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Res."},{"key":"10.1016\/j.expneurol.2019.112977_bb0880","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1089\/neu.2016.4596","article-title":"High-mobility group box 1 (HMGB1) is elevated systemically in persons with acute or chronic traumatic spinal cord injury","volume":"34","author":"Papatheodorou","year":"2017","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2019.112977_bb0885","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0006-3223(00)01088-X","article-title":"Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment","volume":"49","author":"Pariante","year":"2001","journal-title":"Biol. 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Neuroimmunol."},{"key":"10.1016\/j.expneurol.2019.112977_bb0925","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/(SICI)1096-9861(19970120)377:3<443::AID-CNE10>3.0.CO;2-S","article-title":"Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats","volume":"377","author":"Popovich","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2019.112977_bb0930","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1089\/089771501750451866","article-title":"Alterations in immune cell phenotype and function after experimental spinal cord injury","volume":"18","author":"Popovich","year":"2001","journal-title":"J. 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Appl. Soc. Psychol."},{"key":"10.1016\/j.expneurol.2019.112977_bb0960","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.yhbeh.2012.03.010","article-title":"Indoleamine 2, 3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge","volume":"62","author":"Salazar","year":"2012","journal-title":"Horm. 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