{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:08:47Z","timestamp":1793905727308,"version":"4.8.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.expneurol.2025.115288","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:02:27Z","timestamp":1746183747000},"page":"115288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Inhibiting mitochondrial excessive fission alleviates the neuronal damage in Parkinson's disease via regulating PGC-1\u03b1 mediated mitochondrial biogenesis"],"prefix":"10.1016","volume":"391","author":[{"given":"Jingwei","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuzhu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yirong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqi","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2025.115288_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/cells11020308","article-title":"Emerging role of cAMP\/AMPK signaling","volume":"11","author":"Aslam","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.expneurol.2025.115288_bb0010","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2204750120","article-title":"Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics","volume":"120","author":"Campos","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.expneurol.2025.115288_bb0015","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/d41586-021-01173-x","article-title":"Revolutionary view of two ways to split a mitochondrion","volume":"593","author":"Chakrabarti","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2025.115288_bb0020","doi-asserted-by":"crossref","first-page":"7199","DOI":"10.3390\/ijms12107199","article-title":"Roles of oxidative stress, apoptosis, PGC-1alpha and mitochondrial biogenesis in cerebral ischemia","volume":"12","author":"Chen","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.expneurol.2025.115288_bb0025","doi-asserted-by":"crossref","first-page":"8391","DOI":"10.1038\/s41467-023-44242-7","article-title":"Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice","volume":"14","author":"Chen","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.expneurol.2025.115288_bb0030","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.expneurol.2025.115288_bb0035","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1079\/PNS2004335","article-title":"The role of calcium and calcium\/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis","volume":"63","author":"Chin","year":"2004","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.expneurol.2025.115288_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105301","article-title":"Glucocorticoid impairs mitochondrial quality control in neurons","volume":"152","author":"Choi","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2025.115288_bb0045","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020370","article-title":"Astrocytes control synapse formation, function, and elimination","volume":"7","author":"Chung","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.expneurol.2025.115288_bb0050","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12264-022-00934-6","article-title":"Parkinson\u2019s disease: a multisystem disorder","volume":"39","author":"Costa","year":"2023","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.expneurol.2025.115288_bb0055","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1101\/gad.269894.115","article-title":"Mitochondrial biogenesis and dynamics in the developing and diseased heart","volume":"29","author":"Dorn","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.expneurol.2025.115288_bb0060","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2025932118","article-title":"Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy","volume":"118","author":"Drake","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.expneurol.2025.115288_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101856","article-title":"Heat shock protein 22 modulates NRF1\/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1alpha signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats","volume":"40","author":"Fan","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.expneurol.2025.115288_bb0070","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/mds.23651","article-title":"Parkinson\u2019s syndrome and Parkinson\u2019s disease in mitochondrial disorders","volume":"26","author":"Finsterer","year":"2011","journal-title":"Mov. Disord."},{"key":"10.1016\/j.expneurol.2025.115288_bb0075","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1038\/cdd.2012.18","article-title":"Inhibition of Drp1 provides neuroprotection in vitro and in vivo","volume":"19","author":"Grohm","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.expneurol.2025.115288_bb0080","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.expneurol.2025.115288_bb0085","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1080\/15548627.2020.1749490","article-title":"The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses","volume":"17","author":"Hu","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.expneurol.2025.115288_bb0090","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1093\/brain\/awt134","article-title":"Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteins","volume":"136","author":"Hurley","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2025.115288_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107705","article-title":"PPARgamma\/PGC1alpha signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders","volume":"219","author":"Jamwal","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.expneurol.2025.115288_bb0100","doi-asserted-by":"crossref","first-page":"8768","DOI":"10.1073\/pnas.1501831112","article-title":"Neural activity and CaMKII protect mitochondria from fragmentation in aging Caenorhabditis elegans neurons","volume":"112","author":"Jiang","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.expneurol.2025.115288_bb0105","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson's disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.expneurol.2025.115288_bb0110","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41586-021-03510-6","article-title":"Distinct fission signatures predict mitochondrial degradation or biogenesis","volume":"593","author":"Kleele","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2025.115288_bb0115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41586-021-03214-x","article-title":"Function and regulation of the divisome for mitochondrial fission","volume":"590","author":"Kraus","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2025.115288_bb0120","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1038\/s41588-023-01505-9","article-title":"Molecular basis for maternal inheritance of human mitochondrial DNA","volume":"55","author":"Lee","year":"2023","journal-title":"Nat. Genet."},{"issue":"684\u2013697","key":"10.1016\/j.expneurol.2025.115288_bb0125","article-title":"Nucleus-translocated ACSS2 promotes gene transcription for lysosomal biogenesis and autophagy","volume":"66","author":"Li","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.expneurol.2025.115288_bb0130","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1038\/s41467-019-13142-0","article-title":"Brain activity regulates loose coupling between mitochondrial and cytosolic ca (2+) transients","volume":"10","author":"Lin","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.expneurol.2025.115288_bb0135","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7150\/ijbs.33007","article-title":"Empagliflozin attenuates hyperuricemia by upregulation of ABCG2 via AMPK\/AKT\/CREB signaling pathway in type 2 diabetic mice","volume":"16","author":"Lu","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.expneurol.2025.115288_bb0140","doi-asserted-by":"crossref","first-page":"eabj5559","DOI":"10.1126\/science.abj5559","article-title":"Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1","volume":"380","author":"Malik","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2025.115288_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101578","article-title":"Mitochondrial DNA homeostasis impairment and dopaminergic dysfunction: a trembling balance","volume":"76","author":"Manini","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.expneurol.2025.115288_bb0150","doi-asserted-by":"crossref","first-page":"574","DOI":"10.4103\/1673-5374.248108","article-title":"Rescue axonal defects by targeting mitochondrial dynamics in hereditary spastic paraplegias","volume":"14","author":"Mou","year":"2019","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.expneurol.2025.115288_bb0155","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1007\/s10495-010-0476-x","article-title":"Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer's and Parkinson's diseases","volume":"15","author":"Nakamura","year":"2010","journal-title":"Apoptosis"},{"key":"10.1016\/j.expneurol.2025.115288_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.778569","article-title":"Effects of Mdivi-1 on neural mitochondrial dysfunction and mitochondria-mediated apoptosis in ischemia-reperfusion injury after stroke: a systematic review of preclinical studies","volume":"14","author":"Nhu","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.expneurol.2025.115288_bb0165","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1007\/s12035-016-9944-9","article-title":"The interaction of mitochondrial biogenesis and fission\/fusion mediated by PGC-1alpha regulates rotenone-induced dopaminergic neurotoxicity","volume":"54","author":"Peng","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.expneurol.2025.115288_bb0170","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1111\/jcmm.15194","article-title":"Mitochondrial biogenesis: an update","volume":"24","author":"Popov","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.expneurol.2025.115288_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103254","article-title":"NADPH oxidase 2 activity disrupts Calmodulin\/CaMKIIalpha complex via redox modifications of CaMKIIalpha-contained Cys30 and Cys289: Implications in Parkinson\u2019s disease","volume":"75","author":"Pullara","year":"2024","journal-title":"Redox Biol."},{"issue":"885\u2013895","key":"10.1016\/j.expneurol.2025.115288_bb0180","article-title":"KDM3A senses oxygen availability to regulate PGC-1alpha-mediated mitochondrial biogenesis","volume":"76","author":"Qian","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.expneurol.2025.115288_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070760","article-title":"Neurological enhancement effects of melatonin against brain injury-induced oxidative stress, Neuroinflammation, and neurodegeneration via AMPK\/CREB signaling","volume":"8","author":"Rehman","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.expneurol.2025.115288_bb0190","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.febslet.2007.11.034","article-title":"Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways","volume":"582","author":"Rodgers","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.expneurol.2025.115288_bb0195","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/glia.23802","article-title":"Mitochondrial division inhibitor 1 disrupts oligodendrocyte ca (2+) homeostasis and mitochondrial function","volume":"68","author":"Ruiz","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.expneurol.2025.115288_bb0200","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1152\/physrev.00025.2007","article-title":"Transcriptional paradigms in mammalian mitochondrial biogenesis and function","volume":"88","author":"Scarpulla","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.expneurol.2025.115288_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113309","article-title":"Mitochondrial biogenesis as a therapeutic target for traumatic and neurodegenerative CNS diseases","volume":"329","author":"Simmons","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2025.115288_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2023.167992","article-title":"Common mechanisms underlying alpha-Synuclein-induced mitochondrial dysfunction in Parkinson\u2019s disease","volume":"435","author":"Sohrabi","year":"2023","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.expneurol.2025.115288_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102334","article-title":"Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death","volume":"53","author":"Sun","year":"2022","journal-title":"Redox Biol."},{"issue":"Pt 2","key":"10.1016\/j.expneurol.2025.115288_bb0220","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neubiorev.2014.01.012","article-title":"Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: an overview of down syndrome, autism, fragile X and Rett syndrome","volume":"46","author":"Valenti","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.expneurol.2025.115288_bb0225","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1016\/j.bbadis.2017.09.014","article-title":"Inhibition of Drp1-mediated mitochondrial fission improves mitochondrial dynamics and bioenergetics stimulating neurogenesis in hippocampal progenitor cells from a down syndrome mouse model","volume":"1863","author":"Valenti","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.expneurol.2025.115288_bb0230","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011072","article-title":"Mechanisms of mitochondrial fission and fusion","volume":"5","author":"van der Bliek","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.expneurol.2025.115288_bb0235","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.addr.2009.06.006","article-title":"Mitochondrial biogenesis in exercise and in ageing","volume":"61","author":"Vina","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.expneurol.2025.115288_bb0240","doi-asserted-by":"crossref","first-page":"24129","DOI":"10.1038\/s41598-021-03631-y","article-title":"Altered cardiac mitochondrial dynamics and biogenesis in rat after short-term cocaine administration","volume":"11","author":"Wen","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.expneurol.2025.115288_bb0245","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2025.115288_bb0250","doi-asserted-by":"crossref","first-page":"1339295","DOI":"10.3389\/fnagi.2024.1339295","article-title":"Metabolic energy decline coupled dysregulation of catecholamine metabolism in physiologically highly active neurons: implications for selective neuronal death in Parkinson\u2019s disease","volume":"16","author":"Wimalasena","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.expneurol.2025.115288_bb0255","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/cac2.12247","article-title":"Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1","volume":"42","author":"Wu","year":"2022","journal-title":"Cancer Commun. (Lond.)"},{"key":"10.1016\/j.expneurol.2025.115288_bb0260","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.7150\/ijbs.62556","article-title":"Berberine modulates deacetylation of PPARgamma to promote adipose tissue remodeling and thermogenesis via AMPK\/SIRT1 pathway","volume":"17","author":"Xu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.expneurol.2025.115288_bb0265","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1093\/nar\/gkt1360","article-title":"Organization of the human mitochondrial transcription initiation complex","volume":"42","author":"Yakubovskaya","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.expneurol.2025.115288_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101626","article-title":"Metformin alleviates lead-induced mitochondrial fragmentation via AMPK\/Nrf2 activation in SH-SY5Y cells","volume":"36","author":"Yang","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.expneurol.2025.115288_bb0275","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s11658-023-00457-6","article-title":"Empagliflozin improves renal ischemia-reperfusion injury by reducing inflammation and enhancing mitochondrial fusion through AMPK-OPA1 pathway promotion","volume":"28","author":"Yang","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.expneurol.2025.115288_bb0280","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41583-022-00624-2","article-title":"CaMKII: a central molecular organizer of synaptic plasticity, learning and memory","volume":"23","author":"Yasuda","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.expneurol.2025.115288_bb0285","article-title":"Mitochondrial fission as a therapeutic target for metabolic diseases: insights into antioxidant strategies","volume":"12","author":"Yu","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.expneurol.2025.115288_bb0290","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202113943","article-title":"NAD (+) homeostasis in human health and disease","volume":"13","author":"Zapata-Perez","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.expneurol.2025.115288_bb0295","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065785","article-title":"The Drp1-mediated mitochondrial fission protein Interactome as an emerging Core player in mitochondrial dynamics and cardiovascular disease therapy","volume":"24","author":"Zerihun","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.expneurol.2025.115288_bb0300","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12974-021-02250-8","article-title":"NAD (+) improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1\/PGC-1alpha pathway","volume":"18","author":"Zhao","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.expneurol.2025.115288_bb0305","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1016\/j.apsb.2021.03.020","article-title":"Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4\/MyD88\/NF-kappaB pathway through microbiota-gut-brain axis","volume":"11","author":"Zhao","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.expneurol.2025.115288_bb0310","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022113258","article-title":"NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity","volume":"42","author":"Zhao","year":"2023","journal-title":"EMBO J."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488625001529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488625001529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:59:15Z","timestamp":1762149555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488625001529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":62,"alternative-id":["S0014488625001529"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2025.115288","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibiting mitochondrial excessive fission alleviates the neuronal damage in Parkinson's disease via regulating PGC-1\u03b1 mediated mitochondrial biogenesis","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2025.115288","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115288"}}