{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:56:12Z","timestamp":1790506572694,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["G-13-0003069"],"award-info":[{"award-number":["G-13-0003069"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"China-Canada Joint Health Research Initiative","award":["132571"],"award-info":[{"award-number":["132571"]}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2016-04574"],"award-info":[{"award-number":["RGPIN-2016-04574"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2014-06471"],"award-info":[{"award-number":["RGPIN-2014-06471"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.expneurol.2017.06.023","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:36Z","timestamp":1498694436000},"page":"32-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["Transient receptor potential melastatin 2 channels (TRPM2) mediate neonatal hypoxic-ischemic brain injury in mice"],"prefix":"10.1016","volume":"296","author":[{"given":"Sammen","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Turlova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-hua","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Szeto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abussaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5314-986X","authenticated-orcid":false,"given":"Xinzheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Ping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5142-1874","authenticated-orcid":false,"given":"Hong-Shuo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2017.06.023_bb0005","doi-asserted-by":"crossref","first-page":"17264","DOI":"10.1523\/JNEUROSCI.1729-13.2013","article-title":"Modulation of NMDAR subunit expression by TRPM2 channels regulates neuronal vulnerability to ischemic cell death","volume":"33","author":"Alim","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0010","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy","volume":"361","author":"Azzopardi","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0015","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/aps.2011.60","article-title":"TRPM7 in cerebral ischemia and potential target for drug development in stroke","volume":"32","author":"Bae","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0020","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1756-6606-5-11","article-title":"Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons","volume":"5","author":"Belrose","year":"2012","journal-title":"Mol Brain"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0025","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1111\/j.1476-5381.2012.02058.x","article-title":"Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels","volume":"167","author":"Chen","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0030","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13041-015-0102-5","article-title":"TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury","volume":"8","author":"Chen","year":"2015","journal-title":"Mol Brain"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0035","doi-asserted-by":"crossref","first-page":"7239","DOI":"10.1073\/pnas.0811725106","article-title":"Intracellular calcium activates TRPM2 and its alternative spliced isoforms","volume":"106","author":"Du","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0040","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/978-3-642-54215-2_16","article-title":"TRPM2","volume":"222","author":"Faouzi","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0045","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/sj.bjp.0705914","article-title":"TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase","volume":"143","author":"Fonfria","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0050","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/10799890600637522","article-title":"TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia","volume":"26","author":"Fonfria","year":"2006","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0055","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/10799890600637506","article-title":"Tissue distribution profiles of the human TRPM cation channel family","volume":"26","author":"Fonfria","year":"2006","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0060","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1161\/STROKEAHA.114.005836","article-title":"Transient receptor potential melastatin subfamily member 2 cation channel regulates detrimental immune cell invasion in ischemic stroke","volume":"45","author":"Gelderblom","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0065","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1056\/NEJMc053092","article-title":"Hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"354","author":"Gluckman","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0070","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000244109","article-title":"Hypoxia-ischemia in the neonatal rat brain: histopathology after post-treatment with NMDA and non-NMDA receptor antagonists","volume":"66","author":"Hagberg","year":"1994","journal-title":"Biol. Neonate"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0075","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1523\/JNEUROSCI.4703-11.2012","article-title":"TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice","volume":"32","author":"Haraguchi","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0080","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1161\/CIRCRESAHA.107.160176","article-title":"Role of TRPM2 channel in mediating H2O2-induced Ca2+ entry and endothelial hyperpermeability","volume":"102","author":"Hecquet","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0085","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2174\/1566524043479248","article-title":"The rise and fall of NMDA antagonists for ischemic stroke","volume":"4","author":"Hoyte","year":"2004","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0090","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/cns.12683","article-title":"GSK-3beta inhibitor TDZD-8 reduces neonatal hypoxic-ischemic brain injury in mice","volume":"23","author":"Huang","year":"2017","journal-title":"CNS. Neurosci Ther."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0095","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrn2870","article-title":"GSK3 signalling in neural development","volume":"11","author":"Hur","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0100","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1474-4422(02)00164-3","article-title":"Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?","volume":"1","author":"Ikonomidou","year":"2002","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0105","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1203\/00006450-199601000-00006","article-title":"Hypoxic-ischemic brain injury induces an acute microglial reaction in perinatal rats","volume":"39","author":"Ivacko","year":"1996","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0110","doi-asserted-by":"crossref","first-page":"11811","DOI":"10.1523\/JNEUROSCI.5251-14.2015","article-title":"TRPM2, a susceptibility gene for bipolar disorder, regulates glycogen synthase kinase-3 activity in the brain","volume":"35","author":"Jang","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010397","article-title":"Attenuation of reactive gliosis does not affect infarct volume in neonatal hypoxic-ischemic brain injury in mice","volume":"5","author":"Jarlestedt","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0120","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1203\/00006450-200106000-00003","article-title":"Neurobiology of hypoxic-ischemic injury in the developing brain","volume":"49","author":"Johnston","year":"2001","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0125","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1177\/1073858402008003007","article-title":"Mechanisms of hypoxic neurodegeneration in the developing brain","volume":"8","author":"Johnston","year":"2002","journal-title":"Neuroscientist"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0130","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S1474-4422(08)70165-0","article-title":"NMDA receptors in clinical neurology: Excitatory times ahead","volume":"7","author":"Kalia","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0135","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1254\/jphs.FP0060128","article-title":"A critical role of TRPM2 in neuronal cell death by hydrogen peroxide","volume":"101","author":"Kaneko","year":"2006","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0140","doi-asserted-by":"crossref","first-page":"6745","DOI":"10.1073\/pnas.1114193109","article-title":"Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions","volume":"109","author":"Kashio","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0145","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.expneurol.2004.04.004","article-title":"Glycogen synthase kinase 3 beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia","volume":"188","author":"Kelly","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0150","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.molcel.2005.02.033","article-title":"Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels","volume":"18","author":"Kolisek","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0155","doi-asserted-by":"crossref","first-page":"C129","DOI":"10.1152\/ajpcell.00331.2003","article-title":"Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia","volume":"286","author":"Kraft","year":"2004","journal-title":"Am. J. Physiol Cell Physiol"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0160","doi-asserted-by":"crossref","first-page":"46431","DOI":"10.1074\/jbc.M407263200","article-title":"Sites of the NUDT9-H domain critical for ADP-ribose activation of the cation channel TRPM2","volume":"279","author":"Kuhn","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0165","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"Kurinczuk","year":"2010","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0170","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1203\/01.pdr.0000214891.35363.6a","article-title":"Acute hypoxia-ischemia results in hydrogen peroxide accumulation in neonatal but not adult mouse brain","volume":"59","author":"Lafemina","year":"2006","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0175","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2000278","article-title":"TRPM2 functions as a lysosomal Ca2+-release channel in beta cells","volume":"2","author":"Lange","year":"2009","journal-title":"Sci. Signal"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0180","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1096\/fj.09-149997","article-title":"Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases","volume":"24","author":"Lee","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0185","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1602\/neurorx.1.1.101","article-title":"Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults","volume":"1","author":"Lipton","year":"2004","journal-title":"NeuroRx"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0190","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nature13185","article-title":"Transcriptional landscape of the prenatal human brain","volume":"508","author":"Miller","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0195","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s11064-010-0347-4","article-title":"TRPM2 cation channels, oxidative stress and neurological diseases: where are we now?","volume":"36","author":"Naziroglu","year":"2011","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0200","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2478\/s11658-012-0039-y","article-title":"Pharmacological inhibition of GSK3 attenuates DNA damage-induced apoptosis via reduction of p53 mitochondrial translocation and Bax oligomerization in neuroblastoma SH-SY5Y CELLS","volume":"18","author":"Ngok-Ngam","year":"2013","journal-title":"Cellular & Molecular Biology Letters"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0205","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1113\/jphysiol.2008.162289","article-title":"Ca2+-dependent induction of TRPM2 currents in hippocampal neurons","volume":"587","author":"Olah","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0210","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1074\/jbc.M205601200","article-title":"NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase","volume":"278","author":"Perraud","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0215","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/ana.410190202","article-title":"Glutamate and the pathophysiology of hypoxic\u2013ischemic brain damage","volume":"19","author":"Rothman","year":"1986","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0220","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1007\/s10495-007-0141-1","article-title":"Protective effect of erythropoietin against ketamine-induced apoptosis in cultured rat cortical neurons: involvement of PI3K\/Akt and GSK-3 beta pathway","volume":"12","author":"Shang","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0225","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0230","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ejphar.2014.08.023","article-title":"Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca(2+) entry","volume":"742","author":"Shimizu","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0235","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1055\/s-2000-7496","article-title":"MR patterns of hypoxic-ischemic brain damage after prenatal, perinatal or postnatal asphyxia","volume":"31","author":"Sie","year":"2000","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0240","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.tins.2009.08.002","article-title":"Molecular dissection of reactive astrogliosis and glial scar formation","volume":"32","author":"Sofroniew","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0245","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.expneurol.2014.10.003","article-title":"Neuronal K(ATP) channels mediate hypoxic preconditioning and reduce subsequent neonatal hypoxic-ischemic brain injury","volume":"263","author":"Sun","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0250","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.bbagen.2016.06.027","article-title":"Tideglusib, a chemical inhibitor of GSK3beta, attenuates hypoxic-ischemic brain injury in neonatal mice","volume":"1860","author":"Wang","year":"2016","journal-title":"Biochim. Biophys Acta"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0255","doi-asserted-by":"crossref","first-page":"7368","DOI":"10.1523\/JNEUROSCI.5746-12.2013","article-title":"Modeling transformations of neurodevelopmental sequences across mammalian species","volume":"33","author":"Workman","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0260","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s10495-007-0065-9","article-title":"Erythropoietin prevents PC12 cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis via the Akt\/GSK-3 beta\/caspase-3 mediated signaling pathway","volume":"12","author":"Wu","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0265","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/md13010029","article-title":"Marine compound xyloketal B reduces neonatal hypoxic-ischemic brain injury","volume":"13","author":"Xiao","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0270","first-page":"95","article-title":"TRPM2, calcium and neurodegenerative diseases","volume":"2","author":"Xie","year":"2010","journal-title":"Int. J. Physiol Pathophysiol. Pharmacol."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0275","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1756-6606-4-44","article-title":"Dependence of NMDA\/GSK-3beta mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses","volume":"4","author":"Xie","year":"2011","journal-title":"Mol Brain"},{"key":"10.1016\/j.expneurol.2017.06.023_bb0280","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nm1758","article-title":"TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration","volume":"14","author":"Yamamoto","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.expneurol.2017.06.023_bb0285","doi-asserted-by":"crossref","first-page":"E807","DOI":"10.1152\/ajpendo.00239.2011","article-title":"TRPM2 Ca2+ channel regulates energy balance and glucose metabolism","volume":"302","author":"Zhang","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488617301620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488617301620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T13:56:28Z","timestamp":1575381388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488617301620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":57,"alternative-id":["S0014488617301620"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2017.06.023","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transient receptor potential melastatin 2 channels (TRPM2) mediate neonatal hypoxic-ischemic brain injury in mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2017.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}