{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:36:18Z","timestamp":1793918178419,"version":"4.8.0"},"reference-count":179,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003248","name":"Ontario Mental Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003248","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.expneurol.2017.04.017","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T02:46:49Z","timestamp":1493693209000},"page":"217-227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":573,"special_numbering":"PA","title":["The valproic acid-induced rodent model of autism"],"prefix":"10.1016","volume":"299","author":[{"given":"Chiara","family":"Nicolini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-0529","authenticated-orcid":false,"given":"Margaret","family":"Fahnestock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2017.04.017_bb0005","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0959-4388(00)00202-6","article-title":"The neurobiology of social cognition","volume":"11","author":"Adolphs","year":"2001","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0010","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/6338","article-title":"Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems","volume":"2","author":"Alagarsamy","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0015","doi-asserted-by":"crossref","first-page":"D105","DOI":"10.2741\/allen","article-title":"Attention function and dysfunction in autism","volume":"6","author":"Allen","year":"2001","journal-title":"Front. Biosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0020","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatry Association","year":"2013"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0025","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1017\/S0033291700028099","article-title":"Autism as a strongly genetic disorder: evidence from a British twin study","volume":"25","author":"Bailey","year":"1995","journal-title":"Psychol. Med."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0030","first-page":"15","article-title":"Contribution of GABAergic interneurons to the development of spontaneous activity patterns in cultured neocortical networks","volume":"4","author":"Baltz","year":"2010","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0035","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.neulet.2014.09.039","article-title":"Resveratrol prevents social deficits in animal model of autism induced by valproic acid","volume":"583","author":"Bambini-Junior","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0040","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.25486","article-title":"Behavioral neurochemistry: neuroregulators and behavioral states","volume":"200","author":"Barchas","year":"1978","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0045","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1086\/430454","article-title":"Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT","volume":"76","author":"Barnby","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0050","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1192\/bjp.165.5.640","article-title":"Recognition of mental state terms. Clinical findings in children with autism and a functional neuroimaging study of normal adults","volume":"165","author":"Baron-Cohen","year":"1994","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0055","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1046\/j.1460-9568.1999.00621.x","article-title":"Social intelligence in the normal and autistic brain: an fMRI study","volume":"11","author":"Baron-Cohen","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0060","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn2044","article-title":"Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks","volume":"8","author":"Bartos","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0065","doi-asserted-by":"crossref","first-page":"9228","DOI":"10.1523\/JNEUROSCI.3340-04.2004","article-title":"Autism and abnormal development of brain connectivity","volume":"24","author":"Belmonte","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0070","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1152\/physrev.00017.2006","article-title":"GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations","volume":"87","author":"Ben-Ari","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004402","article-title":"Mosaic epigenetic dysregulation of ectodermal cells in autism spectrum disorder","volume":"10","author":"Berko","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0080","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neuroscience.2013.03.030","article-title":"Rearrangement of the dendritic morphology in limbic regions and altered exploratory behavior in a rat model of autism spectrum disorder","volume":"241","author":"Bringas","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0085","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1212\/01.wnl.0000339399.64213.1a","article-title":"Autism spectrum disorders following in utero exposure to antiepileptic drugs","volume":"71","author":"Bromley","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0090","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1111\/j.1528-1167.2010.02668.x","article-title":"Early cognitive development in children born to women with epilepsy: a prospective report","volume":"51","author":"Bromley","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0095","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1136\/jnnp-2012-304270","article-title":"The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs","volume":"84","author":"Bromley","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0100","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nature08002","article-title":"Driving fast-spiking cells induces gamma rhythm and controls sensory responses","volume":"459","author":"Cardin","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0105","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1093\/brain\/awf189","article-title":"Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes","volume":"125","author":"Castelli","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0110","first-page":"1","article-title":"Prevalence of Autism Spectrum Disorder Among Children Aged 8Years \u2014 Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2010","author":"Centers for Disease Control and Prevention","year":"2014"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0115","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1073\/pnas.0835631100","article-title":"Speech-sound-selective auditory impairment in children with autism: they can perceive but do not attend","volume":"100","author":"Ceponiene","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0120","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1046\/j.1471-4159.2000.0721327.x","article-title":"The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3","volume":"72","author":"Chen","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0125","first-page":"76","article-title":"Wnt\/beta-catenin signaling in cerebral cortical development","volume":"4","author":"Chenn","year":"2008","journal-title":"Organ"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0130","doi-asserted-by":"crossref","first-page":"712758","DOI":"10.1155\/2013\/712758","article-title":"What we have learned about autism spectrum disorder from valproic acid","volume":"2013","author":"Chomiak","year":"2013","journal-title":"Pathol. Res. Int."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0135","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1001\/jama.2013.2270","article-title":"Prenatal exposure and risk of autism spectrum disorders and childhood autism","volume":"309","author":"Christensen","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0140","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1469-8749.1994.tb11858.x","article-title":"Fetal valproate syndrome: clinical and neurodevelopmental features in two sibling pairs","volume":"36","author":"Christianson","year":"1994","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0145","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1136\/jmg.32.9.724","article-title":"Fetal valproate syndrome","volume":"32","author":"Clayton-Smith","year":"1995","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0150","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1177\/0269881110367726","article-title":"Opioids and anxiety","volume":"25","author":"Colasanti","year":"2011","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0155","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.biopsych.2005.07.004","article-title":"Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy","volume":"59","author":"Connolly","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0160","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1601-183X.2010.00627.x","article-title":"Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF\/TrkB signaling in autism","volume":"9","author":"Correia","year":"2010","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0165","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1017\/S0954579405050285","article-title":"Autism at the beginning: microstructural and growth abnormalities underlying the cognitive and behavioral phenotype of autism","volume":"17","author":"Courchesne","year":"2005","journal-title":"Dev. Psychopathol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0170","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/mrdd.20039","article-title":"Designing mouse behavioral tasks relevant to autistic-like behaviors","volume":"10","author":"Crawley","year":"2004","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0175","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/adc.2009.176990","article-title":"Neurodevelopment of children exposed in utero to lamotrigine, sodium valproate and carbamazepine","volume":"96","author":"Cummings","year":"2011","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0180","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1017\/S0954579408000370","article-title":"Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder","volume":"20","author":"Dawson","year":"2008","journal-title":"Dev. Psychopathol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0185","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.jaac.2012.08.018","article-title":"Early behavioral intervention is associated with normalized brain activity in young children with autism","volume":"51","author":"Dawson","year":"2012","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0190","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/jmg.39.4.251","article-title":"Long term health and neurodevelopment in children exposed to antiepileptic drugs before birth","volume":"39","author":"Dean","year":"2002","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0195","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nature13772","article-title":"Synaptic, transcriptional and chromatin genes disrupted in autism","volume":"515","author":"De Rubeis","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0200","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/ajmg.1320190308","article-title":"The fetal valproate syndrome","volume":"19","author":"DiLiberti","year":"1984","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0205","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0278-5846(01)00161-0","article-title":"Role of endogenous opioid system in the regulation of the stress response","volume":"25","author":"Drolet","year":"2001","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0210","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1177\/0145445506291396","article-title":"Outcome for children with autism who began intensive behavioral treatment between ages 4 and 7: a comparison controlled study","volume":"31","author":"Eikeseth","year":"2007","journal-title":"Behav. Modif."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0215","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/15374410902851739","article-title":"Meta-analysis of early intensive behavioral intervention for children with autism","volume":"38","author":"Eldevik","year":"2009","journal-title":"J. Clin. Child Adolesc. Psychol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00343800","article-title":"Effect of sodium valproate on mania. The GABA-hypothesis of affective disorders","volume":"229","author":"Emrich","year":"1980","journal-title":"Acta Psychiatr. Nervenkr."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0225","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.eplepsyres.2005.06.001","article-title":"Children exposed to valproate in utero\u2014population based evaluation of risks and confounding factors for long-term neurocognitive development","volume":"65","author":"Eriksson","year":"2005","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0230","series-title":"Autism and Pervasive Developmental Disorders","article-title":"Epidemiological surveys of autism","author":"Fombonne","year":"1998"},{"issue":"Suppl. 2","key":"10.1016\/j.expneurol.2017.04.017_bb0235","first-page":"S4.6","article-title":"Epidemiological trends in rates of autism","volume":"7","author":"Fombonne","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0240","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.chc.2008.06.007","article-title":"Applied behavior analysis treatment of autism: the state of the art","volume":"17","author":"Foxx","year":"2008","journal-title":"Child Adolesc. Psychiatr. Clin. N. Am."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0245","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1001\/archpsyc.63.7.786","article-title":"Gray and white matter brain chemistry in young children with autism","volume":"63","author":"Friedman","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0250","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0028-3932(99)00053-6","article-title":"Reading the mind in cartoons and stories: an fMRI study of \u2018theory of mind\u2019 in verbal and nonverbal tasks","volume":"38","author":"Gallagher","year":"2000","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0255","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.biopsych.2010.09.031","article-title":"Validating \u03b3 oscillations and delayed auditory responses as translational biomarkers of autism","volume":"68","author":"Gandal","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0260","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/NEN.0b013e31824b27e4","article-title":"Altered balance of proteolytic isoforms of pro-brain-derived neurotrophic factor in autism","volume":"71","author":"Garcia","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0265","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/ng.3039","article-title":"Most genetic risk for autism resides with common variation","volume":"46","author":"Gaugler","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0270","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1177\/1362361301005003005","article-title":"Anxiety in high-functioning children with autism","volume":"5","author":"Gillott","year":"2001","journal-title":"Autism"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0275","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00213-006-0317-3","article-title":"Sodium- and magnesium-valproate in vivo modulate glutamatergic and GABAergic synapses in the medial prefrontal cortex","volume":"185","author":"Gobbi","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0280","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1097\/00001756-199509000-00009","article-title":"Modeling other mind","volume":"6","author":"Goel","year":"1995","journal-title":"Neuroreport"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0285","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11689-009-9023-x","article-title":"Common circuit defect of excitatory-inhibitory balance in mouse models of autism","volume":"1","author":"Gogolla","year":"2009","journal-title":"J. Neurodev. Disord."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0290","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1006\/mcne.2002.1117","article-title":"Valproate regulates GSK-3-mediated axonal remodelling and synapsin I clustering in developing neurons","volume":"20","author":"Hall","year":"2002","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0295","series-title":"Neuroreport","first-page":"197","article-title":"\u2018Theory of mind\u2019 in the brain. Evidence from a PET scan study of Asperger syndrome","volume":"8","author":"Happ\u00e9","year":"1996"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0300","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1254\/jphs.12025SC","article-title":"Effect of prenatal valproic acid exposure on cortical morphology in female mice","volume":"118","author":"Hara","year":"2012","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0305","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0926-6410(99)00006-3","article-title":"Neuroanatomic contributions to slowed orienting of attention in children with autism","volume":"8","author":"Harris","year":"1999","journal-title":"Brain Res. Cogn. Brain Res."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0310","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.pnpbp.2006.06.018","article-title":"Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism","volume":"30","author":"Hashimoto","year":"2006","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0315","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","article-title":"Upstream and downstream of mTOR","volume":"18","author":"Hay","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0320","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.rasd.2014.05.006","article-title":"Aggressive behavior problems in children with autism spectrum disorders: prevalence and correlates in a large clinical sample","volume":"8","author":"Hill","year":"2014","journal-title":"Res. Autism Spectr. Disord."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0325","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1023\/A:1025854532079","article-title":"Risperidone and explosive aggressive autism","volume":"27","author":"Horrigan","year":"1997","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0330","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/scan\/nsw006","article-title":"Opioids and social bonding: naltrexone reduces feelings of social connection","volume":"11","author":"Inagaki","year":"2016","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0335","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/ng1136","article-title":"Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism","volume":"34","author":"Jamain","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0340","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/1362361301005001002","article-title":"The economic impact of autism in Britain","volume":"5","author":"J\u04d3rbrink","year":"2001","journal-title":"Autism"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0345","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1523\/JNEUROSCI.2270-05.2005","article-title":"Control of dendritic arborization by the phosphoinositide-3\u2032-kinase-Akt-mammalian target of rapamycin pathway","volume":"25","author":"Jaworski","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0350","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1056\/NEJMoa0907328","article-title":"Valproic acid monotherapy in pregnancy and major congenital malformations","volume":"362","author":"Jentink","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0355","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1101\/lm.5.4.331","article-title":"Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5","volume":"5","author":"Jia","year":"1998","journal-title":"Learn. Mem."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0360","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1527-3458.2003.tb00249.x","article-title":"Valproate: past, present, future","volume":"9","author":"Johannessen","year":"2003","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0365","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-2121-9-66","article-title":"Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21Cip\/WAF1","volume":"9","author":"Jung","year":"2008","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0370","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1093\/brain\/awh199","article-title":"Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity","volume":"127","author":"Just","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0375","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/brain\/awv043","article-title":"Somatosensory cortex functional connectivity abnormalities in autism show opposite trends, depending on direction and spatial scale","volume":"138","author":"Kahn","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0380","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF01538051","article-title":"Speculations on similarities between autism and opiate addiction","volume":"8","author":"Kalat","year":"1978","journal-title":"J. Autism Child. Schizophr."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0385","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fnmol.2015.00017","article-title":"Suppression of NMDA receptor function in mice prenatally exposed to valproic acid improves social deficits and repetitive behaviors","volume":"8","author":"Kang","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0390","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/npp.2013.274","article-title":"Acetylcholine elevation relieves cognitive rigidity and social deficiency in a mouse model of autism","volume":"39","author":"Karvat","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0395","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1017\/S1461145711001714","article-title":"Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid","volume":"16","author":"Kataoka","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0400","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/1362361300004002002","article-title":"The prevalence of anxiety and mood problems among children with autism and Asperger syndrome","volume":"4","author":"Kim","year":"2000","journal-title":"Autism"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0405","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.toxlet.2010.12.018","article-title":"The critical period of valproate exposure to induce autistic symptoms in Sprague-Dawley rats","volume":"201","author":"Kim","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0410","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s12035-013-8535-2","article-title":"Pax6-dependent cortical glutamatergic neuronal differentiation regulates autism-like behavior in prenatally valproic acid-exposed rat offspring","volume":"49","author":"Kim","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0415","article-title":"Subchronic treatment of donepezil rescues impaired social, hyperactive, and stereotypic behavior in valproic acid-induced animal model of autism","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0420","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.neuroscience.2009.07.021","article-title":"Prenatal exposure to valproic acid leads to reduced expression of synaptic adhesion molecule neuroligin 3 in mice","volume":"163","author":"Kolozsi","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0425","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/383535a0","article-title":"Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin","volume":"383","author":"K\u00f6nig","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0430","first-page":"25","article-title":"Dipropylacetamide in the treatment of manic-depressive psychosis","volume":"1","author":"Lambert","year":"1975","journal-title":"Enc\u00e9phale"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0435","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s10803-006-0123-0","article-title":"Comorbid psychiatric disorders in children with autism: interview development and rates of disorders","volume":"36","author":"Leyfer","year":"2006","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0440","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0301-0082(98)00075-6","article-title":"Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action","volume":"58","author":"L\u00f6scher","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0445","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2165\/00023210-200216100-00003","article-title":"Basic pharmacology of valproate: a review after 35years of clinical use for the treatment of epilepsy","volume":"16","author":"L\u00f6scher","year":"2002","journal-title":"CNS Drugs"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0450","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3389\/fnbeh.2014.00430","article-title":"State-dependent \u03bc-opioid modulation of social motivation","volume":"8","author":"Loseth","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0455","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1037\/0022-006X.55.1.3","article-title":"Behavioral treatment and normal educational and intellectual functioning in young autistic children","volume":"55","author":"Lovaas","year":"1987","journal-title":"J. Consult. Clin. Psychol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0460","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0465","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1163\/000579511X596624","article-title":"The brain opioid theory of social attachment: a review of the evidence","volume":"148","author":"Machin","year":"2011","journal-title":"Behaviour"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0470","doi-asserted-by":"crossref","first-page":"48R","DOI":"10.1203\/PDR.0b013e3182130c54","article-title":"Sensory processing in autism: a review of neurophysiologic findings","volume":"69","author":"Marco","year":"2011","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0475","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/aur.1247","article-title":"Children with autism show reduced somatosensory response: An MEG study","volume":"5","author":"Marco","year":"2012","journal-title":"Autism Res."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0480","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/sj.npp.1301453","article-title":"Abnormal fear conditioning and amygdala processing in an animal model of autism","volume":"33","author":"Markram","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0485","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1093\/brain\/awf150","article-title":"Brain anatomy and sensorimotor gating in Asperger's syndrome","volume":"125","author":"McAlonan","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0490","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMoa0803531","article-title":"Cognitive function at 3years of age after fetal exposure to antiepileptic drugs","volume":"360","author":"Meador","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0495","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/brain\/awq352","article-title":"Foetal antiepileptic drug exposure and verbal versus non-verbal abilities at three years of age","volume":"134","author":"Meador","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0500","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026077","article-title":"mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism","volume":"6","author":"Mehta","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0505","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/dev.20130","article-title":"Maternal and littermate deprivation disrupts maternal behavior and social-learning of food preference in adulthood: tactile stimulation, nest odor, and social rearing prevent these effects","volume":"48","author":"Melo","year":"2006","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb9000","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/emboj.2013.107","article-title":"Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity","volume":"32","author":"Menna","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0510","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0387-7604(03)00168-2","article-title":"Serum neurotrophin concentrations in autism and mental retardation: a pilot study","volume":"26","author":"Miyazaki","year":"2004","journal-title":"Brain and Development"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0515","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1017\/S0012162207000059.x","article-title":"Short-latency somatosensory evoked potentials in infantile autism: evidence of hyperactivity in the right primary somatosensory area","volume":"49","author":"Miyazaki","year":"2007","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0520","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bbr.2013.09.049","article-title":"Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice","volume":"257","author":"Moldrich","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0525","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/jmg.37.7.489","article-title":"A clinical study of 57 children with fetal anticonvulsant syndromes","volume":"37","author":"Moore","year":"2000","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0530","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1124\/jpet.105.087908","article-title":"Modulation of N-methyl-d-aspartate receptors by donepezil in rat cortical neurons","volume":"315","author":"Moriguchi","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0535","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1601-1848.2004.00076.x","article-title":"Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice","volume":"3","author":"Moy","year":"2004","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0540","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbr.2008.03.015","article-title":"Social approach and repetitive behavior in eleven inbred mouse strains","volume":"191","author":"Moy","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0545","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1601-183X.2008.00452.x","article-title":"Social approach in genetically engineered mouse lines relevant to autism","volume":"8","author":"Moy","year":"2009","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0550","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1523\/JNEUROSCI.5404-10.2011","article-title":"Wnt signaling regulates neuronal differentiation of cortical intermediate progenitors","volume":"31","author":"Munji","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0555","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1017\/S1355617710001359","article-title":"The Australian brain and cognition and antiepileptic drugs study: IQ in school-aged children exposed to sodium valproate and polytherapy","volume":"17","author":"Nadebaum","year":"2011","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0560","series-title":"Chronic Diseases and Injuries in Canada","article-title":"Findings from the National Epidemiologic Database for the Study of Autism in Canada (NEDSAC): changes in the prevalence of autism spectrum disorders in Newfoundland and Labrador, Prince Edward Island, and Southeastern Ontario","author":"National Epidemiologic Database for the Study of Autism in Canada (NEDSAC)","year":"2012"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0565","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1600-0773.1991.tb01303.x","article-title":"Valproic acid-induced neural tube defects in mouse and human: aspects of chirality, alternative drug development, pharmacokinetics and possible mechanisms","volume":"69","author":"Nau","year":"1991","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0570","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/ana.1024","article-title":"Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation","volume":"49","author":"Nelson","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0575","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40478-015-0184-4","article-title":"Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid","volume":"3","author":"Nicolini","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0580","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbrc.2007.02.135","article-title":"Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism","volume":"356","author":"Nishimura","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0585","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0002-7138(09)60874-8","article-title":"Primary prevention: aspects of program design and evaluation","volume":"21","author":"Offord","year":"1982","journal-title":"J. Am. Acad. Child Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0590","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nature10989","article-title":"Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations","volume":"485","author":"O'Roak","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0595","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2009.02.014","article-title":"Valproic acid in pregnancy: how much are we endangering the embryo and fetus?","volume":"28","author":"Ornoy","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0600","article-title":"Pharmacology of valproate","volume":"37","author":"Owens","year":"2003","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0605","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0166-2236(79)90071-7","article-title":"A neurochemical theory of autism","volume":"2","author":"Panksepp","year":"1979","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0610","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0149-7634(80)90036-6","article-title":"Endogenous opioids and social behavior","volume":"4","author":"Panksepp","year":"1980","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0615","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1176\/appi.ajp.158.7.1058","article-title":"Cholinergic activity in autism: abnormalities in the cerebral cortex and basal forebrain","volume":"158","author":"Perry","year":"2001","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0620","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.rasd.2010.03.011","article-title":"A meta-analytic study on the effectiveness of comprehensive ABA-based early intervention programs for children with autism spectrum disorders","volume":"5","author":"Peters-Scheffer","year":"2011","journal-title":"Res. Autism Spectr. Disord."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0625","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0630","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1093\/brain\/awh289","article-title":"The brain response to personally familiar faces in autism: findings of fusiform activity and beyond","volume":"127","author":"Pierce","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0635","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1111\/j.1460-9568.2004.03794.x","article-title":"Dissociable roles of the human somatosensory and superior temporal cortices for processing social face signals","volume":"20","author":"Pourtois","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0640","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1212\/WNL.57.9.1618","article-title":"Postmortem brain abnormalities of the glutamate neurotransmitter system in autism","volume":"57","author":"Purcell","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0645","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1017\/S0012162205001076","article-title":"Characteristics of fetal anticonvulsant syndrome associated autistic disorder","volume":"47","author":"Rasalam","year":"2005","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0650","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1352\/0895-8017(2007)112[418:EIBIOF]2.0.CO;2","article-title":"Early intensive behavioral intervention: outcomes for children with autism and their parents after two years","volume":"112","author":"Remington","year":"2007","journal-title":"Am. J. Ment. Retard."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0655","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1093\/brain\/122.7.1305","article-title":"Cerebral correlates of preserved cognitive skills in autism: a functional MRI study of embedded figures task performance","volume":"122","author":"Ring","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0660","doi-asserted-by":"crossref","first-page":"13501","DOI":"10.1073\/pnas.0704391104","article-title":"Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid","volume":"104","author":"Rinaldi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0665","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/cercor\/bhm117","article-title":"Hyperconnectivity of local neocortical microcircuitry induced by prenatal exposure to valproic acid","volume":"18","author":"Rinaldi","year":"2008","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0670","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/neuro.04.004.2008","article-title":"Hyper-connectivity and hyper-plasticity in the medial prefrontal cortex in the valproic acid animal model of autism","volume":"2","author":"Rinaldi","year":"2008","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0675","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2","article-title":"Embryological origin for autism: developmental anomalies of the cranial nerve motor nuclei","volume":"370","author":"Rodier","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0680","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.neuroscience.2010.06.069","article-title":"Behavioural and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid","volume":"170","author":"Roullet","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0685","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ntt.2013.01.004","article-title":"In utero exposure to valproic acid and autism\u2014a current review of clinical and animal studies","volume":"36","author":"Roullet","year":"2013","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0690","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1034\/j.1601-183X.2003.00037.x","article-title":"Model of autism: increased ratio of excitation\/inhibition in key neural systems","volume":"2","author":"Rubenstein","year":"2003","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0695","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1001\/jama.2014.4144","article-title":"The familial risk of autism","volume":"311","author":"Sandin","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0700","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0306-9877(86)90135-0","article-title":"Infantile autism: a dysfunction of the opioids?","volume":"19","author":"Sandyk","year":"1986","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0705","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/sj.npp.1300518","article-title":"Behavioural alterations in rats prenatally exposed to valproic acid: animal model of autism","volume":"30","author":"Schneider","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0710","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/sj.npp.1300767","article-title":"Environmental enrichment reverses behavioral alterations in rats prenatally exposed to valproic acid: issues for a therapeutic approach in autism","volume":"31","author":"Schneider","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0715","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00213-007-0795-y","article-title":"Prenatal exposure to valproic acid disturbs the enkephalinergic system functioning, basal hedonic tone, and emotional responses in an animal model of autism","volume":"193","author":"Schneider","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0720","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.psyneuen.2008.02.011","article-title":"Gender-specific behavioural and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid","volume":"33","author":"Schneider","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0725","first-page":"415","article-title":"The role of the fusiform face area in social cognition: Implications for the pathobiology of autism","volume":"358","author":"Schultz","year":"2003","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0730","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fncel.2010.00011","article-title":"GABAergic control of neurite outgrowth and remodeling during development and adult neurogenesis: general rules and differences in diverse systems","volume":"4","author":"Sernagor","year":"2010","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0735","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/dev.10064","article-title":"Effects of preweaning exposure to novel maternal odors on maternal responsiveness and selectivity in adulthood","volume":"41","author":"Shah","year":"2002","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0740","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1212\/WNL.0b013e3182088297","article-title":"Child development following in utero exposure: levetiracetam vs. sodium valproate","volume":"76","author":"Shallcross","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0745","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1476-5381.2010.00894.x","article-title":"Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors","volume":"161","author":"Shen","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0750","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev.ph.55.030193.002025","article-title":"Synchronization of cortical activity and its putative role in information processing and learning","volume":"55","author":"Singer","year":"1993","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0755","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/dev.20337","article-title":"Altered morphology of motor cortex neurons in the VPA rat model of autism","volume":"50","author":"Snow","year":"2008","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0760","series-title":"Parvalbumin Neurons and Gamma Rhythms Enhance Cortical Circuit Performance","first-page":"698","volume":"459","author":"Sohal","year":"2009"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0765","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1001\/archpsyc.59.11.1027","article-title":"Increased amygdala activation to angry and contemptuous faces in generalized social phobia","volume":"59","author":"Stein","year":"2002","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0770","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1476-072X-11-44","article-title":"An ecological study on childhood autism","volume":"11","author":"St-Hilaire","year":"2012","journal-title":"Int. J. Health Geogr."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0775","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jaac.2012.11.007","article-title":"The effect of cognitive-behavioral therapy versus treatment as usual for anxiety in children with autism spectrum disorders: a randomized, controlled trial","volume":"52","author":"Storch","year":"2013","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0780","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2011.52","article-title":"Rare mutations in N-methyl-d-aspartate glutamate receptors in autism spectrum disorders and schizophrenia","volume":"1","author":"Tarabeux","year":"2011","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0785","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/(SICI)1098-2302(199605)29:4<353::AID-DEV4>3.0.CO;2-P","article-title":"Effects of altered olfactory experiences on the development of infant rats' responses to odors","volume":"29","author":"Terry","year":"1996","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0790","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/08039480410005774","article-title":"Why do some individuals develop social phobia? A review with emphasis on the neurobiological influences","volume":"58","author":"Tillfors","year":"2004","journal-title":"Nord. J. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0795","first-page":"53","article-title":"Gene\u00d7environment interactions in autism spectrum disorders: role of epigenetic mechanisms","volume":"5","author":"Tordjman","year":"2014","journal-title":"Front. Psych."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0800","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.biopsych.2007.05.023","article-title":"What do disturbances in neural synchrony tell us about autism?","volume":"62","author":"Uhlhaas","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0805","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019881","article-title":"What is new for an old molecule? Systematic review and recommendations on the use of resveratrol","volume":"6","author":"Vang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0810","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/YCO.0000000000000133","article-title":"An update on anxiety in youth with autism spectrum disorders","volume":"28","author":"Vasa","year":"2015","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0815","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/jamapsychiatry.2013.266","article-title":"Traffic-related air pollution, particulate matter, and autism","volume":"70","author":"Volk","year":"2013","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0820","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/BF00427687","article-title":"Humoral-endorphin blood levels in autistic, schizophrenic and healthy subjects","volume":"82","author":"Weizman","year":"1984","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0825","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/00004583-198807000-00009","article-title":"Low plasma immunoreactive beta-endorphin levels in autism","volume":"27","author":"Weizman","year":"1988","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0830","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ijdevneu.2004.09.002","article-title":"Is autism due to brain desynchronization?","volume":"23","author":"Welsh","year":"2005","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0835","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.annepidem.2011.08.002","article-title":"Use of the antiepileptic medications in pregnancy in relation to risks of birth defects","volume":"21","author":"Werler","year":"2011","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0840","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cpr.2009.01.003","article-title":"Anxiety in children and adolescents with autism spectrum disorders","volume":"29","author":"White","year":"2009","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0845","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10567-009-0062-3","article-title":"Development of a cognitive-behavioral intervention program to treat anxiety and social deficits in teens with high-functioning autism","volume":"13","author":"White","year":"2010","journal-title":"Clin. Child. Fam. Psychol. Rev."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0850","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1469-8749.1997.tb07500.x","article-title":"A male with fetal vaproate syndrome and autism","volume":"39","author":"Williams","year":"1997","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0855","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1469-8749.2001.tb00188.x","article-title":"Fetal valproate syndrome and autism: additional evidence of an association","volume":"43","author":"Williams","year":"2001","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0860","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-1047(05)80039-1","article-title":"Neurobiology of associative learning in the neonate: early olfactory learning","volume":"61","author":"Wilson","year":"1994","journal-title":"Behav. Neural Biol."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0865","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1037\/a0033010","article-title":"Environmental enrichment as an effective treatment for autism: a randomized controlled trial","volume":"127","author":"Woo","year":"2013","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0870","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1037\/bne0000068","article-title":"Environmental enrichment as a therapy for autism: a clinical trial replication and extension","volume":"129","author":"Woo","year":"2015","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0875","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1469-7610.2008.01948.x","article-title":"Cognitive behavioral therapy for anxiety in children with autism spectrum disorders: a randomized, controlled trial","volume":"50","author":"Wood","year":"2009","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.expneurol.2017.04.017_bb0880","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.beth.2014.01.002","article-title":"Cognitive behavioral therapy for early adolescents with autism spectrum disorders and clinical anxiety: a randomized, controlled trial","volume":"46","author":"Wood","year":"2015","journal-title":"Behav. Ther."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0885","article-title":"Automated three-chambered social approach task for mice","volume":"Chapter 8","author":"Yang","year":"2011","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.expneurol.2017.04.017_bb0890","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neulet.2012.01.061","article-title":"Family based association of GRIN2A and GRIN2B with Korean autism spectrum disorders","volume":"512","author":"Yoo","year":"2012","journal-title":"Neurosci. Lett."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488617301103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488617301103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:48:51Z","timestamp":1762148931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488617301103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":179,"alternative-id":["S0014488617301103"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2017.04.017","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The valproic acid-induced rodent model of autism","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2017.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}