{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:53:46Z","timestamp":1790708026389,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["SFRH\/BPD\/108468\/2015"],"award-info":[{"award-number":["SFRH\/BPD\/108468\/2015"]}]},{"name":"International PhD Programme in Neurosciences","award":["NORTE-08-5369-FSC-000026"],"award-info":[{"award-number":["NORTE-08-5369-FSC-000026"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.expneurol.2016.05.029","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T17:22:24Z","timestamp":1464283344000},"page":"159-166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"PB","title":["Impairment of sensory afferents by intrathecal administration of botulinum toxin A improves neurogenic detrusor overactivity in chronic spinal cord injured rats"],"prefix":"10.1016","volume":"285","author":[{"given":"Ana","family":"Coelho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia Duarte","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2016.05.029_bb0005","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1523\/JNEUROSCI.0375-08.2008","article-title":"Long-distance retrograde effects of botulinum neurotoxin A","volume":"28","author":"Antonucci","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0010","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/ncpuro1124","article-title":"Drug insight: biological effects of botulinum toxin A in the lower urinary tract","volume":"5","author":"Chancellor","year":"2008","journal-title":"Nat. Clin. Pract. Urol."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0015","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1128\/MCB.16.3.1157","article-title":"Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153\/Chop10","volume":"16","author":"Chen","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0020","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0006-8993(95)00212-9","article-title":"Effect of capsaicin on micturition and associated reflexes in chronic spinal rats","volume":"678","author":"Cheng","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0025","first-page":"R786","article-title":"Effect of capsaicin on the micturition reflex in normal and chronic spinal cord-injured cats","volume":"277","author":"Cheng","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0030","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.eururo.2009.12.022","article-title":"Distribution of the high-affinity binding site and intracellular target of botulinum toxin type A in the human bladder","volume":"57","author":"Coelho","year":"2010","journal-title":"Eur. Urol."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0035","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.juro.2011.10.130","article-title":"Effect of onabotulinumtoxinA on intramural parasympathetic ganglia: an experimental study in the guinea pig bladder","volume":"187","author":"Coelho","year":"2012","journal-title":"J. Urol."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0040","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.eururo.2012.01.046","article-title":"Spread of onabotulinumtoxinA after bladder injection. Experimental study using the distribution of cleaved SNAP-25 as the marker of the toxin action","volume":"61","author":"Coelho","year":"2012","journal-title":"Eur. Urol."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0050","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1002\/ejp.513","article-title":"Intrathecal administration of botulinum toxin type A improves urinary bladder function and reduces pain in rats with cystitis","volume":"18","author":"Coelho","year":"2014","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.expneurol.2016.05.029_bb0055","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1682\/JRRD.2011.11.0213","article-title":"Functional priorities, assistive technology, and brain-computer interfaces after spinal cord injury","volume":"50","author":"Collinger","year":"2013","journal-title":"J. Rehabil. Res. Dev."},{"issue":"Suppl. 3","key":"10.1016\/j.expneurol.2016.05.029_bb0060","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1002\/nau.22630","article-title":"Chapter 5: clinical data in neurogenic detrusor overactivity (NDO) and overactive bladder (OAB)","volume":"33","author":"Cruz","year":"2014","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0065","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0140-6736(05)63330-2","article-title":"Suppression of bladder hyperreflexia by intravesical resiniferatoxin","volume":"350","author":"Cruz","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.expneurol.2016.05.029_bb0070","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.expneurol.2006.01.016","article-title":"Spinal ERK activation contributes to the regulation of bladder function in spinal cord injured rats","volume":"200","author":"Cruz","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0075","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.eururo.2011.07.002","article-title":"Efficacy and safety of onabotulinumtoxinA in patients with urinary incontinence due to neurogenic detrusor overactivity: a randomised, double-blind, placebo-controlled trial","volume":"60","author":"Cruz","year":"2011","journal-title":"Eur. Urol."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0080","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/0165-1838(90)90105-R","article-title":"Mechanisms underlying the recovery of urinary bladder function following spinal cord injury","volume":"30","author":"de Groat","year":"1990","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0085","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1136\/jnnp.57.2.169","article-title":"Intravesical capsaicin for treatment of detrusor hyperreflexia","volume":"57","author":"Fowler","year":"1994","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.expneurol.2016.05.029_bb0090","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1525-1403.2009.00252.x","article-title":"What do spinal cord injury consumers want? A review of spinal cord injury consumer priorities and neuroprosthesis from the 2008 Neural Interfaces Conference","volume":"13","author":"French","year":"2010","journal-title":"Neuromodulation"},{"key":"10.1016\/j.expneurol.2016.05.029_bb0095","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1523\/JNEUROSCI.0373-14.2015","article-title":"The role of brain-derived neurotrophic factor (BDNF) in the development of neurogenic detrusor overactivity (NDO)","volume":"35","author":"Frias","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0100","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.juro.2012.01.125","article-title":"Phase 3 efficacy and tolerability study of onabotulinumtoxinA for urinary incontinence from neurogenic detrusor overactivity","volume":"187","author":"Ginsberg","year":"2012","journal-title":"J. Urol."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0105","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s12325-013-0054-z","article-title":"OnabotulinumtoxinA is effective in patients with urinary incontinence due to neurogenic detrusor overactivity [corrected] regardless of concomitant anticholinergic use or neurologic etiology","volume":"30","author":"Ginsberg","year":"2013","journal-title":"Adv. Ther."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0110","first-page":"321","article-title":"ATF3 and stress responses","volume":"7","author":"Hai","year":"1999","journal-title":"Gene Expr."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0115","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1152\/jn.1985.53.4.1059","article-title":"Visceral and somatic afferent convergence onto neurons near the central canal in the sacral spinal cord of the cat","volume":"53","author":"Honda","year":"1985","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0830","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1460-9568.2005.04530.x","article-title":"Spinal cord compression and dorsal root injury cause up-regulation of activating transcription factor-3 in large-diameter dorsal root ganglion neurons","volume":"23","author":"Huang","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0120","article-title":"Efficacy and safety of onabotulinumtoxinA therapy are sustained over 4years of treatment in patients with neurogenic detrusor overactivity: final results of a long-term extension study","author":"Kennelly","year":"2015","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2011.00030","article-title":"Activating transcription factor 3, a useful marker for regenerative response after nerve root injury","volume":"2","author":"Linda","year":"2011","journal-title":"Front Neurol."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0125","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/sc.2012.158","article-title":"The global map for traumatic spinal cord injury epidemiology: update 2011, global incidence rate","volume":"52","author":"Lee","year":"2014","journal-title":"Spinal Cord"},{"key":"10.1016\/j.expneurol.2016.05.029_bb0130","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.tox.2015.07.003","article-title":"Botulinum neurotoxin type A: actions beyond SNAP-25?","volume":"335","author":"Matak","year":"2015","journal-title":"Toxicology"},{"key":"10.1016\/j.expneurol.2016.05.029_bb0135","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/cne.902010308","article-title":"The distribution of visceral primary afferents from the pelvic nerve to Lissauer's tract and the spinal gray matter and its relationship to the sacral parasympathetic nucleus","volume":"201","author":"Morgan","year":"1981","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0140","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/cne.902260207","article-title":"The location and morphology of preganglionic neurons and the distribution of visceral afferents from the rat pelvic nerve: a horseradish peroxidase study","volume":"226","author":"Nadelhaft","year":"1984","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0145","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000330195","article-title":"Neuronal injury marker ATF-3 is induced in primary afferent neurons of monoarthritic rats","volume":"19","author":"Nascimento","year":"2011","journal-title":"Neurosignals"},{"key":"10.1016\/j.expneurol.2016.05.029_bb0150","article-title":"Expression of cleaved SNAP-25 after bladder wall injection of onabotulinumtoxinA or abobotulinumtoxinA: a comparative study in the mice","author":"Oliveira","year":"2015","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0155","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.expneurol.2016.05.029_bb0160","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1056\/NEJM200003023420918","article-title":"Treatment of neurogenic incontinence with botulinum toxin A","volume":"342","author":"Schurch","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0165","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1089\/neu.2011.2226","article-title":"The health and life priorities of individuals with spinal cord injury: a systematic review","volume":"29","author":"Simpson","year":"2012","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2016.05.029_bb0170","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1006\/mcne.1999.0814","article-title":"Activating transcription factor 3 (ATF3) induction by axotomy in sensory and motoneurons: a novel neuronal marker of nerve injury","volume":"15","author":"Tsujino","year":"2000","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0175","first-page":"R2084","article-title":"Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury","volume":"295","author":"Zhang","year":"2008","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.expneurol.2016.05.029_bb0180","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.expneurol.2007.01.011","article-title":"Sprouting of CGRP primary afferents in lumbosacral spinal cord precedes emergence of bladder activity after spinal injury","volume":"204","author":"Zinck","year":"2007","journal-title":"Exp. Neurol."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488616301479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488616301479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T07:34:33Z","timestamp":1530862473000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488616301479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":37,"alternative-id":["S0014488616301479"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2016.05.029","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impairment of sensory afferents by intrathecal administration of botulinum toxin A improves neurogenic detrusor overactivity in chronic spinal cord injured rats","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2016.05.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}