{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:34:06Z","timestamp":1784835246769,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.expneurol.2018.07.014","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T12:56:42Z","timestamp":1532523402000},"page":"14-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["A genetic deficiency in folic acid metabolism impairs recovery after ischemic stroke"],"prefix":"10.1016","volume":"309","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3557-7307","authenticated-orcid":false,"given":"Nafisa M.","family":"Jadavji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua T.","family":"Emmerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1252-8043","authenticated-orcid":false,"given":"Ushananthini","family":"Shanmugalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"MacFarlane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Willmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice D.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2018.07.014_bb0005","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1139\/o05-045","article-title":"Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibition","volume":"83","author":"Abu-Farha","year":"2005","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0010","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1023\/A:1022385402197","article-title":"Astrocytes and stroke: networking for survival?","volume":"28","author":"Anderson","year":"2003","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nature17623","article-title":"Astrocyte scar formation aids central nervous system axon regeneration","volume":"532","author":"Anderson","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0020","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s12975-013-0266-1","article-title":"Perlecan domain V is neuroprotective and affords functional improvement in a photothrombotic stroke model in young and aged mice","volume":"4","author":"Bix","year":"2013","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0025","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJMoa055227","article-title":"Homocysteine lowering and cardiovascular events after acute myocardial infarction","volume":"354","author":"B\u00f8naa","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0030","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1365-2362.1992.tb01829.x","article-title":"Hyperhomocysteinaemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors","volume":"22","author":"Brattstrom","year":"1992","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0035","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/ana.20845","article-title":"Cellular and molecular mechanisms of neural repair after stroke: making waves","volume":"59","author":"Carmichael","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10545-006-0106-5","article-title":"Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview","volume":"29","author":"Castro","year":"2006","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0045","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/hmg\/10.5.433","article-title":"Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition","volume":"10","author":"Chen","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0050","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/jcbfm.2013.7","article-title":"Multimodal examination of structural and functional remapping in the mouse photothrombotic stroke model","volume":"33","author":"Clarkson","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0055","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1161\/01.STR.0000169946.31639.af","article-title":"Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis","volume":"36","author":"Cronin","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0060","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1182\/blood-2003-09-3078","article-title":"Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice","volume":"103","author":"Devlin","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0065","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1161\/STROKEAHA.116.013244","article-title":"Thomas Willis lecture: is translational stroke research broken, and if so, how can we fix it?","volume":"47","author":"Dirnagl","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0070","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1161\/01.STR.23.8.1084","article-title":"Measurement of motor recovery after stroke. Outcome assessment and sample size requirements","volume":"23","author":"Duncan","year":"1992","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0075","series-title":"Movement Notation. London","author":"Eshkol","year":"1958"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0080","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1161\/01.STR.0000020714.48349.4E","article-title":"Quantitative and qualitative impairments in skilled reaching in the mouse (Mus musculus) after a focal motor cortex stroke","volume":"33","author":"Farr","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0085","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jneumeth.2005.10.011","article-title":"Bilateral alteration in stepping pattern after unilateral motor cortex injury: a new test strategy for analysis of skilled limb movements in neurological mouse models","volume":"153","author":"Farr","year":"2006","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0090","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000441106","article-title":"Atlas of the global burden of stroke (1990-2013): the GBD 2013 study","volume":"45","author":"Feigin","year":"2015","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0095","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1021\/tx060045z","article-title":"Cytotoxicity and cytoprotective activity of naphthalenediols in rat cortical neurons","volume":"19","author":"Flueraru","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0100","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0105","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1001\/jama.2010.490","article-title":"Effect of B-vitamin therapy on progression of diabetic nephropathy","volume":"303","author":"House","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0110","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1001\/jama.2015.2274","article-title":"Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China","volume":"313","author":"Huo","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0115","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1172\/JCI40000","article-title":"Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation","volume":"120","author":"Iskandar","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0120","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ymgme.2012.03.020","article-title":"Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus","volume":"106","author":"Jadavji","year":"2012","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0125","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.nbd.2017.04.001","article-title":"B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke","volume":"103","author":"Jadavji","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0130","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.neuint.2008.03.001","article-title":"Effects of homocysteine on metabolic pathways in cultured astrocytes","volume":"52","author":"Jin","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0135","first-page":"538","article-title":"Experience-dependent neural plasticity in the adult damaged brain","volume":"44","author":"Kerr","year":"2011","journal-title":"J. Commun. Disord."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0140","series-title":"Neurodegeneration: Methods and Protocols","first-page":"63","article-title":"Isolation and culture of neurons and astrocytes from the mouse brain cortex","author":"Kim","year":"2011"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0145","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1177\/1545968312440745","article-title":"Getting neurorehabilitation right: what can be learned from animal models? Neurorehabil","volume":"26","author":"Krakauer","year":"2012","journal-title":"Neural Repair"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0150","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1523\/JNEUROSCI.1643-04.2004","article-title":"Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity","volume":"24","author":"Lee","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0155","article-title":"Homocysteine induces glial reactivity in adult rat astrocyte cultures","volume":"1\u201311","author":"Longoni","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0160","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease","volume":"354","author":"Lonn","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0165","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0304-3940(03)00655-4","article-title":"Homocysteine induces cell death of rat astrocytes in vitro","volume":"347","author":"Maler","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0170","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0165-0173(99)00086-7","article-title":"Regulation of astrocyte gap junctions by hypoxia-reoxygenation","volume":"32","author":"Mart\u00ednez","year":"2000","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0175","series-title":"Folic Acid and Homocysteine in Age-Related Disease","first-page":"95","volume":"1","author":"Mattson","year":"2002"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0180","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.pneurobio.2011.01.005","article-title":"GFAP in health and disease","volume":"93","author":"Middeldorp","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0185","first-page":"e38","article-title":"Heart disease and stroke Statistics-2016 update: a report from the American Heart Association","volume":"133","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0190","first-page":"1","article-title":"In situ trypan blue staining of monolayer cell cultures for permanent fixation and mounting","volume":"23","author":"Perry","year":"1997","journal-title":"BioTechniques"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0195","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm0603-677","article-title":"Regulation of angiogenesis by hypoxia: role of the HIF system","volume":"9","author":"Pugh","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0200","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1086\/301836","article-title":"Worldwide distribution of a common methylenetetrahydrofolate reductase mutation","volume":"62","author":"Schneider","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0205","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neuint.2016.12.016","article-title":"Reactive astrogliosis in stroke: contributions of astrocytes to recovery of neurological function","volume":"107","author":"Sims","year":"2017","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0210","doi-asserted-by":"crossref","first-page":"747","DOI":"10.33549\/physiolres.932897","article-title":"Effect of homocysteine on survival of human glial cells","volume":"64","author":"\u0160kovierov\u00e1","year":"2015","journal-title":"Physiol. Res."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0215","first-page":"1","article-title":"Association between 5,10-methylenetetrahydrofolate reductase C677T gene polymorphism and risk of ischemic stroke: a meta-analysis","author":"Song","year":"2016","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0220","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S1474-4422(07)70219-3","article-title":"Homocysteine-lowering therapy: a role in stroke prevention?","volume":"6","author":"Spence","year":"2007","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0225","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S1474-4422(17)30180-1","article-title":"B vitamins in stroke prevention: time to reconsider","volume":"16","author":"Spence","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0230","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1177\/1545968314541329","article-title":"Age-dependent reorganization of Peri-infarct \u201cpremotor\u201d cortex with task-specific rehabilitative training in mice. Neurorehabil","volume":"29","author":"Tennant","year":"2015","journal-title":"Neural Repair"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0235","first-page":"1","article-title":"Granulocyte macrophage colony stimulating factor treatment results in recovery of motor function after white matter damage in mice","volume":"43","author":"Theoret","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2018.07.014_bb0240","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/jama.291.5.565","article-title":"Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death","volume":"291","author":"Toole","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0245","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1177\/1545968314562115","article-title":"Generalizability of the proportional recovery model for the upper extremity after an ischemic stroke","volume":"29","author":"Winters","year":"2015","journal-title":"Neurorehabil. Neural Repair"},{"key":"10.1016\/j.expneurol.2018.07.014_bb0250","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.nurt.2010.07.004","article-title":"Targeting astrocytes for stroke therapy","volume":"7","author":"Zhao","year":"2010","journal-title":"Neurotherapeutics"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488618302644?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488618302644?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:50:21Z","timestamp":1762149021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488618302644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":50,"alternative-id":["S0014488618302644"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2018.07.014","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A genetic deficiency in folic acid metabolism impairs recovery after ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2018.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}