEUROSCI.4673-13.2014","article-title":"Terminal Schwann cells participate in neuromuscular synapse remodeling during reinnervation following nerve injury","volume":"34","author":"Kang","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0145","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1126\/science.1086137","article-title":"Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model","volume":"301","author":"Kaspar","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0150","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/glia.20836","article-title":"Live imaging of amyotrophic lateral sclerosis pathogenesis: disease onset is characterized by marked induction of GFAP in Schwann cells","volume":"57","author":"Keller","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0155","doi-asserted-by":"crossref","first-page":"379657","DOI":"10.1155\/2012\/379657","article-title":"Neuromuscular junction protection for the potential treatment of amyotrophic lateral sclerosis","volume":"2012","author":"Krakora","year":"2012","journal-title":"Neurol. Res. Int."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0160","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1038\/mt.2013.108","article-title":"Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model","volume":"21","author":"Krakora","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0165","article-title":"Distinct changes in synaptic protein composition at neuromuscular junctions of extraocular muscles versus limb muscles of ALS donors","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0170","doi-asserted-by":"crossref","first-page":"13046","DOI":"10.1073\/pnas.1002396107","article-title":"Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis","volume":"107","author":"Meissner","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0175","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1212\/01.wnl.0000333251.36681.a5","article-title":"A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis","volume":"72","author":"Mitchell","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0180","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1089\/10430349950017536","article-title":"Intramuscular grafts of myoblasts genetically modified to secrete glial cell line-derived neurotrophic factor prevent motoneuron loss and disease progression in a mouse model of familial amyotrophic lateral sclerosis","volume":"10","author":"Mohajeri","year":"1999","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0185","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fnins.2014.00252","article-title":"ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease","volume":"8","author":"Moloney","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0190","doi-asserted-by":"crossref","first-page":"9246","DOI":"10.1523\/JNEUROSCI.21-23-09246.2001","article-title":"Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease","volume":"21","author":"Nagai","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0195","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.nbd.2013.11.009","article-title":"Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats","volume":"69","author":"Nikodemova","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0200","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/mus.21323","article-title":"Glial fibrillary acidic protein as a marker of axonal damage in chronic neuropathies","volume":"40","author":"Notturno","year":"2009","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0205","doi-asserted-by":"crossref","first-page":"861231","DOI":"10.1155\/2014\/861231","article-title":"Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity","volume":"2014","author":"Olmos","year":"2014","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0210","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1172\/JCI71601","article-title":"Emerging mechanisms of molecular pathology in ALS","volume":"125","author":"Peters","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0215","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1474-4422(11)70015-1","article-title":"Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease","volume":"10","author":"Philips","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0220","first-page":"5.67.1","article-title":"Rodent Models of Amyotrophic Lateral Sclerosis","volume":"69","author":"Philips","year":"2015","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0225","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/nn1653","article-title":"Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF","volume":"9","author":"Pun","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0230","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3389\/fncel.2015.00414","article-title":"The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia","volume":"9","author":"Radford","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0235","first-page":"239","article-title":"Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3","volume":"57","author":"Robinson","year":"1986","journal-title":"Immunology"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0240","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0245","doi-asserted-by":"crossref","first-page":"e689","DOI":"10.1371\/journal.pone.0000689","article-title":"GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS","volume":"2","author":"Suzuki","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2016.01.008_bb0250","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/17482960600982447","article-title":"Sexual dimorphism in disease onset and progression of a rat model of ALS","volume":"8","author":"Suzuki","year":"2007","journal-title":"Amyotroph. Lateral Scler."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0255","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1038\/mt.2008.197","article-title":"Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS","volume":"16","author":"Suzuki","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0260","first-page":"61","article-title":"Trophic factors as modulators of motor neuron physiology and survival: implications for ALS therapy","volume":"8","author":"Tovar","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0265","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.nbd.2008.05.016","article-title":"Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis","volume":"31","author":"Vercelli","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2016.01.008_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.tins.2015.04.003","article-title":"Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker","author":"Yang","year":"2015","journal-title":"Trends Neurosci."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488616300061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488616300061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:48:43Z","timestamp":1762148923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488616300061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":54,"alternative-id":["S0014488616300061"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2016.01.008","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macrophage-mediated inflammation and glial response in the skeletal muscle of a rat model of familial amyotrophic lateral sclerosis (ALS)","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2016.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}