{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:50:26Z","timestamp":1784674226885,"version":"3.55.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T00:00:00Z","timestamp":1587772800000},"content-version":"am","delay-in-days":329,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400971, 81630028, 81571135"],"award-info":[{"award-number":["81400971, 81630028, 81571135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003536","name":"Nanjing Outstanding Youth Foundation","doi-asserted-by":"publisher","award":["JQX16024"],"award-info":[{"award-number":["JQX16024"]}],"id":[{"id":"10.13039\/100003536","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006190","name":"Key Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program of Jiangsu Province of China","award":["BE2016610"],"award-info":[{"award-number":["BE2016610"]}]},{"name":"Jiangsu Province Key Medical Discipline","award":["ZDXKA2016020"],"award-info":[{"award-number":["ZDXKA2016020"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.expneurol.2019.04.005","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T10:34:44Z","timestamp":1554978884000},"page":"52-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["OCT4B-190 protects against ischemic stroke by modulating GSK-3\u03b2\/HDAC6"],"prefix":"10.1016","volume":"316","author":[{"given":"Yanting","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-0319","authenticated-orcid":false,"given":"Yun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2019.04.005_bb0005","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1523\/JNEUROSCI.5379-10.2011","article-title":"Histone deacetylase inhibitors preserve white matter structure and function during ischemia by conserving ATP and reducing excitotoxicity","volume":"31","author":"Baltan","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0010","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12975-013-0283-0","article-title":"Mitochondrial dysfunction induced by nuclear poly(ADP-ribose) polymerase-1: a treatable cause of cell death in stroke","volume":"5","author":"Baxter","year":"2014","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0015","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1096\/fj.13-232280","article-title":"Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein","volume":"27","author":"Beraldo","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0020","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1165\/rcmb.2015-0149OC","article-title":"Cigarette smoke disrupted lung endothelial barrier integrity and increased susceptibility to acute lung injury via histone Deacetylase 6","volume":"54","author":"Borgas","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0025","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.bbi.2010.09.017","article-title":"Cocaine-and amphetamine-regulated transcript modulates peripheral immunity and protects against brain injury in experimental stroke","volume":"25","author":"Chang","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0030","article-title":"HDAC6 regulates mitochondrial transport in hippocampal neurons","volume":"5","author":"Chen","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2019.04.005_bb0035","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.1440-1681.2012.05729.x","article-title":"Expression patterns of histone deacetylases in experimental stroke and potential targets for neuroprotection","volume":"39","author":"Chen","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0040","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.2174\/0929867321666131228203906","article-title":"Targeting microglial activation in stroke therapy: pharmacological tools and gender effects","volume":"21","author":"Chen","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0045","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/jcbfm.2015.16","article-title":"Tat-NR2B9c prevents excitotoxic neuronal superoxide production","volume":"35","author":"Chen","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0050","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neulet.2017.07.022","article-title":"Proteomic analysis of the effects of Nur77 on lipopolysaccharide-induced microglial activation","volume":"659","author":"Chen","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0055","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1089\/hum.2015.065","article-title":"Prospects of Neurotrophic factors for Parkinson's disease: comparison of protein and gene therapy","volume":"26","author":"Domanskyi","year":"2015","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0060","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion--from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0065","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.2174\/0929867324666170209104030","article-title":"Small-molecule modulation of HDAC6 activity: the propitious therapeutic strategy to vanquish neurodegenerative disorders","volume":"24","author":"Ganai","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0070","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/stem.1034","article-title":"The novel function of OCT4B isoform-265 in genotoxic stress","volume":"30","author":"Gao","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.expneurol.2019.04.005_bb0075","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuron.2015.05.041","article-title":"Novel stroke therapeutics: Unraveling stroke pathophysiology and its impact on clinical treatments","volume":"87","author":"George","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.expneurol.2019.04.005_bb0080","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ymeth.2018.04.011","article-title":"MS-based conformation analysis of recombinant proteins in design, optimization and development of biopharmaceuticals","volume":"144","author":"Goswami","year":"2018","journal-title":"Methods"},{"key":"10.1016\/j.expneurol.2019.04.005_bb0085","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1634\/stemcells.2007-0401","article-title":"Oct-4 is critical for survival\/antiapoptosis of murine embryonic stem cells subjected to stress: effects associated with Stat3\/survivin","volume":"26","author":"Guo","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.expneurol.2019.04.005_bb0090","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2174\/1567202611666140520151002","article-title":"Glycogen synthase kinase-beta3 in ischemic neuronal death","volume":"11","author":"Hanumanthappa","year":"2014","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0095","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s12035-010-8102-z","article-title":"Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection","volume":"41","author":"Jung","year":"2010","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0100","doi-asserted-by":"crossref","first-page":"8534","DOI":"10.1021\/jm100941j","article-title":"Discovery of novel GSK-3beta inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening","volume":"53","author":"Khanfar","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0105","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1161\/STROKEAHA.108.540229","article-title":"Targeting histone deacetylases as a multifaceted approach to treat the diverse outcomes of stroke","volume":"40","author":"Langley","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2019.04.005_bb0110","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrd2399","article-title":"Protein therapeutics: a summary and pharmacological classification","volume":"7","author":"Leader","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0115","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1523\/JNEUROSCI.5467-07.2008","article-title":"Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition","volume":"28","author":"Leng","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0120","doi-asserted-by":"crossref","first-page":"17350","DOI":"10.1523\/JNEUROSCI.4901-12.2013","article-title":"Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke","volume":"33","author":"Liesz","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0125","doi-asserted-by":"crossref","first-page":"6712","DOI":"10.1523\/JNEUROSCI.0341-17.2017","article-title":"Opening a new time window for treatment of stroke by targeting HDAC2","volume":"37","author":"Lin","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0130","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41388-018-0487-6","article-title":"OCT4B mediates hypoxia-induced cancer dissemination","volume":"38","author":"Lin","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.expneurol.2019.04.005_bb0135","first-page":"1","article-title":"Molecular switching from ubiquitin-proteasome to autophagy pathways in mice stroke model","author":"Liu","year":"2018","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0140","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1101\/gad.183509.111","article-title":"On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1","volume":"26","author":"Luo","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0145","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3389\/fnins.2018.00799","article-title":"SIRT3 regulation under cellular stress: making sense of the ups and downs","volume":"12","author":"Marcus","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0150","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4161\/cc.7.1.5186","article-title":"HDAC6 a new cellular stress surveillance factor","volume":"7","author":"Matthias","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.expneurol.2019.04.005_bb0155","first-page":"522","article-title":"OCT4B regulates p53 and p16 pathway genes to prevent apoptosis of breast cancer cells","volume":"16","author":"Meng","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0160","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1089\/hum.2004.15.1157","article-title":"The innate immune response to adenovirus vectors","volume":"15","author":"Muruve","year":"2004","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0165","doi-asserted-by":"crossref","first-page":"9633","DOI":"10.1073\/pnas.0803749105","article-title":"HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation","volume":"105","author":"Parmigiani","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0170","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1007\/s12035-016-0149-z","article-title":"HDAC inhibitor sodium butyrate-mediated epigenetic regulation enhances Neuroprotective function of microglia during ischemic stroke","volume":"54","author":"Patnala","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0175","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.tcb.2013.11.010","article-title":"Do all roads lead to Oct4? The emerging concepts of induced pluripotency","volume":"24","author":"Radzisheuskaya","year":"2014","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0180","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.toxrep.2015.05.005","article-title":"The effects of silver nanoparticles on mouse embryonic stem cell self-renewal and proliferation","volume":"2","author":"Rajanahalli","year":"2015","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0185","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neuropharm.2018.07.006","article-title":"Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: opportunities, challenges and future directions for cerebral stroke management","volume":"139","author":"Rana","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.expneurol.2019.04.005_bb0190","doi-asserted-by":"crossref","first-page":"19599","DOI":"10.1073\/pnas.0907935106","article-title":"HDAC6 is a target for protection and regeneration following injury in the nervous system","volume":"106","author":"Rivieccio","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0195","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s12192-017-0763-3","article-title":"HDAC6 regulates sensitivity to cell death in response to stress and post-stress recovery","volume":"22","author":"Ryu","year":"2017","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.expneurol.2019.04.005_bb0200","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-1-4939-9065-8_9","article-title":"Current use of adenovirus vectors and their production methods","volume":"1937","author":"Sayedahmed","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ctrv.2016.10.003","article-title":"Roles of OCT4 in tumorigenesis, cancer therapy resistance and prognosis","volume":"51","author":"Villodre","year":"2016","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines6030081","article-title":"Progress in adenoviral capsid-display vaccines","volume":"6","author":"Vujadinovic","year":"2018","journal-title":"Biomedicines"},{"key":"10.1016\/j.expneurol.2019.04.005_bb0215","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/stem.58","article-title":"Alternative translation of OCT4 by an internal ribosome entry site and its novel function in stress response","volume":"27","author":"Wang","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.expneurol.2019.04.005_bb0220","article-title":"Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of alpha-tubulin acetylation and FGF-21 up-regulation","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0225","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.ejmech.2017.10.040","article-title":"Recent advances in the discovery of potent and selective HDAC6 inhibitors","volume":"143","author":"Wang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0230","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1161\/ATVBAHA.115.307110","article-title":"Cathepsin S activity controls injury-related vascular repair in mice via the TLR2-mediated p38MAPK and PI3K-Akt\/p-HDAC6 Signaling pathway","volume":"36","author":"Wu","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0235","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1080\/21645515.2016.1165908","article-title":"Adenoviral vector-based strategies against infectious disease and cancer","volume":"12","author":"Zhang","year":"2016","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.expneurol.2019.04.005_bb0240","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/acel.12022","article-title":"Hopeahainol a attenuates memory deficits by targeting beta-amyloid in APP\/PS1 transgenic mice","author":"Zhu","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.expneurol.2019.04.005_bb0245","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1017\/S1461145714000315","article-title":"TL-2 attenuates beta-amyloid induced neuronal apoptosis through the AKT\/GSK-3beta\/beta-catenin pathway","volume":"17","author":"Zhu","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488619300664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488619300664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:52:54Z","timestamp":1758001974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488619300664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":49,"alternative-id":["S0014488619300664"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2019.04.005","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"OCT4B-190 protects against ischemic stroke by modulating GSK-3\u03b2\/HDAC6","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2019.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}