{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:31:15Z","timestamp":1793637075724,"version":"4.5.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.expneurol.2019.01.020","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T19:02:30Z","timestamp":1548961350000},"page":"9-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Mild blast-related TBI in a mouse model alters amygdalar neurostructure and circuitry"],"prefix":"10.1016","volume":"315","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5461-7802","authenticated-orcid":false,"given":"Whitney A.","family":"Ratliff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald F.","family":"Mervis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Citron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vardit","family":"Rubovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaul","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaim G.","family":"Pick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2019.01.020_bb0005","doi-asserted-by":"crossref","first-page":"14120","DOI":"10.1073\/pnas.0903183106","article-title":"Human vulnerability to stress depends on amygdala's predisposition and hippocampal plasticity","volume":"106","author":"Admon","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0010","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1002\/hbm.22100","article-title":"Stress-induced reduction in hippocampal volume and connectivity with the ventromedial prefrontal cortex are related to maladaptive responses to stressful military service","volume":"34","author":"Admon","year":"2013","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0015","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.pscychresns.2016.09.008","article-title":"Hippocampal and amygdala volumes in adults with posttraumatic stress disorder secondary to childhood abuse or maltreatment: a systematic review","volume":"256","author":"Ahmed-Leitao","year":"2016","journal-title":"Psychiatry Research. Neuroimaging"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0020","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0025","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1176\/appi.ajp.161.8.1321","article-title":"Acute and delayed posttraumatic stress disorders: a history and some issues","volume":"161","author":"Andreasen","year":"2014","journal-title":"Am. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.expneurol.2019.01.020_bb0030","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s11065-012-9192-3","article-title":"Cognitive sequelae of blast-induced traumatic brain injury: recovery and rehabilitation","volume":"22","author":"Bogdanova","year":"2012","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0035","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.conb.2007.04.009","article-title":"Do thin spines learn to be mushroom spines that remember?","volume":"17","author":"Bourne","year":"2007","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0040","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s00381-014-2446-z","article-title":"Traumatic brain injury alters long-term hippocampal neuron morphology in juvenile, but not immature, rats","volume":"30","author":"Casella","year":"2014","journal-title":"Childs Nerv. Syst."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0045","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1038\/npp.2012.3","article-title":"Prevention of stress-impaired fear extinction through neuropeptide s action in the lateral amygdala","volume":"37","author":"Chauveau","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0050","series-title":"DOD worldwide numbers for TBI","first-page":"1","author":"Defense and Veterans Brain Injury Center","year":"2018"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0055","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/hipo.20188","article-title":"Influence of predator stress on the consolidation versus retrieval of long-term spatial memory and hippocampal spinogenesis","volume":"16","author":"Diamond","year":"2006","journal-title":"Hippocampus"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024566","article-title":"Moderate traumatic brain injury causes acute dendritic and synaptic degeneration in the hippocampal dentate gyrus","volume":"6","author":"Gao","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0065","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1089\/neu.2015.4339","article-title":"Early and persistent dendritic hypertrophy in the basolateral amygdala following experimental diffuse traumatic brain injury","volume":"34","author":"Hoffman","year":"2017","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0070","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1056\/NEJMoa072972","article-title":"Mild traumatic brain injury in U.S. soldiers returning from Iraq","volume":"358","author":"Hoge","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0075","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/jts.22110","article-title":"Mild traumatic brain injury, PTSD, and psychosocial functioning among male and female U.S. OEF\/OIF veterans","volume":"29","author":"Jackson","year":"2016","journal-title":"J. Trauma. Stress."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0080","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1089\/neu.2016.4953","article-title":"Pathophysiological bases of comorbidity: traumatic brain injury and post-traumatic stress disorder","volume":"35","author":"Kaplan","year":"2018","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0085","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0166-2236(03)00162-0","article-title":"Structure-stability-function relationships of dendritic spines","volume":"26","author":"Kasai","year":"2003","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0090","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jneumeth.2013.05.004","article-title":"Establishment of an optimised protocol for a Golgi-electron microscopy method based on a Golgi-Cox staining procedure with a commercial kit","volume":"218","author":"Koyama","year":"2013","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0095","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/mp.2016.68","article-title":"Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant","volume":"22","author":"Lau","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0100","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1111\/ejn.12259","article-title":"Fear extinction deficits following acute stress associate with increased spine density and dendritic retraction in basolateral amygdala neurons","volume":"38","author":"Maroun","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0105","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1089\/neu.2011.2258","article-title":"Galveston Brain Injury Conference 2010: clinical and experimental aspects of blast injury","volume":"29","author":"Masel","year":"2012","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0110","doi-asserted-by":"crossref","first-page":"9371","DOI":"10.1073\/pnas.0504011102","article-title":"Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala","volume":"102","author":"Mitra","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Suppl. 17","key":"10.1016\/j.expneurol.2019.01.020_bb0115","first-page":"47","article-title":"Investigating the pathogenesis of posttraumatic stress disorder with neuroimaging","volume":"62","author":"Pitman","year":"2001","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0120","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8056370","article-title":"Dendritic spines in depression: what we learned from animal models","volume":"2016","author":"Qiao","year":"2016","journal-title":"Neural Plast."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0125","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neuroscience.2011.06.047","article-title":"Effects of chronic immobilization stress on anxiety-like behavior and basolateral amygdala morphology in Fmr1 knockout mice","volume":"194","author":"Qin","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0130","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1038\/s41598-017-03792-9","article-title":"Exendin-4 attenuates blast traumatic brain injury induced cognitive impairments, losses of synaptophysin and in vitro TBI-induced hippocampal cellular degeneration","volume":"7","author":"Rachmany","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0135","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.biopsych.2006.06.004","article-title":"Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and future","volume":"60","author":"Rauch","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psyneuen.2016.04.018","article-title":"Enhanced noradrenergic activity in the amygdala contributes to hyperarousal in an animal model of PTSD","volume":"70","author":"Ronzoni","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0145","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.expneurol.2011.09.018","article-title":"A mouse model of blast-induced mild traumatic brain injury","volume":"232","author":"Rubovitch","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0150","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/SHK.0000000000000311","article-title":"Subacute oxidative stress and glial reactivity in the amygdala are associated with increased anxiety following blast neurotrauma","volume":"1","author":"Sajja","year":"2015","journal-title":"Shock"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058150","article-title":"In search of the trauma memory: a meta-analysis of functional neuroimaging studies of symptom provocation in posttraumatic stress disorder (PTSD)","volume":"8","author":"Sartory","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0160","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1089\/neu.2017.5070","article-title":"Repetitive mild closed head injury alters protein expression and dendritic complexity in a mouse model","volume":"35","author":"Saykally","year":"2017","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0165","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0165-0327(03)00047-8","article-title":"Single photon emission computed tomography in posttraumatic stress disorder before and after treatment with a selective serotonin reuptake inhibitor","volume":"80","author":"Seedat","year":"2004","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0170","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/npp.2009.83","article-title":"The neurocircuitry of fear, stress, and anxiety disorders","volume":"35","author":"Shin","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.expneurol.2019.01.020_bb0175","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3109\/02699052.2013.873821","article-title":"PTSD and TBI co-morbidity: scope, clinical presentation and treatment options","author":"Tanev","year":"2014","journal-title":"Brain Inj."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2013.02.006","article-title":"Changes in mouse cognition and hippocampal gene expression observed in a mild physical- and blast-traumatic brain injury","volume":"54","author":"Tweedie","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0185","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nlm.2013.11.014","article-title":"From Pavlov to PTSD: the extinction of conditioned fear in rodents, humans, and anxiety disorders","volume":"113","author":"VanElzakker","year":"2014","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0190","doi-asserted-by":"crossref","first-page":"6810","DOI":"10.1523\/JNEUROSCI.22-15-06810.2002","article-title":"Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons","volume":"22","author":"Vyas","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.01.020_bb0195","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1089\/neu.2013.2960","article-title":"Controlled cortical impact results in an extensive loss of dendritic spines that is not mediated by injury-induced amyloid-beta accumulation","volume":"30","author":"Winston","year":"2013","journal-title":"J. Neurotrauma"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488619300147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488619300147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:49:25Z","timestamp":1762148965000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488619300147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":39,"alternative-id":["S0014488619300147"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2019.01.020","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mild blast-related TBI in a mouse model alters amygdalar neurostructure and circuitry","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2019.01.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}