{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T11:55:27Z","timestamp":1759838127989,"version":"3.44.0"},"reference-count":117,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.expneurol.2019.113166","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T11:07:21Z","timestamp":1577444841000},"page":"113166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Prenatal intermittent hypoxia sensitizes the laryngeal chemoreflex, blocks serotoninergic shortening of the reflex, and reduces 5-HT3 receptor binding in the NTS in anesthetized rat pups"],"prefix":"10.1016","volume":"326","author":[{"given":"William T.","family":"Donnelly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin L.","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn G.","family":"Commons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drexel J.","family":"Erickson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris M.","family":"Panzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luxi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q. Joyce","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8572-6035","authenticated-orcid":false,"given":"J.C.","family":"Leiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2019.113166_bb0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0034-5687(90)90058-7","article-title":"Water-responsive laryngeal receptors in the dog are not specialized endings","volume":"79","author":"Anderson","year":"1990","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1460-9568.2011.07936.x","article-title":"Projections and interconnections of genetically defined serotonin neurons in mice","volume":"35","author":"Bang","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.113166_bb0015","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1017\/S0317167100030894","article-title":"Neural maturational delay as a link in the chain of events leading to SIDS","volume":"17","author":"Becker","year":"1990","journal-title":"The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques"},{"key":"10.1016\/j.expneurol.2019.113166_bb0020","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1152\/jappl.1982.53.2.455","article-title":"Chemical specificity of a laryngeal apneic reflex in puppies","volume":"53","author":"Boggs","year":"1982","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0025","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/jnen\/nlx071","article-title":"Medullary serotonin neuron abnormalities in an Australian cohort of sudden infant death syndrome","volume":"76","author":"Bright","year":"2017","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184958","article-title":"Abnormalities in substance P neurokinin-1 receptor binding in key brainstem nuclei in sudden infant death syndrome related to prematurity and sex","volume":"12","author":"Bright","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.expneurol.2019.113166_bb0035","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.autneu.2009.10.002","article-title":"Neuroanatomic relationships between the GABAergic and serotonergic systems in the developing human medulla","volume":"154","author":"Broadbelt","year":"2010","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.expneurol.2019.113166_bb0040","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1097\/NEN.0b013e31822c09bc","article-title":"Decreased GABAA receptor binding in the medullary serotonergic system in the sudden infant death syndrome","volume":"70","author":"Broadbelt","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0045","doi-asserted-by":"crossref","first-page":"16354","DOI":"10.1073\/pnas.1004587107","article-title":"Central serotonin neurons are required for arousal to CO2","volume":"107","author":"Buchanan","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2019.113166_bb0050","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1152\/jn.00213.2015","article-title":"5-HT2A receptor activation is necessary for CO2-induced arousal","volume":"114","author":"Buchanan","year":"2015","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0055","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1093\/oxfordjournals.aje.a115221","article-title":"Intrauterine growth retardation and risk of sudden infant death syndrome (SIDS)","volume":"129","author":"Buck","year":"1989","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0060","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1542\/peds.86.4.535","article-title":"Chronic fetal hypoxia and sudden infant death syndrome: interaction between maternal smoking and low hematocrit during pregnancy","volume":"86","author":"Bulterys","year":"1990","journal-title":"Pediatrics"},{"key":"10.1016\/j.expneurol.2019.113166_bb0065","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1111\/j.1471-4159.1989.tb08543.x","article-title":"Postmortem human brain pH and lactate in sudden infant death syndrome","volume":"53","author":"Butterworth","year":"1989","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2019.113166_bb0070","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1001\/jamapediatrics.2016.3345","article-title":"Risk factors, protective factors, and current recommendations to reduce sudden infant death syndrome: a review","volume":"171","author":"Carlin","year":"2017","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.expneurol.2019.113166_bb0075","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1152\/japplphysiol.00003.2013","article-title":"Time- and age-dependent effects of serotonin on gasping and autoresuscitation in neonatal mice","volume":"114","author":"Chen","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0080","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1113\/jphysiol.2011.214445","article-title":"Postnatal loss of brainstem serotonin neurones compromises the ability of neonatal rats to survive episodic severe hypoxia","volume":"589","author":"Cummings","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0085","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1152\/japplphysiol.00906.2004","article-title":"Elevated body temperature enhances the laryngeal chemoreflex in decerebrate piglets","volume":"98","author":"Curran","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0090","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1113\/jphysiol.1991.sp018543","article-title":"Synaptic events in ventral respiratory neurones during apnoea induced by laryngeal nerve stimulation in neonatal piglet","volume":"436","author":"Czyzyk-Krzeska","year":"1991","journal-title":"J. Physiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0095","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/pr.2017.102","article-title":"Early postnatal exposure to intermittent hypoxia in rodents is proinflammatory, impairs white matter integrity, and alters brain metabolism","volume":"82","author":"Darnall","year":"2017","journal-title":"Pediatr. Res."},{"issue":"7","key":"10.1016\/j.expneurol.2019.113166_bb0100","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1113\/EP085716","article-title":"Serotonin in the solitary tract nucleus shortens the laryngeal chemoreflex in anesthetized neonatal rats","volume":"101","author":"Donnelly","year":"2016","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0105","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1113\/EP086082","article-title":"Activation of serotonergic neurons in the medullary caudal raphe shortens the laryngeal chemoreflex in anaesthetized neonatal rats","volume":"102","author":"Donnelly","year":"2017","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0110","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1542\/peds.55.5.640","article-title":"Laryngeal chemosensitivity: a possible mechanism of sudden infant death","volume":"55","author":"Downing","year":"1975","journal-title":"Pediatrics"},{"key":"10.1016\/j.expneurol.2019.113166_bb0115","doi-asserted-by":"crossref","first-page":"8222","DOI":"10.1523\/JNEUROSCI.22-18-08222.2002","article-title":"Vanilloid receptors presynaptically modulate cranial visceral afferent synaptic transmission in nucleus tractus solitarius","volume":"22","author":"Doyle","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.113166_bb0120","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1750-3639.2007.00093.x","article-title":"The effect of maternal smoking and drinking during pregnancy upon (3)H-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome: initial observations in a high risk population","volume":"18","author":"Duncan","year":"2008","journal-title":"Brain Pathol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0125","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1001\/jama.2010.45","article-title":"Brainstem serotonergic deficiency in sudden infant death syndrome","volume":"303","author":"Duncan","year":"2010","journal-title":"Jama"},{"key":"10.1016\/j.expneurol.2019.113166_bb0130","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1152\/japplphysiol.90729.2008","article-title":"Autoresuscitation responses to hypoxia-induced apnea are delayed in newborn 5-HT-deficient Pet-1 homozygous mice","volume":"106","author":"Erikson","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0135","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.resp.2007.06.002","article-title":"Arrest of 5HT neuron differentiation delays respiratory maturation and impairs neonatal homeostatic responses to environmental challenges","volume":"159","author":"Erikson","year":"2007","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0140","doi-asserted-by":"crossref","first-page":"8324","DOI":"10.1523\/JNEUROSCI.0315-14.2014","article-title":"Cannabinoid 1 and transient receptor potential vanilloid 1 receptors discretely modulate evoked glutamate separately from spontaneous glutamate transmission","volume":"34","author":"Fawley","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.113166_bb0145","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/cne.22559","article-title":"Reassessment of the structural basis of the ascending arousal system","volume":"519","author":"Fuller","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0150","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/01.AOG.0000117081.50852.04","article-title":"Maternal and obstetric risk factors for sudden infant death syndrome in the United States","volume":"103","author":"Getahun","year":"2004","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0155","first-page":"02016","article-title":"Intermittent severe hypoxia induces plasticity within serotonergic and catecholaminergic neurons in the neonatal rat ventrolateral medulla","volume":"00048","author":"Givan","year":"2016","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.expneurol.2019.113166_bb0160","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1467-7687.2006.00498.x","article-title":"The effect of prenatal hypoxia on brain development: short- and long-term consequences demonstrated in rodent models","volume":"9","author":"Golan","year":"2006","journal-title":"Dev. Sci."},{"key":"10.1016\/j.expneurol.2019.113166_bb0165","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1542\/peds.2015-4661","article-title":"Sudden unexpected death in fetal life through early childhood","volume":"137","author":"Goldstein","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.expneurol.2019.113166_bb0170","doi-asserted-by":"crossref","DOI":"10.1186\/1741-7015-9-64","article-title":"A perspective on SIDS pathogenesis. The hypotheses: plausibility and evidence","volume":"9","author":"Goldwater","year":"2011","journal-title":"BMC Med."},{"key":"10.1016\/j.expneurol.2019.113166_bb0175","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nri3621","article-title":"Pathological pain and the neuroimmune interface","volume":"14","author":"Grace","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0180","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0306-9877(89)90025-X","article-title":"Interleukin-1 as intermediary causing prolonged sleep apnea and SIDS during respiratory infections","volume":"28","author":"Guntheroth","year":"1989","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.expneurol.2019.113166_bb0185","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1177\/000348948309200106","article-title":"Effect of hyperthermia on the laryngeal closure reflex. Implications in the sudden infant death syndrome","volume":"92","author":"Haraguchi","year":"1983","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0190","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1113\/jphysiol.1978.sp012281","article-title":"Liquid-sensitive laryngeal receptors in the developing sheep, cat and monkey","volume":"277","author":"Harding","year":"1978","journal-title":"J. Physiol. (London)"},{"key":"10.1016\/j.expneurol.2019.113166_bb0195","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0168-0102(00)00218-2","article-title":"Subnuclear distribution of afferents from the oral, pharyngeal and laryngeal regions in the nucleus tractus solitarii of the rat: a study using transganglionic transport of cholera toxin","volume":"39","author":"Hayakawa","year":"2001","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.expneurol.2019.113166_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchemneu.2015.12.003","article-title":"Localization of TRPV1 and P2X3 in unmyelinated and myelinated vagal afferents in the rat","volume":"72","author":"Hermes","year":"2016","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.expneurol.2019.113166_bb0205","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0006-8993(82)90743-0","article-title":"Activity of serotonin-containing neurons in the nucleus raphe pallidus of freely moving cats","volume":"251","author":"Heym","year":"1982","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2019.113166_bb0210","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0095-5108(18)30427-5","article-title":"Epidemiology of the sudden infant death syndrome: maternal, neonatal, and postneonatal risk factors","volume":"19","author":"Hoffman","year":"1992","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0215","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00401-015-1437-9","article-title":"Decreased orexin (hypocretin) immunoreactivity in the hypothalamus and pontine nuclei in sudden infant death syndrome","volume":"130","author":"Hunt","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0220","doi-asserted-by":"crossref","first-page":"9S","DOI":"10.1038\/sj.npp.1395336","article-title":"Activity of serotonergic neurons in behaving animals","volume":"21","author":"Jacobs","year":"1999","journal-title":"Neuropsychopharnacology"},{"key":"10.1016\/j.expneurol.2019.113166_bb0225","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fphys.2015.00176","article-title":"Antenatal maternal hypoxia: criterion for fetal growth restriction in rodents","volume":"6","author":"Jang","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0230","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1113\/jphysiol.2005.085845","article-title":"The role of central 5-HT3 receptors in vagal reflex inputs to neurones in the nucleus tractus solitarius of anaesthetized rats","volume":"566","author":"Jeggo","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0235","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1523\/JNEUROSCI.0753-04.2004","article-title":"Puringergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius","volume":"24","author":"Jin","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.113166_bb0240","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1542\/peds.111.2.358","article-title":"Vascular endothelial growth factor in the cerebrospinal fluid of infants who died of sudden infant death syndrome: evidence for antecedent hypoxia","volume":"111","author":"Jones","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.expneurol.2019.113166_bb0245","doi-asserted-by":"crossref","first-page":"7627","DOI":"10.1523\/JNEUROSCI.0173-13.2013","article-title":"Glutamatergic signaling from the parabrachial nucleus plays a critical role in hypercapnic arousal","volume":"33","author":"Kaur","year":"2013","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.expneurol.2019.113166_bb0250","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0304-3940(88)90287-X","article-title":"The distribution of specific binding of the 5-HT3 receptor ligand [3H]GR65630 in rat brain using quantitative autoradiography","volume":"94","author":"Kilpatrick","year":"1988","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2019.113166_bb0255","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/jnen\/nlz062","article-title":"The serotonin brainstem hypothesis for the sudden infant death syndrome","volume":"78","author":"Kinney","year":"2019","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0260","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1542\/peds.72.2.181","article-title":"Reactive gliosis in the medulla oblongota of victims of the sudden infant death syndrome","volume":"72","author":"Kinney","year":"1983","journal-title":"Pediatrics"},{"key":"10.1016\/j.expneurol.2019.113166_bb0265","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00005072-199101000-00003","article-title":"Delayed central nervous system myelination in the sudden infant death syndrome","volume":"50","author":"Kinney","year":"1991","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0270","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1126\/science.7660131","article-title":"Decreased muscarinic receptor binding in the arcuate nucleus in sudden infant death syndrome","volume":"269","author":"Kinney","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2019.113166_bb0275","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1093\/jnen\/62.11.1178","article-title":"Serotonergic brainstem abnormalities in Northern Plains Indians with the sudden infant death syndrome","volume":"62","author":"Kinney","year":"2003","journal-title":"J. Neuropath. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0280","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1046\/j.1365-3016.2002.00395.x","article-title":"Prenatal and intrapartum events and sudden infant death syndrome","volume":"16","author":"Klonoff-Cohen","year":"2002","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0285","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1080\/01616412.2016.1201632","article-title":"Impaired orexin receptor expression in the Kolliker-fuse nucleus in sudden infant death syndrome: possible involvement of this nucleus in arousal pathophysiology","volume":"38","author":"Lavezzi","year":"2016","journal-title":"Neurol. Res."},{"key":"10.1016\/j.expneurol.2019.113166_bb0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000014125","article-title":"Erythropoietin blood level is increased in sudden infant death","volume":"76","author":"Le Cam-Duchez","year":"1999","journal-title":"Biol. Neonate"},{"key":"10.1016\/j.expneurol.2019.113166_bb0295","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.resp.2007.05.014","article-title":"Mechanisms of pathogenesis in the Sudden Infant Death Syndrome (SIDS)","volume":"159","author":"Leiter","year":"2007","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0300","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1365-3016.2000.00245.x","article-title":"Maternal pre-eclampsia\/eclampsia and the risk of sudden infant death syndrome in offspring","volume":"14","author":"Li","year":"2000","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0305","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00401-008-0468-x","article-title":"Serotonergic receptor 1A in the sudden infant death syndrome brainstem medulla and associatens with clinical risk factors","volume":"117","author":"Machaalani","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0310","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1542\/peds.109.4.661","article-title":"Trends in postneonatal aspiration deaths and reclassification of sudden infant death syndrome: impact of the \u201cBack to Sleep\u201d program","volume":"109","author":"Malloy","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.expneurol.2019.113166_bb0315","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1111\/j.1460-9568.2008.06296.x","article-title":"Dual modulation of synaptic transmission in the nucleus tractus solitarius by prostaglandin E2 synthesized downstream of IL-1beta","volume":"27","author":"Marty","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.113166_bb0320","first-page":"105","article-title":"Maternal smoking and alcohol consumption during pregnancy as risk factors for sudden infant death","volume":"105","author":"McDonnell-Naughton","year":"2012","journal-title":"Ir. Med. J."},{"key":"10.1016\/j.expneurol.2019.113166_bb0325","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1542\/peds.93.1.44","article-title":"Cardiorespiratory recordings from infants dying suddenly and unexpectedly at home","volume":"93","author":"Meny","year":"1994","journal-title":"Pediatrics"},{"key":"10.1016\/j.expneurol.2019.113166_bb0330","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuroscience.2011.07.008","article-title":"Serotonergic inputs to FoxP2 neurons of the pre-locus coeruleus and parabrachial nuclei that project to the ventral tegmental area","volume":"193","author":"Miller","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2019.113166_bb0335","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1046\/j.0953-816x.2001.01872.x","article-title":"Differential subcellular localization of the 5-HT3-as receptor subunit in the rat central nervous system","volume":"15","author":"Miquel","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.113166_bb0340","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1292\/jvms.62.665","article-title":"Effects of perineural capsaicin treatment on cardiopulmonary reflexes elicited by laryngeal instillations of capsaicin and distilled water in sevoflurane-anesthetized dogs","volume":"62","author":"Mutoh","year":"2000","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.expneurol.2019.113166_bb0345","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/00005072-199811000-00004","article-title":"Brainstem 3H-nicotine receptor binding in the sudden infant death syndrome","volume":"57","author":"Nachmanoff","year":"1998","journal-title":"J. Neuropath. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0350","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/ajcp\/66.3.526","article-title":"Brain-stem and adrenal abnormalities in the SIDS","volume":"66","author":"Naeye","year":"1976","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0355","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/scientificamerican0480-56","article-title":"Sudden infant death","volume":"242","author":"Naeye","year":"1980","journal-title":"Sci. Am."},{"key":"10.1016\/j.expneurol.2019.113166_bb0360","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0046-8177(89)90008-7","article-title":"Pregnancy hypertension, placental evidences of low uteroplacental blood flow, and spontaneous premature delivery","volume":"20","author":"Naeye","year":"1989","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0365","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1001\/archpedi.1976.02120120041005","article-title":"Sudden infant death syndrome. A prospective study","volume":"130","author":"Naeye","year":"1976","journal-title":"Am. J. Dis. Child"},{"key":"10.1016\/j.expneurol.2019.113166_bb0370","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0887-8994(96)00217-2","article-title":"Relationship of substance P and gliosis in medulla oblongata in neonatal sudden infant death syndrome","volume":"15","author":"Obonai","year":"1996","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0375","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-3334","article-title":"Prematurity and sudden unexpected infant deaths in the United States","volume":"140","author":"Ostfeld","year":"2017","journal-title":"Pediatrics"},{"issue":"Suppl. 1","key":"10.1016\/j.expneurol.2019.113166_bb0380","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1046\/j.1365-3016.11.s1.17.x","article-title":"Maternal smoking, birthweight and gestational age in sudden infant death syndrome (SIDS) babies and their surviving siblings","volume":"11","author":"Oyen","year":"1997","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0385","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1055\/s-2002-33678","article-title":"Alteration of serotonergic receptors in the brain stems of human patients with respiratory disorders","volume":"33","author":"Ozawa","year":"2002","journal-title":"Neuropediatrics"},{"issue":"Suppl","key":"10.1016\/j.expneurol.2019.113166_bb0390","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/S0379-0738(02)00139-1","article-title":"Developmental neurotransmitter pathology in the brainstem of sudden infant death syndrome: a review and sleep position","volume":"130","author":"Ozawa","year":"2002","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.expneurol.2019.113166_bb0395","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0378-3782(00)00093-1","article-title":"The role of gastro-oesophageal reflux in the aetiology of SIDS","volume":"59","author":"Page","year":"2000","journal-title":"Early Hum. Dev."},{"issue":"11","key":"10.1016\/j.expneurol.2019.113166_bb0400","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1097\/00005072-199711000-00010","article-title":"Decreased kainate receptor binding in the arcuate nucleus of the sudden infant death syndrome","volume":"56","author":"Panigrahy","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0405","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/jnen\/59.5.377","article-title":"Decreased serotonergic receptor binding in rhombic lip-derived regions of the medulla oblongata in the sudden infant death syndrome","volume":"59","author":"Panigrahy","year":"2000","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0410","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.autneu.2005.12.009","article-title":"Serotonergic and glutamatergic neurons at the ventral medullary surface of the human infant: observations relevant to central chemosensitivity in early human life","volume":"124","author":"Paterson","year":"2006","journal-title":"Autonmic Neurosci."},{"key":"10.1016\/j.expneurol.2019.113166_bb0415","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1001\/jama.296.17.2124","article-title":"Multiple serotonergic brainstem abnormalities in the sudden infant death syndrome","volume":"296","author":"Paterson","year":"2006","journal-title":"J.A.M.A."},{"key":"10.1016\/j.expneurol.2019.113166_bb0420","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0006-8993(91)90702-W","article-title":"Afferent projections of the superior and recurrent laryngeal nerves","volume":"539","author":"Patrickson","year":"1991","journal-title":"Brain Res."},{"year":"1998","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","key":"10.1016\/j.expneurol.2019.113166_bb0425"},{"year":"2005","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","key":"10.1016\/j.expneurol.2019.113166_bb0430"},{"key":"10.1016\/j.expneurol.2019.113166_bb0435","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0022-3476(05)80842-X","article-title":"Home event recordings of oxygenation, breathing movements, and heart rate and rhythm in infants with recurrent life-threatening events","volume":"123","author":"Poets","year":"1993","journal-title":"J. Pediatr."},{"key":"10.1016\/j.expneurol.2019.113166_bb0440","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/BF01957372","article-title":"Sudden infant death and maternal cigarette smoking: results from the Lower Saxony Perinatal Working Group","volume":"154","author":"Poets","year":"1995","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.expneurol.2019.113166_bb0445","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1203\/00006450-199903000-00010","article-title":"Gasping and other cardiorespiratory patterns during sudden infant death","volume":"45","author":"Poets","year":"1999","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.expneurol.2019.113166_bb0450","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1523\/JNEUROSCI.5271-08.2009","article-title":"Raphe neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P","volume":"29","author":"Ptak","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.113166_bb0455","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0006-8993(85)90300-2","article-title":"Brainstem immaturity in sudden infant death syndrome: a quantitative rapid golgi study of dendritic spines in 95 infants","volume":"325","author":"Quattrochi","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2019.113166_bb0460","doi-asserted-by":"crossref","first-page":"e1616","DOI":"10.1542\/peds.2013-0700","article-title":"Potential asphyxia and brainstem abnormalities in sudden and unexpected death in infants","volume":"132","author":"Randall","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.expneurol.2019.113166_bb0465","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/BF00580675","article-title":"Reflex prolongation of stage I of expiration","volume":"407","author":"Remmers","year":"1986","journal-title":"Pfl\u00fcgers Arch."},{"key":"10.1016\/j.expneurol.2019.113166_bb0470","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1569-9048(03)00108-3","article-title":"Effects of C fiber blockade on cardiorespiratory responses to laryngeal stimulation in concious lambs","volume":"136","author":"Roulier","year":"2003","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0475","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/ppul.10287","article-title":"Characterization of successful and failed autoresuscitation in human infants","volume":"36","author":"Sridhar","year":"2003","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0480","first-page":"1429","article-title":"Laryngeal chemoreflexes induced by acid, water and saline in non-sedated newborn lambs during quiet sleep","volume":"102","author":"St. Hilaire","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0485","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/japplphysiol.00599.2007","article-title":"Maintenance of gasping and restoration of eupnea after hypoxia is impaired following blockers of \u03b1-1 adrenergic receptors and serotonin 5HT2 receptors J","volume":"104","author":"St. John","year":"2008","journal-title":"Appl. Physiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0490","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1515\/jpme.1994.22.5.421","article-title":"Changes in apnea and autoresuscitation in piglets after intravenous and intrathecal interleukin-1 beta injection","volume":"22","author":"Stoltenberg","year":"1994","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.expneurol.2019.113166_bb0495","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/0014-4886(85)90155-4","article-title":"Developmental abnormalities of medullary 'Respiratory centers' in sudden infant death syndrome","volume":"90","author":"Takashima","year":"1985","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0500","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1055\/s-2008-1071424","article-title":"Delayed dendritic development of catecholaminergic neurons in the ventrolateral medulla of children who died of sudden infant death syndrome","volume":"22","author":"Takashima","year":"1991","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.expneurol.2019.113166_bb0505","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1055\/s-2008-1052547","article-title":"Neuronal development in the medullary reticular formation in sudden infant death syndrome and premature infants","volume":"16","author":"Takashima","year":"1985","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.expneurol.2019.113166_bb0510","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1542\/peds.62.2.155","article-title":"Cerebral white matter lesions in sudden infant death syndrome","volume":"62","author":"Takashima","year":"1978","journal-title":"Pediatrics"},{"key":"10.1016\/j.expneurol.2019.113166_bb0515","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1542\/peds.69.1.33","article-title":"Retardation of neuronal maturation in premature infants compared with term infants of the same postconceptional age","volume":"69","author":"Takashima","year":"1982","journal-title":"Pediatrics"},{"key":"10.1016\/j.expneurol.2019.113166_bb0520","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1442-200X.1994.tb03191.x","article-title":"Developmental brain-stem pathology in sudden infant death syndrome","volume":"36","author":"Takashima","year":"1994","journal-title":"Acta Paediatr. Jpn."},{"key":"10.1016\/j.expneurol.2019.113166_bb0525","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ceca.2016.03.007","article-title":"Role of reactive oxygen species and TRP channels in the cough reflex","volume":"60","author":"Taylor-Clark","year":"2016","journal-title":"Cell Calcium"},{"key":"10.1016\/j.expneurol.2019.113166_bb0530","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1073\/pnas.90.4.1430","article-title":"Nervous system distribution of the serotonin 5-HT3 receptor mRNA","volume":"90","author":"Tecott","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2019.113166_bb0535","doi-asserted-by":"crossref","first-page":"69S","DOI":"10.1016\/S0002-9343(01)00860-9","article-title":"Maturation and transformation of reflexes that protect the laryngeal airway from liquid aspiration from fetal to adult life","volume":"111","author":"Thach","year":"2001","journal-title":"Am. J. Med."},{"key":"10.1016\/j.expneurol.2019.113166_bb0540","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.pupt.2006.11.011","article-title":"Maturation of cough and other reflexes that protect the fetal and neonatal airway","volume":"20","author":"Thach","year":"2007","journal-title":"Pulm. Pharmacol. Therap."},{"key":"10.1016\/j.expneurol.2019.113166_bb0545","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0379-0738(86)90012-5","article-title":"Sudden infant death syndrome. Morphology update for forensic pathologists\u20141985","volume":"30","author":"Valdes-Dapena","year":"1986","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.expneurol.2019.113166_bb0550","first-page":"547","article-title":"Brown fat retention in sudden infant death syndrome","volume":"100","author":"Valdes-Dapena","year":"1976","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.expneurol.2019.113166_bb0555","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1523\/JNEUROSCI.15-07-05346.1995","article-title":"Response of serotonergic caudal raphe neurons in relation to specific motor activities in freely moving cats","volume":"15","author":"Veasey","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2019.113166_bb0560","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1152\/japplphysiol.01103.2002","article-title":"Prolongation of the laryngeal chemoreflex after inhibition of the rostroventral medulla in piglets: a role in SIDS?","volume":"94","author":"van der Velde","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0565","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1152\/japplphysiol.00720.2006","article-title":"Focal warming of the nucleus of the solitary tract prolongs the laryngeal chemoreflex in decerebrate piglets","volume":"102","author":"Xia","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0575","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.resp.2008.11.004","article-title":"Gestational cigarette smoke exposure and hyperthermic enhancement of laryngeal chemoreflex in rat pups","volume":"165","author":"Xia","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0580","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.resp.2010.01.011","article-title":"Gestational nicotine exposure exaggerates hyperthermic enhancement of laryngeal chemoreflex in rat pups","volume":"171","author":"Xia","year":"2010","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0585","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.resp.2011.01.008","article-title":"TRPV1 channels in the nucleus of the solitary tract mediate thermal prolongation of the LCR in decerebrate piglets","volume":"176","author":"Xia","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.expneurol.2019.113166_bb0590","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.resp.2016.05.006","article-title":"Interleukin-1\u03b2 and interleukin-6 enhance thermal prolongation fo the LCR in decerebrate piglets","volume":"230","author":"Xia","year":"2016","journal-title":"Resp. Physiol. Neurobiol."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488619303139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488619303139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:55:42Z","timestamp":1758002142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488619303139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":117,"alternative-id":["S0014488619303139"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2019.113166","relation":{},"ISSN":["0014-4886"],"issn-type":[{"type":"print","value":"0014-4886"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal intermittent hypoxia sensitizes the laryngeal chemoreflex, blocks serotoninergic shortening of the reflex, and reduces 5-HT3 receptor binding in the NTS in anesthetized rat pups","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2019.113166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113166"}}