{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:58:41Z","timestamp":1790517521626,"version":"4.1.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Investissement d'Avenir","award":["ANR-11-INBS-0011"],"award-info":[{"award-number":["ANR-11-INBS-0011"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.expneurol.2016.05.037","type":"journal-article","created":{"date-parts":[[2016,5,29]],"date-time":"2016-05-29T07:15:23Z","timestamp":1464506123000},"page":"57-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"PA","title":["Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome"],"prefix":"10.1016","volume":"283","author":[{"given":"P.","family":"Kurbatova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Wendling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kaminska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rosati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Nabbout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Guerrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Dulac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cornu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Nony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Chiron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Benquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2016.05.037_bb0005","doi-asserted-by":"crossref","first-page":"7715","DOI":"10.1523\/JNEUROSCI.4105-14.2015","article-title":"The contribution of raised intraneuronal chloride to epileptic network activity","volume":"35","author":"Alfonsa","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0010","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn2044","article-title":"Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks","volume":"8","author":"Bartos","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0015","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1152\/physrev.00017.2006","article-title":"GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations","volume":"87","author":"Ben-Ari","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0020","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1177\/1073858412438697","article-title":"The GABA excitatory\/inhibitory shift in brain maturation and neurological disorders","volume":"18","author":"Ben-Ari","year":"2012","journal-title":"Neuroscientist"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0025","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.neuron.2009.03.003","article-title":"Cation-chloride cotransporters and neuronal function","volume":"61","author":"Blaesse","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/527605","article-title":"Altered GABA signaling in early life epilepsies","volume":"2011","author":"Briggs","year":"2011","journal-title":"Neural Plast."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0035","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.yebeh.2013.09.016","article-title":"Pharmacodynamic interaction between stiripentol and benzodiazepines: from molecular to clinical studies","volume":"29","author":"Brigo","year":"2013","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0040","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1528-1167.2011.02996.x","article-title":"Electroencephalographic characteristics of Dravet syndrome: EEG characteristics of Dravet syndrome","volume":"52","author":"Bureau","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0045","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.braindev.2015.10.008","article-title":"Activity-dependent synaptic plasticity modulates the critical phase of brain development","volume":"38","author":"Chaudhury","year":"2016","journal-title":"Brain Dev."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0050","doi-asserted-by":"crossref","first-page":"14646","DOI":"10.1073\/pnas.1211591109","article-title":"Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome","volume":"109","author":"Cheah","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0055","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S0140-6736(00)03157-3","article-title":"Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group","volume":"356","author":"Chiron","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0060","doi-asserted-by":"crossref","first-page":"86","DOI":"10.5698\/1535-7597-14.2.86","article-title":"Untangling the dravet syndrome seizure network: the changing face of a rare genetic epilepsy","volume":"14","author":"Chopra","year":"2014","journal-title":"Epilepsy Curr. Am. Epilepsy Soc."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0065","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1086\/320609","article-title":"De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy","volume":"68","author":"Claes","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0070","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0920-1211(02)00010-4","article-title":"Topiramate as add-on drug in severe myoclonic epilepsy in infancy: an Italian multicenter open trial","volume":"49","author":"Coppola","year":"2002","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0075","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1016\/j.neuroimage.2011.11.045","article-title":"Recording of fast activity at the onset of partial seizures: depth EEG vs. scalp EEG","volume":"59","author":"Cosandier-Rim\u00e9l\u00e9","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0080","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1528-1167.2006.00416.x","article-title":"A brief period of epileptiform activity strengthens excitatory synapses in the rat hippocampus in vitro","volume":"47","author":"Debanne","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0085","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/B978-0-444-52891-9.00065-8","article-title":"Dravet syndrome (severe myoclonic epilepsy in infancy)","volume":"111","author":"Dravet","year":"2013","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0090","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/nm1301","article-title":"NKCC1 transporter facilitates seizures in the developing brain","volume":"11","author":"Dzhala","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0095","doi-asserted-by":"crossref","first-page":"15208","DOI":"10.1523\/JNEUROSCI.1747-14.2014","article-title":"Excitatory effects of parvalbumin-expressing interneurons maintain hippocampal epileptiform activity via synchronous afterdischarges","volume":"34","author":"Ellender","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0100","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/74159","article-title":"Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2","volume":"24","author":"Escayg","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0105","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejphar.2010.12.037","article-title":"Interactions between modulators of the GABAA receptor: stiripentol and benzodiazepines","volume":"654","author":"Fisher","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/neuro.02.005.2008","article-title":"E\/I balance and GABAA receptor plasticity","volume":"1","author":"Fritschy","year":"2008","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0115","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nn.2230","article-title":"Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis","volume":"12","author":"Glickfeld","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0120","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/ana.21519","article-title":"Fast activity at seizure onset is mediated by inhibitory circuits in the entorhinal cortex in vitro","volume":"64","author":"Gnatkovsky","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0125","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.neuroimage.2010.12.074","article-title":"Intermittent spike-wave dynamics in a heterogeneous, spatially extended neural mass model","volume":"55","author":"Goodfellow","year":"2011","journal-title":"NeuroImage"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0130","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1046\/j.1460-9568.2000.00964.x","article-title":"Cell type- and synapse-specific variability in synaptic GABAA receptor occupancy","volume":"12","author":"H\u00e1jos","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0135","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nature11356","article-title":"Autistic-like behaviour in Scn1a+\/\u2212 mice and rescue by enhanced GABA-mediated neurotransmission","volume":"489","author":"Han","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0140","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/brain\/awm002","article-title":"The spectrum of SCN1A-related infantile epileptic encephalopathies","volume":"130","author":"Harkin","year":"2007","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0145","doi-asserted-by":"crossref","first-page":"A3","DOI":"10.1097\/00001756-200201210-00002","article-title":"New concepts in neonatal seizures","volume":"13","author":"Holmes","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0150","doi-asserted-by":"crossref","first-page":"9866","DOI":"10.1523\/JNEUROSCI.2761-07.2007","article-title":"Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy","volume":"27","author":"Huberfeld","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0155","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1111\/epi.12406","article-title":"Shape features of epileptic spikes are a marker of epileptogenesis in mice","volume":"54","author":"Huneau","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0160","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.eplepsyres.2014.02.008","article-title":"Effectiveness of add-on stiripentol to clobazam and valproate in Japanese patients with Dravet syndrome: additional supportive evidence","volume":"108","author":"Inoue","year":"2014","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0165","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/hipo.20804","article-title":"Activity-dependent intracellular chloride accumulation and diffusion controls GABA(A) receptor-mediated synaptic transmission","volume":"21","author":"Jedlicka","year":"2011","journal-title":"Hippocampus"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0170","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1093\/hmg\/ddt275","article-title":"Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons","volume":"22","author":"Jiao","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0175","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1093\/brain\/awu133","article-title":"On the nature of seizure dynamics","volume":"137","author":"Jirsa","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0180","doi-asserted-by":"crossref","first-page":"766","DOI":"10.15252\/embr.201438840","article-title":"Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy","volume":"15","author":"Kahle","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0185","doi-asserted-by":"crossref","first-page":"7662","DOI":"10.1523\/JNEUROSCI.17-20-07662.1997","article-title":"Long-lasting GABA-mediated depolarization evoked by high-frequency stimulation in pyramidal neurons of rat hippocampal slice is attributable to a network-driven, bicarbonate-dependent K+ transient","volume":"17","author":"Kaila","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0190","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1523\/JNEUROSCI.5264-08.2009","article-title":"Synaptic cross talk between perisomatic-targeting interneuron classes expressing cholecystokinin and parvalbumin in hippocampus","volume":"29","author":"Karson","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0195","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1528-1167.2007.01423.x","article-title":"Severe myoclonic epilepsy in infancy: a systematic review and a meta-analysis of individual patient data","volume":"49","author":"Kassa\u00ef","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0200","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1152\/jn.00060.2003","article-title":"Use-dependent shift from inhibitory to excitatory GABAA receptor action in SP-O interneurons in the rat hippocampal CA3 area","volume":"90","author":"Lamsa","year":"2003","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0205","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nn.2806","article-title":"NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor\u2013mediated currents","volume":"14","author":"Lee","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0210","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.nbd.2012.05.016","article-title":"Pyramidal cells accumulate chloride at seizure onset","volume":"47","author":"Lillis","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0215","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2013.00110","article-title":"Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?","volume":"4","author":"Lin","year":"2013","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0220","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/ana.23897","article-title":"Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism","volume":"74","author":"Liu","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0225","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/j.1460-9568.2009.06663.x","article-title":"Rapid plasticity at inhibitory and excitatory synapses in the hippocampus induced by ictal epileptiform discharges","volume":"29","author":"Lopantsev","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0230","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.neuron.2013.10.017","article-title":"EEG and MEG: relevance to neuroscience","volume":"80","author":"Lopes da Silva","year":"2013","journal-title":"Neuron"},{"issue":"Suppl. 2","key":"10.1016\/j.expneurol.2016.05.037_bb0235","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1528-1167.2011.02997.x","article-title":"The genetics of Dravet syndrome","volume":"52","author":"Marini","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0240","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.neuroimage.2009.12.049","article-title":"Computational modeling of high-frequency oscillations at the onset of neocortical partial seizures: from \u201caltered structure\u201d to \u201cdysfunction\u201d","volume":"52","author":"Molaee-Ardekani","year":"2010","journal-title":"NeuroImage"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0245","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.eplepsyres.2008.04.015","article-title":"An unexpected EEG course in Dravet syndrome","volume":"81","author":"Nabbout","year":"2008","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0250","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1111\/j.1528-1167.2011.03107.x","article-title":"Ketogenic diet also benefits Dravet syndrome patients receiving stiripentol: a prospective pilot study","volume":"52","author":"Nabbout","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0255","series-title":"Electroencephalography: Basic Principles, Clinical Applications, and Related Fields","year":"2005"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0260","doi-asserted-by":"crossref","first-page":"9929","DOI":"10.1523\/JNEUROSCI.1714-10.2010","article-title":"Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome","volume":"30","author":"Olmos-Serrano","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0265","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrn919","article-title":"Is there more to gaba than synaptic inhibition?","volume":"3","author":"Owens","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0270","doi-asserted-by":"crossref","first-page":"8465","DOI":"10.1073\/pnas.0602979103","article-title":"Anomalous levels of Cl\u2212 transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory","volume":"103","author":"Palma","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0275","doi-asserted-by":"crossref","first-page":"14012","DOI":"10.1523\/JNEUROSCI.4390-07.2007","article-title":"Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy","volume":"27","author":"Pathak","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0280","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00702-010-0376-9","article-title":"Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down's syndrome","volume":"117","author":"P\u00e9rez-Cremades","year":"2010","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0285","doi-asserted-by":"crossref","first-page":"11356","DOI":"10.1523\/JNEUROSCI.6265-11.2012","article-title":"Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain","volume":"32","author":"Puskarjov","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0290","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/embr.201438749","article-title":"A variant of KCC2 from patients with febrile seizures impairs neuronal Cl\u2212 extrusion and dendritic spine formation","volume":"15","author":"Puskarjov","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0295","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1046\/j.1528-1157.2003.19503.x","article-title":"Effects of antiepileptic drugs on refractory seizures in the intact immature corticohippocampal formation in vitro","volume":"44","author":"Quilichini","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0300","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1528-1167.2006.00497.x","article-title":"Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABAA-receptor channels","volume":"47","author":"Quilichini","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0305","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrneurol.2009.80","article-title":"Epileptogenesis in the immature brain: emerging mechanisms","volume":"5","author":"Rakhade","year":"2009","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0310","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.tins.2005.03.010","article-title":"Trophic actions of GABA on neuronal development","volume":"28","author":"Represa","year":"2005","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0315","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1113\/jphysiol.1994.sp020050","article-title":"Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture","volume":"475","author":"Rogers","year":"1994","journal-title":"J. Physiol."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0320","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.ejpn.2012.04.007","article-title":"Diagnosis and long-term course of Dravet syndrome","volume":"16","author":"Scheffer","year":"2012","journal-title":"Eur. J. Paediatr. Neurol."},{"issue":"Pt 3","key":"10.1016\/j.expneurol.2016.05.037_bb0325","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/brain\/120.3.479","article-title":"Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes","volume":"120","author":"Scheffer","year":"1997","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0330","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S1388-2457(00)00259-5","article-title":"Brain chirps: spectrographic signatures of epileptic seizures","volume":"111","author":"Schiff","year":"2000","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0335","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/ana.24342","article-title":"Interneuron activity leads to initiation of low-voltage fast-onset seizures","volume":"77","author":"Shiri","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0340","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/0883073811419262","article-title":"Electroencephalographic features in Dravet syndrome: five-year follow-up study in 22 patients","volume":"27","author":"Specchio","year":"2012","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0345","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3940(92)90183-8","article-title":"Enhancement of the excitatory actions of GABA by barbiturates and benzodiazepines","volume":"146","author":"Staley","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0350","doi-asserted-by":"crossref","first-page":"8038","DOI":"10.1038\/ncomms9038","article-title":"Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures","volume":"6","author":"St\u00f6dberg","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0355","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/01.wnl.0000265222.24102.db","article-title":"An open-label trial of levetiracetam in severe myoclonic epilepsy of infancy","volume":"69","author":"Striano","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0360","doi-asserted-by":"crossref","first-page":"E3139","DOI":"10.1073\/pnas.1411131111","article-title":"Impaired excitability of somatostatin-and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome","volume":"111","author":"Tai","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0365","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1111\/j.1460-9568.2005.04459.x","article-title":"Slow endogenous activity transients and developmental expression of K+-Cl\u2212 cotransporter 2 in the immature human cortex","volume":"22","author":"Vanhatalo","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0370","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1517\/17425255.2016.1145657","article-title":"Pharmacological considerations in the use of stiripentol for the treatment of epilepsy","volume":"12","author":"Verrotti","year":"2016","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0375","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1046\/j.1460-9568.2002.01985.x","article-title":"Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition","volume":"15","author":"Wendling","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0380","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1111\/j.1460-9568.2012.08039.x","article-title":"Interictal spikes, fast ripples and seizures in partial epilepsies - combining multi-level computational models with experimental data: computational and experimental models of epilepsy","volume":"36","author":"Wendling","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0385","article-title":"Computational models of epileptiform activity","author":"Wendling","year":"2015","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0390","doi-asserted-by":"crossref","DOI":"10.1038\/nature13321","article-title":"Equalizing excitation\u2013inhibition ratios across visual cortical neurons","author":"Xue","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2016.05.037_bb0395","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/nn1754","article-title":"Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy","volume":"9","author":"Yu","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0400","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1152\/physrev.00043.2010","article-title":"Fast synaptic inhibition in spinal sensory processing and pain control","volume":"92","author":"Zeilhofer","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0405","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1523\/JNEUROSCI.4247-11.2012","article-title":"Transition to seizure: ictal discharge is preceded by exhausted presynaptic GABA release in the hippocampal CA3 region","volume":"32","author":"Zhang","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2016.05.037_bb0410","doi-asserted-by":"crossref","first-page":"33853","DOI":"10.1074\/jbc.M112.395830","article-title":"N-methyl-d-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl\u2212 cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain","volume":"287","author":"Zhou","year":"2012","journal-title":"J. Biol. Chem."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488616301571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488616301571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T06:19:44Z","timestamp":1718605184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488616301571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":82,"alternative-id":["S0014488616301571"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2016.05.037","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2016.05.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}