{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:53:03Z","timestamp":1789275183249,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004482","name":"Kuwait University","doi-asserted-by":"publisher","award":["SL02\/23"],"award-info":[{"award-number":["SL02\/23"]}],"id":[{"id":"10.13039\/501100004482","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003286","name":"Kuwait Foundation for the Advancement of Sciences","doi-asserted-by":"publisher","award":["PN23-12MB-2011"],"award-info":[{"award-number":["PN23-12MB-2011"]}],"id":[{"id":"10.13039\/501100003286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003286","name":"Kuwait Foundation for the Advancement of Sciences","doi-asserted-by":"publisher","award":["GM01\/15"],"award-info":[{"award-number":["GM01\/15"]}],"id":[{"id":"10.13039\/501100003286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003286","name":"Kuwait Foundation for the Advancement of Sciences","doi-asserted-by":"publisher","award":["SRUL02\/13"],"award-info":[{"award-number":["SRUL02\/13"]}],"id":[{"id":"10.13039\/501100003286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.expneurol.2026.115652","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T15:43:58Z","timestamp":1769442238000},"page":"115652","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Integrated miRNA-proteomic profiling identifies chronic vesicle-trafficking and proteostasis disruptions after mild traumatic brain injury"],"prefix":"10.1016","volume":"399","author":[{"given":"Hamad","family":"Yadikar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mubeen A.","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2026.115652_bb0005","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20178124","article-title":"Multi-omics factor analysis\u2014a framework for unsupervised integration of multi-omics data sets","volume":"14","author":"Argelaguet","year":"2018","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.expneurol.2026.115652_bb0010","doi-asserted-by":"crossref","DOI":"10.1177\/1179069519832286","article-title":"A review of MicroRNA biomarkers in traumatic brain injury","volume":"13","author":"Atif","year":"2019","journal-title":"J. Exp. Neurosci."},{"key":"10.1016\/j.expneurol.2026.115652_bb0015","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neuroscience.2014.10.035","article-title":"Caveolin expression changes in the neurovascular unit after juvenile traumatic brain injury: signs of blood-brain barrier healing?","volume":"285","author":"Badaut","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2026.115652_bb0020","doi-asserted-by":"crossref","first-page":"80","DOI":"10.55782\/ane-2024-2543","article-title":"Evaluation of neurogranin levels in a rat model of diffuse axonal injury","volume":"84","author":"Baskurt","year":"2024","journal-title":"Acta Neurobiol. Exp. (Wars)"},{"key":"10.1016\/j.expneurol.2026.115652_bb0025","doi-asserted-by":"crossref","first-page":"16084","DOI":"10.1038\/nrdp.2016.84","article-title":"Traumatic brain injuries","volume":"2","author":"Blennow","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.expneurol.2026.115652_bb0030","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s00018-025-05638-4","article-title":"Temporal characterisation and electrophysiological implications of TBI-induced serine\/threonine kinase activity in mouse cortex","volume":"82","author":"Celine","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.expneurol.2026.115652_bb0035","doi-asserted-by":"crossref","first-page":"W244","DOI":"10.1093\/nar\/gkaa467","article-title":"miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology","volume":"48","author":"Chang","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"32","key":"10.1016\/j.expneurol.2026.115652_bb0040","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/01.STR.32.4.1005","article-title":"Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats","volume":"1970","author":"Chen","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2026.115652_bb0045","article-title":"Pneumococcus suppresses host inflammatory response through COMMD2 mediated NF-\u03baB degradation by aggrephagy","author":"Connor","year":"2023","journal-title":"bioRxiv. Preprint"},{"key":"10.1016\/j.expneurol.2026.115652_bb0050","first-page":"9","article-title":"MicroRNA signature of traumatic brain injury: from the biomarker discovery to the point-of-care","author":"Di Pietro","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.expneurol.2026.115652_bb0055","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1089\/neu.2018.6348","article-title":"Traumatic brain injury induces tau aggregation and spreading","volume":"37","author":"Edwards Iii","year":"2020","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2026.115652_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.922","article-title":"Using ExpressAnalyst for comprehensive gene expression analysis in model and non-model organisms","volume":"3","author":"Ewald","year":"2023","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.expneurol.2026.115652_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1371213","article-title":"An overview of preclinical models of traumatic brain injury (TBI): relevance to pathophysiological mechanisms","volume":"18","author":"Fesharaki-Zadeh","year":"2024","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.expneurol.2026.115652_bb0070","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrn.2016.51","article-title":"Autophagy in acute brain injury","volume":"17","author":"Galluzzi","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.expneurol.2026.115652_bb0075","doi-asserted-by":"crossref","first-page":"851","DOI":"10.37349\/eds.2024.00077","article-title":"FDA-approved kinase inhibitors: a promising therapeutic avenue for traumatic brain injury","volume":"2","author":"Gao","year":"2024","journal-title":"Explor. Drug Sci."},{"key":"10.1016\/j.expneurol.2026.115652_bb0080","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.1038\/srep06718","article-title":"miR-21 improves the neurological outcome after traumatic brain injury in rats","volume":"4","author":"Ge","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.expneurol.2026.115652_bb0085","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1742-2094-10-132","article-title":"Prostaglandin F2\u03b1 FP receptor antagonist improves outcomes after experimental traumatic brain injury","volume":"10","author":"Glushakov","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.expneurol.2026.115652_bb0090","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/2211-5463.12092","article-title":"Traumatic brain injury increases levels of miR-21 in extracellular vesicles: implications for neuroinflammation","volume":"6","author":"Harrison","year":"2016","journal-title":"FEBS Open Bio."},{"key":"10.1016\/j.expneurol.2026.115652_bb0095","first-page":"L151","article-title":"Caveolin-1: a critical regulator of lung injury","volume":"300","author":"Jin","year":"2011","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.expneurol.2026.115652_bb0100","first-page":"355","article-title":"Tauopathies","volume":"145","author":"Kovacs","year":"2017","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.expneurol.2026.115652_bb0105","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1101\/pdb.top084970","article-title":"RNA sequencing and analysis","volume":"2015","author":"Kukurba","year":"2015","journal-title":"Cold Spring Harb Protoc"},{"key":"10.1016\/j.expneurol.2026.115652_bb0110","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pneurobio.2017.08.003","article-title":"Chronic traumatic encephalopathy-integration of canonical traumatic brain injury secondary injury mechanisms with tau pathology","volume":"158","author":"Kulbe","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.expneurol.2026.115652_bb0115","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.expneurol.2026.115652_bb0120","doi-asserted-by":"crossref","first-page":"5332","DOI":"10.1007\/s12035-018-1454-5","article-title":"Animal models of traumatic brain injury and assessment of injury severity","volume":"56","author":"Ma","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.expneurol.2026.115652_bb0125","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S1474-4422(17)30371-X","article-title":"Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research","volume":"16","author":"Maas","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.expneurol.2026.115652_bb0130","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3171\/jns.1994.80.2.0291","article-title":"A new model of diffuse brain injury in rats. Part I: pathophysiology and biomechanics","volume":"80","author":"Marmarou","year":"1994","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.expneurol.2026.115652_bb0135","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3390\/jnt2040014","article-title":"The Nanotheranostic researcher\u2019s guide for use of animal models of traumatic brain injury","volume":"2","author":"McDonald","year":"2021","journal-title":"J. Nanotheran."},{"key":"10.1016\/j.expneurol.2026.115652_bb0140","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1001\/jama.2017.16687","article-title":"Chronic traumatic encephalopathy in football players-reply","volume":"318","author":"McKee","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.expneurol.2026.115652_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.565667","article-title":"Wnt pathway: an emerging player in vascular and traumatic mediated brain injuries","volume":"11","author":"Menet","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.expneurol.2026.115652_bb0150","series-title":"A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats. 1940-087X","author":"Mychasiuk","year":"2014"},{"key":"10.1016\/j.expneurol.2026.115652_bb0155","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3389\/fncel.2019.00528","article-title":"Traumatic brain injuries: pathophysiology and potential therapeutic targets","volume":"13","author":"Ng","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.expneurol.2026.115652_bb0160","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/jnr.21945","article-title":"Traumatic brain injury alters expression of hippocampal microRNAs: potential regulators of multiple pathophysiological processes","volume":"87","author":"Redell","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2026.115652_bb0165","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1089\/neu.2010.1481","article-title":"Human traumatic brain injury alters plasma microRNA levels","volume":"27","author":"Redell","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2026.115652_bb0170","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.tins.2021.06.003","article-title":"Synergistic effects of brain injury and aging: common mechanisms of proteostatic dysfunction","volume":"44","author":"Saikumar","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.expneurol.2026.115652_bb0175","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11910-017-0736-z","article-title":"The application of proteomics to traumatic brain and spinal cord injuries","volume":"17","author":"Sarkis","year":"2017","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.expneurol.2026.115652_bb0180","first-page":"14","article-title":"Microglia and Neuroinflammation: crucial pathological mechanisms in traumatic brain injury-induced neurodegeneration","author":"Shao","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.expneurol.2026.115652_bb0185","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.1038\/s41467-019-12221-6","article-title":"Endosomal PI(3)P regulation by the COMMD\/CCDC22\/CCDC93 (CCC) complex controls membrane protein recycling","volume":"10","author":"Singla","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.expneurol.2026.115652_bb0190","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/WCO.0000000000000613","article-title":"Proteomic changes in traumatic brain injury: experimental approaches","volume":"31","author":"Sowers","year":"2018","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.expneurol.2026.115652_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.108849","article-title":"Caveolae disassemble upon membrane lesioning and foster cell survival","volume":"27","author":"\u0160tefl","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.expneurol.2026.115652_bb0200","doi-asserted-by":"crossref","first-page":"14314","DOI":"10.1021\/jacs.8b08645","article-title":"Identification and characterization of DNA aptamers specific for phosphorylation epitopes of tau protein","volume":"140","author":"Teng","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.expneurol.2026.115652_bb0205","first-page":"16","article-title":"Social hierarchy modulates drug reinforcement and protein phosphorylation in the nucleus accumbens","author":"Xu","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.expneurol.2026.115652_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20205213","article-title":"Novel Peptidomic approach for identification of low and high molecular weight tauopathy peptides following Calpain digestion, and primary culture neurotoxic challenges","volume":"20","author":"Yadikar","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.expneurol.2026.115652_bb0215","series-title":"Biomarkers for Traumatic Brain Injury","first-page":"419","article-title":"Chapter 28 - Peptidomics and traumatic brain injury: Biomarker utilities for a theragnostic approach","author":"Yadikar","year":"2020"},{"key":"10.1016\/j.expneurol.2026.115652_bb0220","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.3390\/ijms25126469","article-title":"Deciphering early and progressive molecular signatures in Alzheimer\u2019s disease through integrated longitudinal proteomic and pathway analysis in a rodent model","volume":"25","author":"Yadikar","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.expneurol.2026.115652_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.mex.2024.103118","article-title":"Quantitative evaluation of hindlimb grip strength in mice as a measure of neuromuscular function","volume":"14","author":"Zheng","year":"2025","journal-title":"MethodsX"},{"key":"10.1016\/j.expneurol.2026.115652_bb0230","doi-asserted-by":"crossref","first-page":"W514","DOI":"10.1093\/nar\/gky510","article-title":"OmicsNet: a web-based tool for creation and visual analysis of biological networks in 3D space","volume":"46","author":"Zhou","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.expneurol.2026.115652_bb0235","first-page":"14","article-title":"Persistent neurovascular unit dysfunction: pathophysiological substrate and trigger for late-onset neurodegeneration after traumatic brain injury","author":"Zhou","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.expneurol.2026.115652_bb0240","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41420-025-02337-8","article-title":"High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis","volume":"11","author":"Zou","year":"2025","journal-title":"Cell Death Dis."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488626000154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488626000154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T08:24:14Z","timestamp":1782116654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488626000154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":48,"alternative-id":["S0014488626000154"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2026.115652","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated miRNA-proteomic profiling identifies chronic vesicle-trafficking and proteostasis disruptions after mild traumatic brain injury","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2026.115652","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115652"}}