{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T20:50:53Z","timestamp":1763499053643},"reference-count":57,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.exppara.2011.10.001","type":"journal-article","created":{"date-parts":[[2011,10,16]],"date-time":"2011-10-16T08:22:29Z","timestamp":1318753349000},"page":"39-47","source":"Crossref","is-referenced-by-count":8,"title":["Radio-attenuated leishmanial parasites as immunoprophylactic agent against experimental murine visceral leishmaniasis"],"prefix":"10.1016","volume":"130","author":[{"given":"Sanchita","family":"Datta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupchand","family":"Adak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun Kumar","family":"Haldar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surajit","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anindita","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syamal","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhumita","family":"Manna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2011.10.001_b0005","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1128\/IAI.65.6.2371-2377.1997","article-title":"Adjuvanticity and protective immunity elicited by Leishmania donovani antigens encapsulated in positively charged liposomes","volume":"65","author":"Afrin","year":"1997","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exppara.2011.10.001_b0010","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/0035-9203(82)90232-2","article-title":"A radioattenuated Leishmania major vaccine markedly increases the resistance of CBA mice to subsequent infection with Leishmania mexicana mexicana","volume":"76","author":"Alexander","year":"1982","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.exppara.2011.10.001_b0015","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1242\/jcs.112.18.2993","article-title":"Leishmania species: models of intracellular parasitism","volume":"112","author":"Alexander","year":"1999","journal-title":"Cell Science"},{"key":"10.1016\/j.exppara.2011.10.001_b0020","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2307\/3284319","article-title":"Protection of mice against visceral leishmaniasis by immunization with promastigote antigen incorporated in liposomes","volume":"83","author":"Ali","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2011.10.001_b0025","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1128\/CMR.10.2.298","article-title":"Leishmania and human immunodeficiency virus infections: the first 10 years [review]","volume":"10","author":"Alvar","year":"1997","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.exppara.2011.10.001_b0030","first-page":"492","article-title":"Treatment of mucocutaneous leishmaniasis with pentamidine isethionate","volume":"125","author":"Amato","year":"1990","journal-title":"Annales de Dermatologie et de Venereologie"},{"key":"10.1016\/j.exppara.2011.10.001_b0035","first-page":"238","article-title":"Immune response to leishmania infection","volume":"119","author":"Awasthi","year":"2004","journal-title":"Indian Journal of Medical Research"},{"key":"10.1016\/j.exppara.2011.10.001_b0040","doi-asserted-by":"crossref","first-page":"7160","DOI":"10.4049\/jimmunol.174.11.7160","volume":"174","author":"Basu","year":"2005","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.exppara.2011.10.001_b0045","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1002\/eji.200839017","article-title":"Complete protection against experimental visceral leishmaniasis with complete soluble antigen from attenuated Leishmania donavani promastigotes involves Th-1 immunity and down regulation of IL-10","volume":"39","author":"Bhaumik","year":"2009","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.exppara.2011.10.001_b0050","doi-asserted-by":"crossref","first-page":"6544","DOI":"10.1016\/j.vaccine.2007.05.042","article-title":"Leishmania antigens in liposomes promote protective immunity and provide immunotherapy against visceral leishmaniasis via polarized Th1 response","volume":"25","author":"Bhowmick","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2011.10.001_b0055","first-page":"597","article-title":"Leishmaniasis","volume":"vol. 8","author":"Bittencourt","year":"1995"},{"key":"10.1016\/j.exppara.2011.10.001_b0060","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0020-7519(97)00169-0","article-title":"The immune response to Leishmania: mechanisms of parasite control and evasion","volume":"28","author":"Bogdan","year":"1998","journal-title":"International Journal of Parasitology"},{"key":"10.1016\/j.exppara.2011.10.001_b0065","doi-asserted-by":"crossref","first-page":"11473","DOI":"10.1073\/pnas.90.24.11473","article-title":"Effective immunization against cutaneous leishmaniasis with recombinant bacilli Calmette-Guerin expressing the Leishmania surface proteinase gp63","volume":"90","author":"Connell","year":"1993","journal-title":"Proceedings of the National Academy of Sciences of the United State of America"},{"key":"10.1016\/j.exppara.2011.10.001_b0070","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1128\/CMR.19.1.111-126.2006","article-title":"Drug resistance in leishmaniasis","volume":"19","author":"Croft","year":"2006","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.exppara.2011.10.001_b0075","unstructured":"Datta, S., Naskar, K., Chakraborty, A., Manna, M., 2010. Immunotherapeutic role of radio attenuated Leishmania parasites in experimental murine leishmaniasis. In: Medimond International Proceedings (no.M815S7113). XIIth International Congress on Parasitology, August, Melbourne."},{"key":"10.1016\/j.exppara.2011.10.001_b0080","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cimid.2004.03.004","article-title":"Leishmaniasis: current situation and new perspectives","volume":"27","author":"Desjeux","year":"2004","journal-title":"Comparative Immunology, Microbiology and Infectious Diseases"},{"issue":"Suppl.","key":"10.1016\/j.exppara.2011.10.001_b0085","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1179\/000349803225002499","article-title":"Leishmania\/HIV co-infections: epidemiology in Europe","volume":"97","author":"Desjeux","year":"2003","journal-title":"Annals of Tropical Medicine and Parasitology"},{"key":"10.1016\/j.exppara.2011.10.001_b0095","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-5699(99)01549-2","article-title":"Organ specific immune responses associated with infectious disease","volume":"21","author":"Engwerda","year":"2000","journal-title":"Immunology Today"},{"issue":"5","key":"10.1016\/j.exppara.2011.10.001_b0100","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.vaccine.2005.08.057","article-title":"Imprinting of BALB\/c mice with low Leishmania infantum parasite dose markedly protects spleen against high-dose challenge","volume":"24","author":"Ferrua","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2011.10.001_b0105","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite and [15N] nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.exppara.2011.10.001_b0110","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/4000","article-title":"Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection","volume":"4","author":"Gurunathan","year":"1998","journal-title":"Nature Medicine"},{"key":"10.1016\/j.exppara.2011.10.001_b0115","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0169-4758(97)01060-0","article-title":"Leishmania vaccines: old and new","volume":"13","author":"Handman","year":"1997","journal-title":"Parasitology Today"},{"key":"10.1016\/j.exppara.2011.10.001_b0120","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0014-4894(90)90127-X","article-title":"Leishmania major: production of recombinant gp63, its antigenecity and immunogenecity","volume":"70","author":"Handman","year":"1990","journal-title":"Experimental Parasitology"},{"key":"10.1016\/j.exppara.2011.10.001_b0125","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.4049\/jimmunol.129.5.2206","article-title":"Prophylactic immunization against experimental leishmaniasis: I. Protection induced in mice genetically vulnerable to fatal Leishmania tropica infection","volume":"129","author":"Howard","year":"1982","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.exppara.2011.10.001_b0130","doi-asserted-by":"crossref","first-page":"450","DOI":"10.4049\/jimmunol.132.1.450","article-title":"Prophylactic immunization against experimental leishmaniasis. II. Further characterisation of the protective immunity against fatal Leishmania tropica infection induced by irradiated promastigotes","volume":"132","author":"Howard","year":"1984","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.exppara.2011.10.001_b0135","doi-asserted-by":"crossref","first-page":"464","DOI":"10.4269\/ajtmh.1990.43.464","article-title":"Quantitative in vitro drug potency and drug susceptibility evaluation of Leishmania ssp. from patients unresponsive to pentavalent antimony therapy","volume":"43","author":"Jackson","year":"1990","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.exppara.2011.10.001_b0140","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.4049\/jimmunol.166.2.1141","article-title":"The role of Il-10 promoting disease progression in leishmaniasis","volume":"166","author":"Kane","year":"2001","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.exppara.2011.10.001_b0145","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1016\/j.vaccine.2005.02.015","article-title":"Leishmanization: use of an old method for evaluation of candidate vaccines against leishmaniasis","volume":"23","author":"Khamesipour","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2011.10.001_b0150","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0014-4894(74)90019-8","article-title":"Leishmania enrrietti: radiation effects and evaluation of radioattenuated organisms for vaccination","volume":"35","author":"Lemma","year":"1974","journal-title":"Experimental Parasitology"},{"key":"10.1016\/j.exppara.2011.10.001_b0155","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.4049\/jimmunol.135.3.2095","article-title":"Prophylactic immunization against experimental leishmaniasis. IV. Subcutaneous immunization prevents the induction of protective immunity against fatal Leishmania major infection","volume":"135","author":"Liew","year":"1985","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.exppara.2011.10.001_b0160","first-page":"222","article-title":"Characterization of Indian Kala-azar clinical isolates by MLEE and RAPD-PCR","volume":"11","author":"Manna","year":"2005","journal-title":"Medical Science Monitor"},{"key":"10.1016\/j.exppara.2011.10.001_b0165","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nm1045","article-title":"Reciprocal CD40 signals through p38MAPK and ERK-1\/2 induce counteracting immune response","volume":"10","author":"Mathur","year":"2004","journal-title":"Nature Medicine"},{"key":"10.1016\/j.exppara.2011.10.001_b0170","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.vaccine.2003.09.030","article-title":"A mixed Th1\/Th2 response elicited by a liposomal formulation of Leishmania vaccine instructs Th1 responses and resistance to Leishmania donovani in susceptible BALB\/c mice","volume":"22","author":"Mazumdar","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2011.10.001_b0175","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1128\/IAI.69.8.4719-4725.2001","article-title":"Leishmania donovani p36(LACK) DNA vaccine is highly immunogenic but not protective against experimental visceral leishmaniasis","volume":"69","author":"Melby","year":"2001","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.exppara.2011.10.001_b0180","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0167-5699(96)80606-2","article-title":"The expanding universe of T-cell subsets: Th1, Th2 and more","volume":"17","author":"Mosmann","year":"1996","journal-title":"Immunology Today"},{"key":"10.1016\/j.exppara.2011.10.001_b0190","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0165-2478(03)00021-X","article-title":"Infection pattern and immune response in the spleen and liver of BALB\/c mice intracardially infected with Leishmania donovani amastigotes","volume":"86","author":"Mukherjee","year":"2003","journal-title":"Immunology Letters"},{"key":"10.1016\/j.exppara.2011.10.001_b0195","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0264-410X(98)90017-2","article-title":"Immunoprophylaxis and immunotherapy against experimental visceral leishmaniasis","volume":"17","author":"Mukhopadhyay","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2011.10.001_b0200","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1128\/CDLI.7.2.233-240.2000","article-title":"Use of an attenuated leishmanial parasite as an immunoprophylactic and immunotherapeutic agent against murine visceral leishmaniasis","volume":"7","author":"Mukhopadhyay","year":"2000","journal-title":"Clinical and diagnostic laboratory Immunology"},{"key":"10.1016\/j.exppara.2011.10.001_b0205","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1002\/1521-4141(2001010)31:10<2848::AID-IMMU2848>3.0.CO;2-T","article-title":"IL-10 mediates susceptibility to Leishmania donovani infection","volume":"31","author":"Murphy","year":"2001","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.exppara.2011.10.001_b0215","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1084\/jem.185.5.867","article-title":"Behavior of visceral Leishmania donovani in the experimentally induced T helper cell 2 (Th2)-associated response model","volume":"185","author":"Murray","year":"1997","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.exppara.2011.10.001_b0220","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(05)67629-5","article-title":"Advances in leishmaniasis","volume":"366","author":"Murray","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.exppara.2011.10.001_b0225","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1046\/j.1365-2249.2003.02096.x","article-title":"Live Leishmana promastigotes can directly activate primary human natural killer cells to produce interferon\u2013gamma","volume":"131","author":"Nylen","year":"2003","journal-title":"Clinical and Experimental Immunology"},{"key":"10.1016\/j.exppara.2011.10.001_b0230","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.4049\/jimmunol.150.6.2322","article-title":"Pure protein from Leishmania donovani protects mice against both cutaneous and visceral leishmaniasis","volume":"150","author":"Rachamim","year":"1993","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.exppara.2011.10.001_b0235","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-3024.1993.tb00587.x","article-title":"Vaccine development against cutaneous leishmaniasis: subcutaneous administration of radioattenuated parasites protects CBA mice against virulent Leishmania major challenge","volume":"15","author":"Rivier","year":"1993","journal-title":"Parasite Immunology"},{"key":"10.1016\/j.exppara.2011.10.001_b0240","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1046\/j.1365-3024.1999.00244.x","article-title":"Vaccine against Leishmania major in a CBA mouse model of infection: role of adjuvants and mechanism of protection","volume":"21","author":"Rivier","year":"1999","journal-title":"Parasite Immunology"},{"key":"10.1016\/j.exppara.2011.10.001_b0245","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.4049\/jimmunol.180.7.4825","article-title":"Leishmania major specific B cells are necessary for Th2 cell development and susceptibility to L. major LV 39 in BALB\/c mice","volume":"180","author":"Ronet","year":"2008","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.exppara.2011.10.001_b0250","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0022-1759(85)90235-2","article-title":"A simple method for solubilisation of reduced NBT and its use as a colorimetric assay for activation of human macrophages by g-interferon","volume":"82","author":"Rook","year":"1985","journal-title":"Journal of Immunological Methods"},{"key":"10.1016\/j.exppara.2011.10.001_b0255","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1016\/j.vaccine.2007.04.003","article-title":"Immunization with Leishmania infantum released proteins confers partial protection against parasite infection with a predominant Th 1 specific immune response","volume":"25","author":"Rosa","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2011.10.001_b0260","first-page":"455","article-title":"Genetically modified live attenuated parasites as vaccines for leishmaniasis","volume":"123","author":"Selvapandiyan","year":"2006","journal-title":"Indian Journal of Medical Research"},{"key":"10.1016\/j.exppara.2011.10.001_b0270","doi-asserted-by":"crossref","first-page":"7064","DOI":"10.4049\/jimmunol.165.12.7064","article-title":"Immunization with a recombinant stage-regulated surface protein from Leishmania donovani induces protection against visceral leishmaniasis","volume":"165","author":"Stager","year":"2000","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.exppara.2011.10.001_b0275","first-page":"80","article-title":"Host resistance to the Khartoum strain of Leishmania donovani","volume":"45","author":"Stauber","year":"1958","journal-title":"Rice Institute Pamphlet"},{"key":"10.1016\/j.exppara.2011.10.001_b0280","doi-asserted-by":"crossref","unstructured":"Strober W., 2001. Trypan blue exclusion test of cell viability. Current Protocol of Immunology. Appendix 3: Appendix 3B.","DOI":"10.1002\/0471142735.ima03bs21"},{"key":"10.1016\/j.exppara.2011.10.001_b0285","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1046\/j.1365-3156.2001.00778.x","article-title":"Drug resistances in Indian visceral leishmaniasis","volume":"6","author":"Sundar","year":"2001","journal-title":"Tropical Medicine and International Health"},{"key":"10.1016\/j.exppara.2011.10.001_b0300","doi-asserted-by":"crossref","first-page":"10267","DOI":"10.1073\/pnas.92.22.10267","article-title":"Development of a safe, live leishmania vaccine by gene replacement","volume":"92","author":"Titus","year":"1995","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.exppara.2011.10.001_b0305","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ijpara.2007.08.010","article-title":"Pathogenic role of B cells and antibodies in murine Leishmania amazonensis infection","volume":"38","author":"Wanasen","year":"2008","journal-title":"International Journal of Parasitology"},{"key":"10.1016\/j.exppara.2011.10.001_b0315","unstructured":"World Health Organization report on Leishmania and HIV in gridlock, 1998. WHO\/UNAIDS report, Geneva, pp. 12\u201325."},{"key":"10.1016\/j.exppara.2011.10.001_b0320","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/0264-410X(94)90079-5","article-title":"Genetic vaccination against leishmaniasis","volume":"12","author":"Xu","year":"1994","journal-title":"Vaccine"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489411003018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489411003018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T19:30:19Z","timestamp":1713036619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489411003018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0014489411003018"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2011.10.001","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}