{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:28:44Z","timestamp":1789010924648,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,3,18]],"date-time":"2017-03-18T00:00:00Z","timestamp":1489795200000},"content-version":"am","delay-in-days":321,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005890","name":"Ministry of Health of the People's Republic of China","doi-asserted-by":"publisher","award":["1311200003303"],"award-info":[{"award-number":["1311200003303"]}],"id":[{"id":"10.13039\/501100005890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010878","name":"State Administration for Science, Technology and Industry for National Defense","doi-asserted-by":"publisher","award":["2012BAI04B04"],"award-info":[{"award-number":["2012BAI04B04"]}],"id":[{"id":"10.13039\/501100010878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012336","name":"Major State Basic Research Development Program of China","doi-asserted-by":"publisher","award":["2013CB967404"],"award-info":[{"award-number":["2013CB967404"]}],"id":[{"id":"10.13039\/501100012336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["313037"],"award-info":[{"award-number":["313037"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["IRT0935"],"award-info":[{"award-number":["IRT0935"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270724"],"award-info":[{"award-number":["81270724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330016"],"award-info":[{"award-number":["81330016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.expneurol.2016.03.011","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T11:46:03Z","timestamp":1457783163000},"page":"223-231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["MLKL inhibition attenuates hypoxia-ischemia induced neuronal damage in developing brain"],"prefix":"10.1016","volume":"279","author":[{"given":"Yi","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhi","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2016.03.011_bb0005","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ncb2883","article-title":"Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis","volume":"16","author":"Cai","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.expneurol.2016.03.011_bb0010","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/01.STR.32.4.1005","article-title":"Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2016.03.011_bb0015","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/cr.2013.171","article-title":"Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death","volume":"24","author":"Chen","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.expneurol.2016.03.011_bb0020","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2009.05.037","article-title":"Phosphorylation-driven assembly of the RIP1\u2013RIP3 complex regulates programmed necrosis and virus-induced inflammation","volume":"137","author":"Cho","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2016.03.011_bb0025","doi-asserted-by":"crossref","first-page":"149","DOI":"10.5607\/en.2013.22.3.149","article-title":"Physiological and pathological significance of dynamin-related protein 1 (drp1)-dependent mitochondrial fission in the nervous system","volume":"22","author":"Cho","year":"2013","journal-title":"Experimental Neurobiology"},{"key":"10.1016\/j.expneurol.2016.03.011_bb0030","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/sj.embor.7401062","article-title":"Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death","volume":"8","author":"Cribbs","year":"2007","journal-title":"EMBO Rep."},{"key":"10.1016\/j.expneurol.2016.03.011_bb0035","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.expneurol.2016.03.011_bb0040","doi-asserted-by":"crossref","first-page":"36179","DOI":"10.1074\/jbc.M114.557009","article-title":"Wnt-5a ligand modulates mitochondrial fission-fusion in rat hippocampal neurons","volume":"289","author":"Godoy","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2016.03.011_bb0045","doi-asserted-by":"crossref","first-page":"20054","DOI":"10.1073\/pnas.1116302108","article-title":"Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway","volume":"108","author":"He","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2016.03.011_bb0050","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/sj.jcbfm.9600012","article-title":"S-nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke","volume":"25","author":"Khan","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2016.03.011_bb0055","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000069304","article-title":"Local anesthetics induce human renal cell apoptosis","volume":"23","author":"Lee","year":"2003","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.expneurol.2016.03.011_bb0060","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cell.2012.06.019","article-title":"The RIP1\/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis","volume":"150","author":"Li","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2016.03.011_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2008.12.028","article-title":"TTC, fluoro-jade B and NeuN staining confirm evolving phases of infarction induced by middle cerebral artery occlusion","volume":"179","author":"Liu","year":"2009","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.expneurol.2016.03.011_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.69","article-title":"Akt and mTOR mediate programmed necrosis in neurons","volume":"5","author":"Liu","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.expneurol.2016.03.011_bb0075","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000343360","article-title":"Acetylcholine attenuates hypoxia\/reoxygenation-induced mitochondrial and cytosolic ROS formation in H9c2 cells via M2 acetylcholine receptor","volume":"31","author":"Miao","year":"2013","journal-title":"Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"key":"10.1016\/j.expneurol.2016.03.011_bb0080","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/jcbfm.2010.72","article-title":"Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI","volume":"31","author":"Northington","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2016.03.011_bb0085","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1161\/STROKEAHA.109.553644","article-title":"Proapoptotic role of human growth and transformation-dependent protein in the developing rat brain after hypoxia-ischemia","volume":"40","author":"Qu","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2016.03.011_bb0090","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2016.03.011_bb0095","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/jcbfm.1990.47","article-title":"A semiautomated method for measuring brain infarct volume","volume":"10","author":"Swanson","year":"1990","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2016.03.011_bb0100","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nbd.2014.04.002","article-title":"Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3","volume":"68","author":"Vieira","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2016.03.011_bb0105","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cell.2011.11.030","article-title":"The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways","volume":"148","author":"Wang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2016.03.011_bb0110","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molcel.2014.03.003","article-title":"Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3","volume":"54","author":"Wang","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.expneurol.2016.03.011_bb0115","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.intimp.2012.08.003","article-title":"RIP1-mediated mitochondrial dysfunction and ROS production contributed to tumor necrosis factor alpha-induced L929 cell necroptosis and autophagy","volume":"14","author":"Ye","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.expneurol.2016.03.011_bb0120","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1126\/science.1172308","article-title":"RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis","volume":"325","author":"Zhang","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2016.03.011_bb0125","doi-asserted-by":"crossref","first-page":"24742","DOI":"10.3390\/ijms141224742","article-title":"Necrostatin-1 attenuates ischemia injury induced cell death in rat tubular cell line NRK-52E through decreased Drp1 expression","volume":"14","author":"Zhang","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.expneurol.2016.03.011_bb0130","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1471-4159.2005.03639.x","article-title":"Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia","volume":"96","author":"Zhu","year":"2006","journal-title":"J. Neurochem."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488616300541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488616300541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:47:52Z","timestamp":1762148872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488616300541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":26,"alternative-id":["S0014488616300541"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2016.03.011","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MLKL inhibition attenuates hypoxia-ischemia induced neuronal damage in developing brain","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2016.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}