{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:28:41Z","timestamp":1790522921095,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Beijing Municipal Science & Technology Commission","award":["Z161100002616007"],"award-info":[{"award-number":["Z161100002616007"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"crossref","award":["2016YFC1306300"],"award-info":[{"award-number":["2016YFC1306300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81527901"],"award-info":[{"award-number":["81527901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7082008"],"award-info":[{"award-number":["7082008"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.expneurol.2017.11.006","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T06:30:14Z","timestamp":1510122614000},"page":"135-148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Impaired glutamatergic projection from the motor cortex to the subthalamic nucleus in 6-hydroxydopamine-lesioned hemi-parkinsonian rats"],"prefix":"10.1016","volume":"300","author":[{"given":"Yan-Yan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Fei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Hua","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Min","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2017.11.006_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.902360102","article-title":"Light microscopic analysis of Golgi-impregnated rat subthalamic neurons","volume":"236","author":"Afsharpour","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0010","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0166-2236(89)90074-X","article-title":"The functional anatomy of basal ganglia disorders","volume":"12","author":"Albin","year":"1989","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0015","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.neuroimage.2011.01.017","article-title":"Resting state fMRI reveals increased subthalamic nucleus-motor cortex connectivity in Parkinson's disease","volume":"55","author":"Baudrexel","year":"2011","journal-title":"NeuroImage"},{"key":"10.1016\/j.expneurol.2017.11.006_bb0020","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.cell.2015.07.015","article-title":"Circuit architecture of VTA dopamine neurons revealed by systematic input-output mapping","volume":"162","author":"Beier","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2017.11.006_bb0025","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1152\/jn.1994.72.2.507","article-title":"The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism","volume":"72","author":"Bergman","year":"1994","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0030","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1038\/nn.2925","article-title":"Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold","volume":"14","author":"Cavanagh","year":"2011","journal-title":"Nat. Neurosci."},{"issue":"1306\u20131318","key":"10.1016\/j.expneurol.2017.11.006_bb0035","article-title":"Loss of hyperdirect pathway cortico-subthalamic inputs following degeneration of midbrain dopamine neurons","volume":"95","author":"Chu","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.expneurol.2017.11.006_bb0040","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson's disease: mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.expneurol.2017.11.006_bb0045","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1001\/archneur.64.1.20","article-title":"Circuits and circuit disorders of the basal ganglia","volume":"64","author":"DeLong","year":"2007","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0050","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0896-6273(01)00344-0","article-title":"The expression of vesicular glutamate transporters defines two classes of excitatory synapse","volume":"31","author":"Fremeau","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.expneurol.2017.11.006_bb0055","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0300-9084(00)00221-2","article-title":"The loading of neurotransmitters into synaptic vesicles","volume":"82","author":"Gasnier","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.expneurol.2017.11.006_bb0060","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1073\/pnas.85.9.3260","article-title":"Remodeling of synaptic architecture during hippocampal \u201ckindling\u201d","volume":"85","author":"Geinisman","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0065","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0006-8993(91)91683-R","article-title":"Induction of long-term potentiation is associated with an increase in the number of axospinous synapses with segmented postsynaptic densities","volume":"566","author":"Geinisman","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0070","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1126\/science.1167093","article-title":"Optical deconstruction of parkinsonian neural circuitry","volume":"324","author":"Gradinaru","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2017.11.006_bb0075","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1126\/science.715459","article-title":"Subsynaptic plate perforations: changes with age and experience in the rat","volume":"202","author":"Greenough","year":"1978","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2017.11.006_bb0080","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nn.3997","article-title":"Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson's disease","volume":"18","author":"de Hemptinne","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0085","first-page":"1","article-title":"Cortico-subthalamic inputs from the motor, limbic, and associative areas in normal and dopamine-depleted rats are not fully segregated","volume":"221","author":"Janssen","year":"2016","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0090","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.neuron.2012.09.032","article-title":"Therapeutic deep brain stimulation in parkinsonian rats directly influences motor cortex","volume":"76","author":"Li","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.expneurol.2017.11.006_bb0095","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1056\/NEJM199810153391603","article-title":"Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease","volume":"339","author":"Limousin","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0100","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/brain\/awv018","article-title":"Reduced cortical innervation of the subthalamic nucleus in MPTP-treated parkinsonian monkeys","volume":"138","author":"Mathai","year":"2015","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0105","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neuroscience.2012.01.029","article-title":"Transneuronal tracing of airways-related sensory circuitry using herpes simplex virus 1, strain H129","volume":"207","author":"McGovern","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2017.11.006_bb0110","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jneumeth.2012.05.035","article-title":"Anterograde neuronal circuit tracing using a genetically modified herpes simplex virus expressing EGFP","volume":"209","author":"McGovern","year":"2012","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.expneurol.2017.11.006_bb0115","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1007\/s00429-014-0883-9","article-title":"Evidence for multiple sensory circuits in the brain arising from the respiratory system: an anterograde viral tract tracing study in rodents","volume":"220","author":"McGovern","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0120","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1006\/exnr.2000.7467","article-title":"Alterations in rat striatal glutamate synapses following a lesion of the cortico- and\/or nigrostriatal pathway","volume":"165","author":"Meshul","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0125","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/0959-4388(93)90167-W","article-title":"Basal ganglia intrinsic circuits and their role in behavior","volume":"3","author":"Mink","year":"1993","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0130","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fnsys.2013.00079","article-title":"Subthalamic nucleus long-range synchronization-an independent hallmark of human Parkinson's disease","volume":"7","author":"Moshel","year":"2013","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0135","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0168-0102(02)00027-5","article-title":"Functional significance of the cortico-subthalamo-pallidal \u2018hyperdirect\u2019 pathway","volume":"43","author":"Nambu","year":"2002","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0140","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0149-7634(98)00008-6","article-title":"Herpes simplex virus as a transneuronal tracer","volume":"22","author":"Norgren","year":"1998","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0145","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0361-9230(92)90038-Y","article-title":"Anterograde transport of HSV-1 and HSV-2 in the visual system","volume":"28","author":"Norgren","year":"1992","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085858","article-title":"Independently outgrowing neurons and geometry-based synapse formation produce networks with realistic synaptic connectivity","volume":"9","author":"van Ooyen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2017.11.006_bb0155","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.1172\/JCI75587","article-title":"Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits","volume":"124","author":"Pan","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0160","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0006-8993(79)90359-7","article-title":"Corticosubthalamic projection in the cat: an electron microscopic study","volume":"163","author":"Romansky","year":"1979","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0165","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature14600","article-title":"Viral-genetic tracing of the input-output organization of a central noradrenaline circuit","volume":"524","author":"Schwarz","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2017.11.006_bb0170","doi-asserted-by":"crossref","first-page":"7220","DOI":"10.1523\/JNEUROSCI.4676-12.2013","article-title":"Subthalamic nucleus neurons are synchronized to primary motor cortex local field potentials in Parkinson's disease","volume":"33","author":"Shimamoto","year":"2013","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/7842362","article-title":"Electroacupuncture alleviates depressive-like symptoms and modulates BDNF signaling in 6-hydroxydopamine rats","volume":"2016","author":"Sun","year":"2016","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0180","doi-asserted-by":"crossref","first-page":"15971","DOI":"10.1523\/JNEUROSCI.1702-15.2015","article-title":"NMDA receptors containing the GluN2D subunit control neuronal function in the subthalamic nucleus","volume":"35","author":"Swanger","year":"2015","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0185","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1002\/cne.23511","article-title":"Cortical inputs innervate calbindin-immunoreactive interneurons of the rat basolateral amygdaloid complex","volume":"522","author":"Unal","year":"2014","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0190","doi-asserted-by":"crossref","first-page":"R1049","DOI":"10.1152\/ajpregu.00640.2011","article-title":"Anterograde transneuronal viral tract tracing reveals central sensory circuits from brown fat and sensory denervation alters its thermogenic responses","volume":"302","author":"Vaughan","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0195","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Watson","year":"2007"},{"key":"10.1016\/j.expneurol.2017.11.006_bb0200","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00429-014-0733-9","article-title":"The neuroinvasive profiles of H129 (herpes simplex virus type 1) recombinants with putative anterograde-only transneuronal spread properties","volume":"220","author":"Wojaczynski","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0205","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1227\/NEU.0000000000000297","article-title":"Optogenetic inactivation of the subthalamic nucleus improves forelimb akinesia in a rat model of Parkinson disease","volume":"74","author":"Yoon","year":"2014","journal-title":"Neurosurgery"},{"key":"10.1016\/j.expneurol.2017.11.006_bb0210","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1242\/jcs.157867","article-title":"alpha-Synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons","volume":"128","author":"Zaltieri","year":"2015","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.expneurol.2017.11.006_bb0215","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13024-017-0179-7","article-title":"Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129","volume":"12","author":"Zeng","year":"2017","journal-title":"Mol. Neurodegener."},{"issue":"138\u2013152","key":"10.1016\/j.expneurol.2017.11.006_bb0220","article-title":"A central catecholaminergic circuit controls blood glucose levels during stress","volume":"95","author":"Zhao","year":"2017","journal-title":"Neuron"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488617302972?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488617302972?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T22:35:18Z","timestamp":1750977318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488617302972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":44,"alternative-id":["S0014488617302972"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2017.11.006","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired glutamatergic projection from the motor cortex to the subthalamic nucleus in 6-hydroxydopamine-lesioned hemi-parkinsonian rats","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2017.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}