{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:56:46Z","timestamp":1792814206501,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"am","delay-in-days":315,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004562","name":"Minist\u00e8re de l'Education Nationale, de l'Enseignement Superieur et de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007527","name":"Universit\u00e9 de Rouen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007527","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014810","name":"Normandie Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.expneurol.2019.113087","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T19:42:43Z","timestamp":1572896563000},"page":"113087","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Neonatal cerebral hypoxia-ischemia in mice triggers age-dependent vascular effects and disabilities in adults; implication of tissue plasminogen activator (tPA)"],"prefix":"10.1016","volume":"323","author":[{"given":"Nicolas","family":"Dupr\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Arabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Orset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Maucotel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7996-9759","authenticated-orcid":false,"given":"Yannick","family":"Detroussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Hauchecorne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7176-1320","authenticated-orcid":false,"given":"Bruno J.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Marret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Vivien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0183-5427","authenticated-orcid":false,"given":"Philippe","family":"Leroux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2019.113087_bb0005","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/ana.24132","article-title":"Brain injury in premature neonates: a primary cerebral dysmaturation disorder?","volume":"75","author":"Back","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2019.113087_bb0010","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1080\/02699052.2017.1291990","article-title":"Characteristics associated with physical activity capacity and performance in children and adolescents with an acquired brain injury","volume":"31","author":"Baque","year":"2017","journal-title":"Brain Inj."},{"key":"10.1016\/j.expneurol.2019.113087_bb0015","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/pr.2011.3","article-title":"Increased MMP-9 and TIMP-1 in mouse neonatal brain and plasma and in human neonatal plasma after hypoxia-ischemia: a potential marker of neonatal encephalopathy","volume":"71","author":"Bednarek","year":"2012","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.expneurol.2019.113087_bb0020","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/368419a0","article-title":"Physiological consequences of loss of plasminogen activator gene function in mice","volume":"368","author":"Carmeliet","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2019.113087_bb0025","doi-asserted-by":"crossref","first-page":"8661","DOI":"10.1073\/pnas.1313222111","article-title":"Encoding and storage of spatial information in the retrosplenial cortex","volume":"111","author":"Czajkowski","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2019.113087_bb0030","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.nbd.2018.08.020","article-title":"Time- and sex-dependent efficacy of magnesium sulfate to prevent behavioral impairments and cerebral damage in a mouse model of cerebral palsy","volume":"120","author":"Daher","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2019.113087_bb0035","doi-asserted-by":"crossref","first-page":"9588","DOI":"10.1523\/JNEUROSCI.5977-11.2012","article-title":"Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat","volume":"32","author":"Fernandez-Lopez","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.113087_bb0040","doi-asserted-by":"crossref","first-page":"50850","DOI":"10.1074\/jbc.M407069200","article-title":"Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling","volume":"279","author":"Fernandez-Monreal","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2019.113087_bb0045","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1056\/NEJMra041996","article-title":"Neonatal brain injury","volume":"351","author":"Ferriero","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2019.113087_bb0050","first-page":"154","article-title":"tPA modulation of the blood-brain barrier: a unifying explanation for the pleiotropic effects of tPA in the CNS","volume":"43","author":"Fredriksson","year":"2017","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.expneurol.2019.113087_bb0055","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/jp.2017.23","article-title":"Children born at 32 to 35 weeks with birth asphyxia and later cerebral palsy are different from those born after 35 weeks","volume":"37","author":"Garfinkle","year":"2017","journal-title":"J. Perinatol."},{"key":"10.1016\/j.expneurol.2019.113087_bb0060","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/dmcn.13483","article-title":"Hypoxia-ischemia is not an antecedent of most preterm brain damage: the illusion of validity","volume":"60","author":"Gilles","year":"2018","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.expneurol.2019.113087_bb0065","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/MOP.0000000000000591","article-title":"Blood biomarkers for evaluation of perinatal encephalopathy: state of the art","volume":"30","author":"Graham","year":"2018","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.expneurol.2019.113087_bb0070","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.nbd.2012.10.020","article-title":"High t-PA release by neonate brain microvascular endothelial cells under glutamate exposure affects neuronal fate","volume":"50","author":"Henry","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2019.113087_bb0075","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/jnc.13065","article-title":"Caveolin-1 mediates tissue plasminogen activator-induced MMP-9 up-regulation in cultured brain microvascular endothelial cells","volume":"132","author":"Jin","year":"2015","journal-title":"J. Neurochem."},{"issue":"85\u201392","key":"10.1016\/j.expneurol.2019.113087_bb0080","article-title":"Differentiating the preterm phenotype: distinct profiles of cognitive and behavioral development following late and moderately preterm birth","volume":"193","author":"Johnson","year":"2018","journal-title":"J. Pediatr."},{"key":"10.1016\/j.expneurol.2019.113087_bb0085","doi-asserted-by":"crossref","first-page":"F153","DOI":"10.1136\/adc.2006.108837","article-title":"Pathogenesis of cerebral white matter injury of prematurity","volume":"93","author":"Khwaja","year":"2008","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.expneurol.2019.113087_bb0090","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/295389","article-title":"Modeling the encephalopathy of prematurity in animals: the important role of translational research","volume":"2012","author":"Kinney","year":"2012","journal-title":"Neurol Res Int"},{"key":"10.1016\/j.expneurol.2019.113087_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021361","article-title":"Special care and school difficulties in 8-year-old very preterm children: the Epipage cohort study","volume":"6","author":"Larroque","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2019.113087_bb0100","article-title":"Glutamate controls vessel-associated migration of GABA interneurons from the pial migratory route via NMDA receptors and endothelial protease activation","author":"Leger","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.expneurol.2019.113087_bb0105","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1055\/s-0037-1615036","article-title":"Regulation of gelatinase activity in mice with targeted inactivation of components of the plasminogen\/plasmin system","volume":"79","author":"Lijnen","year":"1998","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.expneurol.2019.113087_bb0110","doi-asserted-by":"crossref","first-page":"5655","DOI":"10.1113\/JP274938","article-title":"The myth of the immature barrier systems in the developing brain: role in perinatal brain injury","volume":"596","author":"Mallard","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.expneurol.2019.113087_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062683","article-title":"Brain injury in very preterm children and neurosensory and cognitive disabilities during childhood: the EPIPAGE cohort study","volume":"8","author":"Marret","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2019.113087_bb0120","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1469-8749.1995.tb12035.x","article-title":"Prevention by magnesium of excitotoxic neuronal death in the developing brain: an animal model for clinical intervention studies","volume":"37","author":"Marret","year":"1995","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.expneurol.2019.113087_bb0125","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nrn.2017.61","article-title":"Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain","volume":"18","author":"McCarthy","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.expneurol.2019.113087_bb0130","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/01.CIR.0000046451.38849.90","article-title":"Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke","volume":"107","author":"Montaner","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.expneurol.2019.113087_bb0135","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.expneurol.2019.113087_bb0140","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1056\/NEJMoa0706475","article-title":"Long-term medical and social consequences of preterm birth","volume":"359","author":"Moster","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2019.113087_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071263","article-title":"Hypoxia-ischemia or excitotoxin-induced tissue plasminogen activator- dependent gelatinase activation in mice neonate brain microvessels","volume":"8","author":"Omouendze","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2019.113087_bb0150","article-title":"Tissue-type plasminogen activator controlled corticogenesis through a mechanism dependent of NMDA receptors expressed on radial glial cells","author":"Pasquet","year":"2018","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.expneurol.2019.113087_bb0155","doi-asserted-by":"crossref","first-page":"18201","DOI":"10.1073\/pnas.0509232102","article-title":"Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus","volume":"102","author":"Pawlak","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2019.113087_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171048","article-title":"Proteomic and transcriptomic study of brain microvessels in neonatal and adult mice","volume":"12","author":"Porte","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2019.113087_bb0165","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1177\/0271678X16630557","article-title":"Major remodeling of brain microvessels during neonatal period in the mouse: a proteomic and transcriptomic study","volume":"37","author":"Porte","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2019.113087_bb0170","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic-ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2019.113087_bb0175","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fneur.2016.00057","article-title":"Rodent hypoxia-ischemia models for cerebral palsy research: a systematic review","volume":"7","author":"Rumajogee","year":"2016","journal-title":"Front. Neurol."},{"key":"10.1016\/j.expneurol.2019.113087_bb0180","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.semcdb.2009.04.006","article-title":"Role of blood vessels in the neuronal migration","volume":"20","author":"Saghatelyan","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.expneurol.2019.113087_bb0185","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.mam.2012.11.006","article-title":"Transporters of the blood-brain and blood-CSF interfaces in development and in the adult","volume":"34","author":"Saunders","year":"2013","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.expneurol.2019.113087_bb0190","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3389\/fncel.2015.00456","article-title":"tPA deficiency in mice leads to rearrangement in the cerebrovascular tree and Cerebroventricular malformations","volume":"9","author":"Stefanitsch","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.expneurol.2019.113087_bb0195","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nm1787","article-title":"Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke","volume":"14","author":"Su","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.expneurol.2019.113087_bb0200","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1182\/blood-2009-02-203919","article-title":"Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein","volume":"114","author":"Suzuki","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.expneurol.2019.113087_bb0205","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1523\/JNEUROSCI.4391-06.2007","article-title":"Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia","volume":"27","author":"Svedin","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.113087_bb0210","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1126\/science.aad3839","article-title":"Oligodendrocyte precursors migrate along vasculature in the developing nervous system","volume":"351","author":"Tsai","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2019.113087_bb0215","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00431-007-0629-2","article-title":"Influence of gestational age on the type of brain injury and neuromotor outcome in high-risk neonates","volume":"167","author":"Van den Broeck","year":"2008","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.expneurol.2019.113087_bb0220","series-title":"Neurology of the Newborn","first-page":"347","article-title":"Hypoxic-ischemic encephalopathy: Neuropathology and pathogenesis","author":"Volpe","year":"2008"},{"key":"10.1016\/j.expneurol.2019.113087_bb0225","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/nm926","article-title":"Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator","volume":"9","author":"Wang","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.expneurol.2019.113087_bb0230","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/brain\/awn215","article-title":"Contributions of multiple proteases to neurotoxicity in a mouse model of intracerebral haemorrhage","volume":"132","author":"Xue","year":"2009","journal-title":"Brain"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488619302341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488619302341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:50:38Z","timestamp":1762149038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488619302341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":46,"alternative-id":["S0014488619302341"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2019.113087","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neonatal cerebral hypoxia-ischemia in mice triggers age-dependent vascular effects and disabilities in adults; implication of tissue plasminogen activator (tPA)","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2019.113087","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113087"}}