{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:44:26Z","timestamp":1791517466030,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.exppara.2013.02.014","type":"journal-article","created":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T19:55:47Z","timestamp":1362426947000},"page":"92-101","source":"Crossref","is-referenced-by-count":45,"title":["Systemic cytokine profiles and splenic toll-like receptor expression during Trichinella spiralis infection"],"prefix":"10.1016","volume":"134","author":[{"given":"Yan-Rong","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Jun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Wei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo-Zhi","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Fen","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2013.02.014_b0005","doi-asserted-by":"crossref","first-page":"582","DOI":"10.2741\/1554","article-title":"Inhibition of Toll Like Receptor immune responses by microbial pathogens","volume":"10","author":"Alvarez","year":"2005","journal-title":"Front Biosci."},{"issue":"4","key":"10.1016\/j.exppara.2013.02.014_b0010","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1365-3024.2012.01353.x","article-title":"Trichinella spiralis-secreted products modulate DC functionality and expand regulatory T cells in vitro","volume":"34","author":"Aranzamendi","year":"2012","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.exppara.2013.02.014_b0015","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.4049\/jimmunol.176.7.3885","article-title":"Diminished T cell TLR expression and function modulates the immune response in human filarial infection","volume":"176","author":"Babu","year":"2006","journal-title":"J. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.exppara.2013.02.014_b0020","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11010-011-1046-4","article-title":"Regulation of cytokine expression in murine macrophages stimulated by excretory\/secretory products from Trichinella spiralis in vitro","volume":"360","author":"Bai","year":"2012","journal-title":"Mol. Cell Biochem."},{"issue":"6","key":"10.1016\/j.exppara.2013.02.014_b0025","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1128\/IAI.72.6.3129-3137.2004","article-title":"Interleukin-10 limits local and body cavity inflammation during infection with muscle-stage Trichinella spiralis","volume":"72","author":"Beiting","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.exppara.2013.02.014_b0030","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.4049\/jimmunol.178.2.1039","article-title":"Coordinated control of immunity to muscle stage Trichinella spiralis by IL-10, regulatory T cells, and TGF-beta","volume":"178","author":"Beiting","year":"2007","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.exppara.2013.02.014_b0035","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nm.2628","article-title":"An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection","volume":"18","author":"Chen","year":"2012","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.exppara.2013.02.014_b0040","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/BOR.0b013e3283535937","article-title":"Parasitic worms and inflammatory disease","volume":"24","author":"Cooke","year":"2012","journal-title":"Curr. Opin. Rheumatol."},{"issue":"5","key":"10.1016\/j.exppara.2013.02.014_b0045","doi-asserted-by":"crossref","first-page":"974","DOI":"10.2307\/3277516","article-title":"Infectivity of the newborn larva of Trichinella spiralis in the rat","volume":"56","author":"Dennis","year":"1970","journal-title":"J. Parasitol."},{"issue":"12","key":"10.1016\/j.exppara.2013.02.014_b0050","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1002\/eji.200737765","article-title":"Mapping immune response profiles: the emerging scenario from helminth immunology","volume":"37","author":"D\u00edaz","year":"2007","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.exppara.2013.02.014_b0055","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1074\/jbc.M109.060368","article-title":"Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3","volume":"285","author":"Donnelly","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exppara.2013.02.014_b0060","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1749-6632.2011.06292.x","article-title":"Helminth-host immunological interactions: prevention and control of immune-mediated diseases","volume":"1247","author":"Elliott","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"3\u20134","key":"10.1016\/j.exppara.2013.02.014_b0065","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.vetpar.2008.10.051","article-title":"Immunity to Trichinella spiralis muscle infection","volume":"159","author":"Fabre","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2013.02.014_b0070","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.0105-2896.2004.00192.x","article-title":"Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites","volume":"201","author":"Finkelman","year":"2004","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.exppara.2013.02.014_b0075","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1128\/CMR.00026-08","article-title":"Epidemiology, diagnosis, treatment, and control of trichinellosis","volume":"22","author":"Gottstein","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"issue":"5","key":"10.1016\/j.exppara.2013.02.014_b0160","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cimid.2011.08.004","article-title":"The impact of Trichinella spiralis excretory\u2013secretory products on dendritic cells","volume":"34","author":"Gruden-Movsesijan","year":"2011","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"issue":"6","key":"10.1016\/j.exppara.2013.02.014_b0085","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1128\/IAI.00919-08","article-title":"The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function","volume":"77","author":"Hamilton","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.exppara.2013.02.014_b0090","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1002\/eji.200324082","article-title":"Contrasting roles for IL-10 in protective immunity to different life cycle stages of intestinal nematode parasites","volume":"33","author":"Helmby","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.exppara.2013.02.014_b0095","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.4049\/jimmunol.171.7.3691","article-title":"IFN-gamma-independent effects of IL-12 during intestinal nematode infection","volume":"171","author":"Helmby","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.exppara.2013.02.014_b0165","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1365-3024.2011.01322.x","article-title":"Trichinella spiralis antigens prime mixed Th1\/Th2 response but do not induce de novo generation of Foxp3+ T cells in vitro","volume":"33","author":"Ilic","year":"2011","journal-title":"Parasite Immunol."},{"issue":"1\u20132","key":"10.1016\/j.exppara.2013.02.014_b0100","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12026-012-8287-5","article-title":"Trichinella spiralis: shaping the immune response","volume":"52","author":"Ilic","year":"2012","journal-title":"Immunol. Res."},{"issue":"5","key":"10.1016\/j.exppara.2013.02.014_b0110","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. immunol."},{"issue":"2","key":"10.1016\/j.exppara.2013.02.014_b0115","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.molimm.2012.03.020","article-title":"Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation","volume":"51","author":"Kuijk","year":"2012","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.exppara.2013.02.014_b0120","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1002\/eji.200535722","article-title":"Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo","volume":"36","author":"Perona-Wright","year":"2006","journal-title":"Eur. J. Immunol."},{"issue":"3","key":"10.1016\/j.exppara.2013.02.014_b0125","doi-asserted-by":"crossref","first-page":"957","DOI":"10.4049\/jimmunol.149.3.957","article-title":"Influence of resistant and susceptible genotype, IL-1, and lymphoid organ on Trichinella spiralis-induced cytokine secretion","volume":"149","author":"Pond","year":"1992","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.exppara.2013.02.014_b0130","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.7150\/ijbs.7.1323","article-title":"TLR2 mediates immunity to experimental cysticercosis","volume":"7","author":"Reyes","year":"2011","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.exppara.2013.02.014_b0135","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1182\/blood-2008-04-149856","article-title":"Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites","volume":"112","author":"Semnani","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.exppara.2013.02.014_b0140","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.4049\/jimmunol.170.4.1930","article-title":"CTLA-4 in filarial infections: implications for a role in diminished T cell reactivity","volume":"170","author":"Steel","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.exppara.2013.02.014_b0145","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.imbio.2007.03.009","article-title":"Chronic helminth infections induce immunomodulation: consequences and mechanisms","volume":"212","author":"van Riet","year":"2007","journal-title":"Immunobiology"},{"issue":"1\u20133","key":"10.1016\/j.exppara.2013.02.014_b0150","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s12026-008-8079-0","article-title":"Activation and regulation of toll-like receptors (TLRs) by helminth parasites","volume":"43","author":"Venugopal","year":"2009","journal-title":"Immunol. Res."},{"issue":"4","key":"10.1016\/j.exppara.2013.02.014_b0155","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-3024.2010.01265.x","article-title":"Toll-like receptor (TLR) 2 and TLR4 deficiencies exert differential in vivo effects against Schistosoma japonicum","volume":"33","author":"Zhang","year":"2011","journal-title":"Parasite Immunol."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489413000568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489413000568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T22:12:33Z","timestamp":1688076753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489413000568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0014489413000568"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2013.02.014","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}