{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:03:04Z","timestamp":1793138584628,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17GRNT33670031"],"award-info":[{"award-number":["17GRNT33670031"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.expneurol.2017.12.008","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T02:51:49Z","timestamp":1513824709000},"page":"70-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"PA","title":["CpG-ODN exerts a neuroprotective effect via the TLR9\/pAMPK signaling pathway by activation of autophagy in a neonatal HIE rat model"],"prefix":"10.1016","volume":"301","author":[{"given":"Lan","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanhui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desislava","family":"Doycheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Malaguit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningbo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2392-9280","authenticated-orcid":false,"given":"Jiping","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.expneurol.2017.12.008_bb0005","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/jcbfm.2011.6","article-title":"Proof of concept: pharmacological preconditioning with a Toll-like receptor agonist protects against cerebrovascular injury in a primate model of stroke","volume":"31","author":"Bahjat","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"4","key":"10.1016\/j.expneurol.2017.12.008_bb0010","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s12975-017-0532-8","article-title":"Preclinical development of a prophylactic neuroprotective therapy for the preventive treatment of anticipated ischemia-reperfusion injury","volume":"8","author":"Bahjat","year":"2017","journal-title":"Transl Stroke Res"},{"issue":"8","key":"10.1016\/j.expneurol.2017.12.008_bb0015","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.4161\/auto.7138","article-title":"Autophagy and toll-like receptors: a new link in cancer cells","volume":"4","author":"Bertin","year":"2008","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.expneurol.2017.12.008_bb0020","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbr.2010.03.043","article-title":"Predicting sensorimotor and memory deficits after neonatal ischemic stroke with reperfusion in the rat","volume":"212","author":"Bouet","year":"2010","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.expneurol.2017.12.008_bb0025","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbadis.2012.08.008","article-title":"CpG-ODN, the TLR9 agonist, attenuates myocardial ischemia\/reperfusion injury: involving activation of PI3K\/Akt signaling","volume":"1832","author":"Cao","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.expneurol.2017.12.008_bb0030","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.nbd.2008.07.022","article-title":"Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury","volume":"32","author":"Carloni","year":"2008","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"10.1016\/j.expneurol.2017.12.008_bb0035","doi-asserted-by":"crossref","first-page":"366","DOI":"10.4161\/auto.6.3.11261","article-title":"Activation of autophagy and Akt\/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia","volume":"6","author":"Carloni","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.expneurol.2017.12.008_bb0040","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.expneurol.2014.03.002","article-title":"Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxia-ischemia: role of protein synthesis and autophagic pathways","volume":"255","author":"Carloni","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2017.12.008_bb0045","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s12975-011-0081-5","article-title":"Prolonged exposure to isoflurane ameliorates infarction severity in the rat pup model of neonatal hypoxia-ischemia","volume":"2","author":"Chen","year":"2011","journal-title":"Transl Stroke Res"},{"issue":"27","key":"10.1016\/j.expneurol.2017.12.008_bb0050","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.1016\/j.biomaterials.2012.05.064","article-title":"Simultaneous induction of autophagy and toll-like receptor signaling pathways by graphene oxide","volume":"33","author":"Chen","year":"2012","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.expneurol.2017.12.008_bb0055","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/sj.icb.7100103","article-title":"Toll-like receptors in the brain and their potential roles in neuropathology","volume":"85","author":"Crack","year":"2007","journal-title":"Immunol. Cell Biol."},{"issue":"3","key":"10.1016\/j.expneurol.2017.12.008_bb0060","doi-asserted-by":"crossref","first-page":"322","DOI":"10.4161\/auto.6.3.11625","article-title":"Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer","volume":"6","author":"Dalby","year":"2010","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.expneurol.2017.12.008_bb0065","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2567.2005.02211.x","article-title":"Differential effects of CpG-DNA in Toll-like receptor-2\/-4\/-9 tolerance and cross-tolerance","volume":"116","author":"Dalpke","year":"2005","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.expneurol.2017.12.008_bb0070","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1042\/BJ20150129","article-title":"Co-operation of \u03b1-galactosylceramide-loaded tumor cells and TLR9 agonists induce potent anti-tumor responses in a murine colon cancer model","volume":"473","author":"Dong","year":"2016","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.expneurol.2017.12.008_bb0075","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12975-012-0225-2","article-title":"Granulocyte-colony stimulating in combination with stem cell factor confers greater neuroprotection after hypoxic-ischemic brain damage in the neonatal rats than a solitary treatment","volume":"4","author":"Doycheva","year":"2013","journal-title":"Transl Stroke Res"},{"issue":"2","key":"10.1016\/j.expneurol.2017.12.008_bb0080","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ceb.2009.10.007","article-title":"mTOR and cancer: many loops in one pathway","volume":"22","author":"Efeyan","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"issue":"9","key":"10.1016\/j.expneurol.2017.12.008_bb0085","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.2174\/1871527313666140806124850","article-title":"Toll-like receptors in Alzheimer's disease: a therapeutic perspective","volume":"13","author":"Gambuzza","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"2","key":"10.1016\/j.expneurol.2017.12.008_bb0095","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2008.03.003","article-title":"AMPK phosphorylation of raptor mediates a metabolic checkpoint","volume":"30","author":"Gwinn","year":"2008","journal-title":"Mol. Cell"},{"issue":"7095","key":"10.1016\/j.expneurol.2017.12.008_bb0100","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature04724","article-title":"Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice","volume":"441","author":"Hara","year":"2006","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.expneurol.2017.12.008_bb0105","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/ncb1753","article-title":"Regulation of TORC1 by Rag GTPases in nutrient response","volume":"10","author":"Kim","year":"2008","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.expneurol.2017.12.008_bb0110","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1189\/jlb.1107775","article-title":"Synthetic oligonucleotides as modulators of inflammation","volume":"84","author":"Klinman","year":"2008","journal-title":"J. Leukoc. Biol."},{"issue":"7095","key":"10.1016\/j.expneurol.2017.12.008_bb0115","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nature04723","article-title":"Loss of autophagy in the central nervous system causes neurodegeneration in mice","volume":"441","author":"Komatsu","year":"2006","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.expneurol.2017.12.008_bb0120","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.addr.2007.12.004","article-title":"TLR9 as a key receptor for the recognition of DNA","volume":"60","author":"Kumagai","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"11","key":"10.1016\/j.expneurol.2017.12.008_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0015394","article-title":"The association of AMPK with ULK1 regulates autophagy","volume":"5","author":"Lee","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.expneurol.2017.12.008_bb0130","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.expneurol.2012.04.003","article-title":"Rodent neonatal germinal matrix hemorrhage mimics the human brain injury, neurological consequences, and post-hemorrhagic hydrocephalus","volume":"236","author":"Lekic","year":"2012","journal-title":"Exp. Neurol."},{"issue":"6","key":"10.1016\/j.expneurol.2017.12.008_bb0135","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1161\/STROKEAHA.114.007889","article-title":"Protease-activated receptor 1 and 4 signal inhibition reduces preterm neonatal hemorrhagic brain injury","volume":"46","author":"Lekic","year":"2015","journal-title":"Stroke"},{"issue":"7330","key":"10.1016\/j.expneurol.2017.12.008_bb0140","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature09782","article-title":"Autophagy in immunity and inflammation","volume":"469","author":"Levine","year":"2011","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.expneurol.2017.12.008_bb0145","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s12975-015-0441-7","article-title":"Acute blockage of notch signaling by DAPT induces neuroprotection and neurogenesis in the neonatal rat brain after stroke","volume":"7","author":"Li","year":"2016","journal-title":"Transl Stroke Res"},{"issue":"3\u20134","key":"10.1016\/j.expneurol.2017.12.008_bb0150","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbrc.2016.10.105","article-title":"The role of TLR9 in stress-dependent autophagy formation","volume":"481","author":"Lim","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.expneurol.2017.12.008_bb0155","first-page":"425","article-title":"A quantitative review of mortality and developmental disability in extremely premature newborns","volume":"152","author":"Lorenz","year":"1998","journal-title":"Arch. Pediatr. Adolesc. Med."},{"issue":"2","key":"10.1016\/j.expneurol.2017.12.008_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.113.000629","article-title":"The TLR9 ligand, CpG-ODN, induces protection against cerebral ischemia\/reperfusion injury via activation of PI3K\/Akt signaling","volume":"3","author":"Lu","year":"2014","journal-title":"J. Am. Heart Assoc."},{"issue":"6","key":"10.1016\/j.expneurol.2017.12.008_bb0165","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s12975-016-0478-2","article-title":"Integrin \u03b28 deletion enhances vascular dysplasia and hemorrhage in the brain of adult Alk1 heterozygous mice","volume":"7","author":"Ma","year":"2016","journal-title":"Transl Stroke Res"},{"issue":"6","key":"10.1016\/j.expneurol.2017.12.008_bb0170","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1053\/j.semperi.2004.10.005","article-title":"Mechanisms of hypoxic-ischemic injury in the term infant","volume":"28","author":"McLean","year":"2004","journal-title":"Semin. Perinatol."},{"issue":"22","key":"10.1016\/j.expneurol.2017.12.008_bb0175","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1101\/gad.1599207","article-title":"Autophagy: process and function","volume":"21","author":"Mizushima","year":"2007","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.expneurol.2017.12.008_bb0180","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s12975-016-0466-6","article-title":"Role of cyclooxygenase-2 in relation to nitric oxide and endothelin-1 on pathogenesis of cerebral vasospasm after subarachnoid hemorrhage in rabbit","volume":"7","author":"Munakata","year":"2016","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.expneurol.2017.12.008_bb0185","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev.immunol.021908.132537","article-title":"Enhancing immunity through autophagy","volume":"27","author":"M\u00fcnz","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.expneurol.2017.12.008_bb0190","doi-asserted-by":"crossref","first-page":"H1485","DOI":"10.1152\/ajpheart.00481.2016","article-title":"Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation","volume":"311","author":"Omiya","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.expneurol.2017.12.008_bb0195","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pneurobio.2013.03.002","article-title":"Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: a challenge for neuroprotection","volume":"105","author":"Puyal","year":"2013","journal-title":"Prog. Neurobiol."},{"issue":"1","key":"10.1016\/j.expneurol.2017.12.008_bb0200","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12885-017-3055-5","article-title":"Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells","volume":"17","author":"Rao","year":"2017","journal-title":"BMC Cancer"},{"issue":"7173","key":"10.1016\/j.expneurol.2017.12.008_bb0205","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nature06421","article-title":"Toll-like receptor signaling in macrophages links the autophagy pathway to phagocytosis","volume":"450","author":"Sanjuan","year":"2007","journal-title":"Nature"},{"issue":"1\u20132","key":"10.1016\/j.expneurol.2017.12.008_bb0210","first-page":"1","article-title":"Postconditioning with a CpG containing oligodeoxynucleotide ameliorates myocardial infarction in a murine closed-chest model","volume":"119","author":"Se-Chan","year":"2014","journal-title":"Life Sci."},{"issue":"Suppl. 3","key":"10.1016\/j.expneurol.2017.12.008_bb0215","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/dmcn.12724","article-title":"Neonatal seizures in hypoxic-ischemic encephalopathy\u2013risks and benefits of anticonvulsant therapy","volume":"57","author":"Shetty","year":"2015","journal-title":"Dev. Med. Child Neurol."},{"issue":"4","key":"10.1016\/j.expneurol.2017.12.008_bb0220","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1177\/0271678X16656201","article-title":"Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups","volume":"37","author":"Shi","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"13","key":"10.1016\/j.expneurol.2017.12.008_bb0225","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1073\/pnas.1219243110","article-title":"TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons","volume":"110","author":"Shintani","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.expneurol.2017.12.008_bb0230","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/embr.201337945","article-title":"Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2","volume":"15","author":"Shintani","year":"2014","journal-title":"EMBO Rep."},{"issue":"5","key":"10.1016\/j.expneurol.2017.12.008_bb0235","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/sj.jcbfm.9600606","article-title":"Toll-like receptor 9: a new target of ischemic preconditioning in the brain","volume":"28","author":"Stevens","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"1\u20132","key":"10.1016\/j.expneurol.2017.12.008_bb0240","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0166-4328(03)00146-3","article-title":"Brain injury and neurofunctional deficit in neonatal mice with hypoxic-ischemic encephalopathy","volume":"145","author":"Ten","year":"2003","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.expneurol.2017.12.008_bb0245","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s12975-015-0433-7","article-title":"Ginkgo biloba extract prevents female mice from ischemic brain damage and the mechanism is independent of the HO1\/Wnt pathway","volume":"7","author":"Tulsulkar","year":"2016","journal-title":"Transl. Stroke Res."},{"issue":"2","key":"10.1016\/j.expneurol.2017.12.008_bb0250","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/(SICI)1097-4547(19990115)55:2<158::AID-JNR3>3.0.CO;2-1","article-title":"Rat model of perinatal hypoxic-ischemic brain damage","volume":"55","author":"Vannucci","year":"1999","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.expneurol.2017.12.008_bb0255","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/jcbfm.2014.193","article-title":"CpG preconditioning regulates miRNA expression that modulates genomic reprogramming associated with neuroprotection against ischemic injury","volume":"35","author":"Vartanian","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"3","key":"10.1016\/j.expneurol.2017.12.008_bb0260","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.120","article-title":"Inhibition of autophagy prevents irradiation-induced neural stem and progenitor cell death in the juvenile mouse brain","volume":"8","author":"Wang","year":"2017","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.expneurol.2017.12.008_bb0265","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s12975-016-0484-4","article-title":"cPKC\u03b3-modulated autophagy in neurons alleviates ischemic injury in brain of mice with ischemic stroke through Akt-mTOR pathway","volume":"7","author":"Wei","year":"2016","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.expneurol.2017.12.008_bb0270","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.lfs.2016.07.016","article-title":"CpG-ODN promotes phagocytosis and autophagy through JNK\/P38 signal pathway in Staphylococcus aureus-stimulated macrophage","volume":"161","author":"Wu","year":"2016","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.expneurol.2017.12.008_bb0275","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbrc.2015.01.006","article-title":"AMP-activated protein kinase-dependent autophagy mediated the protective effect of sonichedgehog pathway on oxygen glucose deprivation-induced injury of cardiomyocytes","volume":"457","author":"Xiao","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.expneurol.2017.12.008_bb0280","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1080\/15548627.2015.1132134","article-title":"Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury","volume":"12","author":"Xie","year":"2016","journal-title":"Autophagy"},{"issue":"9","key":"10.1016\/j.expneurol.2017.12.008_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0024705","article-title":"Timing is critical for an effective anti-metastatic immunotherapy the decisive role of IFN\u03b3 STAT1 mediated activation of autophagy","volume":"6","author":"Yan","year":"2011","journal-title":"PLoS One"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488617303436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488617303436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T00:55:00Z","timestamp":1535158500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488617303436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":56,"alternative-id":["S0014488617303436"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2017.12.008","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CpG-ODN exerts a neuroprotective effect via the TLR9\/pAMPK signaling pathway by activation of autophagy in a neonatal HIE rat model","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2017.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}