{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:28:35Z","timestamp":1773286115038,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Nanotechnology Research Center and Biotechnology Research Center"},{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences (MUMS)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.exppara.2012.06.014","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T04:56:40Z","timestamp":1342760200000},"page":"313-319","source":"Crossref","is-referenced-by-count":19,"title":["The role of liposome\u2013protamine\u2013DNA nanoparticles containing CpG oligodeoxynucleotides in the course of infection induced by Leishmania major in BALB\/c mice"],"prefix":"10.1016","volume":"132","author":[{"given":"Seyedeh Hoda","family":"Alavizadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Badiee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Khamesipour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Amir","family":"Jalali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengameh","family":"Firouzmand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azam","family":"Abbasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud Reza","family":"Jaafari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2012.06.014_b0005","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1128\/CVI.00413-07","article-title":"Coencapsulation of CpG oligodeoxynucleotides with recombinant leishmania major stress-inducible protein 1 in liposome enhances immune response and protection against leishmaniasis in immunized BALB\/c mice","volume":"15","author":"Badiee","year":"2008","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.exppara.2012.06.014_b0010","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00262-007-0390-4","article-title":"A simple but effective cancer vaccine consisting of an antigen and a cationic lipid","volume":"57","author":"Chen","year":"2008","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.exppara.2012.06.014_b0015","first-page":"776","article-title":"The mechanism and efficiency affecting factor of cationic liposome transfection","volume":"23","author":"Chen","year":"2007","journal-title":"Sheng Wu Gong Cheng Xue Bao"},{"key":"10.1016\/j.exppara.2012.06.014_b0020","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1084\/jem.186.10.1623","article-title":"CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity","volume":"186","author":"Chu","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.exppara.2012.06.014_b0025","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1128\/CMR.19.1.111-126.2006","article-title":"Drug resistance in leishmaniasis","volume":"19","author":"Croft","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.exppara.2012.06.014_b0030","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1021\/mp049907k","article-title":"Immunostimulation mechanism of LPD nanoparticle as a vaccine carrier","volume":"2","author":"Cui","year":"2005","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.exppara.2012.06.014_b0035","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1007\/s00262-005-0685-2","article-title":"Liposome-polycation-DNA (LPD) particle as a carrier and adjuvant for protein-based vaccines: Therapeutic effect against cervical cancer","volume":"54","author":"Cui","year":"2005","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.exppara.2012.06.014_b0040","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S1525-0016(03)00064-9","article-title":"Lipid\u2013protamine\u2013DNA-mediated antigen delivery to antigen-presenting cells results in enhanced anti-tumor immune responses","volume":"7","author":"Dileo","year":"2003","journal-title":"Mol. Ther."},{"key":"10.1016\/j.exppara.2012.06.014_b0045","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.4049\/jimmunol.167.6.3324","article-title":"Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides","volume":"167","author":"Gursel","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.exppara.2012.06.014_b0050","doi-asserted-by":"crossref","first-page":"e162","DOI":"10.1371\/journal.pmed.0030162","article-title":"Unresponsiveness to glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant leishmania tropica parasites","volume":"3","author":"Hadighi","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.exppara.2012.06.014_b0055","unstructured":"Hejazi, H., 2010. The Role of liposomal CpG ODN on the course of l. major infection in balb\/c mice. Iranian J. Parasitol. 5."},{"key":"10.1016\/j.exppara.2012.06.014_b0060","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1016\/j.vaccine.2007.05.009","article-title":"The role of CpG ODN in enhancement of immune response and protection in BALB\/c mice immunized with recombinant major surface glycoprotein of Leishmania (rgp63) encapsulated in cationic liposome","volume":"25","author":"Jaafari","year":"2007","journal-title":"Vaccine"},{"issue":"Suppl","key":"10.1016\/j.exppara.2012.06.014_b0065","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1017\/S0031182006001831","article-title":"Leishmania vaccines: progress and problems","volume":"133","author":"Kedzierski","year":"2006","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2012.06.014_b0070","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1016\/j.vaccine.2005.02.015","article-title":"Leishmanization: Use of an old method for evaluation of candidate vaccines against leishmaniasis","volume":"23","author":"Khamesipour","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2012.06.014_b0075","first-page":"423","article-title":"Leishmaniasis vaccine candidates for development: a global overview","volume":"123","author":"Khamesipour","year":"2006","journal-title":"The Ind. J. Med. Res."},{"key":"10.1016\/j.exppara.2012.06.014_b0080","doi-asserted-by":"crossref","unstructured":"Khatami, A., Firooz, A., Gorouhi, F., Dowlati, Y., 2007. Treatment of acute Old World cutaneous leishmaniasis: a systematic review of the randomized controlled trials. Journal of the American Academy of Dermatology 57, 335. e331\u2013335. e329.","DOI":"10.1016\/j.jaad.2007.01.016"},{"key":"10.1016\/j.exppara.2012.06.014_b0085","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1172\/JCI116752","article-title":"Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset","volume":"92","author":"King","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exppara.2012.06.014_b0090","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1586\/14760584.2.2.305","article-title":"CpG DNA as a vaccine adjuvant","volume":"2","author":"Klinman","year":"2003","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.exppara.2012.06.014_b0095","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.0105-2896.2004.00148.x","article-title":"Use of CpG oligodeoxynucleotides as immune adjuvants","volume":"199","author":"Klinman","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.exppara.2012.06.014_b0100","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1073\/pnas.93.7.2879","article-title":"CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma","volume":"93","author":"Klinman","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.exppara.2012.06.014_b0105","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0264-410X(00)00249-8","article-title":"Immune effects and mechanisms of action of CpG motifs","volume":"19","author":"Krieg","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2012.06.014_b0110","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/374546a0","article-title":"CpG motifs in bacterial DNA trigger direct B-cell activation","volume":"374","author":"Krieg","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.exppara.2012.06.014_b0115","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1046\/j.1432-1033.2003.03555.x","article-title":"Antisense technologies. Improvement through novel chemical modifications","volume":"270","author":"Kurreck","year":"2003","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.exppara.2012.06.014_b0120","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1128\/CVI.00249-09","article-title":"Vaccination with live Leishmania major and CpG DNA promotes interleukin-2 production by dermal dendritic cells and NK cell activation","volume":"16","author":"Laabs","year":"2009","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.exppara.2012.06.014_b0125","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/sj.gt.3300482","article-title":"In vivo gene transfer via intravenous administration of cationic lipid\u2013protamine\u2013DNA (LPD) complexes","volume":"4","author":"Li","year":"1997","journal-title":"Gene Ther."},{"key":"10.1016\/j.exppara.2012.06.014_b0130","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/sj.gt.3300683","article-title":"Characterization of cationic lipid\u2013protamine\u2013DNA (LPD) complexes for intravenous gene delivery","volume":"5","author":"Li","year":"1998","journal-title":"Gene Ther."},{"key":"10.1016\/j.exppara.2012.06.014_b0135","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/j.bbamem.2009.06.022","article-title":"Nanoparticles evading the reticuloendothelial system: role of the supported bilayer","volume":"1788","author":"Li","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exppara.2012.06.014_b0140","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/intimm\/8.6.897","article-title":"Allergen-driven limiting dilution analysis of human IL-4 and IFN-\u03b3 production in allergic rhinitis and clinically tolerant individualsz","volume":"8","author":"Li","year":"1996","journal-title":"Int. Immunol."},{"key":"10.1016\/j.exppara.2012.06.014_b0145","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2174\/1568008023340631","article-title":"Vaccination Against Leishmania Infections","volume":"2","author":"Mauel","year":"2002","journal-title":"Current Drug Targets-Immune, Endocrine & Metabolic Disorders"},{"key":"10.1016\/j.exppara.2012.06.014_b0150","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1128\/IAI.71.9.5121-5129.2003","article-title":"Coinjection with CpG-containing immunostimulatory oligodeoxynucleotides reduces the pathogenicity of a live vaccine against cutaneous Leishmaniasis but maintains its potency and durability","volume":"71","author":"Mendez","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.exppara.2012.06.014_b0155","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/eji.1830260138","article-title":"Characterization of the immunological memory state generated in mice susceptible to Leishmania major following exposure to low doses of L. major and resulting in resistance to a normally pathogenic challenge","volume":"26","author":"Menon","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.exppara.2012.06.014_b0160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1475-9292-6-3","article-title":"Consultative meeting to develop a strategy for treatment of cutaneous leishmaniasis. Institute Pasteur, Paris. 13\u201315 June, 2006","volume":"6","author":"Modabber","year":"2007","journal-title":"Kinetoplastid Biol. Dis."},{"key":"10.1016\/j.exppara.2012.06.014_b0165","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/eji.1830250310","article-title":"Dendritic cells in Leishmania major-immune mice harbor persistent parasites and mediate an antigen-specific T cell immune response","volume":"25","author":"Moll","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.exppara.2012.06.014_b0170","first-page":"377","article-title":"Effectiveness of leishmanization in the control of cutaneous leishmaniasis","volume":"76","author":"Nadim","year":"1983","journal-title":"Bulletin de la soci\u00e9t\u00e9 de Pathology Exotique et de ses filiales"},{"key":"10.1016\/j.exppara.2012.06.014_b0175","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.1016\/j.vaccine.2009.05.084","article-title":"Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis: a meta-analysis","volume":"27","author":"Noazin","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2012.06.014_b0180","doi-asserted-by":"crossref","first-page":"6759","DOI":"10.1016\/j.vaccine.2008.09.085","article-title":"First generation leishmaniasis vaccines: a review of field efficacy trials","volume":"26","author":"Noazin","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2012.06.014_b0185","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1016\/j.vaccine.2009.03.045","article-title":"Decrease of the incidence of human and canine visceral leishmaniasis after dog vaccination with Leishmune\u00ae in Brazilian endemic areas","volume":"27","author":"Palatnik de Sousa","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2012.06.014_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/S0399-077X(08)73075-0","article-title":"A-15 Le Cani Leish\u00ae, un vaccin contre le r\u00e9servoir canin de la leishmaniose: des r\u00e9sultats prometteurs pour un futur vaccin humain","volume":"38","author":"Papierok","year":"2008","journal-title":"M\u00e9decine et Maladies Infectieuses"},{"key":"10.1016\/j.exppara.2012.06.014_b0195","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1084\/jem.20020147","article-title":"Vaccination with heat-killed leishmania antigen or recombinant leishmanial protein and CpG oligodeoxynucleotides induces long-term memory CD4+and CD8+T Cell responses and protection against leishmania major infection","volume":"195","author":"Rhee","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.exppara.2012.06.014_b0200","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4049\/jimmunol.139.1.221","article-title":"Vaccination against cutaneous leishmaniasis in a murine model. I. Induction of protective immunity with a soluble extract of promastigotes","volume":"139","author":"Scott","year":"1987","journal-title":"J. Immunol."},{"key":"10.1016\/j.exppara.2012.06.014_b0205","first-page":"183","article-title":"Control and prophylaxis of cutaneous leishmaniasis in the middle Asia republics of the former USSR","volume":"10","author":"Sergiev","year":"1992","journal-title":"Bulletin de la Soci\u00e9t\u00e9 fran\u00e7aise de parasitologie"},{"key":"10.1016\/j.exppara.2012.06.014_b0210","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/S0140-6736(98)09552-X","article-title":"Randomised vaccine trial of single dose of killed Leishmania major plus BCG against anthroponotic cutaneous leishmaniasis in Bam, Iran","volume":"351","author":"Sharifi","year":"1998","journal-title":"The Lancet"},{"key":"10.1016\/j.exppara.2012.06.014_b0215","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2217\/17460875.1.1.35","article-title":"Liposomal encapsulation enhances the activity of immunostimulatory oligonucleotides","volume":"1","author":"Tam","year":"2006","journal-title":"Future Lipidology"},{"key":"10.1016\/j.exppara.2012.06.014_b0220","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.4049\/jimmunol.126.4.1614","article-title":"Limiting dilution assays for the determination of immunocompetent cell frequencies I. Data analysis","volume":"126","author":"Taswell","year":"1981","journal-title":"J. Immunol."},{"key":"10.1016\/j.exppara.2012.06.014_b0225","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1365-3024.1985.tb00098.x","article-title":"A limiting dilution assay for quantifying Leishmania major in tissues of infected mice","volume":"7","author":"Titus","year":"1985","journal-title":"Parasite Immunol."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489412002019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489412002019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T08:42:02Z","timestamp":1714207322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489412002019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0014489412002019"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2012.06.014","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}