{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:05:28Z","timestamp":1793135128118,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:00:00Z","timestamp":1491350400000},"content-version":"am","delay-in-days":308,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000182","name":"Department of Defense (USAMRMC)","doi-asserted-by":"publisher","award":["W81XWH-11-1-0502"],"award-info":[{"award-number":["W81XWH-11-1-0502"]}],"id":[{"id":"10.13039\/100000182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS088608"],"award-info":[{"award-number":["NS088608"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.expneurol.2016.03.022","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T23:46:49Z","timestamp":1458863209000},"page":"30-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Differential effects of rapamycin treatment on tonic and phasic GABAergic inhibition in dentate granule cells after focal brain injury in mice"],"prefix":"10.1016","volume":"280","author":[{"given":"Corwin R.","family":"Butler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery A.","family":"Boychuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bret N.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2016.03.022_bb0005","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.expneurol.2004.11.025","article-title":"Regional distribution of fluoro-jade B staining in the hippocampus following traumatic brain injury","volume":"193","author":"Anderson","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0010","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJM199801013380104","article-title":"A population-based study of seizures after traumatic brain injuries","volume":"338","author":"Annegers","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2016.01.005","article-title":"Enduring changes in tonic GABAA receptor signaling in dentate granule cells after controlled cortical impact brain injury in mice","author":"Boychuk","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0020","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/sj.bjp.0704795","article-title":"Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors","volume":"136","author":"Brown","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0025","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1523\/JNEUROSCI.4852-10.2011","article-title":"Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy","volume":"31","author":"Buckmaster","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0030","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0920-1211(94)90030-2","article-title":"Hyperexcitability in the dentate gyrus of the epileptic Mongolian gerbil","volume":"18","author":"Buckmaster","year":"1994","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0035","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1111\/j.1528-1167.2011.03253.x","article-title":"Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy","volume":"52","author":"Buckmaster","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2016.03.022_bb0040","doi-asserted-by":"crossref","first-page":"8259","DOI":"10.1523\/JNEUROSCI.4179-08.2009","article-title":"Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy","volume":"29","author":"Buckmaster","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0045","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fnsys.2015.00163","article-title":"Effects of rapamycin treatment on neurogenesis and synaptic reorganization in the dentate gyrus after controlled cortical impact injury in mice","volume":"9","author":"Butler","year":"2015","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0050","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3171\/jns.1979.50.5.0545","article-title":"The nature of posttraumatic epilepsy","volume":"50","author":"Caveness","year":"1979","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0055","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0079-6123(07)63014-3","article-title":"Functional regulation of the dentate gyrus by GABA-mediated inhibition","volume":"163","author":"Coulter","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0060","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1001\/archneur.57.11.1611","article-title":"Neurophysiologic and neuroradiologic features of intractable epilepsy after traumatic brain injury in adults","volume":"57","author":"Diaz-Arrastia","year":"2000","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0065","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0026-895X(25)09839-6","article-title":"Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations","volume":"46","author":"Ebert","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0070","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1053\/apmr.2003.50022","article-title":"Analyzing risk factors for late posttraumatic seizures: a prospective, multicenter investigation","volume":"84","author":"Englander","year":"2003","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0075","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1113\/jphysiol.2007.134460","article-title":"The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus","volume":"582","author":"Glykys","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0080","article-title":"Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury","volume":"8","author":"Guo","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2016.03.022_bb0085","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1523\/JNEUROSCI.4141-11.2012","article-title":"Decrease in tonic inhibition contributes to increase in dentate semilunar granule cell excitability after brain injury","volume":"32","author":"Gupta","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0090","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1152\/jn.00147.2010","article-title":"Excitatory input onto hilar somatostatin interneurons is increased in a chronic model of epilepsy","volume":"104","author":"Halabisky","year":"2010","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0095","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1089\/neu.2005.22.669","article-title":"Lack of a gender difference in post-traumatic neurodegeneration in the mouse controlled cortical impact injury model","volume":"22","author":"Hall","year":"2005","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2016.03.022_bb0100","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1089\/neu.2005.22.252","article-title":"Spatial and temporal characteristics of neurodegeneration after controlled cortical impact in mice: more than a focal brain injury","volume":"22","author":"Hall","year":"2005","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2016.03.022_bb0105","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neuroscience.2015.08.023","article-title":"Molecular and functional changes in glucokinase expression in the brainstem dorsal vagal complex in a murine model of type 1 diabetes","volume":"306","author":"Halmos","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2016.03.022_bb0110","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1111\/epi.12246","article-title":"High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy","volume":"54","author":"Heng","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2016.03.022_bb0115","doi-asserted-by":"crossref","first-page":"8926","DOI":"10.1523\/JNEUROSCI.5161-12.2013","article-title":"Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity","volume":"33","author":"Hester","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0120","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/neu.1993.10.405","article-title":"Mild experimental brain injury in the rat induces cognitive deficits associated with regional neuronal loss in the hippocampus","volume":"10","author":"Hicks","year":"1993","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2016.03.022_bb0125","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/00001199-200407000-00003","article-title":"Evaluation of seizure-like episodes in survivors of moderate and severe traumatic brain injury","volume":"19","author":"Hudak","year":"2004","journal-title":"J. Head Trauma Rehabil."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0130","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.expneurol.2008.10.005","article-title":"Posttraumatic epilepsy after controlled cortical impact injury in mice","volume":"215","author":"Hunt","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0135","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1152\/jn.00957.2009","article-title":"Regionally localized recurrent excitation in the dentate gyrus of a cortical contusion model of posttraumatic epilepsy","volume":"103","author":"Hunt","year":"2010","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0140","doi-asserted-by":"crossref","first-page":"6880","DOI":"10.1523\/JNEUROSCI.0032-11.2011","article-title":"Synaptic reorganization of inhibitory hilar interneuron circuitry after traumatic brain injury in mice","volume":"31","author":"Hunt","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0145","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.eplepsyres.2011.10.011","article-title":"Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains","volume":"99","author":"Hunt","year":"2012","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2014.12.029","article-title":"PTEN deletion from adult-generated dentate granule cells disrupts granule cell mossy fiber axon structure","author":"LaSarge","year":"2015","journal-title":"Neurobiol. Dis"},{"key":"10.1016\/j.expneurol.2016.03.022_bb0155","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1523\/JNEUROSCI.12-12-04846.1992","article-title":"Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus","volume":"12","author":"Lowenstein","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0160","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.tins.2004.07.002","article-title":"Diversity of inhibitory neurotransmission through GABA(A) receptors","volume":"27","author":"Mody","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0165","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.nbd.2010.03.012","article-title":"Increase of GABA A receptor-mediated tonic inhibition in dentate granule cells after traumatic brain injury","volume":"38","author":"Mtchedlishvili","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0170","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1089\/neu.1997.14.369","article-title":"Immunohistochemical study of calpain-mediated breakdown products to \u03b1-spectrin following controlled cortical impact injury in the rat","volume":"14","author":"Newcomb","year":"1997","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2016.03.022_bb0175","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1523\/JNEUROSCI.20-09-03354.2000","article-title":"Novel hippocampal interneuronal subtypes identified using transgenic mice that express green fluorescent protein in GABAergic interneurons","volume":"20","author":"Oliva","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0180","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1158\/0008-5472.CAN-05-2925","article-title":"mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt","volume":"66","author":"O'Reilly","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0185","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuroscience.2011.07.074","article-title":"Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats","volume":"194","author":"Pavlov","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2016.03.022_bb0190","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1089\/neu.2012.2483","article-title":"GABAa receptor regulation after experimental traumatic brain injury","volume":"29","author":"Raible","year":"2012","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2016.03.022_bb0195","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.expneurol.2015.07.001","article-title":"JAK\/STAT pathway regulation of GABA A receptor expression after differing severities of experimental TBI","volume":"271","author":"Raible","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0200","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1089\/neu.2006.23.1241","article-title":"Differential behavioral and histopathological responses to graded cortical impact injury in mice","volume":"23","author":"Saatman","year":"2006","journal-title":"J. Neurotrauma"},{"issue":"Pt 1","key":"10.1016\/j.expneurol.2016.03.022_bb0205","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1469-7793.2000.00117.x","article-title":"Granule cell hyperexcitability in the early post-traumatic rat dentate gyrus: the \u2018irritable mossy cell\u2019 hypothesis","volume":"524","author":"Santhakumar","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0210","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1200\/JCO.2007.14.5482","article-title":"Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors","volume":"26","author":"Tabernero","year":"2008","journal-title":"J. Clin. Oncol."},{"issue":"Suppl. 2","key":"10.1016\/j.expneurol.2016.03.022_bb0215","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1528-1167.2008.02005.x","article-title":"Preventing and treating posttraumatic seizures: the human experience","volume":"50","author":"Temkin","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2016.03.022_bb0220","first-page":"179","article-title":"Clinical trials for seizure prevention","volume":"76","author":"Temkin","year":"1998","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0225","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.2165\/00003495-200161080-00002","article-title":"Antiepileptogenic agents: how close are we?","volume":"61","author":"Temkin","year":"2001","journal-title":"Drugs"},{"key":"10.1016\/j.expneurol.2016.03.022_bb0230","doi-asserted-by":"crossref","first-page":"8106","DOI":"10.1523\/JNEUROSCI.17-21-08106.1997","article-title":"Instantaneous perturbation of dentate interneuronal networks by a pressure wave-transient delivered to the neocortex","volume":"17","author":"Toth","year":"1997","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0235","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0896-6273(03)00356-8","article-title":"Control of synaptic strength, a novel function of Akt","volume":"38","author":"Wang","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.expneurol.2016.03.022_bb0240","doi-asserted-by":"crossref","first-page":"11441","DOI":"10.1523\/JNEUROSCI.1283-12.2012","article-title":"Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission","volume":"32","author":"Weston","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0245","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.eplepsyres.2004.01.002","article-title":"Recurrent excitation in the dentate gyrus of a murine model of temporal lobe epilepsy","volume":"58","author":"Winokur","year":"2004","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0250","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.1523\/JNEUROSCI.16-14-04438.1996","article-title":"Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rats","volume":"16","author":"Wuarin","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0255","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ana.21331","article-title":"Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex","volume":"63","author":"Zeng","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2016.03.022_bb0260","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1523\/JNEUROSCI.0066-09.2009","article-title":"The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy","volume":"29","author":"Zeng","year":"2009","journal-title":"J. Neurosci."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488616300644?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488616300644?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:48:45Z","timestamp":1758001725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488616300644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":52,"alternative-id":["S0014488616300644"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2016.03.022","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential effects of rapamycin treatment on tonic and phasic GABAergic inhibition in dentate granule cells after focal brain injury in mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2016.03.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}