{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:17:51Z","timestamp":1787318271354,"version":"build-2736575974"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.exppara.2005.12.019","type":"journal-article","created":{"date-parts":[[2006,2,16]],"date-time":"2006-02-16T07:21:15Z","timestamp":1140074475000},"page":"154-160","source":"Crossref","is-referenced-by-count":21,"title":["Refinement of the mouse model of congenital toxoplasmosis"],"prefix":"10.1016","volume":"113","author":[{"given":"A.","family":"Freyre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Falc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2005.12.019_bib1","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1128\/IAI.72.3.1397-1401.2004","article-title":"Role of NK cells and \u03b3 interferon in transplacental passage of Toxoplasma gondii in a mouse model of primary infection","volume":"72","author":"Abou-Bacar","year":"2004","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exppara.2005.12.019_bib2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/aja.1000300303","article-title":"The oestrus cycle in the mouse","volume":"30","author":"Allen","year":"1922","journal-title":"American Journal of Anatomy"},{"key":"10.1016\/j.exppara.2005.12.019_bib3","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1128\/JCM.11.6.562-568.1980","article-title":"Direct agglutination test for diagnosis of Toxoplasma infection. Methods for increasing sensitivity and specificity","volume":"11","author":"Desmonts","year":"1980","journal-title":"Journal of Clinical Microbiology"},{"key":"10.1016\/j.exppara.2005.12.019_bib4","series-title":"Toxoplasmosis of Animals and Man","year":"1988"},{"key":"10.1016\/j.exppara.2005.12.019_bib5","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1128\/IAI.59.9.3301-3302.1991","article-title":"Rat model of congenital toxoplasmosis","volume":"59","author":"Dubey","year":"1991","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exppara.2005.12.019_bib6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1590\/S0074-02762001000100011","article-title":"Vertical toxoplasmosis in a murine model. Protection after immunization with antigens of Toxoplasma gondii incorporated into liposomes","volume":"96","author":"Elsaid","year":"2001","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"key":"10.1016\/j.exppara.2005.12.019_bib7","volume":"vol. III","author":"Foster","year":"1983"},{"key":"10.1016\/j.exppara.2005.12.019_bib8","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.2307\/3284058","article-title":"Separation of Toxoplasma cysts from brain tissue and liberation of viable bradyzoites","volume":"81","author":"Freyre","year":"1995","journal-title":"Journal of Parasitology"},{"key":"10.1016\/j.exppara.2005.12.019_bib9","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s004360100487","article-title":"Some factors influencing transmission of Toxoplasma in pregnant rats fed cysts","volume":"87","author":"Freyre","year":"2001","journal-title":"Parasitology Research"},{"key":"10.1016\/j.exppara.2005.12.019_bib10","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s00436-002-0759-4","article-title":"Fetal Toxoplasma infection after oocysts inoculation of pregnants rats","volume":"89","author":"Freyre","year":"2003","journal-title":"Parasitology Research"},{"key":"10.1016\/j.exppara.2005.12.019_bib11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1590\/S0074-02762000000100020","article-title":"Experimental toxoplasmosis in BALB\/c mice. Prevention of vertical disease transmission by treatment and reproductive failure in chronic infection","volume":"95","author":"Fux","year":"2000","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"key":"10.1016\/j.exppara.2005.12.019_bib12","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1530\/jrf.0.0900395","article-title":"Lipopolysaccharide induced fetal resorption in mice is associated with the intrauterine production of tumor necrosis factor-\u03b1","volume":"90","author":"Gendron","year":"1990","journal-title":"Reproduction and Fertility"},{"key":"10.1016\/j.exppara.2005.12.019_bib13","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1128\/IAI.42.3.1126-1135.1983","article-title":"Toxofactor associated with Toxoplasma gondii infection is toxic and teratogenic to mice","volume":"42","author":"Grimwood","year":"1983","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exppara.2005.12.019_bib14","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/0264-410X(95)00011-O","article-title":"Adjuvants for human vaccines-current status, problems and future prospects","volume":"13","author":"Gupta","year":"1995","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2005.12.019_bib15","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1093\/infdis\/172.6.1561","article-title":"Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease","volume":"172","author":"Howe","year":"1995","journal-title":"Journal of Infectious Diseases"},{"key":"10.1016\/j.exppara.2005.12.019_bib16","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1128\/IAI.60.5.1979-1983.1992","article-title":"A protective role for endogenous tumor necrosis factor in Toxoplasma gondii infection","volume":"60","author":"Johnson","year":"1992","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exppara.2005.12.019_bib17","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1128\/IAI.71.11.6615-6619.2003","article-title":"Vaccination with Toxoplasma gondii SAG-1 protein is protective against congenital toxoplasmosis in BALB\/c mice","volume":"71","author":"Letscher-Bru","year":"2003","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exppara.2005.12.019_bib18","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.4049\/jimmunol.140.5.1632","article-title":"Subcutaneous and intestinal vaccination with tachyzoites of Toxoplasma gondii and acquisition of immunity to peroral and congenital Toxoplasma challenge","volume":"140","author":"Mc Leod","year":"1988","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.exppara.2005.12.019_bib19","first-page":"41","article-title":"Estimation of the number of parasites contained within a Cyst, and growth and distribution of cysts in the brains of mice infected with Toxoplasma gondii","volume":"12","author":"Motomoura","year":"1970","journal-title":"Tropical Medicine (Nagasaki)"},{"key":"10.1016\/j.exppara.2005.12.019_bib20","series-title":"Congenital Toxoplasmosis","first-page":"314","article-title":"Strategies for development of vaccines against Toxoplasma gondii","author":"Nielsen","year":"2000"},{"key":"10.1016\/j.exppara.2005.12.019_bib21","series-title":"Infectious Diseases of the Fetus and Newborn Infant","first-page":"90","article-title":"Toxoplasmosis","author":"Remington","year":"1990"},{"key":"10.1016\/j.exppara.2005.12.019_bib22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1017\/S0031182000060753","article-title":"Studies on a murine model of congenital toxoplasmosis: vertical disease transmission only occurs in BALB\/c mice infected for the first time during pregnancy","volume":"104","author":"Roberts","year":"1992","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2005.12.019_bib23","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/0264-410X(94)90147-3","article-title":"Congenital toxoplasmosis in the BALB\/c mouse: prevention of vertical disease transmission and fetal death by vaccination","volume":"12","author":"Roberts","year":"1994","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2005.12.019_bib24","series-title":"Epidemiolog\u00eda Diagn\u00f3stica","author":"Tarabla","year":"2000"},{"key":"10.1016\/j.exppara.2005.12.019_bib25","first-page":"279","article-title":"Immune response in a murine model of congenital toxoplasmosis: increased susceptibility of pregnant mice and transplacental passage of Toxoplasma gondii are Type-2 dependent","volume":"39","author":"Thouvenin","year":"1997","journal-title":"Parasitologia"},{"key":"10.1016\/j.exppara.2005.12.019_bib26","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1128\/IAI.61.1.360-363.1993","article-title":"Rat model of congenital toxoplasmosis: rate of transmission of three Toxoplasma strains to fetuses and protective effects of a chronic infection","volume":"61","author":"Zenner","year":"1993","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exppara.2005.12.019_bib27","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1046\/j.1365-3024.1999.00229.x","article-title":"Protective immunity on the rat model of congenital toxoplasmosis and the potential of excreted-secreted antigens as vaccine components","volume":"21","author":"Zenner","year":"1999","journal-title":"Parasite Immunology"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489405003498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489405003498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T10:16:21Z","timestamp":1683368181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489405003498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S0014489405003498"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2005.12.019","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}