{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:47:32Z","timestamp":1761598052693,"version":"3.37.3"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005191","name":"Neilsen Foundation","doi-asserted-by":"publisher","award":["385706"],"award-info":[{"award-number":["385706"]}],"id":[{"id":"10.13039\/100005191","id-type":"DOI","asserted-by":"publisher"}]},{"name":"American Association for Immunologist Careers in Immunology Fellowship"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.expneurol.2019.03.010","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T16:44:10Z","timestamp":1553100250000},"page":"298-307","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Chronic spinal cord injury impairs primary CD8 T cell antiviral immunity but does not affect generation or function of memory CD8 T cells"],"prefix":"10.1016","volume":"317","author":[{"given":"Diana M.","family":"Norden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anas","family":"Qatanani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Bethea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2019.03.010_bb0005","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.vaccine.2014.11.054","article-title":"Virus-specific T cells as correlate of (cross-)protective immunity against influenza","volume":"33","author":"Altenburg","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.expneurol.2019.03.010_bb0010","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.3390\/v20801530","article-title":"Animal models for influenza virus pathogenesis and transmission","volume":"2","author":"Bouvier","year":"2010","journal-title":"Viruses"},{"key":"10.1016\/j.expneurol.2019.03.010_bb0015","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12974-016-0574-y","article-title":"Chronic spinal cord injury attenuates influenza virus-specific antiviral immunity","volume":"13","author":"Bracchi-Ricard","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.expneurol.2019.03.010_bb0020","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/WCO.0000000000000550","article-title":"Emerging targets for reprograming the immune response to promote repair and recovery of function after spinal cord injury","volume":"33","author":"Brennan","year":"2018","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0025","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.apmr.2004.03.016","article-title":"Etiology and incidence of rehospitalization after traumatic spinal cord injury: a multicenter analysis","volume":"85","author":"Cardenas","year":"2004","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0030","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature14282","article-title":"IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis","volume":"522","author":"Coffelt","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2019.03.010_bb0035","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2010.04.005","article-title":"The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights","volume":"335","author":"Coutinho","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0040","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.vaccine.2005.07.090","article-title":"Identification of protective and non-protective T cell epitopes in influenza","volume":"24","author":"Crowe","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.expneurol.2019.03.010_bb0045","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/10790268.2005.11753837","article-title":"New CDC recommendations: annual influenza vaccination recommended for individuals with spinal cord injuries","volume":"28","author":"Goldstein","year":"2005","journal-title":"J. Spinal Cord Med."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0050","doi-asserted-by":"crossref","first-page":"11730","DOI":"10.1073\/pnas.0705007104","article-title":"Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection","volume":"104","author":"Hand","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0055","doi-asserted-by":"crossref","first-page":"11756","DOI":"10.1128\/JVI.01460-06","article-title":"Cellular immune responses in children and adults receiving inactivated or live attenuated influenza vaccines","volume":"80","author":"He","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0060","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.pain.2009.11.023","article-title":"Aberrant sensory responses are dependent on lesion severity after spinal cord contusion injury in mice","volume":"148","author":"Hoschouer","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2019.03.010_bb0065","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1009","article-title":"Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells","volume":"4","author":"Kaech","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0070","first-page":"643","article-title":"Future influenza vaccines and the use of genetic recombinants","volume":"41","author":"Kilbourne","year":"1969","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0075","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.coi.2014.02.005","article-title":"Eliciting broadly protective antibody responses against influenza","volume":"28","author":"Kirchenbaum","year":"2014","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0080","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3389\/fimmu.2015.00471","article-title":"How neutrophils shape adaptive immune responses","volume":"6","author":"Leliefeld","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0085","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.expneurol.2007.05.019","article-title":"Impaired antibody synthesis after spinal cord injury is level dependent and is due to sympathetic nervous system dysregulation","volume":"207","author":"Lucin","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0090","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrn1765","article-title":"Central nervous system injury-induced immune deficiency syndrome","volume":"6","author":"Meisel","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0095","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12974-018-1191-8","article-title":"Impaired CD8 T cell antiviral immunity following acute spinal cord injury","volume":"15","author":"Norden","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.expneurol.2019.03.010_bb0100","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.4049\/jimmunol.1101934","article-title":"Chronic spinal cord injury impairs primary antibody responses but spares existing humoral immunity in mice","volume":"188","author":"Oropallo","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0105","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1089\/089771501750451866","article-title":"Alterations in immune cell phenotype and function after experimental spinal cord injury","volume":"18","author":"Popovich","year":"2001","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2019.03.010_bb0110","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1038\/nn.4643","article-title":"Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex","volume":"20","author":"Pruss","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0115","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1172\/JCI81261","article-title":"Inflammatory IL-15 is required for optimal memory T cell responses","volume":"125","author":"Richer","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0120","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.copbio.2007.11.002","article-title":"Influenza virus-specific cytotoxic T lymphocytes: a correlate of protection and a basis for vaccine development","volume":"18","author":"Rimmelzwaan","year":"2007","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0125","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.4049\/jimmunol.168.10.4827","article-title":"Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells","volume":"168","author":"Schluns","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0130","doi-asserted-by":"crossref","first-page":"678","DOI":"10.3389\/fimmu.2018.00678","article-title":"The CD8 T cell response to respiratory virus infections","volume":"9","author":"Schmidt","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0135","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/10790268.2007.11753951","article-title":"Acute respiratory tract infection visits of veterans with spinal cord injuries and disorders: rates, trends, and risk factors","volume":"30","author":"Smith","year":"2007","journal-title":"J. Spinal Cord Med."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0140","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/sj.sc.3101080","article-title":"Causes of death after spinal cord injury","volume":"38","author":"Soden","year":"2000","journal-title":"Spinal Cord"},{"key":"10.1016\/j.expneurol.2019.03.010_bb0145","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nri2054","article-title":"Scientific barriers to developing vaccines against avian influenza viruses","volume":"7","author":"Subbarao","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0150","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12974-016-0736-y","article-title":"Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship","volume":"13","author":"Sun","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.expneurol.2019.03.010_bb0155","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.1128\/JVI.03413-12","article-title":"Splenic priming of virus-specific CD8 T cells following influenza virus infection","volume":"87","author":"Turner","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0160","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1016\/j.celrep.2018.08.073","article-title":"Repeated antigen exposure extends the durability of influenza-specific lung-resident memory CD8(+) T cells and heterosubtypic immunity","volume":"24","author":"Van Braeckel-Budimir","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0165","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1099\/jgv.0.000651","article-title":"Establishment of memory CD8+ T cells with live attenuated influenza virus across different vaccination doses","volume":"97","author":"Wang","year":"2016","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0170","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1128\/JVI.78.11.5535-5545.2004","article-title":"Memory CD8 T-cell differentiation during viral infection","volume":"78","author":"Wherry","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0175","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.4049\/jimmunol.168.9.4455","article-title":"Generation of CD8(+) T cell memory in response to low, high, and excessive levels of epitope","volume":"168","author":"Wherry","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2019.03.010_bb0180","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1742-2094-11-65","article-title":"Chronic thoracic spinal cord injury impairs CD8+ T-cell function by up-regulating programmed cell death-1 expression","volume":"11","author":"Zha","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.expneurol.2019.03.010_bb0185","doi-asserted-by":"crossref","first-page":"12970","DOI":"10.1523\/JNEUROSCI.1974-13.2013","article-title":"Autonomic dysreflexia causes chronic immune suppression after spinal cord injury","volume":"33","author":"Zhang","year":"2013","journal-title":"J. Neurosci."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488619300470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488619300470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T19:10:23Z","timestamp":1739819423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488619300470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":37,"alternative-id":["S0014488619300470"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2019.03.010","relation":{},"ISSN":["0014-4886"],"issn-type":[{"type":"print","value":"0014-4886"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic spinal cord injury impairs primary CD8 T cell antiviral immunity but does not affect generation or function of memory CD8 T cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2019.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}