{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:25:29Z","timestamp":1778055929836,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.exppara.2011.03.001","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T14:30:18Z","timestamp":1300285818000},"page":"250-255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Trypanosoma brucei: Two mitogen activated protein kinase kinases are dispensable for growth and virulence of the bloodstream form"],"prefix":"10.1016","volume":"128","author":[{"given":"Bryan C.","family":"Jensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles T.","family":"Kifer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2011.03.001_b0005","doi-asserted-by":"crossref","first-page":"e298","DOI":"10.1371\/journal.pntd.0000298","article-title":"RNA Interference of Trypanosoma brucei cathepsin B and L Affects disease progression in a mouse model","volume":"2","author":"Abdulla","year":"2008","journal-title":"PLoS Neglected and Tropical Diseases"},{"key":"10.1016\/j.exppara.2011.03.001_b0010","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1111\/j.1365-2958.2005.04498.x","article-title":"LmxMPK9, a mitogen-activated protein kinase homologue affects flagellar length in Leishmania mexicana","volume":"55","author":"Bengs","year":"2005","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.exppara.2011.03.001_b0015","doi-asserted-by":"crossref","first-page":"e4075","DOI":"10.1371\/journal.pone.0004075","article-title":"Genetic variation stimulated by epigenetic modification","volume":"3","author":"Cummings","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.exppara.2011.03.001_b0020","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1242\/jcs.111.17.2615","article-title":"Distinct domains of a nucleolar protein mediate protein kinase binding, interaction with nucleic acids and nucleolar localization","volume":"111","author":"Das","year":"1998","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.exppara.2011.03.001_b0025","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1128\/EC.00094-06","article-title":"A mitogen-activated protein kinase controls differentiation of bloodstream forms of Trypanosoma brucei","volume":"5","author":"Domenicali","year":"2006","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.exppara.2011.03.001_b0030","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1111\/j.1365-2958.2004.04218.x","article-title":"A novel ERK-like, CRK-like protein kinase that modulates growth in Trypanosoma brucei via an autoregulatory C-terminal extension","volume":"53","author":"Ellis","year":"2004","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.exppara.2011.03.001_b0035","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1128\/EC.00086-10","article-title":"Calflagin inhibition prolongs host survival and suppresses parasitemia in Trypanosoma brucei infection","volume":"9","author":"Emmer","year":"2010","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.exppara.2011.03.001_b0040","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1091\/mbc.e05-10-0976","article-title":"Interacting protein kinases Involved in the regulation of flagellar length","volume":"17","author":"Erdmann","year":"2006","journal-title":"Molecular Biology of the Cell"},{"key":"10.1016\/j.exppara.2011.03.001_b0045","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1128\/EC.00106-10","article-title":"A novel protein kinase localized to lipid droplets is required for droplet biogenesis in trypanosomes","volume":"9","author":"Flaspohler","year":"2010","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.exppara.2011.03.001_b0050","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1756-8722-3-8","article-title":"From basic research to clinical development of MEK1\/2 inhibitors for cancer therapy","volume":"3","author":"Fremin","year":"2010","journal-title":"Journal of Hematology & Oncolology"},{"key":"10.1016\/j.exppara.2011.03.001_b0055","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.molbiopara.2007.02.001","article-title":"A mitogen-activated protein kinase of Trypanosoma brucei confers resistance to temperature stress","volume":"153","author":"Guttinger","year":"2007","journal-title":"Molecular and Biochemical Parasitology"},{"key":"10.1016\/j.exppara.2011.03.001_b0060","doi-asserted-by":"crossref","first-page":"10797","DOI":"10.1074\/jbc.272.16.10797","article-title":"Interferon-gamma activation of a mitogen-activated protein kinase, KFR1, in the bloodstream form of Trypanosoma brucei","volume":"272","author":"Hua","year":"1997","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.exppara.2011.03.001_b0065","doi-asserted-by":"crossref","first-page":"32204","DOI":"10.1074\/jbc.M304198200","article-title":"The NOG1 GTP-binding protein is required for biogenesis of the 60S ribosomal subunit","volume":"278","author":"Jensen","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.exppara.2011.03.001_b0070","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.molbiopara.2006.10.002","article-title":"Characterization of protein kinase CK2 from Trypanosoma brucei","volume":"151","author":"Jensen","year":"2007","journal-title":"Molecular and Biochemical Parasitology"},{"key":"10.1016\/j.exppara.2011.03.001_b0075","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1186\/1471-2164-10-482","article-title":"Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei","volume":"10","author":"Jensen","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.exppara.2011.03.001_b0080","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bbapap.2005.08.017","article-title":"MAPK signalling pathways as molecular targets for anti-inflammatory therapy\u2013from molecular mechanisms to therapeutic benefits","volume":"1754","author":"Kaminska","year":"2005","journal-title":"Biochimica Biophysica Acta"},{"key":"10.1016\/j.exppara.2011.03.001_b0085","doi-asserted-by":"crossref","first-page":"e1001090","DOI":"10.1371\/journal.ppat.1001090","article-title":"The transcriptome of the human pathogen Trypanosoma brucei at single-nucleotide resolution","volume":"6","author":"Kolev","year":"2010","journal-title":"PLoS Pathogens"},{"key":"10.1016\/j.exppara.2011.03.001_b0090","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.canlet.2009.01.022","article-title":"Targeting the RAF-MEK-ERK pathway in cancer therapy","volume":"283","author":"Montagut","year":"2009","journal-title":"Cancer Letters"},{"key":"10.1016\/j.exppara.2011.03.001_b0095","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1091\/mbc.e02-02-0093","article-title":"Stage-specific requirement of a mitogen-activated protein kinase by Trypanosoma brucei","volume":"13","author":"Muller","year":"2002","journal-title":"Molecular Biology of the Cell"},{"key":"10.1016\/j.exppara.2011.03.001_b0100","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1242\/jcs.114.1.173","article-title":"A novel nucleolar G-protein conserved in eukaryotes","volume":"114","author":"Park","year":"2001","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.exppara.2011.03.001_b0105","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1471-2164-6-127","article-title":"Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi","volume":"6","author":"Parsons","year":"2005","journal-title":"BMC Genomics"},{"key":"10.1016\/j.exppara.2011.03.001_b0110","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.molbiopara.2008.04.009","article-title":"Fly transmission and mating of Trypanosoma brucei brucei strain 427","volume":"160","author":"Peacock","year":"2008","journal-title":"Molecular and Biochemical Parasitology"},{"key":"10.1016\/j.exppara.2011.03.001_b0115","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1242\/jcs.02470","article-title":"MAP kinase pathways","volume":"118","author":"Qi","year":"2005","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.exppara.2011.03.001_b0120","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/352731a0","article-title":"Basal body movements as a mechanism for mitochondrial genome segregation in the trypanosome cell cycle","volume":"352","author":"Robinson","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.exppara.2011.03.001_b0125","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.mib.2010.09.001","article-title":"Regulation of cross-talk in yeast MAPK signaling pathways","volume":"13","author":"Saito","year":"2010","journal-title":"Current Opinion in Microbiology"},{"key":"10.1016\/j.exppara.2011.03.001_b0130","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1101\/gad.1790409","article-title":"Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei","volume":"23","author":"Siegel","year":"2009","journal-title":"Genes and Development"},{"key":"10.1016\/j.exppara.2011.03.001_b0135","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1093\/nar\/gkq237","article-title":"Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites","volume":"38","author":"Siegel","year":"2010","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.exppara.2011.03.001_b0140","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.ijpara.2010.02.004","article-title":"LmxMPK4, an essential mitogen-activated protein kinase of Leishmania mexicana is phosphorylated and activated by the STE7-like protein kinase LmxMKK5","volume":"40","author":"von Freyend","year":"2010","journal-title":"International Journal of Parasitology"},{"key":"10.1016\/j.exppara.2011.03.001_b0145","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1475-9292-4-6","article-title":"LmxMPK4, a mitogen-activated protein (MAP) kinase homologue essential for promastigotes and amastigotes of Leishmania mexicana","volume":"4","author":"Wang","year":"2005","journal-title":"Kinetoplastid Biology and Disease"},{"key":"10.1016\/j.exppara.2011.03.001_b0150","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1093\/emboj\/17.9.2619","article-title":"A mitogen-activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host","volume":"17","author":"Wiese","year":"1998","journal-title":"EMBO Journal"},{"key":"10.1016\/j.exppara.2011.03.001_b0155","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1128\/EC.2.4.769-777.2003","article-title":"Protein kinase involved in flagellar-length control","volume":"2","author":"Wiese","year":"2003","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.exppara.2011.03.001_b0160","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0166-6851(99)00002-X","article-title":"A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei","volume":"99","author":"Wirtz","year":"1999","journal-title":"Molecular and Biochemical Parasitology"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489411000907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489411000907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T06:21:52Z","timestamp":1758003712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489411000907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0014489411000907"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2011.03.001","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trypanosoma brucei: Two mitogen activated protein kinase kinases are dispensable for growth and virulence of the bloodstream form","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2011.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}