{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:04:53Z","timestamp":1792073093272,"version":"4.4.0"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.expneurol.2017.08.013","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T14:45:31Z","timestamp":1503585931000},"page":"31-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":178,"special_numbering":"PA","title":["AMPK activation: Role in the signaling pathways of neuroinflammation and neurodegeneration"],"prefix":"10.1016","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7008-5930","authenticated-orcid":false,"given":"Christina Alves","family":"Peixoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma Helena de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyrlene Meiry da Racho","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Karolina Santana","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2017.08.013_bb0005","doi-asserted-by":"crossref","first-page":"156","DOI":"10.14336\/AD.2014.0330","article-title":"Hypoglycemia in older people - a less well recognized risk factor for frailty","volume":"6","author":"Abdelhafiz","year":"2015","journal-title":"Aging Dis."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0010","first-page":"2015","article-title":"The protective effects of Areca catechu extract on cognition and social interaction deficits in a cuprizone-induced demyelination model","author":"Adilijiang","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0015","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.75.103004.142702","article-title":"LKB1-dependent signaling pathways","volume":"75","author":"Alessi","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0020","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13024-016-0082-7","article-title":"Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy","volume":"11","author":"Barini","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0025","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1523\/JNEUROSCI.4373-15.2016","article-title":"Ghrelin-AMPK signalling mediates the neuroprotective effects of calorie restriction in Parkinson's disease","volume":"36","author":"Bayliss","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0030","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-065X.2012.01157.x","article-title":"LKB1 and AMPK: central regulators of lymphocyte metabolism and function","volume":"249","author":"Blagih","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1042\/BJ20120546","article-title":"AMP-activated protein kinase: new regulation, new roles?","volume":"445","author":"Carling","year":"2012","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.expneurol.2017.08.013_bb9000","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1189\/jlb.0313157","article-title":"AMPK\u03b11 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling","volume":"94","author":"Casey Carroll","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0040","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1073\/pnas.0807991106","article-title":"Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription","volume":"106","author":"Chen","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0045","first-page":"1","article-title":"Amelioration of LPS-induced inflammation response in microglia by AMPK activation","volume":"2014","author":"Chen","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0050","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S1474-4422(08)70259-X","article-title":"Cognitive impairment in multiple sclerosis","volume":"7","author":"Chiaravalloti","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0055","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.bbrc.2009.11.022","article-title":"AMP-activated protein kinase is activated in Parkinson's disease models mediated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine","volume":"391","author":"Choi","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0060","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1471-4159.2005.03029.x","article-title":"CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model","volume":"93","author":"Chou","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0065","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.abb.2010.05.003","article-title":"Regulation of SIRT1 in cellular functions: role of polyphenols","volume":"501","author":"Chung","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0070","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.brainres.2011.12.063","article-title":"Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation","volume":"1441","author":"Correia","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0075","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1056\/NEJMoa1215740","article-title":"Glucose levels and risk of dementia","volume":"369","author":"Crane","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0080","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1385\/JMN:17:1:45","article-title":"AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation","volume":"17","author":"Culmsee","year":"2001","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.tips.2015.11.007","article-title":"Evolving lessons on the complex role of AMPK in normal physiology and cancer","author":"Dasgupta","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0090","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1007\/s12035-014-9033-x","article-title":"Chikusetsu saponin IVa ameliorates cerebral ischemia reperfusion injury in diabetic mice via adiponectin-mediated AMPK\/GSK-3\u03b2 pathway in vivo and in vitro","volume":"53","author":"Duan","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0095","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neulet.2003.10.012","article-title":"5-Aminoimidazole-4-carboxamide-ribonucleoside enhances oxidative stress-induced apoptosis through activation of nuclear factor-k B in mouse Neuro 2a neuroblastoma cells","volume":"354","author":"Eun","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0100","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.pharmthera.2010.11.002","article-title":"AMPK and vasculoprotection","volume":"131","author":"Ewart","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0105","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1172\/JCI63967","article-title":"Malonyl-CoA: the regulator of fatty acid synthesis and oxidation","volume":"122","author":"Foster","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0110","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1189\/jlb.0613335","article-title":"Editorial: \u201cpresenting\u201d an adaptive role for AMPK","volume":"94","author":"Fullerton","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0115","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1172\/JCI58577","article-title":"Hematopoietic AMPK \u03b21 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity","volume":"121","author":"Galic","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0120","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0306-4522(02)00836-9","article-title":"5\u2032-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells","volume":"117","author":"Garcia-Gil","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0125","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","article-title":"Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease","volume":"349","author":"Goate","year":"1991","journal-title":"Nature"},{"issue":"36","key":"10.1016\/j.expneurol.2017.08.013_bb0130","first-page":"2981","article-title":"Comment on Moore et al. Increased risk of cognitive impairment in patients with diabetes is associated with metformin","volume":"2013","author":"Goodarzi","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0135","doi-asserted-by":"crossref","first-page":"30107","DOI":"10.1074\/jbc.M705325200","article-title":"The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor","volume":"282","author":"Greer","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0140","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/mds.23455","article-title":"Glia: initiators and progressors of pathology in Parkinson's disease","volume":"26","author":"Halliday","year":"2011","journal-title":"Mov. Disord."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0145","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1002\/ejp.511","article-title":"Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling","volume":"18","author":"Han","year":"2014","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0150","article-title":"Mitochondrial dysfunction and Parkinson disease: a Parkin-AMPK alliance in neuroprotection","volume":"37\u201347","author":"Hang","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0155","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nrm2249","article-title":"AMP-activated\/SNF1 protein kinases: conserved guardians of cellular energy","volume":"8","author":"Hardie","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceb.2014.09.004","article-title":"AMPK: positive and negative regulation, and its role in whole-body energy homeostasis","volume":"33","author":"Hardie","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0165","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0014-5793(03)00560-X","article-title":"Management of cellular energy by the AMP-activated protein kinase system","volume":"546","author":"Hardie","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0170","doi-asserted-by":"crossref","DOI":"10.1007\/s10787-016-0275-2","article-title":"Anti-inflammatory effect of AMPK signaling pathway in rat model of diabetic neuropathy","author":"Hasanvand","year":"2016","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0175","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.mce.2012.06.018","article-title":"Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver","volume":"366","author":"Hasenour","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0180","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.febslet.2008.04.037","article-title":"High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-\u03baB activation in vascular endothelial cells","volume":"582","author":"Hattori","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0185","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1475-4924-2-28","article-title":"Complexes between the LKB1 tumor suppressor, STRAD alpha\/beta and MO25 alpha\/beta are upstream kinases in the AMP-activated protein kinase cascade","volume":"2","author":"Hawley","year":"2003","journal-title":"J. Biol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0190","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1128\/MCB.00285-15","article-title":"Sestrin2 protects dopaminergic cells against rotenone toxicity through AMPK-dependent autophagy activation","volume":"35","author":"Hou","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0195","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41531-016-0002-0","article-title":"The gut-brain axis: is intestinal inflammation a silent driver of Parkinson's disease pathogenesis?","volume":"3","author":"Houser","year":"2017","journal-title":"npj Park. Dis."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0200","doi-asserted-by":"crossref","first-page":"29060","DOI":"10.1074\/jbc.M503824200","article-title":"The Ca2+\/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases","volume":"280","author":"Hurley","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0205","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/j.1532-5415.2012.03916.x","article-title":"Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study","volume":"60","author":"Imfeld","year":"2012","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0210","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0304-3940(92)90839-Y","article-title":"Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments","volume":"148","author":"Ishiguro","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0215","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.taap.2016.03.004","article-title":"Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic system","volume":"298","author":"Ismaiel","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0220","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.81","article-title":"Regulation and function of AMPK in physiology and diseases","volume":"48","author":"Jeon","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0225","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1080\/10715762.2016.1222374","article-title":"Marein protects against methylglyoxal-induced apoptosis by activating the AMPK pathway in PC12 cells","volume":"50","author":"Jiang","year":"2016","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0230","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000350435","article-title":"Neurodegeneration in streptozotocin-induced diabetic rats is attenuated by treatment with resveratrol","volume":"98","author":"Jing","year":"2013","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0235","series-title":"Circulating Immune Cells in Multiple Sclerosis Short Title: Circulating Immune Cells in Multiple Sclerosis","first-page":"1","author":"Jones","year":"2016"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0240","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1083\/jcb.201105010","article-title":"Nuclear translocation of AMPK-\u03b11 potentiates striatal neurodegeneration in Huntington's disease","volume":"194","author":"Ju","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0245","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.bbadis.2014.06.012","article-title":"AMPK-\u03b11 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease","volume":"1842","author":"Ju","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0250","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2004.12.003","article-title":"AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism","volume":"1","author":"Kahn","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0255","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12868-016-0268-5","article-title":"Neuroprotective effect of activated 5\u2032-adenosine monophosphate-activated protein kinase on cone system function during retinal inflammation","volume":"17","author":"Kamoshita","year":"2016","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0260","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1096\/fj.14-262048","article-title":"Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease","volume":"29","author":"Kapogiannis","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0265","doi-asserted-by":"crossref","first-page":"e919","DOI":"10.1038\/cddis.2013.447","article-title":"(ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson's disease","volume":"4","author":"Kim","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0270","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.16","article-title":"AMPK activators: mechanisms of action and physiological activities","volume":"48","author":"Kim","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0275","doi-asserted-by":"crossref","first-page":"26797","DOI":"10.3390\/ijms161125990","article-title":"The function of autophagy in neurodegenerative diseases","volume":"16","author":"Kiriyama","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0280","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/cns.12404","article-title":"DPP-4 inhibitor Linagliptin attenuates a \u03b2 -induced cytotoxicity through activation of AMPK in neuronal cells","volume":"21","author":"Kornelius","year":"2015","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0285","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S1734-1140(10)70343-1","article-title":"Metformin has adenosine-monophosphate activated protein kinase (AMPK)-independent effects on LPS-stimulated rat primary microglial cultures","volume":"62","author":"\u0141abuzek","year":"2010","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0290","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.molmed.2008.09.007","article-title":"AMPK: a metabolic gauge regulating whole-body energy homeostasis","volume":"14","author":"Lage","year":"2008","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0295","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","article-title":"Candidate gene for the chromosome 1 familial Alzheimer's disease locus","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0300","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.pbb.2012.03.002","article-title":"Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice","volume":"101","author":"Li","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0305","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1523\/JNEUROSCI.6554-10.2012","article-title":"Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease","volume":"32","author":"Lim","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0310","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nm0602-620","article-title":"CNTF is a major protective factor in demyelinating CNS disease: a neurotrophic cytokine as modulator in neuroinflammation","volume":"8","author":"Linker","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0315","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/hmg\/ddu497","article-title":"Activation of AMP-activated protein kinase a1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis","volume":"24","author":"Liu","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ijnp\/pyw047","article-title":"Metformin prevents dopaminergic neuron death in MPTP\/P-induced mouse model of Parkinson's disease via autophagy and mitochondrial ROS clearance","volume":"19","author":"Lu","year":"2016","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0325","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12915-014-0082-4","article-title":"Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy","volume":"12","author":"Luengo","year":"2014","journal-title":"BMC Biol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0330","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ejphar.2015.06.010","article-title":"Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin","volume":"764","author":"Ma","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0335","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1007\/s11064-015-1803-y","article-title":"Beneficial effect of metformin on nerve regeneration and functional recovery after sciatic nerve crush injury in diabetic rats","volume":"41","author":"Ma","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0340","doi-asserted-by":"crossref","first-page":"490","DOI":"10.18632\/aging.100047","article-title":"The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway","volume":"1","author":"Maclaine","year":"2009","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0345","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/314560","article-title":"Protective mechanisms of flavonoids in Parkinson's disease","author":"Magalingam","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0350","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4103\/1673-5374.179032","article-title":"Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR","volume":"11","author":"Maiese","year":"2016","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0355","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1750-3639.2001.tb00385.x","article-title":"The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system","volume":"11","author":"Matsushima","year":"2001","journal-title":"Brain Pathol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0360","doi-asserted-by":"crossref","first-page":"20493","DOI":"10.1074\/jbc.M409985200","article-title":"Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke","volume":"280","author":"McCullough","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0365","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4049\/jimmunol.1202390","article-title":"AMP-activated protein kinase restricts IFN-\u03b3 signaling","volume":"190","author":"Meares","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0370","doi-asserted-by":"crossref","first-page":"25336","DOI":"10.1074\/jbc.M604399200","article-title":"Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro","volume":"281","author":"Momcilovic","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National Institute on Aging\u2013Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0380","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.2337\/dc13-0229","article-title":"Increased risk of cognitive impairment in patients with diabetes is associated with metformin","volume":"36","author":"Moore","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-016-0779-0","article-title":"Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease","volume":"14","author":"Moussa","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0390","doi-asserted-by":"crossref","first-page":"566","DOI":"10.4049\/jimmunol.175.1.566","article-title":"5-Aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis","volume":"175","author":"Nath","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0395","doi-asserted-by":"crossref","first-page":"8005","DOI":"10.4049\/jimmunol.0803563","article-title":"Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis","volume":"182","author":"Nath","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0400","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bbrc.2009.05.106","article-title":"Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity","volume":"386","author":"Nath","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0405","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.brainres.2015.09.008","article-title":"Involvement of AMPK, IK\u03b2\u03b1-NF\u03baB and eNOS in the sildenafil anti-inflammatory mechanism in a demyelination model","volume":"1627","author":"Nunes","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0410","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11010-016-2733-y","article-title":"\u03b2-Caryophyllene, a phytocannabinoid attenuates oxidative stress, neuroinflammation, glial activation, and salvages dopaminergic neurons in a rat model of Parkinson disease","volume":"418","author":"Ojha","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0415","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.brainres.2016.05.013","article-title":"Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice","volume":"1644","author":"Oliveira","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0420","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ajpath.2013.04.030","article-title":"AMP-activated protein kinase signaling protects oligodendrocytes that restore central nervous system functions in an experimental autoimmune encephalomyelitis model","volume":"183","author":"Paintlia","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0425","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1038\/onc.2008.26","article-title":"Foxo in the immune system","volume":"27","author":"Peng","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0430","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3233\/JAD-140444","article-title":"Neuroprotective role of trans\u2011resveratrol in a murine model of familial Alzheimer's disease","volume":"42","author":"Porquet","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0435","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ejphar.2015.03.042","article-title":"Animal models of multiple sclerosis","volume":"759","author":"Procaccini","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0440","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/ana.24063","article-title":"Diabetes, markers of brain pathology and cognitive function: the Age, Gene\/Environment Susceptibility-Reykjavik Study","volume":"75","author":"Qiu","year":"2014","journal-title":"Ann. Neurol."},{"issue":"362","key":"10.1016\/j.expneurol.2017.08.013_bb0445","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer's disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0450","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1113\/jphysiol.2006.110122","article-title":"Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain","volume":"574","author":"Ramamurthy","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0455","doi-asserted-by":"crossref","first-page":"628192","DOI":"10.1155\/2015\/628192","article-title":"Insights into neuroinflammation in Parkinson's disease: from biomarkers to anti-inflammatory based therapies","volume":"2015","author":"Rocha","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0460","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jns.2013.03.002","article-title":"Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination","volume":"333","author":"Rostami","year":"2013","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0465","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.25868","article-title":"Resveratrol ameliorates palmitate-induced inflammation in skeletal muscle cells by attenuating oxidative stress and JNK\/NF-KB pathway in a SIRT1-independent mechanism","author":"Sadeghi","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0470","doi-asserted-by":"crossref","first-page":"8633","DOI":"10.4049\/jimmunol.181.12.8633","article-title":"Adenosine 5\u2032-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype","volume":"181","author":"Sag","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0475","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.cellsig.2010.10.012","article-title":"Control of p53 and NF-\u03baB signaling by WIP1 and MIF: role in cellular senescence and organismal aging","volume":"23","author":"Salminen","year":"2011","journal-title":"Cell. Signal."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0480","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/bies.20799","article-title":"SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?","volume":"30","author":"Salminen","year":"2008","journal-title":"BioEssays"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0485","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1042\/BJ20061520","article-title":"Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade","volume":"403","author":"Sanders","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0490","first-page":"1","article-title":"Efecto neuroprotector de fitoqu\u00edmicos en cultivo de neuronas dopamin\u00e9rgicas","author":"Sandoval-Avila","year":"2016","journal-title":"Neurologia"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0495","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.1411576","article-title":"Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14","volume":"258","author":"Schellenberg","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0500","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1212\/WNL.0b013e3181ffe4f6","article-title":"Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study","volume":"75","author":"Schrijvers","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0505","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1097\/ALN.0000000000000856","article-title":"Activation of adenosine monophosphate\u2013activated protein kinase suppresses neuroinflammation and ameliorates bone cancer pain","volume":"123","author":"Song","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0510","doi-asserted-by":"crossref","first-page":"836","DOI":"10.2337\/db06-1119","article-title":"Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study","volume":"56","author":"Sriwijitkamol","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0515","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/physrev.00011.2008","article-title":"AMPK in health and disease","volume":"89","author":"Steinberg","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0520","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/ana.10488","article-title":"Neuroprotection in Parkinson's disease: clinical trials","author":"Stocchi","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0525","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1142\/S0192415X15500548","article-title":"(+)-Catechin attenuates NF-\u03baB activation through regulation of Akt, MAPK, and AMPK signaling pathways in LPS-induced BV-2 microglial cells","volume":"43","author":"Syed Hussein","year":"2015","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0530","first-page":"510","article-title":"Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention","volume":"37","author":"Tansey","year":"2010","journal-title":"Natl. Ins. Health"},{"key":"10.1016\/j.expneurol.2017.08.013_bb0535","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2007.07.004","article-title":"Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention","volume":"208","author":"Tansey","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0540","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/cns.12218","article-title":"Anthocyanins protect against kainic acid-induced excitotoxicity and apoptosis via ROS-activated AMPK pathway in hippocampal neurons","volume":"20","author":"Ullah","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0545","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1097\/NEN.0b013e3181587d46","article-title":"Platelet-derived growth factor promotes repair of chronically demyelinated white matter","volume":"66","author":"Vana","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0550","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms4017","article-title":"Structural basis of AMPK regulation by small molecule activators","volume":"4","author":"Xiao","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0555","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.phrs.2012.10.010","article-title":"Negative regulation of inflammation by SIRT1","volume":"67","author":"Xie","year":"2013","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0560","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1194\/jlr.P022905","article-title":"Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue","volume":"53","author":"Xu","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0565","article-title":"Adenosine monophosphate-activated protein kinase abates hyperglycaemia-induced neuronal injury in experimental models of diabetic neuropathy: effects on mitochondrial biogenesis, autophagy and neuroinflammation","volume":"1\u201312","author":"Yerra","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0570","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neuint.2013.05.011","article-title":"The protective effects of resveratrol on Schwann cells with toxicity induced by ethanol in vitro","volume":"63","author":"Yuan","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.expneurol.2017.08.013_bb0575","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1161\/01.ATV.0000221230.08596.98","article-title":"AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress","volume":"26","author":"Zhang","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488617302182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488617302182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T15:44:44Z","timestamp":1570031084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488617302182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":116,"alternative-id":["S0014488617302182"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2017.08.013","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AMPK activation: Role in the signaling pathways of neuroinflammation and neurodegeneration","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2017.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}