{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:19:59Z","timestamp":1772792399158,"version":"3.50.1"},"reference-count":59,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.exppara.2011.03.006","type":"journal-article","created":{"date-parts":[[2011,3,28]],"date-time":"2011-03-28T22:42:12Z","timestamp":1301352132000},"page":"230-235","source":"Crossref","is-referenced-by-count":31,"title":["Schistosoma mansoni: N-acetylcysteine downregulates oxidative stress and enhances the antischistosomal activity of artemether in mice"],"prefix":"10.1016","volume":"128","author":[{"given":"Sayed H.","family":"Seif el-Din","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir M.","family":"Al-Hroob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma A.","family":"Ebeid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2011.03.006_b0005","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1478-3231.1999.tb00082.x","article-title":"Visualization of oxygen radical production in mouse liver in response to infection with Schistosoma mansoni","volume":"19","author":"Abdallahi","year":"1999","journal-title":"Liver"},{"issue":"2","key":"10.1016\/j.exppara.2011.03.006_b0010","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1590\/S0074-02761991000600042","article-title":"Activity of the artemether in experimental Schistosomiasis mansoni","volume":"86","author":"Ara\u00fajo","year":"1991","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"key":"10.1016\/j.exppara.2011.03.006_b0015","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/0006-2952(92)90255-H","article-title":"Induction of glutathione-S-transferase in mouse liver by oltipraz","volume":"43","author":"Backela","year":"1992","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.exppara.2011.03.006_b0020","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/08820139209069382","article-title":"Schistosomiasis: from effector and regulation mechanisms in rodents to vaccine strategies in humans","volume":"21","author":"Capron","year":"1992","journal-title":"Immunological Investigations"},{"key":"10.1016\/j.exppara.2011.03.006_b0025","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2165\/00002018-200022020-00005","article-title":"Utility of acetylcysteine in treating poisonings and adverse drug reactions","volume":"22","author":"Chyka","year":"2000","journal-title":"Drug Safety"},{"key":"10.1016\/j.exppara.2011.03.006_b0030","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/00001432-200012000-00014","article-title":"Praziquantel: is there real resistence and are there alternatives?","volume":"13","author":"Cioli","year":"2000","journal-title":"Current Opinion in Infectious Diseases"},{"key":"10.1016\/j.exppara.2011.03.006_b0035","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0008-6363(00)00018-3","article-title":"Effects of N-acetylcysteine in a rat model of ischemia and reperfusion injury","volume":"47","author":"Cuzzocrea","year":"2000","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.exppara.2011.03.006_b0040","first-page":"87","article-title":"Albumin standards and measurement of serum albumin with bromocresol green Clinica chimica acta","volume":"31","author":"Doumas","year":"1971","journal-title":"International Journal of Clinical Chemistry"},{"key":"10.1016\/j.exppara.2011.03.006_b0045","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4269\/ajtmh.1967.16.483","article-title":"Technique for recovering adult schistosomes from laboratory animals","volume":"16","author":"Duvall","year":"1967","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.exppara.2011.03.006_b0050","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"88","author":"Ellman","year":"1959","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.exppara.2011.03.006_b0055","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0014-2964(79)90039-2","article-title":"Study on the etiological factors of bilharzial bladder cancer in Egypt. 1: Nitrosamines and their precursors in urine","volume":"15","author":"El-Merzabani","year":"1979","journal-title":"European Journal of Cancer"},{"key":"10.1016\/j.exppara.2011.03.006_b0060","first-page":"325","article-title":"Effect of praziquantel treatment on the activities of some liver microsomal enzymes in mice infected with Schistosoma mansoni","volume":"51","author":"Ezzat","year":"2001","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.exppara.2011.03.006_b0065","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0168-8278(99)80189-5","article-title":"Development of eosinophil peroxidase activity and concomitant alteration of the antioxidant defenses in the liver of mice infected with Schistosoma mansoni","volume":"30","author":"Gharib","year":"1999","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.exppara.2011.03.006_b0070","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione-S-transferase: the first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.exppara.2011.03.006_b0075","first-page":"107","article-title":"Effect of praziquantel on some biochemical aspects in experimental schistosomiasis","volume":"3","author":"Hammad","year":"2000","journal-title":"Recent Research Development in Biotechnology and Bioengineering"},{"key":"10.1016\/j.exppara.2011.03.006_b0080","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/carcin\/11.3.451","article-title":"Glutathione-S-transferase and glutathione peroxidase expression in normal and tumor human tissues","volume":"11","author":"Howie","year":"1990","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.exppara.2011.03.006_b0085","doi-asserted-by":"crossref","first-page":"696","DOI":"10.4269\/ajtmh.1977.26.696","article-title":"Schistosoma mansoni and S. haematobium infections in Egypt: technique for recovery of worms at necropsy","volume":"26","author":"Kamel","year":"1977","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.exppara.2011.03.006_b0090","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1046\/j.1365-3156.1997.d01-269.x","article-title":"Schistosoma mansoni-related morbidity on Ukerewe island, Tanzania: Clinical, ultrasonographical and biochemical parameters","volume":"2","author":"Kardorff","year":"1997","journal-title":"Tropical Medecine and International Health"},{"key":"10.1016\/j.exppara.2011.03.006_b0095","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1590\/S0034-89102004000100010","article-title":"Antichistosomal activity of artemether in experimental schistosomiasis mansoni","volume":"38","author":"Lescano","year":"2004","journal-title":"Revista de Saud Publica"},{"key":"10.1016\/j.exppara.2011.03.006_b0100","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.4049\/jimmunol.146.6.1909","article-title":"Regulation by glutathione of the effect of lymphokines on differentiation of primary activated lymphocytes. Influence of glutathione on cytotoxic activity of CD3-AK","volume":"146","author":"Liang","year":"1991","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.exppara.2011.03.006_b0105","unstructured":"Liang, Y.S., John, B.I., Boyd, D.A., 1987. Laboratory cultivation of schistosome vector snails and maintenance of schistosome life cycles. Proceeding of the 1st Sino-American Symposium 1, 34\u201348."},{"key":"10.1016\/j.exppara.2011.03.006_b0110","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with Folin\u2013phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.exppara.2011.03.006_b0115","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1645\/GE-322R","article-title":"Artemether as adjuvant therapy to praziquantel in murine Egyptian schistosomiasis mansoni","volume":"91","author":"Mahmoud","year":"2005","journal-title":"Journal of Parasitology"},{"key":"10.1016\/j.exppara.2011.03.006_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-8741(01)00310-5","article-title":"The effect of Nigella sativa oil against liver damage induced by Schistosoma mansoni infection in mice","volume":"79","author":"Mahmoud","year":"2002","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.exppara.2011.03.006_b0125","first-page":"294","article-title":"Effect of combined chemotherapy and anti-inflammatory drugs on murine schistosomiasis","volume":"52","author":"Mahmoud","year":"2002","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.exppara.2011.03.006_b0130","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000244323","article-title":"Glutathione status in diabetes-induced embryopathies","volume":"69","author":"Menegola","year":"1996","journal-title":"Biology of the Neonate"},{"key":"10.1016\/j.exppara.2011.03.006_b0135","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/carcin\/15.4.619","article-title":"Nitrate, nitrite and volatile N-nitroso compounds in the urine of Schistosoma haematobium and Schistosoma mansoni-infected patients","volume":"15","author":"Mostafa","year":"1994","journal-title":"Carcinigenesis"},{"key":"10.1016\/j.exppara.2011.03.006_b0140","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/hep.1840220225","article-title":"Protective effect of N-acetylcysteine on hypothermic ischemia-reperfusion injury of rat liver","volume":"22","author":"Nakano","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.exppara.2011.03.006_b0145","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0014-4894(90)90122-S","article-title":"Schistosoma mansoni: levels of antioxidants and resistance to oxidants increase during development","volume":"70","author":"Nare","year":"1990","journal-title":"Experimental Parasitology"},{"key":"10.1016\/j.exppara.2011.03.006_b0150","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia","year":"1967","journal-title":"The Journal of Laboratory and Clinical Medicine"},{"key":"10.1016\/j.exppara.2011.03.006_b0155","first-page":"1655","article-title":"Oxidative stress and antioxidant defense in alcoholic liver disease and chronic hepatitis C","volume":"141","author":"Par","year":"2000","journal-title":"Orvosi Hetilap"},{"key":"10.1016\/j.exppara.2011.03.006_b0160","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0168-8278(97)80183-3","article-title":"Antioxidant enzyme status in biliary obstructed rats: effects of N-acetylcysteine","volume":"27","author":"Pastor","year":"1997","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.exppara.2011.03.006_b0165","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4269\/ajtmh.1962.11.201","article-title":"New approach to the screening of drugs in experimental schistosomiasis mansoni in mice","volume":"11","author":"Pellegrino","year":"1962","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.exppara.2011.03.006_b0170","first-page":"421","article-title":"A new method for the determination of gamma-glutamyltransferase in serum","volume":"14","author":"Persijn","year":"1976","journal-title":"Journal of Clinical Chemistry and Clinical Biochemistry"},{"key":"10.1016\/j.exppara.2011.03.006_b0175","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0197-0186(99)00126-6","article-title":"In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain","volume":"36","author":"Pocernich","year":"2000","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.exppara.2011.03.006_b0180","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s00436-004-1078-8","article-title":"Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schistosomiasis","volume":"92","author":"Pyrrho","year":"2004","journal-title":"Parasitology Research"},{"key":"10.1016\/j.exppara.2011.03.006_b0185","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nri1573","article-title":"Immunology of hepatitis B virus and hepatitis-C virus infection","volume":"5","author":"Rehermann","year":"2005","journal-title":"Nature reviews. Immunology"},{"key":"10.1016\/j.exppara.2011.03.006_b0190","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colourimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"American Journal of Clinical Pathology"},{"key":"10.1016\/j.exppara.2011.03.006_b0195","first-page":"67","article-title":"Protective effects of -carotene, N-acetyl-cysteine with and without praziquantel treatment in Schistosoma mansoni-infected mice","volume":"28","author":"Seif el-Din","year":"2006","journal-title":"Egyptian Journal of Schistosomiasis and Infectious and Endemic Diseases"},{"key":"10.1016\/j.exppara.2011.03.006_b0200","first-page":"94","article-title":"Effect of praziquantel treatment on lipid peroxide levels and superoxide dismutase activity in tissues of healthy and Schistosoma mansoni-infected mice","volume":"44","author":"Shaheen","year":"1994","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.exppara.2011.03.006_b0205","first-page":"119","article-title":"Schistosomiasis induced-changes in glutathione levels and glutathione reductase\/glutathione s-transferase activities in human liver","volume":"56","author":"Sheweita","year":"1997","journal-title":"Biomedical Letters"},{"key":"10.1016\/j.exppara.2011.03.006_b0210","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0304-3835(95)04034-X","article-title":"N-nitrosamines and their effects on the level of glutathione, glutathione-S-transferase and glutathione reductase activities in the liver of male mice","volume":"99","author":"Sheweita","year":"1996","journal-title":"Cancer Letters"},{"key":"10.1016\/j.exppara.2011.03.006_b0215","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0376-8716(99)00040-X","article-title":"Protective effect of N-acetylcysteine on reduced glutathione, reduced glutathione-related enzymes and lipid peroxidation in methanol intoxication","volume":"57","author":"Skrzydlewska","year":"1999","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1016\/j.exppara.2011.03.006_b0220","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/0041-008X(82)90306-4","article-title":"Effect of microsomal enzyme inducers on the soluble enzymes of hepatic phase II biotransformation","volume":"66","author":"Thompson","year":"1982","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.exppara.2011.03.006_b0225","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0035-9203(02)90110-0","article-title":"Comparative study of the effects of artemether and artesunate on juvenile and adult Schistosoma mansoni in experimentally infected mice","volume":"96","author":"Utzinger","year":"2002","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.exppara.2011.03.006_b0230","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1517\/14656566.5.2.263","article-title":"Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control","volume":"5","author":"Utzinger","year":"2004","journal-title":"Expert Opinion on Pharmacotherapy"},{"key":"10.1016\/j.exppara.2011.03.006_b0235","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0020-7519(01)00297-1","article-title":"The potential of artemether for the control of schistosomiasis","volume":"31","author":"Utzinger","year":"2001","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.exppara.2011.03.006_b0240","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1006\/taap.2001.9234","article-title":"Increased oxidative stress in dimethylnitrosamine-induced liver fibrosis in the rat: effect of N-acetylcysteine and interferon-alpha","volume":"175","author":"Vendemiale","year":"2001","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.exppara.2011.03.006_b0245","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/ajcp\/16.3_ts.40","article-title":"An accurate and rapid method for determination of protein in small amounts of blood serum and plasma","volume":"16","author":"Weichselbaum","year":"1946","journal-title":"American Journal of Clinical Pathology"},{"key":"10.1016\/j.exppara.2011.03.006_b0250","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/00075197-199911000-00010","article-title":"Modulation of endogenous glutathione availability","volume":"2","author":"Wernerman","year":"1999","journal-title":"Current Opinion in Clinical Nutrition and Metabolic Care"},{"key":"10.1016\/j.exppara.2011.03.006_b0255","first-page":"1","article-title":"Prevention and control of schistosomiasis and soiltransmitted helminthiasis","volume":"912","year":"2002","journal-title":"World Health Organization Technical Report Series"},{"key":"10.1016\/j.exppara.2011.03.006_b0260","first-page":"337","article-title":"The estimation of red cell superoxide dismutase activity","volume":"85","author":"Winterbourn","year":"1975","journal-title":"The Journal of Laboratory and Clinical Medicine"},{"key":"10.1016\/j.exppara.2011.03.006_b0265","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.actatropica.2005.07.010","article-title":"Development of antischistosomal drugs in China, with particular consideration to praziquantel and the artemisinins","volume":"96","author":"Xiao","year":"2005","journal-title":"Acta Tropica"},{"key":"10.1016\/j.exppara.2011.03.006_b0270","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0001-706X(01)00187-5","article-title":"Transmission electron microscopic observation on ultrastructural damage in Schistosoma mansoni caused by artemether","volume":"81","author":"Xiao","year":"2002","journal-title":"Acta Tropica"},{"key":"10.1016\/j.exppara.2011.03.006_b0275","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0169-4758(99)01601-4","article-title":"The prophlactic effects of artemether against Schistosoma japonicum infections","volume":"16","author":"Xiao","year":"2000","journal-title":"Parasitology Today"},{"key":"10.1016\/j.exppara.2011.03.006_b0280","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1128\/AAC.33.9.1557","article-title":"In vitro and in vivo studies of the effect of artemether on Schistosoma mansoni","volume":"33","author":"Xiao","year":"1989","journal-title":"Antimicobial Agents and Chemotherapy"},{"key":"10.1016\/j.exppara.2011.03.006_b0285","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1383-5769(00)00028-3","article-title":"Preventive effect of artemether in experimental animals infected with Schistosoma mansoni","volume":"49","author":"Xiao","year":"2000","journal-title":"Parasitology International"},{"key":"10.1016\/j.exppara.2011.03.006_b0290","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3748\/wjg.v9.i1.152","article-title":"Effects of pentoxifylline on the hepatic content of TGF- and collagen in schistosomiasis japonica mice with liver fibrosis","volume":"9","author":"Xiong","year":"2003","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.exppara.2011.03.006_b0295","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0003-9861(79)90415-6","article-title":"Rabbit liver glutathione reductase: purification and properties","volume":"198","author":"Zanetti","year":"1979","journal-title":"Archives of Biochemistry and Biophysics"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489411001056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489411001056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T23:03:20Z","timestamp":1686006200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489411001056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0014489411001056"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2011.03.006","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}