{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:58:14Z","timestamp":1776689894469,"version":"3.51.2"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.exppara.2010.08.008","type":"journal-article","created":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T04:39:32Z","timestamp":1283402372000},"page":"270-276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Schistosoma mansoni: Schistosomicidal effect of mefloquine and primaquine in vitro"],"prefix":"10.1016","volume":"127","author":[{"given":"M.C.","family":"Holtfreter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Loebermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Klammt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sombetzki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Bodammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Riebold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kinzelbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.C.","family":"Reisinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2010.08.008_b0005","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1126\/science.160.3833.1233","article-title":"Primaquine-induced changes in morphology of exoerythrocytic stages of malaria","volume":"160","author":"Beaudoin","year":"1968","journal-title":"Science"},{"key":"10.1016\/j.exppara.2010.08.008_b0010","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/00034983.1983.11811754","article-title":"The chemotherapy of rodent malaria, XXXIV. Causal prophylaxis Part III: Ultrastructural changes induced in exo-erythrocytic schizonts of Plasmodium yoilii by primaquine","volume":"77","author":"Boulard","year":"1983","journal-title":"Annals of Tropical Medicine and Parasitology"},{"key":"10.1016\/j.exppara.2010.08.008_b0015","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s004360100476","article-title":"Acidic vesicles of Schistosoma mansoni","volume":"87","author":"Carneiro-Santos","year":"2001","journal-title":"Parasitology Research"},{"key":"10.1016\/j.exppara.2010.08.008_b0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00436-002-0751-z","article-title":"Praziquantel","volume":"90","author":"Cioli","year":"2003","journal-title":"Parasitology Research"},{"key":"10.1016\/j.exppara.2010.08.008_b0025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0020-7519(72)90036-7","article-title":"The effects of immune rhesus monkey serum on schistosomula of Schistosoma mansoni during cultivation in vitro","volume":"2","author":"Clegg","year":"1972","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.exppara.2010.08.008_b0030","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0968-4328(01)00019-1","article-title":"Ultrastructure of the Schistosoma mansoni cercaria","volume":"33","author":"Dorsey","year":"2002","journal-title":"Micron"},{"key":"10.1016\/j.exppara.2010.08.008_b0035","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4269\/ajtmh.1967.16.483","article-title":"An improved perfusion technique for recovering adult schistosomes from laboratory animals","volume":"16","author":"Duvall","year":"1967","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.exppara.2010.08.008_b0040","doi-asserted-by":"crossref","first-page":"951","DOI":"10.4269\/ajtmh.2006.74.951","article-title":"Lack of sex effect on the pharmacokinetics of primaquine","volume":"74","author":"Elmes","year":"2006","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.exppara.2010.08.008_b0045","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0020-7519(96)00191-9","article-title":"Schistosoma mansoni oviposition in vitro reflects worm fecundity in vivo: individual-, parasite age- and host-dependent variations","volume":"27","author":"El-Ridi","year":"1997","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.exppara.2010.08.008_b0050","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0006-2952(01)00878-4","article-title":"Differential effects of 4-aminoquinoline-containing antimalarial drugs on haemoglobin digestion in Plasmodium falciparum-infected erythrocytes","volume":"63","author":"Famin","year":"2002","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.exppara.2010.08.008_b0055","first-page":"217","article-title":"A study of the effect of 8-aminoquinolines (primaquine, pamaquine, pentaquine) on the guinea-pig isolated ileum","volume":"275","author":"Fontaine","year":"1985","journal-title":"Archives Internationale de Pharmacodynamie et de Th\u00e9rapie"},{"key":"10.1016\/j.exppara.2010.08.008_b0060","first-page":"255","article-title":"Effects of mefloquine on Ca2+ uptake by crude microsomes of rabbit skeletal muscle","volume":"329","author":"Go","year":"1995","journal-title":"Archives Internationale de Pharmacodynamie et de Th\u00e9rapie"},{"key":"10.1016\/j.exppara.2010.08.008_b0065","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/215207a0","article-title":"Forked tail of the cercaria of Schistosoma mansoni \u2013 a rowing divice","volume":"215","author":"Graefe","year":"1967","journal-title":"Nature"},{"key":"10.1016\/j.exppara.2010.08.008_b0070","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1042\/bst0150068","article-title":"Praziquantel: mode of action","volume":"15","author":"Harder","year":"1987","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.exppara.2010.08.008_b0075","doi-asserted-by":"crossref","unstructured":"Holtfreter, M.C., Loebermann, M., Frei, E., Riebold, D., Wolff, D., Hartung, G., Kinzelbach, R., Reisinger, E.C., 2010. Schistosomula, pre-adults and adults of Schistosoma mansoni ingest fluorescence-labelled albumin in vitro and in vivo: Implication for a drug targeting model. Parasitology 26, 1-8 (Epub ahead of print).","DOI":"10.1017\/S0031182010000405"},{"key":"10.1016\/j.exppara.2010.08.008_b0080","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4269\/ajtmh.1987.36.9","article-title":"An ultrastructural study of the effects of mefloquine on malaria parasites","volume":"36","author":"Jacobs","year":"1987","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.exppara.2010.08.008_b0085","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2165\/00003088-199019040-00002","article-title":"Clinical pharmacokinetics of mefloquine","volume":"19","author":"Karbwang","year":"1990","journal-title":"Clinical Pharmacokinetics"},{"key":"10.1016\/j.exppara.2010.08.008_b0090","doi-asserted-by":"crossref","first-page":"e350","DOI":"10.1371\/journal.pntd.0000350","article-title":"Mefloquine - An aminoalcohol with promising antischistosomal properties in mice","volume":"3","author":"Keiser","year":"2009","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"10.1016\/j.exppara.2010.08.008_b0095","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1086\/651682","article-title":"Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against Schistosoma haematobium: randomized, exploratory open-label trial","volume":"50","author":"Keiser","year":"2010","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/j.exppara.2010.08.008_b0100","first-page":"441","article-title":"Mefloquine concentration profiles during prophylactic dose regimens","volume":"112","author":"Kollaritsch","year":"2000","journal-title":"Wiener Klinische Wochenschrift"},{"key":"10.1016\/j.exppara.2010.08.008_b0105","unstructured":"Lademann, M., Stoevesand, J., Loebermann, M., Riebold, D., Hemmer, C., Reisinger, E.C., 2005. Inhibitory effect of mefloquine on S. mansoni in vitro and in a mouse model. Infection 33, 201 Abstract P15."},{"key":"10.1016\/j.exppara.2010.08.008_b0110","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/BF00928413","article-title":"Effect of the 8-aminoquinoline primaquine on culture-derived gametocytes of the malaria parasite Plasmodium falciparum","volume":"177","author":"Lanners","year":"1991","journal-title":"Parasitology Research"},{"key":"10.1016\/j.exppara.2010.08.008_b0115","first-page":"158","article-title":"Effects of mefloquine on the isolated chick biventer cervicis and rat phrenic nerve hemidiaphragm preparations","volume":"312","author":"Lee","year":"1991","journal-title":"Archives Internationale de Pharmacodynamie et de Th\u00e9rapie"},{"key":"10.1016\/j.exppara.2010.08.008_b0120","series-title":"Tropenmedizin in Klinik und Praxis","first-page":"101","article-title":"Schistosomiasis (Bilharziose) und andere Trematodeninfektionen","author":"L\u00f6scher","year":"2000"},{"key":"10.1016\/j.exppara.2010.08.008_b0125","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1017\/S0031182009990965","article-title":"Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni","volume":"137","author":"Manneck","year":"2010","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2010.08.008_b0130","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1017\/S0031182000050253","article-title":"Migration of the schistosomula of Schistosoma mansoni from skin to the lungs","volume":"77","author":"Miller","year":"1978","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2010.08.008_b0135","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0169-4758(96)80640-5","article-title":"Praziquantel: An urgent and exciting challenge","volume":"12","author":"Redman","year":"1996","journal-title":"Parasitology Today"},{"key":"10.1016\/j.exppara.2010.08.008_b0140","unstructured":"Roche. 2009. Summary of Product Characteristics: Lariam. http:\/\/emc.medicines.org.uk\/medicine\/1701\/SPC\/Lariam\/ (last visited 30Jan2010)."},{"key":"10.1016\/j.exppara.2010.08.008_b0145","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1590\/S0037-86822003000300004","article-title":"Chemotherapeutic effects on larval stages of Schistosoma mansoni during infection and re-infection of mice","volume":"36","author":"Silva","year":"2003","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"key":"10.1016\/j.exppara.2010.08.008_b0150","first-page":"527","article-title":"Pharmacokinetics of primaquine in healthy volunteers","volume":"22","author":"Singhasivanon","year":"1991","journal-title":"The Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"10.1016\/j.exppara.2010.08.008_b0155","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1128\/AAC.47.5.1487-1495.2003","article-title":"Combination chemotherapy of schistosomiasis in laboratory studies and clinical trials","volume":"47","author":"Utzinger","year":"2003","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.exppara.2010.08.008_b0160","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2307\/3282590","article-title":"Anti-filarial effects of nine quinoline-containing drugs on adult filariae in vitro","volume":"75","author":"VandeWaa","year":"1989","journal-title":"The Journal of Parasitology"},{"key":"10.1016\/j.exppara.2010.08.008_b0165","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.tmaid.2008.06.006","article-title":"Schistosomicidal activity of the antimalarial drug, mefloquine, in Schistosoma mansoni-infected mice","volume":"6","author":"Van Nassauw","year":"2008","journal-title":"Travel Medicine and Infectious Disease"},{"key":"10.1016\/j.exppara.2010.08.008_b0170","first-page":"55","article-title":"Filaricidal effect of mefloquine on adults and microfilariae of Brugia patei and Brugia malayi","volume":"38","author":"Walter","year":"1987","journal-title":"Tropical Medicine and Parasitology"},{"key":"10.1016\/j.exppara.2010.08.008_b0175","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00436-009-1656-x","article-title":"The in vitro effect of mefloquine and praziquantel against juvenile and adult Schistosoma japonicum","volume":"106","author":"Xiao","year":"2009","journal-title":"Parasitology Research"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489410002730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489410002730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T06:22:02Z","timestamp":1758003722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489410002730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0014489410002730"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2010.08.008","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Schistosoma mansoni: Schistosomicidal effect of mefloquine and primaquine in vitro","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2010.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}