{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:28:38Z","timestamp":1791044918587,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.exppara.2009.12.009","type":"journal-article","created":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T09:08:54Z","timestamp":1262682534000},"page":"409-420","source":"Crossref","is-referenced-by-count":50,"title":["Schistosoma mansoni: Egg-induced downregulation of hepatic stellate cell activation and fibrogenesis"],"prefix":"10.1016","volume":"124","author":[{"given":"Barrie","family":"Anthony","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Mathieson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"de Castro-Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2009.12.009_bib1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1590\/S0074-02761999000100018","article-title":"Myofibroblasts in schistosomal portal fibrosis of man","volume":"94","author":"Andrade","year":"1999","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"key":"10.1016\/j.exppara.2009.12.009_bib2","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.ijpara.2006.04.015","article-title":"A contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis","volume":"36","author":"Bartley","year":"2006","journal-title":"International Journal of Parasitology"},{"key":"10.1016\/j.exppara.2009.12.009_bib3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1096\/fasebj.5.3.2001786","article-title":"Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis","volume":"5","author":"Blomhoff","year":"1991","journal-title":"FASEB Journal"},{"key":"10.1016\/j.exppara.2009.12.009_bib4","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.4049\/jimmunol.172.2.1295","article-title":"Periportal fibrosis in human Schistosoma mansoni infection is associated with low IL-10, low IFN-gamma, high TNF-alpha, or low RANTES, depending on age and gender","volume":"172","author":"Booth","year":"2004","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.exppara.2009.12.009_bib5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4269\/ajtmh.1983.32.78","article-title":"Induction of collagen synthesis in cultured human fibroblasts by live Schistosoma mansoni eggs and soluble egg antigens (SEA)","volume":"32","author":"Boros","year":"1983","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.exppara.2009.12.009_bib6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-3024.2009.01098.x","article-title":"Immunopathogenesis of human schistosomiasis","volume":"31","author":"Burke","year":"2009","journal-title":"Parasite Immunology"},{"key":"10.1016\/j.exppara.2009.12.009_bib7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.actatropica.2008.05.027","article-title":"Human schistosomiasis mansoni: immune responses during acute and chronic phases of the infection","volume":"108","author":"Caldas","year":"2008","journal-title":"Acta Tropica"},{"key":"10.1016\/j.exppara.2009.12.009_bib8","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.actatropica.2005.12.006","article-title":"Hepatic stellate cells in human Schistosomiasis mansoni: a comparative immunohistochemical study with liver cirrhosis","volume":"97","author":"Chang","year":"2006","journal-title":"Acta Tropica"},{"key":"10.1016\/j.exppara.2009.12.009_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0001-706X(00)00122-4","article-title":"The global status of schistosomiasis and its control","volume":"77","author":"Chitsulo","year":"2000","journal-title":"Acta Tropica"},{"key":"10.1016\/j.exppara.2009.12.009_bib10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2307\/3285768","article-title":"How much human helminthiasis is there in the world?","volume":"85","author":"Crompton","year":"1999","journal-title":"Journal of Parasitology"},{"key":"10.1016\/j.exppara.2009.12.009_bib11","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1128\/IAI.72.6.3391-3397.2004","article-title":"Association of type 2 cytokines with hepatic fibrosis in human Schistosoma mansoni infection","volume":"72","author":"de Jesus","year":"2004","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exppara.2009.12.009_bib12","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1002\/eji.200737765","article-title":"Mapping immune response profiles: the emerging scenario from helminth immunology","volume":"37","author":"Diaz","year":"2007","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.exppara.2009.12.009_bib13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0014-5793(01)02656-4","volume":"502","author":"Dooley","year":"2001","journal-title":"FEBS Letters"},{"key":"10.1016\/j.exppara.2009.12.009_bib14","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1006\/bbrc.2001.4811","article-title":"Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblasts","volume":"283","author":"Dooley","year":"2001","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.exppara.2009.12.009_bib15","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1084\/jem.20082460","article-title":"Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses","volume":"206","author":"Everts","year":"2009","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.exppara.2009.12.009_bib16","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/eji.200323717","article-title":"Schistosome N-glycans containing core alpha 3-fucose and core beta 2-xylose epitopes are strong inducers of Th2 responses in mice","volume":"33","author":"Faveeuw","year":"2003","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.exppara.2009.12.009_bib17","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1053\/j.gastro.2004.02.025","article-title":"A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis","volume":"126","author":"Forbes","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.exppara.2009.12.009_bib18","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/infdis\/158.3.556","article-title":"Eggs of Schistosoma mansoni stimulate endothelial cell proliferation in vitro","volume":"158","author":"Freedman","year":"1988","journal-title":"Journal of Infectious Disease"},{"key":"10.1016\/j.exppara.2009.12.009_bib19","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"Friedman","year":"2000","journal-title":"Journal of Biological Chemistry"},{"issue":"Suppl. 1","key":"10.1016\/j.exppara.2009.12.009_bib20","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/S0168-8278(02)00429-4","article-title":"Liver fibrosis \u2013 from bench to bedside","volume":"38","author":"Friedman","year":"2003","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.exppara.2009.12.009_bib21","first-page":"783","article-title":"Portal fibrosis: intrahepatic portal vein pathology in chronic human Schistosomiasis mansoni","volume":"18","author":"Grimaud","year":"1986","journal-title":"Journal of Submicroscopic Cytology"},{"key":"10.1016\/j.exppara.2009.12.009_bib22","first-page":"135","article-title":"Hepatic fibrosis and cirrhosis: the (myo)fibroblastic cell subpopulations involved","volume":"38","author":"Guyot","year":"2006","journal-title":"International Journal of Biochemistry and Cell Biology"},{"key":"10.1016\/j.exppara.2009.12.009_bib23","doi-asserted-by":"crossref","first-page":"11392","DOI":"10.1074\/jbc.M310284200","article-title":"Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells","volume":"279","author":"Hazra","year":"2004","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.exppara.2009.12.009_bib24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000101322","article-title":"Liver fibrosis: possible involvement of EMT","volume":"185","author":"Ikegami","year":"2007","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.exppara.2009.12.009_bib25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.molbiopara.2005.08.001","article-title":"Characterisation and partial purification of Schistosoma mansoni egg-derived pro-angiogenic factor","volume":"144","author":"Kanse","year":"2005","journal-title":"Molecular and Biochemical Parasitology"},{"key":"10.1016\/j.exppara.2009.12.009_bib26","series-title":"Human Schistosomiasis","first-page":"195","article-title":"Schistosoma mansoni: pathological and clinical aspects","author":"Lambertucci","year":"1993"},{"key":"10.1016\/j.exppara.2009.12.009_bib27","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB Journal"},{"key":"10.1016\/j.exppara.2009.12.009_bib28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1017\/S0031182000052689","article-title":"A comparative study of the life-histories of mammalian schistosomes","volume":"87","author":"Loker","year":"1983","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2009.12.009_bib29","doi-asserted-by":"crossref","unstructured":"Mathieson, W., Wilson, R.A., 2009. A comparative proteomic study of the undeveloped and developed Schistosoma mansoni egg and its contents: the miracidium, hatch fluid and secretions. International Journal for Parasitology, doi:10.1016\/j.ijpara.2009.10.014.","DOI":"10.1016\/j.ijpara.2009.10.014"},{"issue":"Suppl. 1","key":"10.1016\/j.exppara.2009.12.009_bib30","doi-asserted-by":"crossref","first-page":"S122","DOI":"10.1111\/j.1440-1746.2007.05297.x","article-title":"Transforming growth factor-beta and hepatocyte transdifferentiation in liver fibrogenesis","volume":"23","author":"Meindl-Beinker","year":"2008","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.exppara.2009.12.009_bib31","doi-asserted-by":"crossref","first-page":"35715","DOI":"10.1074\/jbc.M006577200","article-title":"Peroxisome proliferator-activated receptors and hepatic stellate cell activation","volume":"275","author":"Miyahara","year":"2000","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.exppara.2009.12.009_bib31a","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.ijpara.2006.02.003","article-title":"Dendritic cell activation and function in response to Schistosoma mansoni","volume":"36","author":"Perona-Wright","year":"2006","journal-title":"International Journal of Parasitology"},{"key":"10.1016\/j.exppara.2009.12.009_bib32","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.exppara.2009.12.009_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1386-6346(03)00115-3","article-title":"Connective tissue growth factor (CTGF\/CCN2) in hepatic fibrosis","volume":"26","author":"Rachfal","year":"2003","journal-title":"Hepatology Research"},{"key":"10.1016\/j.exppara.2009.12.009_bib34","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/gut.50.4.571","article-title":"Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension","volume":"50","author":"Reynaert","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.exppara.2009.12.009_bib35","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/eji.200323501","article-title":"IL-10 is crucial for the transition from acute to chronic disease state during infection of mice with Schistosoma mansoni","volume":"33","author":"Sadler","year":"2003","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.exppara.2009.12.009_bib36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/cbir.1998.0234","article-title":"Induction of cellular processes containing collagenase and retinoid by integrin-binding to interstitial collagen in hepatic stellate cell culture","volume":"22","author":"Sato","year":"1998","journal-title":"Cell Biology International"},{"key":"10.1016\/j.exppara.2009.12.009_bib37","doi-asserted-by":"crossref","first-page":"18384","DOI":"10.1074\/jbc.M300497200","article-title":"Molecular characterization of an interleukin-4-inducing factor from Schistosoma mansoni eggs","volume":"278","author":"Schramm","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.exppara.2009.12.009_bib38","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1006\/cbir.1996.0065","article-title":"Three-dimensional structure of extracellular matrix reversibly regulates morphology, proliferation and collagen metabolism of perisinusoidal stellate cells (vitamin A-storing cells)","volume":"20","author":"Senoo","year":"1996","journal-title":"Cell Biology International"},{"key":"10.1016\/j.exppara.2009.12.009_bib39","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1074\/jbc.M410078200","article-title":"Adipogenic transcriptional regulation of hepatic stellate cells","volume":"280","author":"She","year":"2005","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.exppara.2009.12.009_bib39a","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1017\/S0031182000086248","article-title":"The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms","volume":"55","author":"Smithers","year":"1965","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2009.12.009_bib40","doi-asserted-by":"crossref","first-page":"C740","DOI":"10.1152\/ajpcell.00333.2007","article-title":"Connective tissue growth factor inhibits adipocyte differentiation","volume":"295","author":"Tan","year":"2008","journal-title":"American Journal of Physiology: Cell Physiology"},{"key":"10.1016\/j.exppara.2009.12.009_bib41","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2302\/kjm.54.190","article-title":"Fat paradox in liver disease","volume":"54","author":"Tsukamoto","year":"2005","journal-title":"Keio Journal of Medicine"},{"key":"10.1016\/j.exppara.2009.12.009_bib42","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1091\/mbc.E05-02-0149","article-title":"Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization","volume":"16","author":"Uemura","year":"2005","journal-title":"Molecular Biology of the Cell"},{"key":"10.1016\/j.exppara.2009.12.009_bib43","unstructured":"WHO, 2002. Prevention and control of schistosomiasis and soil-transmitted helminthiasis. WHO Technical Report Series 912."},{"key":"10.1016\/j.exppara.2009.12.009_bib44","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0006-291X(02)00669-1","article-title":"Quantitative monitoring of the mRNA expression pattern of the TGF-beta-isoforms (beta 1, beta 2, beta 3) during transdifferentiation of hepatic stellate cells using a newly developed real-time SYBR Green PCR","volume":"295","author":"Wickert","year":"2002","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.exppara.2009.12.009_bib45","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/sj.icb.7100014","article-title":"Immunopathology of schistosomiasis","volume":"85","author":"Wilson","year":"2007","journal-title":"Immunology and Cell Biology"},{"key":"10.1016\/j.exppara.2009.12.009_bib46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1128\/IAI.38.1.103-108.1982","article-title":"Direct and indirect effects of soluble extracts of Schistosoma mansoni eggs on fibroblast proliferation in vitro","volume":"38","author":"Wyler","year":"1982","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exppara.2009.12.009_bib47","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.0105-2896.2004.00176.x","article-title":"Immunopathogenesis of schistosomiasis","volume":"201","author":"Wynn","year":"2004","journal-title":"Immunology Reviews"},{"key":"10.1016\/j.exppara.2009.12.009_bib48","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","article-title":"Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis","volume":"54","author":"Xu","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.exppara.2009.12.009_bib49","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bbrc.2006.09.069","article-title":"PPARgamma agonists prevent TGFbeta1\/Smad3-signaling in human hepatic stellate cells","volume":"350","author":"Zhao","year":"2006","journal-title":"Biochemical and Biophysical Research Communications"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489409003452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489409003452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T11:41:49Z","timestamp":1590493309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489409003452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0014489409003452"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2009.12.009","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}