{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:59:21Z","timestamp":1777525161956,"version":"3.51.4"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Special Fund for Public Welfare Industry of Ministry of Agriculture of China","award":["200903036-04"],"award-info":[{"award-number":["200903036-04"]}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.exppara.2014.08.011","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T19:26:03Z","timestamp":1409167563000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Immunoglobulin and cytokine changes induced following immunization with a DNA vaccine encoding Toxoplasma gondii selenium-dependent glutathione reductase protein"],"prefix":"10.1016","volume":"146","author":[{"given":"Ibrahim A.","family":"Hassan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LiXin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RuoFeng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiaoKai","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiangRui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2014.08.011_bib0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0020-7519(97)00168-9","article-title":"The role of IL-4 in adult acquired and congenital toxoplasmosis","volume":"28","author":"Alexander","year":"1998","journal-title":"Int. J. Parasitol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0015","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1098\/rstb.1997.0120","article-title":"Mechanisms of innate resistance to Toxoplasma gondii infection","volume":"352","author":"Alexander","year":"1997","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci"},{"key":"10.1016\/j.exppara.2014.08.011_bib0020","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.actatropica.2008.04.018","article-title":"Comparison of immunogenicity, protective efficacy of single and cocktail DNA vaccine of Brugia malayi abundant larval transcript (ALT-2) and thioredoxin peroxidase (TPX) in mice","volume":"107","author":"Anand","year":"2008","journal-title":"Acta Trop"},{"key":"10.1016\/j.exppara.2014.08.011_bib0025","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1128\/IAI.61.10.4126-4130.1993","article-title":"Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors","volume":"61","author":"Bermudez","year":"1993","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.08.011_bib0030","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1286-4579(03)00048-0","article-title":"Development of a vaccine for toxoplasmosis: current status","volume":"5","author":"Bhopale","year":"2003","journal-title":"Microbes Infect"},{"key":"10.1016\/j.exppara.2014.08.011_bib0035","unstructured":"Bruna-Romero, O., de Oliveira, D.M., de Andrade-Neto, V.F., Toxoplasmosis: Advances and Vaccine Perspectives."},{"key":"10.1016\/j.exppara.2014.08.011_bib0040","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0169-4758(88)90162-7","article-title":"Helminth anti-oxidant enzymes: a protective mechanism against host oxidants?","volume":"4","author":"Callahan","year":"1988","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.exppara.2014.08.011_bib0045","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1128\/IAI.70.2.434-443.2002","article-title":"CD8+-T-cell immunity against Toxoplasma gondii can be induced but not maintained in mice lacking conventional CD4+ T cells","volume":"70","author":"Casciotti","year":"2002","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.08.011_bib0050","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1128\/IAI.58.5.1240-1246.1990","article-title":"Antibody responses to Toxoplasma gondii in sera, intestinal secretions, and milk from orally infected mice and characterization of target antigens","volume":"58","author":"Chardes","year":"1990","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.08.011_bib0055","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.vaccine.2013.01.027","article-title":"Protective immunity induced by a DNA vaccine expressing eIF4A of Toxoplasma gondii against acute toxoplasmosis in mice","volume":"31","author":"Chen","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2014.08.011_bib0060","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12026-007-8014-9","article-title":"Th17 cells: a new fate for differentiating helper T cells","volume":"41","author":"Chen","year":"2008","journal-title":"Immunol. Res"},{"key":"10.1016\/j.exppara.2014.08.011_bib0065","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1128\/IAI.73.8.4913-4921.2005","article-title":"NK cells help to induce CD8+-T-cell immunity against Toxoplasma gondii in the absence of CD4+ T cells","volume":"73","author":"Combe","year":"2005","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.08.011_bib0070","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1365-3024.2007.00982.x","article-title":"Congenital and acquired toxoplasmosis: diversity and role of antibodies in different compartments of the host","volume":"29","author":"Correa","year":"2007","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0075","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1016\/S0264-410X(03)00163-4","article-title":"DNA vaccination with the immunodominant tachyzoite surface antigen (SAG-1) protects against adult acquired Toxoplasma gondii infection but does not prevent maternofoetal transmission","volume":"21","author":"Couper","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2014.08.011_bib0080","doi-asserted-by":"crossref","first-page":"8060","DOI":"10.1128\/IAI.73.12.8060-8068.2005","article-title":"Toxoplasma gondii-specific immunoglobulin M limits parasite dissemination by preventing host cell invasion","volume":"73","author":"Couper","year":"2005","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.08.011_bib0085","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1128\/CMR.11.4.569","article-title":"Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection","volume":"11","author":"Denkers","year":"1998","journal-title":"Clin. Microbiol. Rev"},{"key":"10.1016\/j.exppara.2014.08.011_bib0090","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00281-012-0339-3","article-title":"Immune response and immunopathology during toxoplasmosis","volume":"34","author":"Dupont","year":"2012","journal-title":"Semin. Immunopathol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0095","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-3024.2007.01016.x","article-title":"Advances in the use of genetically engineered parasites to study immunity to Toxoplasma gondii","volume":"30","author":"Dzierszinski","year":"2008","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0100","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1348-0421.2005.tb03656.x","article-title":"Protective effect of vaccination with Toxoplasma lysate antigen and CpG as an adjuvant against Toxoplasma gondii in susceptible C57BL\/6 mice","volume":"49","author":"El-Malky","year":"2005","journal-title":"Microbiol. Immunol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0105","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM200005043421807","article-title":"Role of transforming growth factor \u03b2 in human disease","volume":"342","author":"Epstein","year":"2000","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.exppara.2014.08.011_bib0110","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1146\/annurev.mi.46.100192.003403","article-title":"Metabolism and functions of trypanothione in the Kinetoplastida","volume":"46","author":"Fairlamb","year":"1992","journal-title":"Annu. Rev. Microbiol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0115","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4049\/jimmunol.149.1.175","article-title":"Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii","volume":"149","author":"Gazzinelli","year":"1992","journal-title":"J. Immunol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0120","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1128\/IAI.58.8.2446-2451.1990","article-title":"Isotypic profiles of antibody responses to Toxoplasma gondii infection in rats and mice: kinetic study and characterization of target antigens of immunoglobulin A antibodies","volume":"58","author":"Godard","year":"1990","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.08.011_bib0125","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.pt.2010.06.004","article-title":"Immunogenetics of Toxoplasma gondii informs vaccine design","volume":"26","author":"Henriquez","year":"2010","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0130","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S1471-4922(02)02293-6","article-title":"The diversity and evolution of thioredoxin reductase: new perspectives","volume":"18","author":"Hirt","year":"2002","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0135","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.exppara.2009.11.015","article-title":"Comparison of immune response in sheep immunized with DNA vaccine encoding Toxoplasma gondii GRA7 antigen in different adjuvant formulations","volume":"124","author":"Hiszczynska-Sawicka","year":"2010","journal-title":"Exp. Parasitol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0140","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.exppara.2009.10.010","article-title":"Toxoplasma gondii: recombinant GRA5 antigen for detection of immunoglobulin G antibodies using enzyme-linked immunosorbent assay","volume":"124","author":"Holec-Gasior","year":"2010","journal-title":"Exp. Parasitol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0145","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/eji.1830250420","article-title":"Transforming growth factor inhibits interleukin 12 induced production of interferon by natural killer cells: a role for transforming growth factor in the regulation of T cell independent resistance to Toxoplasma gondii","volume":"25","author":"Hunter","year":"1995","journal-title":"Eur. J. Immunol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0150","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.4049\/jimmunol.169.7.3900","article-title":"Divergent role for TNF-\u03b1 in IFN-\u03b3-induced killing of Toxoplasma gondii and Salmonella typhimurium contributes to selective susceptibility of patients with partial IFN-\u03b3 receptor 1 deficiency","volume":"169","author":"Janssen","year":"2002","journal-title":"J. Immunol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0155","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1365-3024.2007.00961.x","article-title":"GRA7 provides protective immunity in cocktail DNA vaccines against Toxoplasma gondii","volume":"29","author":"Jongert","year":"2007","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0160","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1017\/S0031182003004414","article-title":"Natural IgM antibodies in sera from various animals but not the cat kill Toxoplasma gondii by activating the classical complement pathway","volume":"128","author":"Kaneko","year":"2004","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2014.08.011_bib0165","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0169-4758(97)01212-X","article-title":"Some opportunistic parasitic infections in AIDS: candidiasis, pneumocystosis, cryptosporidiosis, toxoplasmosis","volume":"14","author":"Kasper","year":"1998","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.exppara.2014.08.011_bib0170","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.4049\/jimmunol.148.5.1493","article-title":"Antigen-specific (p30) mouse CD8+ T cells are cytotoxic against Toxoplasma gondii-infected peritoneal macrophages","volume":"148","author":"Kasper","year":"1992","journal-title":"J. Immunol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0175","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1128\/IAI.73.1.617-621.2005","article-title":"Interleukin-17\/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection","volume":"73","author":"Kelly","year":"2005","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.08.011_bib0180","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1128\/IAI.73.1.298-307.2005","article-title":"Both innate immunity and type 1 humoral immunity to Streptococcus pneumoniae are mediated by MyD88 but differ in their relative levels of dependence on toll-like receptor 2","volume":"73","author":"Khan","year":"2005","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.08.011_bib0185","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.4049\/jimmunol.147.10.3501","article-title":"A purified parasite antigen (p30) mediates CD8+ T cell immunity against fatal Toxoplasma gondii infection in mice","volume":"147","author":"Khan","year":"1991","journal-title":"J. Immunol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0190","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00436-013-3716-5","article-title":"Efficacy of Leishmania donovani trypanothione reductase, identified as a potent Th1 stimulatory protein, for its immunogenicity and prophylactic potential against experimental visceral leishmaniasis","volume":"113","author":"Khare","year":"2014","journal-title":"Parasitol. Res"},{"key":"10.1016\/j.exppara.2014.08.011_bib0195","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1017\/S003118200006368X","article-title":"Naturally occurring immunoglobulin M antibodies: enhancement of phagocytic and microbicidal activities of human neutrophils against Toxoplasma gondii","volume":"104","author":"Konishi","year":"1992","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2014.08.011_bib0200","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1365-2958.2003.03823.x","article-title":"The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury","volume":"51","author":"Kwok","year":"2004","journal-title":"Mol. Microbiol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0205","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2174\/156802608783790857","article-title":"Taenia solium: antioxidant metabolism enzymes as targets for cestocidal drugs and vaccines","volume":"8","author":"Landa","year":"2008","journal-title":"Curr. Top. Med. Chem"},{"key":"10.1016\/j.exppara.2014.08.011_bib0210","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1128\/IAI.71.11.6615-6619.2003","article-title":"Vaccination with Toxoplasma gondii SAG-1 protein is protective against congenital toxoplasmosis in BALB\/c mice but not in CBA\/J mice","volume":"71","author":"Letscher-Bru","year":"2003","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.08.011_bib0215","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.micinf.2005.11.013","article-title":"Immunization with MIC1 and MIC4 induces protective immunity against Toxoplasma gondii","volume":"8","author":"Louren\u00e7o","year":"2006","journal-title":"Microbes Infect"},{"key":"10.1016\/j.exppara.2014.08.011_bib0220","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1590\/S0074-02762004000900007","article-title":"Vaccination with antioxidant enzymes confers protective immunity against challenge infection with Schistosoma mansoni","volume":"99","author":"LoVerde","year":"2004","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.exppara.2014.08.011_bib0225","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/mi.2007.6","article-title":"The immune geography of IgA induction and function","volume":"1","author":"Macpherson","year":"2008","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0230","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.exppara.2011.09.013","article-title":"A recombinant thioredoxin-glutathione reductase from Fasciola hepatica induces a protective response in rabbits","volume":"129","author":"Maggioli","year":"2011","journal-title":"Exp. Parasitol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0235","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.4049\/jimmunol.170.9.4665","article-title":"Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways","volume":"170","author":"Miyamoto","year":"2003","journal-title":"J. Immunol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0240","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1128\/IAI.64.1.176-181.1996","article-title":"Human CD4+ and CD8+ T lymphocytes are both cytotoxic to Toxoplasma gondii-infected cells","volume":"64","author":"Montoya","year":"1996","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.08.011_bib0245","first-page":"41","article-title":"DNA vaccination: an immunological perspective","volume":"23","author":"Moreno","year":"2004","journal-title":"Inmunologia"},{"key":"10.1016\/j.exppara.2014.08.011_bib0250","doi-asserted-by":"crossref","first-page":"10383","DOI":"10.1073\/pnas.93.19.10383","article-title":"Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania","volume":"93","author":"Mukhopadhyay","year":"1996","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1016\/j.exppara.2014.08.011_bib0255","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1128\/IAI.67.12.6358-6363.1999","article-title":"Complete protection against lethal Toxoplasma gondii infection in mice immunized with a plasmid encoding the SAG1 gene","volume":"67","author":"Nielsen","year":"1999","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.08.011_bib0260","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1074-7613(00)80533-6","article-title":"Cytokines induce the development of functionally heterogeneous T helper cell subsets","volume":"8","author":"O\u2019Garra","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.exppara.2014.08.011_bib0265","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.4049\/jimmunol.0901843","article-title":"IL-6 promotes NK cell production of IL-17 during toxoplasmosis","volume":"184","author":"Passos","year":"2010","journal-title":"J. Immunol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0270","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1128\/JCM.28.8.1739-1743.1990","article-title":"Detection of specific immunoglobulin E in patients with toxoplasmosis","volume":"28","author":"Pinon","year":"1990","journal-title":"J. Clin. Microbiol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0275","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1128\/IAI.64.10.4330-4338.1996","article-title":"CD4-mediated and CD8-mediated cytotoxic and proliferative immune responses to Toxoplasma gondii in seropositive humans","volume":"64","author":"Purner","year":"1996","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.08.011_bib0280","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/30989","article-title":"A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell","volume":"393","author":"Ridge","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.exppara.2014.08.011_bib0285","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1128\/IAI.64.3.897-904.1996","article-title":"Different roles for interleukin-4 during the course of Toxoplasma gondii infection","volume":"64","author":"Roberts","year":"1996","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.08.011_bib0290","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1517\/13543776.2012.668886","article-title":"New antibacterials for the treatment of toxoplasmosis; a patent review","volume":"22","author":"Rodriguez","year":"2012","journal-title":"Expert Opin. Ther. Pat"},{"key":"10.1016\/j.exppara.2014.08.011_bib0295","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nm0897-849","article-title":"Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants","volume":"3","author":"Roman","year":"1997","journal-title":"Nat. Med"},{"key":"10.1016\/j.exppara.2014.08.011_bib0300","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0378-1135(00)00193-0","article-title":"Dynamics of lymphocyte subpopulation changes in the cecal tonsils of chickens infected with Salmonella enteritidis","volume":"74","author":"Sasai","year":"2000","journal-title":"Vet. Microbiol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0305","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1002\/(SICI)1521-4141(199804)28:04<1181::AID-IMMU1181>3.0.CO;2-O","article-title":"IFN-\u03b3 inhibits the production of latent transforming growth factor-\u03b21 by mouse inflammatory macrophages","volume":"28","author":"Schindler","year":"1998","journal-title":"Eur. J. Immunol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0310","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1128\/IAI.71.1.309-316.2003","article-title":"A GRA1 DNA vaccine primes cytolytic CD8+ T cells to control acute Toxoplasma gondii infection","volume":"71","author":"Scorza","year":"2003","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.08.011_bib0315","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.exppara.2009.05.011","article-title":"Toxoplasma gondii: the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection","volume":"123","author":"Silva","year":"2009","journal-title":"Exp. Parasitol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0320","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1016\/j.vaccine.2012.03.068","article-title":"Leishmaniasis: vaccine candidates and perspectives","volume":"30","author":"Singh","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2014.08.011_bib0325","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.exppara.2010.05.015","article-title":"Efficacy of DNA vaccines carrying Eimeria acervulina lactate dehydrogenase antigen gene against coccidiosis","volume":"126","author":"Song","year":"2010","journal-title":"Exp. Parasitol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0330","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1126\/science.3128869","article-title":"Interferon-gamma: the major mediator of resistance against Toxoplasma gondii","volume":"240","author":"Suzuki","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.exppara.2014.08.011_bib0335","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.4049\/jimmunol.140.11.3943","article-title":"Dual regulation of resistance against Toxoplasma gondii infection by Lyt-2+ and Lyt-1+, L3T4+ T cells in mice","volume":"140","author":"Suzuki","year":"1988","journal-title":"J. Immunol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0340","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1128\/IAI.68.1.38-45.2000","article-title":"DNA vaccination with genes encoding Toxoplasma gondii antigens GRA1, GRA7, and ROP2 induces partially protective immunity against lethal challenge in mice","volume":"68","author":"Vercammen","year":"2000","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.08.011_bib0345","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10875-008-9251-y","article-title":"TGF-beta and regulatory T cell in immunity and autoimmunity","volume":"28","author":"Wan","year":"2008","journal-title":"J. Clin. Immunol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0350","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1128\/JCM.31.11.2952-2959.1993","article-title":"Role of specific immunoglobulin E in diagnosis of acute toxoplasma infection and toxoplasmosis","volume":"31","author":"Wong","year":"1993","journal-title":"J. Clin. Microbiol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0355","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/path.1877","article-title":"The function of immunoglobulin A in immunity","volume":"208","author":"Woof","year":"2006","journal-title":"J. Pathol"},{"key":"10.1016\/j.exppara.2014.08.011_bib0360","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1084\/jem.194.4.519","article-title":"Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense","volume":"194","author":"Ye","year":"2001","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.exppara.2014.08.011_bib0365","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S2095-3119(12)60133-6","article-title":"Isolation and molecular characterization of Toxoplasma gondii from chickens in China","volume":"11","author":"Zhao","year":"2012","journal-title":"J. Integr. Agric"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448941400201X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448941400201X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T07:51:06Z","timestamp":1689493866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448941400201X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":72,"alternative-id":["S001448941400201X"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2014.08.011","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunoglobulin and cytokine changes induced following immunization with a DNA vaccine encoding Toxoplasma gondii selenium-dependent glutathione reductase protein","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2014.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}