{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:11:33Z","timestamp":1793308293574,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["13POST16860015"],"award-info":[{"award-number":["13POST16860015"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of General Medical Sciences of the National Institutes of Health","award":["1R01-HD-057100"],"award-info":[{"award-number":["1R01-HD-057100"]}]},{"name":"National Institute of General Medical Sciences of the National Institutes of Health","award":["R21-NS096525"],"award-info":[{"award-number":["R21-NS096525"]}]},{"name":"National Institute of General Medical Sciences of the National Institutes of Health","award":["P20 RR018728"],"award-info":[{"award-number":["P20 RR018728"]}]},{"name":"National Institute of General Medical Sciences of the National Institutes of Health","award":["P20GM103537"],"award-info":[{"award-number":["P20GM103537"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.expneurol.2018.09.007","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T02:29:05Z","timestamp":1536719345000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["High-mobility group box-1 translocation and release after hypoxic ischemic brain injury in neonatal rats"],"prefix":"10.1016","volume":"311","author":[{"given":"Xiaodi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boram","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhant","family":"Jaitpal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven S.","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwame","family":"Adjepong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayumi","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Wake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Nishibori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward G.","family":"Stopa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara S.","family":"Stonestreet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2018.09.007_bb0005","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0143-4160(03)00141-6","article-title":"Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity","volume":"34","author":"Arundine","year":"2003","journal-title":"Cell Calcium"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0010","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/sj.jcbfm.9600344","article-title":"Hypoxia-ischemia preferentially triggers glutamate depletion from oligodendroglia and axons in perinatal cerebral white matter","volume":"27","author":"Back","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0015","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4161\/auto.5.2.7363","article-title":"Autophagy in hypoxia-ischemia induced brain injury: evidence and speculations","volume":"5","author":"Balduini","year":"2009","journal-title":"Autophagy"},{"issue":"Suppl. 1","key":"10.1016\/j.expneurol.2018.09.007_bb0020","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3109\/14767058.2012.663176","article-title":"Autophagy in hypoxia-ischemia induced brain injury","volume":"25","author":"Balduini","year":"2012","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0025","doi-asserted-by":"crossref","first-page":"C1318","DOI":"10.1152\/ajpcell.00616.2005","article-title":"The extracellular release of HMGB1 during apoptotic cell death","volume":"291","author":"Bell","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0030","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1093\/emboj\/cdg516","article-title":"Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion","volume":"22","author":"Bonaldi","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0035","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.nbd.2008.07.022","article-title":"Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury","volume":"32","author":"Carloni","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3940(97)00445-X","article-title":"Identification of necrotic cell death by the TUNEL assay in the hypoxic-ischemic neonatal rat brain","volume":"230","author":"de Torres","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0045","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1471-4159.2007.04788.x","article-title":"High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo","volume":"103","author":"Faraco","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0050","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.clp.2009.07.011","article-title":"Hypoxic-ischemic encephalopathy in the term infant","volume":"36","author":"Fatemi","year":"2009","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0055","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/jnen\/nlx004","article-title":"Location, location, location: appraising the pleiotropic function of HMGB1 in fetal brain","volume":"76","author":"Frasch","year":"2017","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0060","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12974-016-0567-x","article-title":"Decreased neuroinflammation correlates to higher vagus nerve activity fluctuations in near-term ovine fetuses: a case for the afferent cholinergic anti-inflammatory pathway?","volume":"13","author":"Frasch","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0065","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/s41598-017-01325-y","article-title":"Therapeutic effects of anti-HMGB1 monoclonal antibody on pilocarpine-induced status epilepticus in mice","volume":"7","author":"Fu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0070","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.nbd.2014.01.020","article-title":"Fetal hypoxia increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of glucocorticoid receptors","volume":"65","author":"Gonzalez-Rodriguez","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/srep23431","article-title":"Nuquantus: machine learning software for the characterization and quantification of cell nuclei in complex immunofluorescent tissue images","volume":"6","author":"Gross","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0080","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1567-133X(02)00093-5","article-title":"HMGB1, an architectural chromatin protein and extracellular signalling factor, has a spatially and temporally restricted expression pattern in mouse brain","volume":"3","author":"Guazzi","year":"2003","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0085","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1073\/pnas.1121146109","article-title":"Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery","volume":"109","author":"Hayakawa","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0090","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.jcrc.2012.10.003","article-title":"Relationship between plasma high-mobility group box-1 levels and clinical outcomes of ischemic stroke","volume":"28","author":"Huang","year":"2013","journal-title":"J. Crit. Care"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0095","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1523\/JNEUROSCI.3815-05.2006","article-title":"HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain","volume":"26","author":"Kim","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0100","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/jnr.21555","article-title":"Induction and subcellular localization of high-mobility group box-1 (HMGB1) in the postischemic rat brain","volume":"86","author":"Kim","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0105","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pneurobio.2012.05.010","article-title":"Fetal stress and programming of hypoxic\/ischemic-sensitive phenotype in the neonatal brain: mechanisms and possible interventions","volume":"98","author":"Li","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0110","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3892\/ijmm.2014.1820","article-title":"High-mobility group box 1 released from astrocytes promotes the proliferation of cultured neural stem\/progenitor cells","volume":"34","author":"Li","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0115","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/364626a0","article-title":"A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds","volume":"364","author":"Lipton","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0120","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1161\/01.STR.25.7.1481","article-title":"Tumor necrosis factor-alpha expression in ischemic neurons","volume":"25","author":"Liu","year":"1994","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0125","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1096\/fj.07-8770com","article-title":"Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats","volume":"21","author":"Liu","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0130","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jnr.21825","article-title":"Effects of maternal antenatal glucocorticoid treatment on apoptosis in the ovine fetal cerebral cortex","volume":"87","author":"Malaeb","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0135","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/561494","article-title":"The role of cytokines and inflammatory cells in perinatal brain injury","volume":"2012","author":"McAdams","year":"2012","journal-title":"Neurol. Res. Int."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0140","doi-asserted-by":"crossref","first-page":"16722","DOI":"10.1016\/S0021-9258(18)55361-8","article-title":"30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane","volume":"266","author":"Merenmies","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0145","doi-asserted-by":"crossref","first-page":"12023","DOI":"10.1523\/JNEUROSCI.2435-08.2008","article-title":"The HMGB1 receptor RAGE mediates ischemic brain damage","volume":"28","author":"Muhammad","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0150","doi-asserted-by":"crossref","first-page":"7994","DOI":"10.1523\/JNEUROSCI.20-21-07994.2000","article-title":"Apoptosis has a prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat","volume":"20","author":"Nakajima","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0155","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1155\/2013\/327604","article-title":"Brain hypothermic therapy dramatically decreases elevated blood concentrations of high mobility group box 1 in neonates with hypoxic-ischemic encephalopathy","volume":"35","author":"Nakamura","year":"2013","journal-title":"Dis. Markers"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0160","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.clp.2018.01.015","article-title":"Perinatal Brain Injury: Mechanisms, Prevention, and Outcomes","volume":"45","author":"Novak","year":"2018","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0165","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/ana.23602","article-title":"Anti-high mobility group box-1 antibody therapy for traumatic brain injury","volume":"72","author":"Okuma","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0170","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuroscience.2017.04.047","article-title":"Human neural stem\/progenitor cells derived from the olfactory epithelium express the TrkB receptor and migrate in response to BDNF","volume":"355","author":"Ortiz-Lopez","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0175","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0306-4522(97)00352-7","article-title":"Stimulated astrocytes release high-mobility group 1 protein, an inducer of LAN-5 neuroblastoma cell differentiation","volume":"82","author":"Passalacqua","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0180","series-title":"The Rat Brain in Stereotaxic Coordinates: Compact","author":"Paxinos","year":"2017"},{"issue":"Suppl. 1","key":"10.1016\/j.expneurol.2018.09.007_bb0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/14767058.2012.663168","article-title":"New pharmacologic and therapeutic approaches for hypoxic-ischemic encephalopathy in the newborn","volume":"25","author":"Perrone","year":"2012","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0190","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1161\/01.STR.29.12.2622","article-title":"Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia","volume":"29","author":"Pulera","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0195","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/sj.jcbfm.9600582","article-title":"Early release of HMGB-1 from neurons after the onset of brain ischemia","volume":"28","author":"Qiu","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0200","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic-ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0205","doi-asserted-by":"crossref","first-page":"H179","DOI":"10.1152\/ajpheart.00828.2009","article-title":"Maternal glucocorticoid exposure alters tight junction protein expression in the brain of fetal sheep","volume":"298","author":"Sadowska","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0210","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3940(96)12460-5","article-title":"Early increases in TNF-alpha, IL-6 and IL-1 beta levels following transient cerebral ischemia in gerbil brain","volume":"206","author":"Saito","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0215","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1 by necrotic cells triggers inflammation","volume":"418","author":"Scaffidi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0220","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.ijdevneu.2009.05.009","article-title":"Modeling premature brain injury and recovery","volume":"27","author":"Scafidi","year":"2009","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0225","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3109\/08916934.2012.750302","article-title":"During apoptosis HMGB1 is translocated into apoptotic cell-derived membranous vesicles","volume":"46","author":"Schiller","year":"2013","journal-title":"Autoimmunity"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0230","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000368294","article-title":"Cerebral oxygenation during intermittent hypoxemia and bradycardia in preterm infants","volume":"107","author":"Schmid","year":"2015","journal-title":"Neonatology"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0235","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1056\/NEJMc0912848","article-title":"Hypothermia for perinatal asphyxial encephalopathy","volume":"362","author":"Shankaran","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0240","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1056\/NEJMoa1112066","article-title":"Childhood outcomes after hypothermia for neonatal encephalopathy","volume":"366","author":"Shankaran","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0245","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0197-0186(96)00072-1","article-title":"Cytokines and perinatal brain injury","volume":"30","author":"Silverstein","year":"1997","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0250","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jpeds.2009.09.042","article-title":"Neurobehavioral assessment predicts motor outcome in preterm infants","volume":"156","author":"Stephens","year":"2010","journal-title":"J. Pediatr."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0255","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/cdd.2008.143","article-title":"Autophagy regulates selective HMGB1 release in tumor cells that are destined to die","volume":"16","author":"Thorburn","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0260","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.expneurol.2014.07.012","article-title":"Effects of inter-alpha inhibitor proteins on neonatal brain injury: Age, task and treatment dependent neurobehavioral outcomes","volume":"261","author":"Threlkeld","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0265","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/YCO.0b013e3283387a8c","article-title":"The effects of early adversity on the adult and developing brain","volume":"23","author":"Tomalski","year":"2010","journal-title":"Curr Opin Psychiatry"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0270","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cytogfr.2006.01.003","article-title":"High-mobility group box 1 (HMGB1) protein: friend and foe","volume":"17","author":"Ulloa","year":"2006","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0275","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1046\/j.1471-4159.1998.71031215.x","article-title":"Hypoxic preconditioning and hypoxic-ischemic brain damage in the immature rat: pathologic and metabolic correlates","volume":"71","author":"Vannucci","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0280","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","article-title":"HMG-1 as a late mediator of endotoxin lethality in mice","volume":"285","author":"Wang","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0285","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2217\/fnl.10.1","article-title":"Microglia in ischemic brain injury","volume":"5","author":"Weinstein","year":"2010","journal-title":"Future Neurol."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0290","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/jcbfm.2009.202","article-title":"High-mobility group protein box-1 and its relevance to cerebral ischemia","volume":"30","author":"Yang","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0295","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1161\/STROKEAHA.110.598334","article-title":"Anti-high mobility group box-1 monoclonal antibody protects the blood-brain barrier from ischemia-induced disruption in rats","volume":"42","author":"Zhang","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0300","article-title":"Creating rat model for hypoxic brain damage in neonates by oxygen deprivation","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2018.09.007_bb0305","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/jnen\/nlw030","article-title":"HMGB1 Translocation after Ischemia in the Ovine Fetal Brain","volume":"75","author":"Zhang","year":"2016","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2018.09.007_bb0310","first-page":"4333","article-title":"Clinical significance of dynamic measurements of seric TNF-alpha, HMGBl, and NSE levels and aEEG monitoring in neonatal asphyxia","volume":"21","author":"Zhang","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488618304588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488618304588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T03:30:41Z","timestamp":1662003041000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488618304588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":62,"alternative-id":["S0014488618304588"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2018.09.007","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-mobility group box-1 translocation and release after hypoxic ischemic brain injury in neonatal rats","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2018.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}